TR201907655T4 - Geliştirilmiş l-amino asit verimliliğine sahip mikroorganizmalar ve bunları kullanarak l-amino asitlerin üretilmesine yönelik proses. - Google Patents

Geliştirilmiş l-amino asit verimliliğine sahip mikroorganizmalar ve bunları kullanarak l-amino asitlerin üretilmesine yönelik proses. Download PDF

Info

Publication number
TR201907655T4
TR201907655T4 TR2019/07655T TR201907655T TR201907655T4 TR 201907655 T4 TR201907655 T4 TR 201907655T4 TR 2019/07655 T TR2019/07655 T TR 2019/07655T TR 201907655 T TR201907655 T TR 201907655T TR 201907655 T4 TR201907655 T4 TR 201907655T4
Authority
TR
Turkey
Prior art keywords
amino acid
improved
production
microorganisms
amino acids
Prior art date
Application number
TR2019/07655T
Other languages
English (en)
Inventor
Sung Koh Eun
Yon Kwon Su
Ho Lee Kwang
Sun Lee Ji
Jang Juno
Cheol Lee Keun
Pyo Hong Hyeong
Original Assignee
Cj Cheiljedang Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cj Cheiljedang Corp filed Critical Cj Cheiljedang Corp
Publication of TR201907655T4 publication Critical patent/TR201907655T4/tr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • C12P13/04—Alpha- or beta- amino acids
    • C12P13/22—Tryptophan; Tyrosine; Phenylalanine; 3,4-Dihydroxyphenylalanine
    • C12P13/227—Tryptophan
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/26—Processes using, or culture media containing, hydrocarbons
    • C12N1/28—Processes using, or culture media containing, hydrocarbons aliphatic
    • C12N1/30—Processes using, or culture media containing, hydrocarbons aliphatic having five or less carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/70—Vectors or expression systems specially adapted for E. coli
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/24—Hydrolases (3) acting on glycosyl compounds (3.2)
    • C12N9/2497—Hydrolases (3) acting on glycosyl compounds (3.2) hydrolysing N- glycosyl compounds (3.2.2)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/78—Hydrolases (3) acting on carbon to nitrogen bonds other than peptide bonds (3.5)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • C12P13/04—Alpha- or beta- amino acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • C12P13/04—Alpha- or beta- amino acids
    • C12P13/08—Lysine; Diaminopimelic acid; Threonine; Valine
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y302/00—Hydrolases acting on glycosyl compounds, i.e. glycosylases (3.2)
    • C12Y302/02—Hydrolases acting on glycosyl compounds, i.e. glycosylases (3.2) hydrolysing N-glycosyl compounds (3.2.2)
    • C12Y302/02004—AMP nucleosidase (3.2.2.4)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y305/00—Hydrolases acting on carbon-nitrogen bonds, other than peptide bonds (3.5)
    • C12Y305/04—Hydrolases acting on carbon-nitrogen bonds, other than peptide bonds (3.5) in cyclic amidines (3.5.4)
    • C12Y305/04004—Adenosine deaminase (3.5.4.4)

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Molecular Biology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Virology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Plant Pathology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

Geliştirilmiş L-amino asit verimliliğine sahip bir rekombinant mikroorganizma, burada rekombinant mikroorganizma, adenozin deaminaz ve AMP nükleosidazın en az birinin giderilmiş veya azaltılmış aktivitesine sahip olmak için dönüştürülmektedir, ve rekombinant mikroorganizma kullanılarak bir L-amino asit üretmek için bir yöntem açıklanmaktadır. Rekombinant mikroorganizmanın kullanılması, oldukça etkili bir şekilde L-amino asit üretimi sağlayabilmektedir.
TR2019/07655T 2014-03-21 2015-03-17 Geliştirilmiş l-amino asit verimliliğine sahip mikroorganizmalar ve bunları kullanarak l-amino asitlerin üretilmesine yönelik proses. TR201907655T4 (tr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
KR1020140033698A KR101599800B1 (ko) 2014-03-21 2014-03-21 Ｌ-아미노산의 생산능이 향상된 미생물 및 이를 이용하여 ｌ-아미노산을 생산하는 방법

