TR201909510T4 - Hücre süspansiyonlarının saptamalarına yönelik bir yöntem ve bir sistem. - Google Patents

Hücre süspansiyonlarının saptamalarına yönelik bir yöntem ve bir sistem.

Info

Publication number
TR201909510T4
TR201909510T4 TR2019/09510T TR201909510T TR201909510T4 TR 201909510 T4 TR201909510 T4 TR 201909510T4 TR 2019/09510 T TR2019/09510 T TR 2019/09510T TR 201909510 T TR201909510 T TR 201909510T TR 201909510 T4 TR201909510 T4 TR 201909510T4
Authority
TR
Turkey
Prior art keywords
substance
concentration
regional
determining
cell suspension
Prior art date
Application number
TR2019/09510T
Other languages
English (en)
Inventor
Agersnap Larsen Niels
Original Assignee
Koninklijke Philips Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Koninklijke Philips Nv filed Critical Koninklijke Philips Nv
Publication of TR201909510T4 publication Critical patent/TR201909510T4/tr

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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/72—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving blood pigments, e.g. haemoglobin, bilirubin or other porphyrins; involving occult blood
    • G01N33/721—Haemoglobin
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502707—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by the manufacture of the container or its components
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/01—Arrangements or apparatus for facilitating the optical investigation
    • G01N21/03—Cuvette constructions
    • G01N21/0303—Optical path conditioning in cuvettes, e.g. windows; adapted optical elements or systems; path modifying or adjustment
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/483—Physical analysis of biological material
    • G01N33/487—Physical analysis of biological material of liquid biological material
    • G01N33/49—Blood
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/14—Process control and prevention of errors
    • B01L2200/148—Specific details about calibrations
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0809—Geometry, shape and general structure rectangular shaped
    • B01L2300/0816—Cards, e.g. flat sample carriers usually with flow in two horizontal directions
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/04—Moving fluids with specific forces or mechanical means
    • B01L2400/0403—Moving fluids with specific forces or mechanical means specific forces
    • B01L2400/0406—Moving fluids with specific forces or mechanical means specific forces capillary forces
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/01—Arrangements or apparatus for facilitating the optical investigation
    • G01N21/03—Cuvette constructions
    • G01N2021/0378—Shapes
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/01—Arrangements or apparatus for facilitating the optical investigation
    • G01N21/03—Cuvette constructions
    • G01N2021/0389—Windows
    • G01N2021/0392—Nonplanar windows
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2201/00—Features of devices classified in G01N21/00
    • G01N2201/06—Illumination; Optics
    • G01N2201/066—Modifiable path; multiple paths in one sample

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • Analytical Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Immunology (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Biochemistry (AREA)
  • Urology & Nephrology (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Food Science & Technology (AREA)
  • Clinical Laboratory Science (AREA)
  • Dispersion Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Ecology (AREA)
  • Biophysics (AREA)
  • Microbiology (AREA)
  • Cell Biology (AREA)
  • Biotechnology (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Investigating Or Analysing Materials By Optical Means (AREA)
  • Optical Measuring Cells (AREA)

Abstract

Buluş bir hücre süspansiyonunda bir maddenin bir konsantrasyonunun saptanmasına yönelik bir yöntem ile ilgilidir, söz konusu yöntem şu adımları içermektedir: - maddenin konsantrasyonunun şunlar ile saptanması: - söz konusu absorpsiyon ölçümlerine dayanarak saptanan bölgesel numune hacimlerinde hücre süspansiyonunu ve bölgesel madde konsantrasyonunu içeren bir oda düzenlemesinin farklı ortalama oda yüksekliklerinde barındırılan n bölgesel numune hacimlerinde gerçekleştirilen absorpsiyon ölçümlerinin sonuçlarının kullanılması; - oda yüksekliğinin bir fonksiyonu olarak bölgesel madde konsantrasyonunu içeren bir madde konsantrasyon modelinin kullanılması, ve - söz konusu madde konsantrasyon modeli ve saptanan bölgesel madde konsantrasyonları kullanılarak sonsuz oda yükseklik maddesi konsantrasyonu olarak madde konsantrasyonunun saptanması, burada n, en az 4 gibi, en az 3 gibi en az 2?dir, burada opsiyonel olarak, hücre süspansiyonu tam kandır ve madde Hb?dir ve burada yöntem ayrıca saptanan Hb konsantrasyonuna ve saptanan Ortalama Eritrosik Hemoglobine (MCH) dayanarak cRBC?nin saptanmasını içermektedir. Buluş aynı zamanda yöntemi yürütmeye yönelik bir sistem ile ilgilidir.
TR2019/09510T 2015-12-24 2016-12-22 Hücre süspansiyonlarının saptamalarına yönelik bir yöntem ve bir sistem. TR201909510T4 (tr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP15202725 2015-12-24

Publications (1)

Publication Number Publication Date
TR201909510T4 true TR201909510T4 (tr) 2019-07-22

Family

ID=55129454

Family Applications (1)

Application Number Title Priority Date Filing Date
TR2019/09510T TR201909510T4 (tr) 2015-12-24 2016-12-22 Hücre süspansiyonlarının saptamalarına yönelik bir yöntem ve bir sistem.

