TR201907590T4 - Ssao inhibitörleri olarak imidazo[4,5-c]piridin ve pirrolo[2,3-c]piridin türevleri. - Google Patents

Ssao inhibitörleri olarak imidazo[4,5-c]piridin ve pirrolo[2,3-c]piridin türevleri. Download PDF

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Publication number
TR201907590T4
TR201907590T4 TR2019/07590T TR201907590T TR201907590T4 TR 201907590 T4 TR201907590 T4 TR 201907590T4 TR 2019/07590 T TR2019/07590 T TR 2019/07590T TR 201907590 T TR201907590 T TR 201907590T TR 201907590 T4 TR201907590 T4 TR 201907590T4
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pyridine
pyrrolo
imidazo
compounds
ssao inhibitors
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TR2019/07590T
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English (en)
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Espensen Max
Patient Lee
Evans David
Simpson Iain
Savory Edward
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Proximagen Llc
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    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
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Abstract

Mevcut buluş, SSAO aktivitesi inhibitörleri olan bileşikler ile ilgilidir. Buluş ayrıca, bu bileşikleri içeren farmasötik bileşimler ile ve SSAO aktivitesinin inhibisyonunun faydalı olduğu, inflamatuvar hastalıklar, immün rahatsızlıkları ve tümör büyümesinin inhibisyonu gibi medikal durumların tedavisinde veya önlenmesinde bu bileşiklerin kullanımı ile ilgilidir.
TR2019/07590T 2013-03-13 2014-03-13 Ssao inhibitörleri olarak imidazo[4,5-c]piridin ve pirrolo[2,3-c]piridin türevleri. TR201907590T4 (tr)

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GBGB1304526.5A GB201304526D0 (en) 2013-03-13 2013-03-13 New compounds

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TR201907590T4 true TR201907590T4 (tr) 2019-06-21

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US (9) US9676769B2 (tr)
EP (1) EP2970260B1 (tr)
JP (2) JP6334577B2 (tr)
KR (1) KR102187811B1 (tr)
CN (1) CN105189494B (tr)
AU (1) AU2014229763B2 (tr)
BR (1) BR112015022011B1 (tr)
CA (1) CA2902121C (tr)
DK (1) DK2970260T3 (tr)
EA (1) EA034066B1 (tr)
ES (1) ES2727977T3 (tr)
GB (1) GB201304526D0 (tr)
HU (1) HUE043456T2 (tr)
MX (1) MX368149B (tr)
NZ (1) NZ711229A (tr)
PL (1) PL2970260T3 (tr)
PT (1) PT2970260T (tr)
SG (2) SG11201507182TA (tr)
TR (1) TR201907590T4 (tr)
WO (1) WO2014140592A1 (tr)
ZA (1) ZA201506182B (tr)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB201304526D0 (en) 2013-03-13 2013-04-24 Proximagen Ltd New compounds
GB201304527D0 (en) 2013-03-13 2013-04-24 Proximagen Ltd New compounds
GB201404498D0 (en) * 2014-03-13 2014-04-30 Proximagen Ltd New compounds
WO2015189534A1 (en) 2014-06-12 2015-12-17 Proximagen Limited Vap-1 inhibitors for treating muscular dystrophy
WO2015188368A1 (en) * 2014-06-13 2015-12-17 Merck Sharp & Dohme Corp. Pyrrolo[2,3-c]pyridines as imaging agents for neurofibrilary tangles
GB201416444D0 (en) * 2014-09-17 2014-10-29 Proximagen Ltd New compounds
GB201416446D0 (en) * 2014-09-17 2014-10-29 Proximagen Ltd New enzyme inhibitor compounds
GB201507031D0 (en) * 2015-04-24 2015-06-10 Proximagen Ltd New pharmaceutical salt forms
CA3007768A1 (en) * 2015-12-07 2017-06-15 Benevolentai Cambridge Limited Vap-1 inhibitors for treating pain
GB201709136D0 (en) * 2017-06-08 2017-07-26 Proximagen Ltd New therapeutic uses of enzyme inhibitors
CN107311988B (zh) * 2017-07-15 2018-08-21 上海普康药业有限公司 一种治疗阿尔茨海默病的药物
AU2018334290A1 (en) 2017-09-18 2020-04-02 Goldfinch Bio, Inc. Pyridazinones and methods of use thereof
GB201806004D0 (en) * 2018-04-11 2018-05-23 Karin & Sten Mortstedt Cbd Solutions Ab Selective ligands for TAU aggregates
AU2020367204A1 (en) * 2019-10-15 2022-04-14 Aucentra Therapeutics Pty Ltd Derivatives of 4-(imidazo[1,2-a]pyridin-3-yl)-N-(pyridin-3-yl) pyrimidin-2- amine for treating proliferative diseases and conditions
US20230190728A1 (en) * 2020-03-26 2023-06-22 Proximagen, Llc New therapeutic uses of compounds
TWI782769B (zh) * 2021-10-28 2022-11-01 行政院原子能委員會核能研究所 一種新穎神經纖維糾結微管相關蛋白質Tau造影化合物、其製備方法及用途
AU2023295214A1 (en) * 2022-06-14 2025-03-06 Amygdala Neurosciences, Inc. Aldh-2 inhibitor compounds and methods of use
EP4612139A1 (en) 2022-11-03 2025-09-10 Sentonix, Inc. Selective ligands for tau aggregates
WO2026049331A1 (ko) * 2024-08-26 2026-03-05 이화여자대학교 산학협력단 신규한 이미다조피리딘 또는 이미다조피라진 유도체 및 이의 용도

