TR201908291T4 - Şifrelenmiş bir tümör antijeninin ekspresyonunun arttırılmasına yönelik bir histon sap-ilmiği ve bir poli(a) sekansı veya bir poliadenilasyon sinyali içeren veya bunun için kodlama yapan nükleik asit. - Google Patents

Şifrelenmiş bir tümör antijeninin ekspresyonunun arttırılmasına yönelik bir histon sap-ilmiği ve bir poli(a) sekansı veya bir poliadenilasyon sinyali içeren veya bunun için kodlama yapan nükleik asit. Download PDF

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Publication number
TR201908291T4
TR201908291T4 TR2019/08291T TR201908291T TR201908291T4 TR 201908291 T4 TR201908291 T4 TR 201908291T4 TR 2019/08291 T TR2019/08291 T TR 2019/08291T TR 201908291 T TR201908291 T TR 201908291T TR 201908291 T4 TR201908291 T4 TR 201908291T4
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Turkey
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nucleic acid
sequence
poly
expression
loop
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TR2019/08291T
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English (en)
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Thess Andreas
Schlake Thomas
Probst Jochen
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Curevac Ag
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Publication of TR201908291T4 publication Critical patent/TR201908291T4/tr

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Abstract

Mevcut buluş, bir tümör antijeni veya bunun bir fragmanını, varyantını veya türevini içeren en az bir peptidi veya proteini şifreleyen bir kodlama bölgesi, en az bir histon sap-ilmiği ve bir poli(A) sekansı veya bir poliadenilasyon sinyali içeren veya bunlar için kodlama yapan bir nükleik asit sekansı ile ilgilidir. Ek olarak mevcut buluş, nükleik asidin, adı geçen şifrelenmiş peptidin veya proteinin ekspresyonunu arttırmak amacıyla kullanılmasını sunar. Bu ayrıca bunun, farmasötik bir kompozisyonun, özellikle bir aşının hazırlanmasında, örn. kanserin veya tümör hastalıklarının tedavisinde kullanılmaya yönelik kullanımını açıklar. Mevcut buluş ayrıca bir tümör antijeni veya bunun bir fragmanını, varyantını veya türevini içeren bir peptidin veya proteinin ekspresyonunun, bir histon sap-ilmiği ve bir poli(A) sekansı veya bir poliadenilasyon sinyali içeren veya bunlar için kodlama yapan nükleik asit kullanılarak arttırılmasına yönelik bir yöntem tarif eder.
TR2019/08291T 2012-02-15 2013-02-15 Şifrelenmiş bir tümör antijeninin ekspresyonunun arttırılmasına yönelik bir histon sap-ilmiği ve bir poli(a) sekansı veya bir poliadenilasyon sinyali içeren veya bunun için kodlama yapan nükleik asit. TR201908291T4 (tr)

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