TR201905447T4 - Yeni mhc bağımsız tümörle ilişkili antijenler. - Google Patents

Yeni mhc bağımsız tümörle ilişkili antijenler. Download PDF

Info

Publication number
TR201905447T4
TR201905447T4 TR2019/05447T TR201905447T TR201905447T4 TR 201905447 T4 TR201905447 T4 TR 201905447T4 TR 2019/05447 T TR2019/05447 T TR 2019/05447T TR 201905447 T TR201905447 T TR 201905447T TR 201905447 T4 TR201905447 T4 TR 201905447T4
Authority
TR
Turkey
Prior art keywords
antigens
cells
cell
tumor associated
nucleic acids
Prior art date
Application number
TR2019/05447T
Other languages
English (en)
Inventor
Schadendorf Dirk
Paschen Anette
Lübcke Silke
Fatho Martina
Eberts Daniela
Echchannaoui Hakim
Lennerz Volker
Wölfel Catherine
Wölfel Thomas
Original Assignee
Biontech Rna Pharmaceuticals Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Biontech Rna Pharmaceuticals Gmbh filed Critical Biontech Rna Pharmaceuticals Gmbh
Publication of TR201905447T4 publication Critical patent/TR201905447T4/tr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/14—Blood; Artificial blood
    • A61K35/17—Lymphocytes; B-cells; T-cells; Natural killer cells; Interferon-activated or cytokine-activated lymphocytes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/0005—Vertebrate antigens
    • A61K39/0011—Cancer antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/0005—Vertebrate antigens
    • A61K39/0011—Cancer antigens
    • A61K39/001102—Receptors, cell surface antigens or cell surface determinants
    • A61K39/001116—Receptors for cytokines
    • A61K39/001118—Receptors for colony stimulating factors [CSF]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/0005—Vertebrate antigens
    • A61K39/0011—Cancer antigens
    • A61K39/001154—Enzymes
    • A61K39/001156—Tyrosinase and tyrosinase related proteinases [TRP-1 or TRP-2]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
    • C07K14/7051—T-cell receptor (TcR)-CD3 complex
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/715—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons
    • C07K14/7153—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons for colony-stimulating factors [CSF]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/90—Isomerases (5.)
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/5044—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics involving specific cell types
    • G01N33/5047—Cells of the immune system
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
    • G01N33/56966—Animal cells
    • G01N33/56972—White blood cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/57—Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2
    • A61K2039/572—Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2 cytotoxic response
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/58—Medicinal preparations containing antigens or antibodies raising an immune response against a target which is not the antigen used for immunisation
    • A61K2039/585—Medicinal preparations containing antigens or antibodies raising an immune response against a target which is not the antigen used for immunisation wherein the target is cancer
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y503/00—Intramolecular oxidoreductases (5.3)
    • C12Y503/03—Intramolecular oxidoreductases (5.3) transposing C=C bonds (5.3.3)
    • C12Y503/03012—L-Dopachrome isomerase (5.3.3.12)

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Cell Biology (AREA)
  • Biomedical Technology (AREA)
  • Organic Chemistry (AREA)
  • Microbiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Molecular Biology (AREA)
  • Hematology (AREA)
  • Zoology (AREA)
  • Epidemiology (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Oncology (AREA)
  • Genetics & Genomics (AREA)
  • Urology & Nephrology (AREA)
  • Mycology (AREA)
  • Toxicology (AREA)
  • Wood Science & Technology (AREA)
  • Virology (AREA)
  • Analytical Chemistry (AREA)
  • Food Science & Technology (AREA)
  • Physics & Mathematics (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biophysics (AREA)
  • Gastroenterology & Hepatology (AREA)

Abstract

Mevcut buluş, MHC aracılığıyla bir CD8 pozitif T hücre yanıtı prezentasyonundan bağımsız olarak ortaya çıkan yeni tümörle ilişkili antijenler ile ilgilidir. GM-CSF Reseptörü alfa zincirinin (CSF2RA) ve Tirozinaz ilişkili proteinin (2) (TRP-2), HLA I negatif melanom hücrelerinin yüzeyindeki proteinleri saptayabilecek CD8 pozitif T hücre klonlarının hedefleri olduğu bulundu. Dolayısıyla, buluş ilaç olarak, örneğin, bir tümör hastalığının tedavisi, teşhisi ve önlenmesi için kullanıma yönelik yeni antijenlerin proteinlerini, protein fragmanlarını ve polipeptidlerini sağlar. Ayrıca, buluşun antijenlerini eksprese eden nükleik asitler, buluşun antijenlerine özel, buluşun antijenlerine karşı reaktif olan ve buluşun T hücresi reseptörlerini eksprese eden T hücresi reseptörü zincirleri ve izole edilmiş T hücreleri gibi bağlayıcı maddeler sağlanmaktadır. Buluş ayrıca, buluşa uygun olarak antijenler, nükleik asitler, bağlayıcı maddeler veya T hücreleri içeren farmasötik bileşimleri, özellikle aşı bileşimleri ve bir MHC bağımsız şeklinde buluşun antijenlerine özellikle reaktif T hücrelerini oluşturma yöntemleri ile ilgilidir.
TR2019/05447T 2012-12-14 2013-12-16 Yeni mhc bağımsız tümörle ilişkili antijenler. TR201905447T4 (tr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP12197289 2012-12-14