Country Status (6)

Country Link
US (1) US10782306B2 (tr)
EP (1) EP3394616B1 (tr)
JP (1) JP6518016B2 (tr)
CN (1) CN108431600A (tr)
TR (1) TR201909510T4 (tr)
WO (1) WO2017109068A1 (tr)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11389799B2 (en) * 2019-01-17 2022-07-19 The Regents Of The University Of Michigan Microfluidic device for size and deformability measurements and applications thereof
CN113899659A (zh) * 2020-06-22 2022-01-07 苏州中加康美科技有限公司 一种载玻片及血细胞分析仪
WO2022192683A1 (en) * 2021-03-11 2022-09-15 Virginia Tech Intellectual Properties, Inc. Methods and apparatus for evaporation based liquid transport

Family Cites Families (53)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4790640A (en) 1985-10-11 1988-12-13 Nason Frederic L Laboratory slide
JP2652293B2 (ja) * 1991-12-06 1997-09-10 キヤノン株式会社 検体測定装置
NL1000607C1 (nl) 1995-02-07 1996-08-07 Hendrik Jan Westendorp Telkamer en werkwijze voor het vervaardigen van een telkamer
US5692503A (en) 1995-03-10 1997-12-02 Kuenstner; J. Todd Method for noninvasive (in-vivo) total hemoglobin, oxyhemogolobin, deoxyhemoglobin, carboxyhemoglobin and methemoglobin concentration determination
JP3586743B2 (ja) * 1995-10-09 2004-11-10 アークレイ株式会社 ヘマトクリット値を補正した測定方法
AT403412B (de) 1996-04-02 1998-02-25 Avl Verbrennungskraft Messtech Vorrichtung und verfahren zur bestimmung der konzentration von hämoglobinderivaten in einer unverdünnten, unhämolysierten vollblutprobe
AT404513B (de) 1996-07-12 1998-12-28 Avl Verbrennungskraft Messtech Verfahren und messanordnung zur optischen bestimmung der totalen hämoglobinkonzentration
FR2751088B1 (fr) 1996-07-12 1998-11-06 Thomson Csf Procede de determination du module de la vitesse du porteur d'un radar
US6127184A (en) 1998-03-07 2000-10-03 Robert A. Levine Calibration of a whole blood sample analyzer
US6350613B1 (en) 1998-03-07 2002-02-26 Belton Dickinson & Co. Determination of white blood cell differential and reticulocyte counts
US6723290B1 (en) * 1998-03-07 2004-04-20 Levine Robert A Container for holding biologic fluid for analysis
US6358475B1 (en) 1998-05-27 2002-03-19 Becton, Dickinson And Company Device for preparing thin liquid for microscopic analysis
US6180314B1 (en) 1998-05-27 2001-01-30 Becton, Dickinson And Company Method for preparing thin liquid samples for microscopic analysis
DE19834457A1 (de) 1998-07-30 2000-02-10 Siemens Ag Röntgenanordnung
US6387325B1 (en) 1999-10-08 2002-05-14 Becton Dickinson & Company Assembly for separating formed constituents from a liquid constituent in a complex biologic fluid sample
SE518539C2 (sv) 2000-06-28 2002-10-22 Migrata U K Ltd Sätt och kyvett för kvantitativ hemoglobinbestämning i outspätt helblod
US6555387B1 (en) 2000-09-27 2003-04-29 Becton, Dickinson And Company Method for producing thin liquid samples for microscopic analysis
SE0104443D0 (sv) 2001-12-28 2001-12-28 Hemocue Ab Analysis method and cuvette therefor
DE10313201A1 (de) * 2003-03-21 2004-10-07 Steag Microparts Gmbh Mikrostrukturierte Trennvorrichtung und mikrofluidisches Verfahren zum Abtrennen von flüssigen Bestandteilen aus einer Flüssigkeit, die Partikel enthält
JP2005024472A (ja) 2003-07-04 2005-01-27 Sysmex Corp 幼若血小板測定装置
EP1733226B1 (en) 2004-04-07 2015-07-29 Levine, Robert Aaron Disposable chamber for analyzing biologic fluids
WO2006031095A1 (en) 2004-09-13 2006-03-23 Leja Holding B.V. Capillary-loading slide and method of microscopic research with correction of the serge silberberg effect
SE530896C2 (sv) * 2005-04-01 2008-10-14 Diaspect Medical Ab Anordning för att fastställa en hemoglobinkoncentration i blod
JP2007040814A (ja) * 2005-08-03 2007-02-15 Matsushita Electric Ind Co Ltd 吸光度測定用センサ及び吸光度測定方法
US20080285823A1 (en) * 2005-11-23 2008-11-20 Koninklijke Philips Electronics, N.V. Device for Imaging an Interior of a Turbid Medium
