TR201904662T4 - Anti-fxı antikorları ve kullanma yöntemleri. - Google Patents

Anti-fxı antikorları ve kullanma yöntemleri. Download PDF

Info

Publication number
TR201904662T4
TR201904662T4 TR2019/04662T TR201904662T TR201904662T4 TR 201904662 T4 TR201904662 T4 TR 201904662T4 TR 2019/04662 T TR2019/04662 T TR 2019/04662T TR 201904662 T TR201904662 T TR 201904662T TR 201904662 T4 TR201904662 T4 TR 201904662T4
Authority
TR
Turkey
Prior art keywords
fxi
monoclonal antibodies
antibodies
patent application
fxiia
Prior art date
Application number
TR2019/04662T
Other languages
English (en)
Inventor
Gruber Andras
I Tucker Erik
Gailani David
Original Assignee
Gruber Andras
Gailani David
I Tucker Erik
Univ Oregon Health & Science
Univ Vanderbilt
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Gruber Andras, Gailani David, I Tucker Erik, Univ Oregon Health & Science, Univ Vanderbilt filed Critical Gruber Andras
Publication of TR201904662T4 publication Critical patent/TR201904662T4/tr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/36—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against blood coagulation factors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/569—Single domain, e.g. dAb, sdAb, VHH, VNAR or nanobody®
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Hematology (AREA)
  • Biochemistry (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Diabetes (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

Bu patent başvurusunda, faktör XI (fXI) için spesifik olan ve faktör XIIa (fXIIa) ile fXI aktivasyonunu önleyen monoklonal antikorlar açıklanmaktadır. Bu monoklonal antikorlar, test edilen tüm memeli türlerini bağlama kabiliyeti bulunan evrensel fXI antikorlarıdırlar. Anti-fXI monoklonal antikorları, memeli plazmalarında pıhtılaşma süresini uzatırlar. Ayrıca, bu patent başvurusunda açıklanan fXI monoklonal antikorlarının uygulanması, trombozun hayvan modellerinde, trombozun hemostazı değiştirmeden inhibe edilmesiyle sonuçlanmaktadır. Dolayısıyla, bu patent başvurusunda, fXI için spesifik olan ve fXIIa ile fXI aktivasyonunu bloke eden monoklonal antikorlar, bu tür antikorları içeren bileşimler ve immünokonjügatlar ve ayrıca, bunları kullanma yöntemleri açıklanmaktadır.
TR2019/04662T 2008-12-18 2009-12-18 Anti-fxı antikorları ve kullanma yöntemleri. TR201904662T4 (tr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US13859008P 2008-12-18 2008-12-18

Publications (1)

Publication Number Publication Date
TR201904662T4 true TR201904662T4 (tr) 2019-05-21

Family

ID=42317079

Family Applications (1)

Application Number Title Priority Date Filing Date
TR2019/04662T TR201904662T4 (tr) 2008-12-18 2009-12-18 Anti-fxı antikorları ve kullanma yöntemleri.

Country Status (15)

