TR200102012T2 - Yumurtalık kanserinin tedavi yöntemleri, poli (fosfoester) bileşimler ile bunlara ait biyolojik olarak parçalanabilir maddeler. - Google Patents
Yumurtalık kanserinin tedavi yöntemleri, poli (fosfoester) bileşimler ile bunlara ait biyolojik olarak parçalanabilir maddeler.Info
- Publication number
- TR200102012T2 TR200102012T2 TR2001/02012T TR200102012T TR200102012T2 TR 200102012 T2 TR200102012 T2 TR 200102012T2 TR 2001/02012 T TR2001/02012 T TR 2001/02012T TR 200102012 T TR200102012 T TR 200102012T TR 200102012 T2 TR200102012 T2 TR 200102012T2
- Authority
- TR
- Turkey
- Prior art keywords
- experiment
- phosphoester
- ovarian cancer
- antineoplastic agent
- poly
- Prior art date
Links
- 239000000203 mixture Substances 0.000 title abstract 4
- 206010033128 Ovarian cancer Diseases 0.000 title abstract 2
- 206010061535 Ovarian neoplasm Diseases 0.000 title abstract 2
- 238000000034 method Methods 0.000 title abstract 2
- 239000000126 substance Substances 0.000 title abstract 2
- 229940034982 antineoplastic agent Drugs 0.000 abstract 4
- 239000002246 antineoplastic agent Substances 0.000 abstract 4
- 229920000642 polymer Polymers 0.000 abstract 3
- 229920002988 biodegradable polymer Polymers 0.000 abstract 2
- 239000004621 biodegradable polymer Substances 0.000 abstract 2
- 241000124008 Mammalia Species 0.000 abstract 1
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- 201000011510 cancer Diseases 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 238000011534 incubation Methods 0.000 abstract 1
- 210000004303 peritoneum Anatomy 0.000 abstract 1
- 230000004083 survival effect Effects 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1641—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
- A61K9/1647—Polyesters, e.g. poly(lactide-co-glycolide)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
- A61K9/7007—Drug-containing films, membranes or sheets
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S977/00—Nanotechnology
- Y10S977/902—Specified use of nanostructure
- Y10S977/904—Specified use of nanostructure for medical, immunological, body treatment, or diagnosis
- Y10S977/908—Mechanical repair performed/surgical
- Y10S977/911—Cancer cell destruction
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S977/00—Nanotechnology
- Y10S977/902—Specified use of nanostructure
- Y10S977/904—Specified use of nanostructure for medical, immunological, body treatment, or diagnosis
- Y10S977/908—Mechanical repair performed/surgical
- Y10S977/912—Cancer cell repair
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Inorganic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Biological Depolymerization Polymers (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Abstract
Yumurtalik kanseri memeli deneyin tedavisinde pertion içine verilmeye elverisli biyolojik olarak parçalanabilir polimer bilesimleri açiklanmaktadir. Bilesim (a) en azindan bir antineoplastik ajan ile (b) biyolojik olarak parçalanabilir bir fosfoester polimeri ihtiva eder. Burada polimer bilesimi antineoplastik ajanin deneyin peritonu içine uzatilmis süre ile verilebilmesini saglar. Deneye antineoplastik ajanla birlikte verilen polimer bilesimi, ayni dozaja sahip ancak bulusa konu biyolojik olarak parçalanabilir polimer olmaksizin deneye verilen antineoplastik ajanin sagladigi hayatta kalma oranini en azindan %10 arttirmaktadir. Yumurtalik kanserinin tedavisiyle ilgili kati madde ve yöntemler de tariflenmektedir.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US09/227,852 US6350464B1 (en) | 1999-01-11 | 1999-01-11 | Methods for treating ovarian cancer, poly (phosphoester) compositions, and biodegradable articles for same |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| TR200102012T2 true TR200102012T2 (tr) | 2002-01-21 |