SE530244C2 (sv) 2006-05-05 2008-04-08 Hemocue Ab Förfarande och system för kvantitativ hemoglobinbestämning
SE531041C2 (sv) 2006-07-17 2008-11-25 Hemocue Ab Räkning av trombocyter
US7773901B2 (en) 2006-12-18 2010-08-10 Samsung Electronics Co., Ltd. Image forming apparatus and control method thereof
TWI336854B (en) 2006-12-29 2011-02-01 Ibm Video-based biometric signature data collecting method and apparatus
US8310695B2 (en) 2007-09-12 2012-11-13 Xerox Corporation Integrated adaptable accounting system for a print job
SE532499C2 (sv) * 2008-01-18 2010-02-09 Hemocue Ab Metod och apparat för analys av partiklar i ett vätskeformigt prov
UY31720A1 (es) 2008-03-19 2009-09-30 Procedimiento y aparato para separar particulas en un fluido
EP2271937B1 (en) * 2008-03-21 2016-01-13 Abbott Point Of Care, Inc. Method and apparatus for detecting and counting platelets individually and in aggregate clumps
CN102027368B (zh) * 2008-03-21 2014-02-26 艾博特健康公司 利用红细胞内含有的血红蛋白的本征色素沉着来确定血样的红细胞指数的方法及设备
WO2009152269A2 (en) 2008-06-11 2009-12-17 Health Research, Inc. Methods of quantifying biomarkers
US8247191B2 (en) * 2008-11-13 2012-08-21 Ritzen Kalle Disposable cassette and method of use for blood analysis on blood analyzer
EP2198966A1 (en) 2008-12-19 2010-06-23 Nederlandse Organisatie voor toegepast-natuurwetenschappelijk Onderzoek TNO Micro-fluidic device and a method of providing a sample
FR2945126B1 (fr) 2009-04-29 2019-11-01 Commissariat A L'energie Atomique Procede et appareil de comptage des thrombocytes
US8748186B2 (en) 2009-12-22 2014-06-10 Abbott Laboratories Method for performing a blood count and determining the morphology of a blood smear
EP2519820B1 (en) 2009-12-31 2013-11-06 Abbott Point Of Care, Inc. Method and apparatus for determining mean cell volume of red blood cells
US8906308B2 (en) 2010-01-15 2014-12-09 Abbott Laboratories Method for determining volume and hemoglobin content of individual red blood cells
US8472693B2 (en) * 2010-03-18 2013-06-25 Abbott Point Of Care, Inc. Method for determining at least one hemoglobin related parameter of a whole blood sample
WO2011135566A1 (en) * 2010-04-27 2011-11-03 Yeda Research And Development Co. Ltd. Niche system for biological culturing
AU2012287302B2 (en) * 2011-07-22 2015-02-19 Roche Diagnostics Hematology, Inc. Sample applicator sensing and positioning
US9046473B2 (en) 2011-09-28 2015-06-02 Abbott Point Of Care, Inc. Method and apparatus for detecting the presence of intraerythrocytic parasites
WO2013155115A1 (en) * 2012-04-09 2013-10-17 Mec Dynamics Corporation Measurement of total hemoglobin in whole blood
WO2014183049A1 (en) * 2013-05-09 2014-11-13 Abbott Point Of Care, Inc. Method and apparatus for determining hemoglobin based parameters in an unlysed blood sample
DE102013210952B4 (de) * 2013-06-12 2020-03-19 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. Verfahren zur Bestimmung von ungelösten Teilchen in einem Fluid
WO2014205576A1 (en) * 2013-06-26 2014-12-31 Alentic Microscience Inc. Sample processing improvements for microscopy
KR20150039050A (ko) 2013-10-01 2015-04-09 삼성전자주식회사 시료 중의 당화단백질을 측정하는 카트리지, 시스템, 및 이를 이용한 당화단백질 측정 방법
EP3071515A2 (en) * 2013-11-18 2016-09-28 Rubius Therapeutics, Inc. Synthetic membrane-receiver complexes
WO2015176744A1 (en) * 2014-05-20 2015-11-26 Siemens Aktiengesellschaft Cartridge for a magnetic flow cytometer, a magnetic flow cytometer, and method for analysing a sample with such a cartridge
WO2016183482A1 (en) * 2015-05-13 2016-11-17 Rubius Therapeutics, Inc. Membrane-receiver complex therapeutics

Also Published As

Publication number Publication date
JP6518016B2 (ja) 2019-05-22
US20180372758A1 (en) 2018-12-27
US10782306B2 (en) 2020-09-22
CN108431600A (zh) 2018-08-21
WO2017109068A1 (en) 2017-06-29
EP3394616A1 (en) 2018-10-31
JP2019506600A (ja) 2019-03-07
EP3394616B1 (en) 2019-04-24

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