TR201909510T4 - Hücre süspansiyonlarının saptamalarına yönelik bir yöntem ve bir sistem. - Google Patents

Hücre süspansiyonlarının saptamalarına yönelik bir yöntem ve bir sistem.

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Publication number
TR201909510T4
TR201909510T4 TR2019/09510T TR201909510T TR201909510T4 TR 201909510 T4 TR201909510 T4 TR 201909510T4 TR 2019/09510 T TR2019/09510 T TR 2019/09510T TR 201909510 T TR201909510 T TR 201909510T TR 201909510 T4 TR201909510 T4 TR 201909510T4
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TR
Turkey
Prior art keywords
substance
concentration
regional
determining
cell suspension
Prior art date
Application number
TR2019/09510T
Other languages
English (en)
Inventor
Agersnap Larsen Niels
Original Assignee
Koninklijke Philips Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Application filed by Koninklijke Philips Nv filed Critical Koninklijke Philips Nv
Publication of TR201909510T4 publication Critical patent/TR201909510T4/tr

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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/72—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving blood pigments, e.g. haemoglobin, bilirubin or other porphyrins; involving occult blood
    • G01N33/721—Haemoglobin
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502707—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by the manufacture of the container or its components
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/01—Arrangements or apparatus for facilitating the optical investigation
    • G01N21/03—Cuvette constructions
    • G01N21/0303—Optical path conditioning in cuvettes, e.g. windows; adapted optical elements or systems; path modifying or adjustment
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/483—Physical analysis of biological material
    • G01N33/487—Physical analysis of biological material of liquid biological material
    • G01N33/49—Blood
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/14—Process control and prevention of errors
    • B01L2200/148—Specific details about calibrations
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0809—Geometry, shape and general structure rectangular shaped
    • B01L2300/0816—Cards, e.g. flat sample carriers usually with flow in two horizontal directions
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/04—Moving fluids with specific forces or mechanical means
    • B01L2400/0403—Moving fluids with specific forces or mechanical means specific forces
    • B01L2400/0406—Moving fluids with specific forces or mechanical means specific forces capillary forces
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/01—Arrangements or apparatus for facilitating the optical investigation
    • G01N21/03—Cuvette constructions
    • G01N2021/0378—Shapes
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/01—Arrangements or apparatus for facilitating the optical investigation
    • G01N21/03—Cuvette constructions
    • G01N2021/0389—Windows
    • G01N2021/0392—Nonplanar windows
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2201/00—Features of devices classified in G01N21/00
    • G01N2201/06—Illumination; Optics
    • G01N2201/066—Modifiable path; multiple paths in one sample

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Immunology (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Urology & Nephrology (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Dispersion Chemistry (AREA)
  • Clinical Laboratory Science (AREA)
  • Ecology (AREA)
  • Biophysics (AREA)
  • Biotechnology (AREA)
  • Cell Biology (AREA)
  • Microbiology (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Investigating Or Analysing Materials By Optical Means (AREA)
  • Optical Measuring Cells (AREA)

Abstract

Buluş bir hücre süspansiyonunda bir maddenin bir konsantrasyonunun saptanmasına yönelik bir yöntem ile ilgilidir, söz konusu yöntem şu adımları içermektedir: - maddenin konsantrasyonunun şunlar ile saptanması: - söz konusu absorpsiyon ölçümlerine dayanarak saptanan bölgesel numune hacimlerinde hücre süspansiyonunu ve bölgesel madde konsantrasyonunu içeren bir oda düzenlemesinin farklı ortalama oda yüksekliklerinde barındırılan n bölgesel numune hacimlerinde gerçekleştirilen absorpsiyon ölçümlerinin sonuçlarının kullanılması; - oda yüksekliğinin bir fonksiyonu olarak bölgesel madde konsantrasyonunu içeren bir madde konsantrasyon modelinin kullanılması, ve - söz konusu madde konsantrasyon modeli ve saptanan bölgesel madde konsantrasyonları kullanılarak sonsuz oda yükseklik maddesi konsantrasyonu olarak madde konsantrasyonunun saptanması, burada n, en az 4 gibi, en az 3 gibi en az 2?dir, burada opsiyonel olarak, hücre süspansiyonu tam kandır ve madde Hb?dir ve burada yöntem ayrıca saptanan Hb konsantrasyonuna ve saptanan Ortalama Eritrosik Hemoglobine (MCH) dayanarak cRBC?nin saptanmasını içermektedir. Buluş aynı zamanda yöntemi yürütmeye yönelik bir sistem ile ilgilidir.
TR2019/09510T 2015-12-24 2016-12-22 Hücre süspansiyonlarının saptamalarına yönelik bir yöntem ve bir sistem. TR201909510T4 (tr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP15202725 2015-12-24

Publications (1)

Publication Number Publication Date
TR201909510T4 true TR201909510T4 (tr) 2019-07-22

Family

ID=55129454

Family Applications (1)

Application Number Title Priority Date Filing Date
TR2019/09510T TR201909510T4 (tr) 2015-12-24 2016-12-22 Hücre süspansiyonlarının saptamalarına yönelik bir yöntem ve bir sistem.

Country Status (6)

Country Link
US (1) US10782306B2 (tr)
EP (1) EP3394616B1 (tr)
JP (1) JP6518016B2 (tr)
CN (1) CN108431600A (tr)
TR (1) TR201909510T4 (tr)
WO (1) WO2017109068A1 (tr)

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Also Published As

Publication number Publication date
EP3394616A1 (en) 2018-10-31
US20180372758A1 (en) 2018-12-27
JP6518016B2 (ja) 2019-05-22
CN108431600A (zh) 2018-08-21
US10782306B2 (en) 2020-09-22
WO2017109068A1 (en) 2017-06-29
EP3394616B1 (en) 2019-04-24
JP2019506600A (ja) 2019-03-07

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