TR201005221A2 - Geliştirilmiş sentez metodu. - Google Patents

Geliştirilmiş sentez metodu.

Info

Publication number
TR201005221A2
TR201005221A2 TR2010/05221A TR201005221A TR201005221A2 TR 201005221 A2 TR201005221 A2 TR 201005221A2 TR 2010/05221 A TR2010/05221 A TR 2010/05221A TR 201005221 A TR201005221 A TR 201005221A TR 201005221 A2 TR201005221 A2 TR 201005221A2
Authority
TR
Turkey
Prior art keywords
synthesis method
improved synthesis
improved
hydroxyd
azoniatricyclo
Prior art date
Application number
TR2010/05221A
Other languages
English (en)
Inventor
Bi̇lgi̇ç Mahmut
Original Assignee
Bi̇lgi̇ç Mahmut
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from TR2010/02520A external-priority patent/TR201002520A2/tr
Application filed by Bi̇lgi̇ç Mahmut filed Critical Bi̇lgi̇ç Mahmut
Priority to TR2010/05221A priority Critical patent/TR201005221A2/tr
Priority to PCT/TR2011/000051 priority patent/WO2011123079A1/en
Priority to EP11713099.7A priority patent/EP2552912B1/en
Publication of TR201005221A2 publication Critical patent/TR201005221A2/tr
Priority to US13/632,593 priority patent/US8957209B2/en
Priority to US14/605,618 priority patent/US9242979B2/en
Priority to US15/005,136 priority patent/US9440945B2/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
    • C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
    • C07D451/06—Oxygen atoms
    • C07D451/10—Oxygen atoms acylated by aliphatic or araliphatic carboxylic acids, e.g. atropine, scopolamine

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

Mevcut buluş (la, 2p, 4p, 5a, 7P)-7-[(hidroksidi-2-tieni asetil)oksi]-9,9-dimetil-3-oksa-9-azoniatrisiklo[3.3.1.0 ]nonan-bromid imal etmeye yönelik yeni bir yöntem ile ilgilidir.
TR2010/05221A 2010-04-01 2010-06-28 Geliştirilmiş sentez metodu. TR201005221A2 (tr)

Priority Applications (6)

Application Number Priority Date Filing Date Title
TR2010/05221A TR201005221A2 (tr) 2010-04-01 2010-06-28 Geliştirilmiş sentez metodu.
PCT/TR2011/000051 WO2011123079A1 (en) 2010-04-01 2011-02-23 Synthesis method for producing tiotropium bromide
EP11713099.7A EP2552912B1 (en) 2010-04-01 2011-02-23 Synthesis method for producing tiotropium bromide
US13/632,593 US8957209B2 (en) 2010-04-01 2012-10-01 Methods for the synthesis of tiotropium bromide
US14/605,618 US9242979B2 (en) 2010-04-01 2015-01-26 Methods for the synthesis of tiotropium bromide
US15/005,136 US9440945B2 (en) 2010-04-01 2016-01-25 Methods for the synthesis of tiotropium bromide

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
TR2010/02520A TR201002520A2 (tr) 2010-04-01 2010-04-01 Tiotropyum bromür imalat metodu.
TR2010/05221A TR201005221A2 (tr) 2010-04-01 2010-06-28 Geliştirilmiş sentez metodu.

Publications (1)

Publication Number Publication Date
TR201005221A2 true TR201005221A2 (tr) 2012-01-23

Family

ID=43881214

Family Applications (1)

Application Number Title Priority Date Filing Date
TR2010/05221A TR201005221A2 (tr) 2010-04-01 2010-06-28 Geliştirilmiş sentez metodu.

Country Status (3)

Country Link
EP (1) EP2552912B1 (tr)
TR (1) TR201005221A2 (tr)
WO (1) WO2011123079A1 (tr)

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3931041C2 (de) 1989-09-16 2000-04-06 Boehringer Ingelheim Kg Ester von Thienylcarbonsäuren mit Aminoalkoholen, ihre Quaternierungsprodukte, Verfahren zu ihrer Herstellung und diese enthaltende Arzneimittel
DE10200943A1 (de) * 2002-01-12 2003-07-24 Boehringer Ingelheim Pharma Verfahren zur Herstellung von Scopinestern
WO2008089852A1 (de) * 2007-01-26 2008-07-31 Boehringer Ingelheim Pharma Gmbh & Co.Kg Neues verfahren zur herstellung von tiotropiumsalzen
EP2240477B8 (en) * 2008-01-10 2014-12-10 Generics [UK] Limited Novel process for the preparation of scopine esters

Also Published As

Publication number Publication date
WO2011123079A1 (en) 2011-10-06
EP2552912A1 (en) 2013-02-06
EP2552912B1 (en) 2017-08-02

Similar Documents

Publication Publication Date Title
MA34818B1 (fr) Anticorps anti-pcsk9 et procédés d&#39;utilisation
MX341133B (es) Compuestos y metodos para la inhibición de hdac.
UY34216A (es) Nuevos compuestos que inhiben la actividad de la Lp-PLA2
MX2010007840A (es) Formas cristalinas del dimetoxi-docetaxel y sus procedimientos de preparacion.
UY32292A (es) Agonistas de s1p1 y métodos de preparación y uso
BR112012019874A2 (pt) &#34;armações organometálicas derivadas a partir de metais carbenofilicos e método de produção das mesmas.&#34;
UY34350A (es) Derivados de pirazolquinolinona, su preparación y su uso terapéutico.
EP2566477A4 (en) AMINO-QUINOLINES AS KINASE INHIBITORS
UA122324C2 (uk) Терапевтично активні сполуки і способи їх застосування
WO2011106322A3 (en) Biomarkers for acute ischemic stroke
ATE495176T1 (de) Spiroindolinon-derivate
EP2599005A4 (en) Highly reliable cross-session web application instrumentation
NI201100149A (es) Derivados de tiadiazoles y oxadiazoles, su preparación y su aplicación en terapia.
MX2014001134A (es) Estructuras fibrosas.
MY159814A (en) Cellulosic material such as tobacco comprising one or more smoke diluents
MX349563B (es) Formulacion farmaceutica de fenofibrato nanonizado.
PA8852001A1 (es) Derivados de lisina y ornitina marcados con radioisótopos, su uso y procesos para su preparación
TR201005221A2 (tr) Geliştirilmiş sentez metodu.
TR200904500A2 (tr) Ezetimib nanokristallerinin hazırlanması için yöntem ve farmasötik formülasyonları.
GR20120100608A (el) Προ-συναρμολογημενη εκθεσιακη κατασκευη
CO6561812A2 (es) Derivados de 2-aldoximino-5-fluoropirimidina
TR201005222A2 (tr) Tiotropyum bromür sentez yöntemi
MX2011011180A (es) Compuestos que tienen efecto fisiologico.
EA201400882A1 (ru) Способ стереоселективного синтеза 9-гидрокси-5-оксо-1,4-диазаспиро[5.5]ундеканов, содержащих защитные группы в 1,4-положениях
WO2011119771A3 (en) Methods and compositions for detecting protein modifications