Country Link
US (3) US8388959B2 (tr)
EP (1) EP2373691B1 (tr)
AU (1) AU2009335643B2 (tr)
CA (1) CA2747519C (tr)
CY (1) CY1121562T1 (tr)
DK (1) DK2373691T3 (tr)
ES (1) ES2720594T3 (tr)
HR (1) HRP20190605T1 (tr)
HU (1) HUE042940T2 (tr)
LT (1) LT2373691T (tr)
PL (1) PL2373691T3 (tr)
PT (1) PT2373691T (tr)
SI (1) SI2373691T1 (tr)
TR (1) TR201904662T4 (tr)
WO (1) WO2010080623A2 (tr)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20160046728A1 (en) * 2007-10-31 2016-02-18 Bioxodes Sa Identification and molecular characterisation of proteins, expressed in the ixodes ricinus salivary glands
TR201904662T4 (tr) * 2008-12-18 2019-05-21 Gruber Andras Anti-fxı antikorları ve kullanma yöntemleri.
CN102600471A (zh) * 2012-02-15 2012-07-25 中国人民解放军军事医学科学院微生物流行病研究所 一种败血症治疗的靶点
EP2847228B1 (en) * 2012-05-10 2018-07-25 Bayer Pharma Aktiengesellschaft Antibodies capable of binding to the coagulation factor xi and/or its activated form factor xia and uses thereof
US9574013B2 (en) 2012-12-07 2017-02-21 Vanderbilt University Antibodies against factor XII and uses thereof
IL253180B2 (en) 2015-01-02 2023-04-01 Dyax Corp Bispecific antibodies against plasma kallikrein and factor xii
JOP20200312A1 (ar) 2015-06-26 2017-06-16 Novartis Ag الأجسام المضادة للعامل xi وطرق الاستخدام
KR102794955B1 (ko) 2015-07-21 2025-04-15 다케다 파머수티컬 컴패니 리미티드 Xiia 인자의 단일클론 항체 저해제
US11066481B2 (en) 2015-07-23 2021-07-20 The Regents Of The University Of California Antibodies to coagulation factor XIa and uses thereof
BR112018014810A2 (pt) * 2016-01-22 2018-12-11 Merck Sharp & Dohme Corp. anticorpos anti-fator xi de coagulação
CN109153726A (zh) 2016-03-23 2019-01-04 普希克斯私人有限公司 抗因子xi的活性位点的单克隆抗体及其用途
EP3455636B1 (en) * 2016-05-13 2023-08-23 The Scripps Research Institute Compositions and methods for anti-thrombotic and hemostatic therapies
TW201802121A (zh) 2016-05-25 2018-01-16 諾華公司 抗因子XI/XIa抗體之逆轉結合劑及其用途
CN116425879A (zh) * 2016-06-14 2023-07-14 默沙东有限责任公司 抗-凝血因子xi抗体
CN110099927A (zh) * 2016-09-20 2019-08-06 拜耳医药股份公司 对抗xi因子的新型抗体及其用途
KR102702288B1 (ko) * 2016-12-23 2024-09-05 노파르티스 아게 항-인자 XI/XIa 항체를 사용한 치료 방법
US11168147B2 (en) 2016-12-23 2021-11-09 Novartis Ag Factor XI antibodies and methods of use
US11958911B2 (en) * 2017-02-10 2024-04-16 Shanghai Benemae Pharmaceutical Anti-coagulation factor XI antibody
CN108409863B (zh) 2017-02-10 2023-09-26 上海仁会生物制药股份有限公司 抗凝血因子xi抗体
CA3083210A1 (en) 2017-11-22 2018-11-20 Novartis Ag Reversal binding agents for anti-factor xi/xia antibodies and uses thereof
BR112021002472A2 (pt) * 2018-08-09 2021-07-27 Shanghai Benemae Pharmaceutical Corporation anticorpos antifator xi
CN113474373B (zh) * 2019-01-21 2025-09-02 阿罗诺拉股份有限公司 具有抗血栓形成和抗炎作用的新型抗因子xi人源化抗体及其用途
JP7650807B2 (ja) 2019-04-16 2025-03-25 シチュアン ケルン－バイオテック バイオファーマシューティカル カンパニー リミテッド 抗ＦＸＩ／ＦＸＩａ抗体及びその使用
JP2023106635A (ja) 2020-04-17 2023-08-02 中外製薬株式会社 二重特異性抗原結合分子ならびに、それに関連する組成物、組成物の製造のための使用、キット、および方法
US20230220111A1 (en) * 2020-07-02 2023-07-13 Beijing Tuo Jie Biopharmaceutical Co. Ltd. Anti-fxi/fxia antibody, antigen-binding fragment thereof, and pharmaceutical use thereof
WO2022002233A1 (zh) 2020-07-03 2022-01-06 苏州康宁杰瑞生物科技有限公司 凝血因子xi(fxi)结合蛋白
IL312308A (en) 2021-10-22 2024-06-01 Regeneron Pharma Antibodies that bind to the A2 domain of factor XI and their uses

Family Cites Families (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030235587A1 (en) 1998-08-07 2003-12-25 Feuerstein Giora Z. Anticoagulant agents useful in treatment of thrombosis
GB9701425D0 (en) 1997-01-24 1997-03-12 Bioinvent Int Ab A method for in vitro molecular evolution of protein function
WO2000007626A1 (en) * 1998-08-07 2000-02-17 Smithkline Beecham Corporation Use of anti-coagulation factor antibodies as long-lasting protective agents
US20080138837A1 (en) * 2004-07-19 2008-06-12 Robert Greenfield Methods and kits for detecting and measuring ADAMTS13/FXI complexes
US7270976B2 (en) * 2004-07-19 2007-09-18 American Diagnostica, Inc. Methods for measuring ADAMTS13 activity and protein on platelets and in plasma
US8574849B2 (en) * 2007-10-03 2013-11-05 The University Of Vermont And State Agriculture College Methods of detection of factor XIa and tissue factor
ES2566963T3 (es) * 2007-11-21 2016-04-18 Oregon Health & Science University Anticuerpos monoclonales anti-factor XI y métodos de uso de los mismos
US20110159006A1 (en) 2008-06-19 2011-06-30 Erik Hack Use of anti-factor xi antibodies for prevention of thrombus formation
WO2010065275A1 (en) 2008-11-25 2010-06-10 Merck Sharp & Dohme Corp. Soluble guanylate cyclase activators
TR201904662T4 (tr) * 2008-12-18 2019-05-21 Gruber Andras Anti-fxı antikorları ve kullanma yöntemleri.
EP2575473B1 (en) 2010-05-27 2016-01-20 Merck Sharp & Dohme Corp. Soluble guanylate cyclase activators
US20130158028A1 (en) 2010-06-25 2013-06-20 Bayer Intellectual Property Gmbh Use of stimulators and activators of soluble guanylate cyclase for treating sickle-cell anemia and conserving blood substitutes
PH12013500055A1 (en) 2010-07-09 2017-08-23 Bayer Ip Gmbh Ring-fused pyrimidines and triazines and use thereof for the treatment and/or prophylaxis of cardiovascular diseases
DE102010040233A1 (de) 2010-09-03 2012-03-08 Bayer Schering Pharma Aktiengesellschaft Bicyclische Aza-Heterocyclen und ihre Verwendung
ES2583086T3 (es) 2011-04-21 2016-09-19 Bayer Intellectual Property Gmbh Pirazolopiridinas sustituidas con fluoroalquilo y su uso
EP2705037B1 (de) 2011-05-06 2016-06-22 Bayer Intellectual Property GmbH Substituierte imidazopyridine und imidazopyridazine und ihre verwendung
EP2763990B1 (en) 2011-09-01 2017-02-22 F. Hoffmann-La Roche AG Pyrrolopyrazine kinase inhibitors
MX348470B (es) 2011-09-02 2017-06-13 Bayer Ip Gmbh Pirimidinas anilladas sustituidas y uso de las mismas.
EP2847228B1 (en) 2012-05-10 2018-07-25 Bayer Pharma Aktiengesellschaft Antibodies capable of binding to the coagulation factor xi and/or its activated form factor xia and uses thereof