Family
ID=22854735
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| TR2001/02012T TR200102012T2 (tr) | 1999-01-11 | 1999-12-23 | Yumurtalık kanserinin tedavi yöntemleri, poli (fosfoester) bileşimler ile bunlara ait biyolojik olarak parçalanabilir maddeler. |
Country Status (20)
| Country | Link |
|---|---|
| US (4) | US6350464B1 (tr) |
| EP (1) | EP1140028B1 (tr) |
| JP (1) | JP2002534456A (tr) |
| KR (1) | KR20010101472A (tr) |
| CN (1) | CN1337878A (tr) |
| AT (1) | ATE310506T1 (tr) |
| AU (1) | AU779182B2 (tr) |
| BR (1) | BR9916881A (tr) |
| CA (1) | CA2359109C (tr) |
| CZ (1) | CZ20012416A3 (tr) |
| DE (1) | DE69928567T2 (tr) |
| HU (1) | HUP0202670A3 (tr) |
| IL (2) | IL145087A0 (tr) |
| IN (1) | IN2001CH01053A (tr) |
| MX (1) | MX236541B (tr) |
| NO (1) | NO20013402L (tr) |
| RU (1) | RU2001122708A (tr) |
| TR (1) | TR200102012T2 (tr) |
| WO (1) | WO2000041678A1 (tr) |
| ZA (1) | ZA200106499B (tr) |
Families Citing this family (30)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1096957A1 (en) | 1998-06-18 | 2001-05-09 | Johns Hopkins University School of Medicine | Methods and reagents for intramuscular delivery of nucleic acids |
| US6537585B1 (en) * | 1999-03-26 | 2003-03-25 | Guilford Pharmaceuticals, Inc. | Methods and compositions for treating solid tumors |
| AU6536400A (en) * | 1999-08-11 | 2001-03-05 | Alkermes Controlled Therapeutics, Inc. | Method of delivering a chemotherapeutic agent to a solid tumor |
| WO2002003957A2 (en) * | 2000-07-07 | 2002-01-17 | Guilford Pharmaceuticals, Inc. | Compositions for sustained release of antineoplastic taxanes, and methods of making and using the same |
| WO2002005800A2 (en) * | 2000-07-17 | 2002-01-24 | Guilford Pharmaceuticals, Inc. | Compositions for sustained release of analgesic agents, and methods of making and using the same |
| WO2002028372A2 (en) * | 2000-10-06 | 2002-04-11 | Johns Hopkins University | Systemic delivery of compounds through non-invasive bladder administration |
| US20020198135A1 (en) * | 2000-10-12 | 2002-12-26 | Wenbin Dang | Compositions for release of radiosensitizers, and methods of making and using the same |
| US20020141966A1 (en) * | 2000-11-16 | 2002-10-03 | Wenbin Dang | Compositions for treatment of malignant effusions, and methods of making and using the same |
| WO2003007914A2 (en) * | 2001-07-19 | 2003-01-30 | Guilford Pharmaceuticals, Inc. | Biocompatible polymer containing composition for treatment of prostate cancers |
| WO2003007915A2 (en) * | 2001-07-19 | 2003-01-30 | Guilford Pharmaceuticals, Inc. | Compositions for treatment of head and neck cancers, and methods of making and using the same |
| US20050238616A1 (en) * | 2002-01-09 | 2005-10-27 | Guilford Pharmaceuticals, Inc. | Compositions for treatment of central nervous system neoplasms, and methods of making and using the same |