Publications (1)

Publication Number Publication Date
TR201905447T4 true TR201905447T4 (tr) 2019-05-21

Family

ID=47355928

Family Applications (1)

Application Number Title Priority Date Filing Date
TR2019/05447T TR201905447T4 (tr) 2012-12-14 2013-12-16 Yeni mhc bağımsız tümörle ilişkili antijenler.

Country Status (13)

Country Link
US (2) US9861688B2 (tr)
EP (1) EP2932264B1 (tr)
JP (1) JP6475166B2 (tr)
AU (2) AU2013357239B2 (tr)
CA (2) CA2894966C (tr)
DK (1) DK2932264T3 (tr)
ES (1) ES2721159T3 (tr)
HU (1) HUE042967T2 (tr)
PL (1) PL2932264T3 (tr)
PT (1) PT2932264T (tr)
SI (1) SI2932264T1 (tr)
TR (1) TR201905447T4 (tr)
WO (1) WO2014091034A1 (tr)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2014144885A2 (en) * 2013-03-15 2014-09-18 The Trustees Of The University Of Pennsylvania Cancer vaccines and methods of treatment using the same
JP7013240B2 (ja) 2015-02-16 2022-01-31 ザ トラスティーズ オブ ザ ユニバーシティ オブ ペンシルバニア Ｈｅｒ２／Ｎｅｕ （ＥＲＢＢ２）受容体タンパク質に由来する３６９～３７７位エピトープに特異的な完全ヒトＴ細胞受容体
AU2019216982B2 (en) * 2018-02-11 2024-07-04 Memorial Sloan-Kettering Cancer Center Non-HLA restricted T cell receptors and uses thereof
JP2023546993A (ja) * 2020-10-27 2023-11-08 ティー－キュア バイオサイエンス，インコーポレイテッド Ｎｙ－ｅｓｏ－１および／またはｌａｇｅ－１ａ癌抗原に結合する組み換えｔ細胞受容体
US20240425563A1 (en) * 2021-01-13 2024-12-26 Washington University MHC-INDEPENDENT TCRs AND METHODS OF MAKING AND USING SAME
JP2024529467A (ja) 2021-07-27 2024-08-06 イマティクス バイオテクノロジーズ ゲーエムベーハー Ｃｔ４５に特異的に結合する抗原結合タンパク質
EP4527849A1 (en) 2023-09-19 2025-03-26 Universitätsmedizin der Johannes Gutenberg-Universität Mainz Hla-independent antigen binders, such as t-cell receptors, against pd-l1

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1991002063A1 (en) * 1989-08-11 1991-02-21 Amrad Corporation Limited Improvements in granulocyte-macrophage colony-stimulating factor receptor and derivatives thereof
US5840839A (en) 1996-02-09 1998-11-24 The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Alternative open reading frame DNA of a normal gene and a novel human cancer antigen encoded therein
WO2002048370A2 (en) 2000-10-31 2002-06-20 Diadexus, Inc. Compositions and methods relating to colon specific genes and proteins
ES2395839T3 (es) * 2006-03-27 2013-02-15 Medimmune Limited Miembro de unión para el receptor GM-CSF
AU2007248019B2 (en) * 2006-05-03 2012-10-11 Government Of The United States Of America, Represented By The Secretary, Department Of Health And Human Services Chimeric T cell receptors and related materials and methods of use
WO2008039818A2 (en) 2006-09-26 2008-04-03 Government Of The United States Of America, Represented By The Secretary, Department Of Health And Human Services Modified t cell receptors and related materials and methods
WO2008052277A1 (en) * 2006-11-03 2008-05-08 St. Vincent's Institute Of Medical Research Crystalline composition of gm-csf/gm-csfr
WO2010088160A1 (en) 2009-01-28 2010-08-05 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services T cell receptors and related materials and methods of use
WO2011029126A1 (en) * 2009-09-14 2011-03-17 Walter And Eliza Hall Institute Of Medical Research Methods and reagents for producing antibodies against autoantigens
AU2011304728A1 (en) * 2010-09-20 2013-03-14 Biontech Ag Antigen-specific T cell receptors and T cell epitopes

