TR200100444T2 - Paroksetin Hidroklorid'in bir kristalin olmayan anhidrat formunun hazırlanma yöntemi - Google Patents

Paroksetin Hidroklorid'in bir kristalin olmayan anhidrat formunun hazırlanma yöntemi

Info

Publication number
TR200100444T2
TR200100444T2 TR2001/00444T TR200100444T TR200100444T2 TR 200100444 T2 TR200100444 T2 TR 200100444T2 TR 2001/00444 T TR2001/00444 T TR 2001/00444T TR 200100444 T TR200100444 T TR 200100444T TR 200100444 T2 TR200100444 T2 TR 200100444T2
Authority
TR
Turkey
Prior art keywords
paroxetine hydrochloride
preparation
anhydrate form
crystalline anhydrate
propan
Prior art date
Application number
TR2001/00444T
Other languages
English (en)
Inventor
Witold Jacewicz Victor
Ward Neal
Original Assignee
Smithkline Beecham P.L.C.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB9817196.0A external-priority patent/GB9817196D0/en
Priority claimed from GBGB9828777.4A external-priority patent/GB9828777D0/en
Application filed by Smithkline Beecham P.L.C. filed Critical Smithkline Beecham P.L.C.
Publication of TR200100444T2 publication Critical patent/TR200100444T2/tr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/4525—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with oxygen as a ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biomedical Technology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Propan-2-ol un çikartilmasi için paroksetin hidroklorid propan-2-ol-solvat desolvatlanir ve paroksetin hidroklorid anhidrat, solvat kitlesi isitilarak ve bu solvat kitlesindeki propan-2-ol miktari azaldikça isitma sicakligi artirilarak hazirlanir.
TR2001/00444T 1998-08-07 1999-08-06 Paroksetin Hidroklorid'in bir kristalin olmayan anhidrat formunun hazırlanma yöntemi TR200100444T2 (tr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB9817196.0A GB9817196D0 (en) 1998-08-07 1998-08-07 Novel process
GBGB9828777.4A GB9828777D0 (en) 1998-12-29 1998-12-29 Novel compounds

Publications (1)

Publication Number Publication Date
TR200100444T2 true TR200100444T2 (tr) 2001-07-23

Family

ID=26314179

Family Applications (1)

Application Number Title Priority Date Filing Date
TR2001/00444T TR200100444T2 (tr) 1998-08-07 1999-08-06 Paroksetin Hidroklorid'in bir kristalin olmayan anhidrat formunun hazırlanma yöntemi

Country Status (23)

Country Link
EP (2) EP1100796B1 (tr)
JP (1) JP2002522434A (tr)
KR (1) KR20010072323A (tr)
CN (1) CN1321155A (tr)
AP (2) AP0102072A0 (tr)
AT (1) ATE239016T1 (tr)
AU (1) AU5428999A (tr)
BG (1) BG105310A (tr)
BR (1) BR9912858A (tr)
CA (1) CA2339857A1 (tr)
DE (1) DE69907467T2 (tr)
DK (1) DK1100796T3 (tr)
EA (1) EA200100221A1 (tr)
ES (1) ES2198940T3 (tr)
HU (1) HUP0105466A3 (tr)
ID (1) ID27914A (tr)
IL (1) IL141286A0 (tr)
NO (1) NO20010629L (tr)
PL (1) PL345885A1 (tr)
PT (1) PT1100796E (tr)
SK (1) SK1972001A3 (tr)
TR (1) TR200100444T2 (tr)
WO (1) WO2000008017A1 (tr)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0812827B1 (en) 1996-06-13 2009-09-02 Sumitomo Chemical Company, Limited Piperidine derivative as intermediates for the preparation of paroxetine and process for their preparation
JP3796351B2 (ja) * 1998-04-13 2006-07-12 住友化学株式会社 パロキセチン塩酸塩無水和物の乾燥方法
GB9923446D0 (en) * 1999-10-04 1999-12-08 Smithkline Beecham Plc Novel process
DE60135489D1 (de) * 2000-11-17 2008-10-02 Lilly Co Eli Lactam dipeptid und dessen verwendung zur inhibierung der beta-amyloid peptid frisetzung
US8697094B2 (en) 2002-10-16 2014-04-15 Takeda Pharmaceutical Company Limited Stable solid preparations

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1422263A (en) * 1973-01-30 1976-01-21 Ferrosan As 4-phenyl-piperidine compounds
EP0223403B1 (en) * 1985-10-25 1993-08-04 Beecham Group Plc Piperidine derivative, its preparation, and its use as medicament
SK283608B6 (sk) * 1995-02-06 2003-10-07 Smithkline Beecham Plc Bezvodý hydrochlorid paroxetínu, spôsob jeho výroby a použitie
NZ336587A (en) * 1997-01-15 2001-01-26 Smithkline Beecham P Spray dried paroxetine compositions using organic solvent selected from pyridine, acetic acid, acetonitrile, acetone, ethanol, propan-1-ol or tetrahydrofuran
JP3796351B2 (ja) * 1998-04-13 2006-07-12 住友化学株式会社 パロキセチン塩酸塩無水和物の乾燥方法

Also Published As

Publication number Publication date
DE69907467T2 (de) 2004-03-11
EP1100796A1 (en) 2001-05-23
ID27914A (id) 2001-05-03
AU5428999A (en) 2000-02-28
NO20010629D0 (no) 2001-02-06
WO2000008017A1 (en) 2000-02-17
BR9912858A (pt) 2001-11-20
KR20010072323A (ko) 2001-07-31
JP2002522434A (ja) 2002-07-23
HUP0105466A3 (en) 2002-11-28
EP1100796B1 (en) 2003-05-02
ES2198940T3 (es) 2004-02-01
HK1038230A1 (en) 2002-03-08
AP0102072A0 (en) 2001-02-06
IL141286A0 (en) 2002-03-10
EA200100221A1 (ru) 2001-08-27
EP1321465A2 (en) 2003-06-25
PT1100796E (pt) 2003-09-30
DE69907467D1 (de) 2003-06-05
AP2001002072A0 (en) 2001-03-31
DK1100796T3 (da) 2003-08-25
HUP0105466A2 (hu) 2002-05-29
CA2339857A1 (en) 2000-02-17
CN1321155A (zh) 2001-11-07
PL345885A1 (en) 2002-01-14
SK1972001A3 (en) 2001-08-06
NO20010629L (no) 2001-03-20
ATE239016T1 (de) 2003-05-15
BG105310A (en) 2001-12-29
EP1321465A3 (en) 2003-09-03

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