| ITMI20020680A1 (it) * | 2002-03-29 | 2003-09-29 | Acs Dobfar Spa | Composizione antitumorale migliorata a base di paclitaxel e metodo per il suo ottenimento |
| US20050244402A1 (en) * | 2004-04-30 | 2005-11-03 | Villanueva Julie M | Absorption of pain-causing agents |
| WO2006002365A2 (en) * | 2004-06-24 | 2006-01-05 | Angiotech International Ag | Microparticles with high loadings of a bioactive agent |
| US8563328B2 (en) * | 2004-07-26 | 2013-10-22 | University Of Louisville Research Foundation, Inc. | Fiber-optic biosensor and biosensing methods |
| US7871573B2 (en) * | 2004-07-26 | 2011-01-18 | University Of Louisville Research Foundation, Inc. | Enhancement of sensitivity of fluorophore mediated biosensing and bioimaging |
| US7517914B2 (en) * | 2005-04-04 | 2009-04-14 | Boston Scientificscimed, Inc. | Controlled degradation materials for therapeutic agent delivery |
| US8580814B2 (en) * | 2006-04-03 | 2013-11-12 | Sunesis Pharmaceuticals, Inc. | Methods of using (+)-1,4-dihydro-7-[(3S,4S)-3-methoxy-4-(methylamino)-1-pyrrolidinyl]-4- oxo-1-(2-thiazolyl)-1,8-naphthyridine-3-carboxylic acid for treatment of cancer |
| GB0525864D0 (en) * | 2005-12-20 | 2006-02-01 | Novartis Ag | Organic compounds |
| EP3061791B1 (en) | 2006-07-20 | 2019-01-16 | OrbusNeich Medical, Inc. | Bioabsorbable polymeric composition for a medical device |
| US20090169628A1 (en) | 2006-10-17 | 2009-07-02 | Armark Authentication Technologies, Llc | Article and method for focused delivery of therapeutic and/or diagnostic materials |
| US7959942B2 (en) | 2006-10-20 | 2011-06-14 | Orbusneich Medical, Inc. | Bioabsorbable medical device with coating |
| EP2073754A4 (en) | 2006-10-20 | 2012-09-26 | Orbusneich Medical Inc | BIOABSORBABLE POLYMER COMPOSITION AND MEDICAL DEVICE BACKGROUND |
| CA2709712C (en) | 2007-12-20 | 2016-05-10 | Surmodics Pharmaceuticals, Inc. | Process for preparing microparticles having a low residual solvent volume |
| EP2242481A1 (en) * | 2007-12-31 | 2010-10-27 | Armark Authentication Technologies, LLC | Article and method for focused delivery of therapeutic and/or diagnostic materials |
| US20100078848A1 (en) * | 2008-09-29 | 2010-04-01 | Armark Authentication Technologies, Llc | Spinneret and method of spinning fiber |
| US20100291214A1 (en) * | 2008-12-23 | 2010-11-18 | Armark Authentication Technologies, Llc | Three-dimensional microfiber extrudate structure and process for forming three-dimensional microfiber extrudate structure |
| WO2010132763A1 (en) * | 2009-05-15 | 2010-11-18 | Armark Authentication Technologies, Llc | Fiber having non-uniform composition and method for making same |
| JP2014523444A (ja) * | 2011-07-19 | 2014-09-11 | エスティーシー. ユーエヌエム | 癌の炎症性環境に基づいて治療用積載物を放出する、腹腔内投与されるナノ担体 |
| US10058688B2 (en) * | 2012-05-09 | 2018-08-28 | Massachusetts Institute Of Technology | Medicament, method, and drug delivery device for treatment of ovarian cancer |
Family Cites Families (41)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA597473A (en) | 1960-05-03 | Starck Werner | Process for the manufacture of phosphorus-containing polyesters and copolymers thereof | |
| US2891915A (en) | 1954-07-02 | 1959-06-23 | Du Pont | Organophosphorus polymers |
| US3271329A (en) | 1958-09-19 | 1966-09-06 | Eastman Kodak Co | Method for producing polymers derived from phosphites and glycols |