Also Published As

Publication number Publication date
CA3108192A1 (en) 2014-06-19
US20150313978A1 (en) 2015-11-05
SI2932264T1 (sl) 2019-05-31
HUE042967T2 (hu) 2019-07-29
ES2721159T3 (es) 2019-07-29
AU2019236675B2 (en) 2022-02-24
EP2932264A1 (en) 2015-10-21
CA2894966A1 (en) 2014-06-19
WO2014091034A1 (en) 2014-06-19
US20180099033A1 (en) 2018-04-12
US10987413B2 (en) 2021-04-27
AU2013357239B2 (en) 2019-10-17
AU2013357239A1 (en) 2015-06-18
CA2894966C (en) 2021-03-30
US9861688B2 (en) 2018-01-09
CA3108192C (en) 2026-02-24
PT2932264T (pt) 2019-05-21
EP2932264B1 (en) 2019-01-30
PL2932264T3 (pl) 2019-09-30
JP6475166B2 (ja) 2019-02-27
JP2016501268A (ja) 2016-01-18
DK2932264T3 (da) 2019-05-06
AU2019236675A1 (en) 2019-10-17

Similar Documents

Publication Publication Date Title
MX2024004610A (es) Receptores de celulas t restringidas a hla de clase ii contra ras mutado.
MX2016015383A (es) Receptores de celulas t anti - papilomavirus 16 e7 humano.
CY1122720T1 (el) Υποδοχεις τ κυτταρων που αναγνωριζουν περιορισμενη μαgε-α3 μηc ταξης ii
MX2020005765A (es) Receptores de celulas t restringidos a antigeno leucocitario humano (hla) clase i contra sarcoma de rata (ras) mutado.
CL2021002997A1 (es) Construcción de reconocimiento de antígeno y su uso para el tratamiento de enfermedades proliferativas y para la detección in vitro de un cáncer (divisional de la solicitud 201901535)
MX395287B (es) Nuevos receptores de linfocitos t e inmunoterapia basada en el uso de los mismos.
MX2020003504A (es) Receptores de celulas t que reconocen p53 mutado.
MX2019006724A (es) Nuevos receptores de celulas t y terapia inmunologica que los utiliza.
MX2019004708A (es) Celulas que presentan antigeno artificial manipulado por ingenieria para expansion linfocitica infiltrante de tumores.
SA520420658B1 (ar) جزيئات ربط ضد bcma واستخداماتها
CL2021001794A1 (es) Péptido, ácido nucleico, célula, composición farmacéutica, linfocito t activado, agente de unión aislado, y tcr, para su uso en inmunoterapia contra el cáncer; y métodos para producirlos (divisional de la solicitud no. 201600227)
BR112014008694A2 (pt) moléculas de ácido nucleico policistrônico recombinante
FI2884999T4 (fi) Menetelmä ja koostumuksia soluimmunoterapiaa varten
CA2848209C (en) T cell receptors recognizing hla-a1- or hla-cw7-restricted mage
CY1121466T1 (el) Αντισωματα εναντι προσδεματων υποδοχεα β1 βραδυκινινης
BR112017007093A2 (pt) composições e métodos de uso para aumento da resposta imune e terapia do câncer
MX2017006865A (es) Receptores de células t de kras anti-mutado.
PH12018501335A1 (en) Novel generation of antigen-specific tcrs
ES2721159T3 (es) Antígenos asociados a tumor independientes de MHC novedosos
EP2528937A4 (en) MODIFIED MELK-PEPTIDES AND VACCINES CONTAINING THEREOF
TR201901466T4 (tr) Opti̇mi̇ze edi̇lmi̇ş feli̇n lösemi̇ vi̇rüsü zarf geni̇ni̇ i̇çeren rekombi̇nant feli̇n lösemi̇ vi̇rüsü
BR112013013158B1 (pt) composições farmacêutica para uso no tratamento de câncer, métodos in vitro para induzir célula apresentadora de antígeno, bem como vetor, e uso
MX2020005188A (es) Nuevos peptidos y nueva combinacion de peptidos para el uso en la inmunoterapia contra el carcinoma hepatocelular (chc) y otros tipos de cancer.
MX2015011485A (es) Nuevas vacunas contra multiples subtipos del virus del dengue.
AR121811A2 (es) Péptido, vector de expresión, célula huésped, linfocito t activado, anticuerpo, receptor de células t, composición farmacéutica, kit y métodos relacionados