Family Cites Families (36)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP3559572B2 (ja) 1993-01-29 2004-09-02 住友製薬株式会社 急性痛および慢性痛用鎮痛剤
CA2306870A1 (en) 1997-10-20 1999-04-29 David Michael Goldstein Bicyclic kinase inhibitors
US6962151B1 (en) 1999-11-05 2005-11-08 Pari GmbH Spezialisten für effektive Inhalation Inhalation nebulizer
AU2002214505A1 (en) 2000-11-09 2002-05-21 Biovitrum Ab New use of 4, 5, 6, 7-tetrahydroimidazo-(4,5-c)pyridine derivatives
US6982286B2 (en) 2001-07-12 2006-01-03 Biotie Therapies Corp. Carbocyclic hydrazino inhibitors of copper-containing amine oxidases
GB0206860D0 (en) * 2002-03-22 2002-05-01 Glaxo Group Ltd Compounds
DE10220048A1 (de) 2002-05-04 2003-11-13 Merck Patent Gmbh Semicarbazidderivate
US20050096360A1 (en) 2003-08-08 2005-05-05 Salter-Cid Luisa M. Inhibitors of semicarbazide-sensitive amine oxidase (SSAO) and VAP-1 mediated adhesion useful for treatment of diseases
JP2007504238A (ja) * 2003-09-04 2007-03-01 アベンティス・ファーマスーティカルズ・インコーポレイテツド ポリ（ａｄｐ−リボース）ポリメラーゼ（ｐａｒｐ）の阻害剤としての置換インドール
MX2007001337A (es) 2004-08-02 2008-03-13 Genmedica Therapeutics Sl Compuestos para inhibir amina-oxidasas que contienen cobre y usos de los mismos.
WO2006094201A2 (en) 2005-03-02 2006-09-08 La Jolla Pharmaceutical Company Semicarbazide-sensitive amide oxidase inhibitors
WO2007120528A2 (en) 2006-03-31 2007-10-25 La Jolla Pharmaceutical Company Inhibitors of semicarbazide-sensitive amine oxidase (ssao) and vap-1 mediated adhesion useful for treatment and prevention of diseases
WO2007146188A2 (en) 2006-06-07 2007-12-21 The Board Of Trustees Of The Leland Stanford Junior University Anti-leukocyte recruitment therapy for the treatment of seizures and epilepsy
US7947723B2 (en) 2008-02-01 2011-05-24 Spelman College Synthesis and anti-proliferative effect of benzimidazole derivatives
EP2328895B1 (en) * 2008-09-16 2013-03-27 Proximagen Limited Pyrazolo[4,3-c]pyridine compounds and their use as inhibitors of SSAO
PT2334672E (pt) 2008-09-16 2014-01-02 Proximagen Ltd Compostos novos i
DK2376490T3 (da) 2008-12-04 2013-04-15 Proximagen Ltd Imidazopyridinforbindelser
EP2417133A1 (en) 2009-04-06 2012-02-15 PTC Therapeutics, Inc. Compounds and methods for antiviral treatment
GB201004311D0 (en) * 2010-03-15 2010-04-28 Proximagen Ltd New enzyme inhibitor compounds
EP2518071A1 (en) 2011-04-29 2012-10-31 Almirall, S.A. Imidazopyridine derivatives as PI3K inhibitors
GB201115853D0 (en) 2011-09-14 2011-10-26 Proximagen Ltd New enzyme inhibitor compounds
US9150574B2 (en) * 2011-09-14 2015-10-06 Proximagen Limited Enzyme inhibitor compounds
WO2013078254A1 (en) * 2011-11-22 2013-05-30 Array Biopharma Inc. Bicyclic heteroaryl derivatives as kinase inhibitors
SI2844637T1 (en) 2012-05-02 2018-07-31 Boehringer Ingelheim International Gmbh Substituted 3-haloallylamine inhibitors of ssao and uses thereof
GB201304526D0 (en) 2013-03-13 2013-04-24 Proximagen Ltd New compounds
GB201304527D0 (en) * 2013-03-13 2013-04-24 Proximagen Ltd New compounds
GB201404498D0 (en) 2014-03-13 2014-04-30 Proximagen Ltd New compounds
ES2714125T3 (es) 2014-04-15 2019-05-27 Pecsi Tudomanyegyetem Inhibidores de la amino oxidasa sensible a la semicarbazida para uso como analgésicos en una neuropatía traumática y una inflamación neurogénica
WO2015189534A1 (en) 2014-06-12 2015-12-17 Proximagen Limited Vap-1 inhibitors for treating muscular dystrophy
GB201416446D0 (en) * 2014-09-17 2014-10-29 Proximagen Ltd New enzyme inhibitor compounds
GB201416444D0 (en) * 2014-09-17 2014-10-29 Proximagen Ltd New compounds
KR102337550B1 (ko) 2015-04-16 2021-12-13 에스에프씨주식회사 신규한 헤테로고리 화합물 및 이를 포함하는 유기 발광 소자
GB201507048D0 (en) 2015-04-24 2015-06-10 Proximagen Ltd Treatment of pain
CA3007768A1 (en) * 2015-12-07 2017-06-15 Benevolentai Cambridge Limited Vap-1 inhibitors for treating pain
GB201709136D0 (en) * 2017-06-08 2017-07-26 Proximagen Ltd New therapeutic uses of enzyme inhibitors
US20230190728A1 (en) * 2020-03-26 2023-06-22 Proximagen, Llc New therapeutic uses of compounds

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