| US3442982A (en) | 1965-10-15 | 1969-05-06 | Weston Chemical Corp | Polyphosphites of 2,2-dimethyl-3-hydroxypropyl - 2 - dimethyl - 3-hydroxypropionate |
| FR2219193B1 (tr) | 1973-02-28 | 1976-05-21 | Rhone Poulenc Sa | |
| US3932566A (en) | 1974-09-16 | 1976-01-13 | Celanese Corporation | Phosphonate polymers |
| US4100354A (en) | 1976-08-05 | 1978-07-11 | Owens-Corning Fiberglass Corporation | Terephthalate ester polyols |
| US4259222A (en) | 1978-08-16 | 1981-03-31 | Basf Wyandotte Corporation | Linear saturated polyesters of phosphoric acid and halogenated diols as flame-retardant additives and coatings |
| DE2925206A1 (de) | 1979-06-22 | 1981-01-29 | Bayer Ag | Aromatische polyesterphosphonate, verfahren zu ihrer herstellung und ihre verwendung zur herstellung thermoplastischer formkoerper |
| FR2498612A1 (fr) | 1981-01-26 | 1982-07-30 | Peters Ligatures | Nouveaux polymeres insolubles a biodegradabilite reglable a volonte, leurs procedes de preparation et leur application en tant que biomateriaux |
| US4757128A (en) | 1986-08-01 | 1988-07-12 | Massachusetts Institute Of Technology | High molecular weight polyanhydride and preparation thereof |
| US4474937A (en) | 1983-10-03 | 1984-10-02 | The Dow Chemical Company | Phosphorus-modified polyestercarbonate resins |
| US4481353A (en) | 1983-10-07 | 1984-11-06 | The Children's Medical Center Corporation | Bioresorbable polyesters and polyester composites |
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| US5256765A (en) | 1989-03-09 | 1993-10-26 | The Johns Hopkins University School Of Medicine | Biodegradable poly(phosphate esters) |
| US5194581A (en) | 1989-03-09 | 1993-03-16 | Leong Kam W | Biodegradable poly(phosphoesters) |
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| UA54505C2 (uk) | 1997-04-03 | 2003-03-17 | Гілфорд Фармасьютікалз Інк. | Полімери, що біологічно розкладаються, зшиті фосфатами, композиції, вироби і способи для їх виготовлення і використання |
| KR20010006026A (ko) | 1997-04-03 | 2001-01-15 | 존스 홉킨스 유니버시티 스쿨 오브 메디슨 | 생물분해성 테레프탈레이트 폴리에스테르-폴리(포스페이트) 중합체, 조성물, 약품 및 그의 제조방법과 이용방법 |
| US5912225A (en) | 1997-04-14 | 1999-06-15 | Johns Hopkins Univ. School Of Medicine | Biodegradable poly (phosphoester-co-desaminotyrosyl L-tyrosine ester) compounds, compositions, articles and methods for making and using the same |
| NZ501184A (en) | 1997-04-30 | 2002-08-28 | Guilford Pharm Inc | Biodegradable poly (phosphodiester) compositions that degrade in vivo into non-toxic residues |
| WO1998058012A1 (en) | 1997-06-18 | 1998-12-23 | Guilford Pharmaceuticals Inc. | Two-stage solution polymerization of high molecular weight poly(phosphoesters) |
| US6028163A (en) | 1997-06-27 | 2000-02-22 | Guilford Pharmaceuticals Inc. | Solution polymerization of high molecular weight poly(phosphoesters) in toluene |
| US6419709B1 (en) | 1998-10-02 | 2002-07-16 | Guilford Pharmaceuticals, Inc. | Biodegradable terephthalate polyester-poly(Phosphite) compositions, articles, and methods of using the same |
| US6153212A (en) * | 1998-10-02 | 2000-11-28 | Guilford Pharmaceuticals Inc. | Biodegradable terephthalate polyester-poly (phosphonate) compositions, articles, and methods of using the same |
| EP1117441A2 (en) | 1998-10-02 | 2001-07-25 | Guilford Pharmaceuticals Inc. | Biodegradable terephthalate polyester-poly(phosphonate) and polyester-poly(phosphite) compositions, articles, and methods of using them |