Publications (1)

Publication Number Publication Date
TR201907655T4 true TR201907655T4 (tr) 2019-06-21

Family

ID=54144919

Family Applications (1)

Application Number Title Priority Date Filing Date
TR2019/07655T TR201907655T4 (tr) 2014-03-21 2015-03-17 Geliştirilmiş l-amino asit verimliliğine sahip mikroorganizmalar ve bunları kullanarak l-amino asitlerin üretilmesine yönelik proses.

Country Status (16)

Country Link
US (1) US10113191B2 (tr)
EP (1) EP3119874B1 (tr)
JP (1) JP6494643B2 (tr)
KR (1) KR101599800B1 (tr)
CN (1) CN105980545B (tr)
AR (1) AR099811A1 (tr)
BR (1) BR112016017592B1 (tr)
DK (1) DK3119874T3 (tr)
ES (1) ES2728970T3 (tr)
HU (1) HUE045306T2 (tr)
MY (1) MY180267A (tr)
PL (1) PL3119874T3 (tr)
TR (1) TR201907655T4 (tr)
TW (2) TWI639698B (tr)
UA (1) UA118276C2 (tr)
WO (1) WO2015142021A1 (tr)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN116254242B (zh) * 2022-12-21 2024-01-30 江南大学 一种atp磷酸核苷转移酶突变体及产l-组氨酸的谷氨酸棒杆菌
CN118048349B (zh) * 2024-02-21 2026-04-28 扬州联澳生物医药有限公司 一种脱氨酶突变体及其应用
CN119061094A (zh) * 2024-09-26 2024-12-03 大连理工大学 一种酶法制备β-烟酰胺单核苷酸的方法

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100697551B1 (ko) * 1997-07-18 2007-03-21 아지노모토 가부시키가이샤 발효에 의한 퓨린 뉴클레오사이드의 제조 방법
KR100270510B1 (ko) 1998-08-14 2000-11-01 고두모 신규 미생물 및 이를 이용한 엘- 쓰레오닌의 제조방법
RU2175351C2 (ru) * 1998-12-30 2001-10-27 Закрытое акционерное общество "Научно-исследовательский институт "Аджиномото-Генетика" (ЗАО "АГРИ") Фрагмент днк из escherichia coli, определяющий повышенную продукцию l-аминокислот (варианты), и способ получения l-аминокислот
WO2002097086A1 (fr) * 2001-05-29 2002-12-05 Kyowa Hakko Kogyo Co., Ltd. Micro-organismes utiles a echelle industrielle
KR100792095B1 (ko) * 2006-12-29 2008-01-04 씨제이 주식회사 Ｌ-페닐알라닌 생산능을 갖는 대장균 변이주로부터유전자조작된 ｌ-트립토판 생산능을 갖는 재조합 대장균균주 및 이를 이용한 트립토판 제조방법
KR100966324B1 (ko) 2008-01-08 2010-06-28 씨제이제일제당 (주) 향상된 ｌ－쓰레오닌 생산능을 갖는 대장균 및 이를 이용한ｌ－쓰레오닌의 생산 방법
KR101599977B1 (ko) 2008-02-25 2016-03-04 아지노모토 가부시키가이샤 5'-구아닐산의 제조법
ES2809560T3 (es) * 2009-02-26 2021-03-04 Advanced Cooling Therapy Inc Dispositivos para controlar la temperatura del paciente
KR101261147B1 (ko) * 2011-01-18 2013-05-06 씨제이제일제당 (주) Ｌ-아미노산의 생산능이 향상된 미생물 및 이를 이용하여 ｌ-아미노산을 생산하는 방법
KR101327093B1 (ko) 2012-01-06 2013-11-07 씨제이제일제당 (주) Ｌ-아미노산을 생산할 수 있는 미생물 및 이를 이용하여 ｌ-아미노산을 생산하는 방법

