TR200101030T2 - İnsanlara özgü NK3 reseptörlerinin seçici antagonistleri olarak üreidopiperidin türevleri - Google Patents

İnsanlara özgü NK3 reseptörlerinin seçici antagonistleri olarak üreidopiperidin türevleri

Info

Publication number
TR200101030T2
TR200101030T2 TR2001/01030T TR200101030T TR200101030T2 TR 200101030 T2 TR200101030 T2 TR 200101030T2 TR 2001/01030 T TR2001/01030 T TR 2001/01030T TR 200101030 T TR200101030 T TR 200101030T TR 200101030 T2 TR200101030 T2 TR 200101030T2
Authority
TR
Turkey
Prior art keywords
uureidopiperidine
receptors
derivatives
human
specific
Prior art date
Application number
TR2001/01030T
Other languages
English (en)
Inventor
Aulombard Alain
Edmonds-Alt Xavier
Proietto Vincenzo
Van Broeck Didiler
Original Assignee
Sanofi-Synthelabo
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi-Synthelabo filed Critical Sanofi-Synthelabo
Publication of TR200101030T2 publication Critical patent/TR200101030T2/tr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/60—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D211/62—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals attached in position 4
    • C07D211/64—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals attached in position 4 having an aryl radical as the second substituent in position 4
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/451—Non condensed piperidines, e.g. piperocaine having a carbocyclic group directly attached to the heterocyclic ring, e.g. glutethimide, meperidine, loperamide, phencyclidine, piminodine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/56—Nitrogen atoms
    • C07D211/58—Nitrogen atoms attached in position 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pain & Pain Management (AREA)
  • Pulmonology (AREA)
  • Epidemiology (AREA)
  • Hydrogenated Pyridines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Mevcut bulus; rasemik veya optik olarak saf formdaki, formül (I)'e sahip bilesikler, bahsedilen bilesikleri elde etmek için metotlar ve bu bilesikleri içeren farmasötik kompozisyonlar ile ilgilidir. Söz konusu bilesikler, seçici NK3 reseptör antagonistleridirler.
TR2001/01030T 1998-10-09 1999-10-04 İnsanlara özgü NK3 reseptörlerinin seçici antagonistleri olarak üreidopiperidin türevleri TR200101030T2 (tr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR9812859A FR2784377B3 (fr) 1998-10-09 1998-10-09 Nouveaux composes derives d'ureidopiperidine, antagonistes selectifs des recepteurs nk3 humains, procede pour leur obtention et compositions pharmaceutiques les contenant

Publications (1)

Publication Number Publication Date
TR200101030T2 true TR200101030T2 (tr) 2001-08-21

Family

ID=9531536

Family Applications (1)

Application Number Title Priority Date Filing Date
TR2001/01030T TR200101030T2 (tr) 1998-10-09 1999-10-04 İnsanlara özgü NK3 reseptörlerinin seçici antagonistleri olarak üreidopiperidin türevleri

Country Status (25)

Country Link
US (1) US6465489B1 (tr)
EP (1) EP1119552A1 (tr)
JP (1) JP2002527423A (tr)
KR (1) KR20010085903A (tr)
CN (1) CN1133622C (tr)
AR (1) AR029148A1 (tr)
AU (1) AU751592B2 (tr)
BR (1) BR9914397A (tr)
CA (1) CA2346729A1 (tr)
CO (1) CO5180555A1 (tr)
DZ (1) DZ2905A1 (tr)
EA (1) EA003613B1 (tr)
EE (1) EE200100214A (tr)
FR (1) FR2784377B3 (tr)
HU (1) HUP0201709A3 (tr)
IL (1) IL142362A0 (tr)
IS (1) IS5897A (tr)
NO (1) NO20011779L (tr)
NZ (1) NZ510779A (tr)
PL (1) PL347910A1 (tr)
SK (1) SK4642001A3 (tr)
TR (1) TR200101030T2 (tr)
TW (1) TW539669B (tr)
WO (1) WO2000021931A1 (tr)
YU (1) YU26001A (tr)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2001238690A1 (en) 2000-03-14 2001-09-24 Sepracor, Inc. 3-substituted piperidines comprising urea functionality, and methods of use thereof
US20060128752A1 (en) * 2002-07-03 2006-06-15 Giuseppe Alvaro Chemical compounds
US20110144081A1 (en) 2009-12-15 2011-06-16 Henner Knust Pyrrolidine derivatives
US9554659B2 (en) 2012-10-22 2017-01-31 Uwm Research Foundation, Inc. Infant sleep pod
USD711152S1 (en) 2013-10-22 2014-08-19 UMW Research Foundation, Inc. Infant sleep pod
CN113194948A (zh) * 2018-11-15 2021-07-30 国立大学法人九州大学 Il-31介导性疾病的预防或治疗剂及医药组合物

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL99320A (en) 1990-09-05 1995-07-31 Sanofi Sa Arylalkylamines, their preparation and pharmaceutical compositions containing them
FR2676055B1 (fr) 1991-05-03 1993-09-03 Sanofi Elf Composes polycycliques amines et leurs enantiomeres, procede pour leur preparation et compositions pharmaceutiques les contenant.
FR2688219B1 (fr) 1992-03-03 1994-07-08 Sanofi Elf Sels d'ammonium quaternaires de composes aromatiques amines, leur preparation et compositions pharmaceutiques les contenant.
FR2719311B1 (fr) * 1994-03-18 1998-06-26 Sanofi Sa Composés antagonistes sélectifs du récepteur NK3 humain et leur utilisation comme médicaments et outils de diagnostic.
FR2738819B1 (fr) 1995-09-14 1997-12-05 Sanofi Sa Nouveaux composes antagonistes selectifs du recepteur nk3 humain, procede pour leur obtention et compositions pharmaceutiques les contenant
WO1998011090A2 (en) 1996-09-16 1998-03-19 Warner-Lambert Company 3-alkyl-3-phenyl-piperidines

Also Published As

Publication number Publication date
IS5897A (is) 2001-03-16
PL347910A1 (en) 2002-04-22
AU751592B2 (en) 2002-08-22
FR2784377B3 (fr) 2000-11-17
NO20011779L (no) 2001-06-07
DZ2905A1 (fr) 2004-03-01
EA003613B1 (ru) 2003-06-26
HUP0201709A2 (en) 2002-09-28
KR20010085903A (ko) 2001-09-07
NZ510779A (en) 2003-07-25
CA2346729A1 (en) 2000-04-20
CN1133622C (zh) 2004-01-07
FR2784377A1 (fr) 2000-04-14
US6465489B1 (en) 2002-10-15
EP1119552A1 (fr) 2001-08-01
EA200100299A1 (ru) 2001-10-22
CO5180555A1 (es) 2002-07-30
WO2000021931A1 (fr) 2000-04-20
YU26001A (sh) 2003-04-30
IL142362A0 (en) 2002-03-10
JP2002527423A (ja) 2002-08-27
EE200100214A (et) 2002-08-15
CN1329594A (zh) 2002-01-02
NO20011779D0 (no) 2001-04-06
SK4642001A3 (en) 2001-09-11
HUP0201709A3 (en) 2003-03-28
AU5988799A (en) 2000-05-01
TW539669B (en) 2003-07-01
BR9914397A (pt) 2001-06-26
AR029148A1 (es) 2003-06-18

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