| US6537585B1 (en) * | 1999-03-26 | 2003-03-25 | Guilford Pharmaceuticals, Inc. | Methods and compositions for treating solid tumors |
| CA2369740A1 (en) | 1999-04-22 | 2000-11-02 | American Biosciences, Inc. | Long term administration of pharmacologically active agents |
-
1999
- 1999-01-11 US US09/227,852 patent/US6350464B1/en not_active Expired - Fee Related
- 1999-02-25 IL IL14508799A patent/IL145087A0/xx unknown
- 1999-12-23 WO PCT/US1999/030814 patent/WO2000041678A1/en not_active Ceased
- 1999-12-23 CN CN99816287A patent/CN1337878A/zh active Pending
- 1999-12-23 CA CA2359109A patent/CA2359109C/en not_active Expired - Fee Related
- 1999-12-23 KR KR1020017008774A patent/KR20010101472A/ko not_active Withdrawn
- 1999-12-23 JP JP2000593290A patent/JP2002534456A/ja active Pending
- 1999-12-23 MX MXPA01007018 patent/MX236541B/es not_active IP Right Cessation
- 1999-12-23 HU HU0202670A patent/HUP0202670A3/hu unknown
- 1999-12-23 AT AT99964321T patent/ATE310506T1/de not_active IP Right Cessation
- 1999-12-23 EP EP99964321A patent/EP1140028B1/en not_active Expired - Lifetime
- 1999-12-23 AU AU20591/00A patent/AU779182B2/en not_active Expired - Fee Related
- 1999-12-23 DE DE69928567T patent/DE69928567T2/de not_active Expired - Lifetime
- 1999-12-23 TR TR2001/02012T patent/TR200102012T2/tr unknown
- 1999-12-23 RU RU2001122708/15A patent/RU2001122708A/ru unknown
- 1999-12-23 CZ CZ20012416A patent/CZ20012416A3/cs unknown
- 1999-12-23 BR BR9916881-2A patent/BR9916881A/pt not_active Application Discontinuation
- 1999-12-23 IL IL14408799A patent/IL144087A0/xx unknown
-
2001
- 2001-03-28 US US09/819,376 patent/US6479067B2/en not_active Expired - Fee Related
- 2001-07-09 NO NO20013402A patent/NO20013402L/no not_active Application Discontinuation
- 2001-07-25 IN IN1053CH2001 patent/IN2001CH01053A/xx unknown
- 2001-08-07 ZA ZA200106499A patent/ZA200106499B/xx unknown
-
2002
- 2002-10-04 US US10/264,793 patent/US6641833B2/en not_active Expired - Fee Related
-
2003
- 2003-08-14 US US10/641,301 patent/US20040071774A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| HUP0202670A3 (en) | 2003-02-28 |
| IL145087A0 (en) | 2002-06-30 |
| EP1140028A1 (en) | 2001-10-10 |
| HUP0202670A2 (hu) | 2002-11-28 |
| US20030138493A1 (en) | 2003-07-24 |
| CA2359109C (en) | 2011-02-22 |
| EP1140028B1 (en) | 2005-11-23 |
| JP2002534456A (ja) | 2002-10-15 |
| KR20010101472A (ko) | 2001-11-14 |
| US20010038849A1 (en) | 2001-11-08 |
| MX236541B (es) | 2006-05-04 |
| ATE310506T1 (de) | 2005-12-15 |
| DE69928567T2 (de) | 2006-08-17 |
| IL144087A0 (en) | 2002-05-23 |
| CN1337878A (zh) | 2002-02-27 |
| ZA200106499B (en) | 2002-11-07 |
| CA2359109A1 (en) | 2000-07-20 |
| AU2059100A (en) | 2000-08-01 |
| US6479067B2 (en) | 2002-11-12 |
| US6641833B2 (en) | 2003-11-04 |
| AU779182B2 (en) | 2005-01-13 |
| WO2000041678A1 (en) | 2000-07-20 |
| RU2001122708A (ru) | 2004-02-20 |
| BR9916881A (pt) | 2002-05-07 |
| NO20013402D0 (no) | 2001-07-09 |
| US20040071774A1 (en) | 2004-04-15 |
| DE69928567D1 (de) | 2005-12-29 |
| IN2001CH01053A (en) | 2005-03-04 |
| MXPA01007018A (es) | 2005-07-01 |
| US6350464B1 (en) | 2002-02-26 |
| NO20013402L (no) | 2001-09-11 |
| CZ20012416A3 (cs) | 2001-11-14 |
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