Also Published As

Publication number Publication date
EP3119874A4 (en) 2017-11-15
US20170002388A1 (en) 2017-01-05
KR20150109990A (ko) 2015-10-02
EP3119874B1 (en) 2019-05-08
JP6494643B2 (ja) 2019-04-03
ES2728970T3 (es) 2019-10-29
PL3119874T3 (pl) 2019-10-31
CN105980545A (zh) 2016-09-28
MY180267A (en) 2020-11-26
UA118276C2 (uk) 2018-12-26
TW201538725A (zh) 2015-10-16
EP3119874A1 (en) 2017-01-25
KR101599800B1 (ko) 2016-03-04
TW201734199A (zh) 2017-10-01
JP2017504349A (ja) 2017-02-09
WO2015142021A1 (en) 2015-09-24
DK3119874T3 (da) 2019-07-22
CN105980545B (zh) 2019-12-24
US10113191B2 (en) 2018-10-30
AR099811A1 (es) 2016-08-17
BR112016017592A2 (pt) 2017-10-03
TWI639698B (zh) 2018-11-01
HUE045306T2 (hu) 2019-12-30
BR112016017592B1 (pt) 2023-11-14

Similar Documents

Publication Publication Date Title
BR112015031233A2 (pt) métodos de produção de derivados de ácidos graxos omega-hidroxilados
MX2020000369A (es) Metodos biologicos para preparar terpenos.
PH12015500792A1 (en) Method for producing l-amino acid
MY172080A (en) Microorganisms having putrescine productivity and process for producing putrescine using the same
SG10201805568TA (en) Processing biomass to obtain hydroxylcarboxylic acids
MX383750B (es) Método para el cultivo de akkermansia
CL2019000318A1 (es) Método para producir un l-aminoácido tal como l-lisina.
PH12018500130A1 (en) Protein-rich biomass of thraustochytrids, culturing method, and uses
PH12017502240A1 (en) Recombinant microorganism for improved production of alanine
PH12020500328A1 (en) Microorganism for producing a mycosporine-like amino acid and method for producing a mycosporine-like amino acid using the same
SG10201806655TA (en) Microorganism producing o-acetyl-homoserine and method for producing o-acetylhomoserine using the same
MX2016003737A (es) Microorganismo recombinante para la mejora de produccion de productos quimicos finos.
PH12016501094A1 (en) Recombinant microorganism for improved production of fine chemicals
PH12020551274A1 (en) Mycosporine-like amino acid-producing microorganism and method for production of mycosporine-like amino acids by using same
MY171648A (en) Microorganism producing l-lysine and method for producing l-lysine using the same
MY198780A (en) Process for the biological production of methacrylic acid and derivatives thereof
MX2016002651A (es) Microorganismo modificado para la produccion mejorada de alanina.
MX2017012554A (es) Microalgas adaptadas para condiciones de cultivo heterotrofo.
PH12021550347A1 (en) MICROORGANISM FOR PRODUCING L-AMINO ACID WITH ENHANCED ACTIVITY OF a-GLUCOSIDASE AND METHOD FOR PRODUCING L-AMINO ACID USING THE SAME
EA201791659A1 (ru) Компьютеризированный способ создания модели процесса ферментации
PH12018500069A1 (en) Novel lactobacillus sp. microorganisms, and composition for animal feed comprising same
MY184391A (en) Microorganism having improved intracellular energy level and method for producing l-amino acid using same
MY181143A (en) Microorganisms producing l-amino acids and process for producing l-amino acids using the same
MY180267A (en) Microorganisms having enhanced l-amino acids productivity and process for producing l-amino acids using the same
MX391630B (es) Procesos para la producción de composiciones con perfil de seguridad mejorado teniendo actividad lipasa y composiciones adecuadas para medicamentos