Also Published As

Publication number Publication date
US20110250207A1 (en) 2011-10-13
US8940883B2 (en) 2015-01-27
US20150093395A1 (en) 2015-04-02
CY1121562T1 (el) 2020-05-29
WO2010080623A2 (en) 2010-07-15
AU2009335643A1 (en) 2011-07-07
US20130129745A1 (en) 2013-05-23
PL2373691T3 (pl) 2019-07-31
AU2009335643B2 (en) 2014-05-29
DK2373691T3 (en) 2019-04-15
WO2010080623A3 (en) 2010-11-18
LT2373691T (lt) 2019-05-27
US9637550B2 (en) 2017-05-02
CA2747519A1 (en) 2010-07-15
HUE042940T2 (hu) 2019-07-29
ES2720594T3 (es) 2019-07-23
US8388959B2 (en) 2013-03-05
HRP20190605T1 (hr) 2019-05-31
EP2373691A4 (en) 2012-10-31
PT2373691T (pt) 2019-05-08
EP2373691A2 (en) 2011-10-12
CA2747519C (en) 2019-04-02
SI2373691T1 (sl) 2019-05-31
EP2373691B1 (en) 2019-01-23

Similar Documents

Publication Publication Date Title
TR201904662T4 (tr) Anti-fxı antikorları ve kullanma yöntemleri.
CY1121536T1 (el) Ανθρωπινα αντισωματα εναντι-αλφα-συνουκλεϊνης
PH12019501126A1 (en) Bispecific antibodies binding to coagulation factor ix and ciagulation factor x
EA200970210A1 (ru) Prlr-специфическое антитело и его применения
AR061246A1 (es) Anticuerpos anti- dill4 y metodos que los usan
EA201100300A1 (ru) Композиции и способы, предназначенные для направленного воздействия антител на белок c5 системы комплемента
NO20083397L (no) Anti-EphB4-antistoffer og fremgangsmater for anvendelse av disse
BR112016016916A8 (pt) uso de um anticorpo que se liga à calicreína plasmática ativa para tratamento de angiodema hereditário (hae)
MX2018005512A (es) Agentes de union de esclerostina.
MX2019007554A (es) Proteínas de uníon al antígeno anti-neuropilina, y sus métodos de uso.
EA200901313A1 (ru) Ингибиторы тирозинкиназы брутона
NO20084878L (no) Humanisert C-kit antistoff
EA200702278A1 (ru) Антитела, специфичные в отношении tgf-бета 1
EA201270553A1 (ru) Ингибиторы тирозинкиназы брутона
EA201591091A1 (ru) Антигенсвязывающие белки для bcma
BRPI1013688A8 (pt) Proteínas de ligação de il-17.
EA201101520A1 (ru) Способы диагностики онкологических заболеваний, использующие эпиметаболические переключатели, многоаспектные внутриклеточные молекулы или факторы влияния
DOP2012000089A (es) Anticuerpos monoclonales
EA201590630A1 (ru) Способы лечения и диагностики, связанные с лизилоксидазоподобным белком 2 (loxl2)
DK2021794T3 (da) Anvendelse af protein S100A 12 som en markør for colorektal cancer
CY1117414T1 (el) Παραγοντες αναστροφης αντιπηκτικου
NO20083593L (no) Anti-EphrinB2-antistoffer og fremgangsmater for anvendelse av disse
NO20084320L (no) Antistoffer mot EGFL7 og fremgangsmater for anvendelse av disse
EA201991506A1 (ru) Системы и способы для тестирования и скрининга с использованием связанных с соединениями субстратов
ATE514793T1 (de) Zusammensetzungen und verfahren für il13- biomarker