TW200416045A - Oil-in-water emulsion composition and manufacturing method thereof - Google Patents

Oil-in-water emulsion composition and manufacturing method thereof Download PDF

Info

Publication number: TW200416045A
Authority: TW; Taiwan
Prior art keywords: oil; water; supplement; formula; straight
Prior art date: 2002-12-27

Application number

TW92126607A

Other languages

English (en)

Chinese (zh)

Other versions

TWI342220B (de

Inventor

Yukihisa Hashimoto

Chiaki Sone

Atsuyuki Kiba

Original Assignee

Kao Corp

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2002-12-27

Filing date

2003-09-26

Publication date

2004-09-01

2003-09-26 Application filed by Kao Corp filed Critical Kao Corp

2004-09-01 Publication of TW200416045A publication Critical patent/TW200416045A/zh

2011-05-21 Application granted granted Critical

2011-05-21 Publication of TWI342220B publication Critical patent/TWI342220B/zh

Links

239000000203 mixture Substances 0.000 title claims abstract description 55
238000004519 manufacturing process Methods 0.000 title claims abstract description 11
239000007764 o/w emulsion Substances 0.000 title claims description 10
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 48
150000002632 lipids Chemical class 0.000 claims abstract description 38
150000001298 alcohols Chemical class 0.000 claims abstract description 13
238000002156 mixing Methods 0.000 claims abstract description 7
239000003093 cationic surfactant Substances 0.000 claims description 23
239000013589 supplement Substances 0.000 claims description 23
125000000217 alkyl group Chemical group 0.000 claims description 16
OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims description 15
229920006395 saturated elastomer Polymers 0.000 claims description 15
229910052799 carbon Inorganic materials 0.000 claims description 12
229930195735 unsaturated hydrocarbon Natural products 0.000 claims description 11
229930195734 saturated hydrocarbon Natural products 0.000 claims description 10
239000012736 aqueous medium Substances 0.000 claims description 6
150000003863 ammonium salts Chemical class 0.000 claims description 5
150000001450 anions Chemical class 0.000 claims description 5
239000000126 substance Substances 0.000 claims description 5
125000001183 hydrocarbyl group Chemical group 0.000 claims description 3
150000003839 salts Chemical class 0.000 claims description 3
QGZKDVFQNNGYKY-UHFFFAOYSA-O Ammonium Chemical class [NH4+] QGZKDVFQNNGYKY-UHFFFAOYSA-O 0.000 claims description 2
-1 quaternary ammonium salt cation Chemical class 0.000 abstract description 40
239000000839 emulsion Substances 0.000 abstract description 26
239000004094 surface-active agent Substances 0.000 abstract description 15
YDNKGFDKKRUKPY-JHOUSYSJSA-N C16 ceramide Natural products CCCCCCCCCCCCCCCC(=O)N[C@@H](CO)[C@H](O)C=CCCCCCCCCCCCCC YDNKGFDKKRUKPY-JHOUSYSJSA-N 0.000 abstract description 4
229940106189 ceramide Drugs 0.000 abstract description 4
ZVEQCJWYRWKARO-UHFFFAOYSA-N ceramide Natural products CCCCCCCCCCCCCCC(O)C(=O)NC(CO)C(O)C=CCCC=C(C)CCCCCCCCC ZVEQCJWYRWKARO-UHFFFAOYSA-N 0.000 abstract description 4
VVGIYYKRAMHVLU-UHFFFAOYSA-N newbouldiamide Natural products CCCCCCCCCCCCCCCCCCCC(O)C(O)C(O)C(CO)NC(=O)CCCCCCCCCCCCCCCCC VVGIYYKRAMHVLU-UHFFFAOYSA-N 0.000 abstract description 4
CRJGESKKUOMBCT-VQTJNVASSA-N N-acetylsphinganine Chemical compound CCCCCCCCCCCCCCC[C@@H](O)[C@H](CO)NC(C)=O CRJGESKKUOMBCT-VQTJNVASSA-N 0.000 abstract description 3
150000001768 cations Chemical class 0.000 abstract 1
239000007762 w/o emulsion Substances 0.000 abstract 1
239000012071 phase Substances 0.000 description 40
239000003921 oil Substances 0.000 description 39
235000019198 oils Nutrition 0.000 description 39
LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 25
125000004432 carbon atom Chemical group C* 0.000 description 25
PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 23
150000002430 hydrocarbons Chemical group 0.000 description 20
125000002887 hydroxy group Chemical group [H]O* 0.000 description 15
239000000463 material Substances 0.000 description 14
238000000034 method Methods 0.000 description 14
210000003491 skin Anatomy 0.000 description 13
239000002537 cosmetic Substances 0.000 description 12
239000006071 cream Substances 0.000 description 12
125000003545 alkoxy group Chemical group 0.000 description 10
235000011187 glycerol Nutrition 0.000 description 10
239000004973 liquid crystal related substance Substances 0.000 description 10
230000002378 acidificating effect Effects 0.000 description 9
230000000694 effects Effects 0.000 description 9
238000003860 storage Methods 0.000 description 8
150000001875 compounds Chemical class 0.000 description 7
239000011521 glass Substances 0.000 description 7
125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 7
LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 description 6
OGQYPPBGSLZBEG-UHFFFAOYSA-N dimethyl(dioctadecyl)azanium Chemical compound CCCCCCCCCCCCCCCCCC[N+](C)(C)CCCCCCCCCCCCCCCCCC OGQYPPBGSLZBEG-UHFFFAOYSA-N 0.000 description 6
NOPFSRXAKWQILS-UHFFFAOYSA-N docosan-1-ol Chemical compound CCCCCCCCCCCCCCCCCCCCCCO NOPFSRXAKWQILS-UHFFFAOYSA-N 0.000 description 6
239000004615 ingredient Substances 0.000 description 6
229920001296 polysiloxane Polymers 0.000 description 6
239000007787 solid Substances 0.000 description 6
PRAKJMSDJKAYCZ-UHFFFAOYSA-N squalane Chemical compound CC(C)CCCC(C)CCCC(C)CCCCC(C)CCCC(C)CCCC(C)C PRAKJMSDJKAYCZ-UHFFFAOYSA-N 0.000 description 6
239000002253 acid Substances 0.000 description 5
125000002947 alkylene group Chemical group 0.000 description 5
125000004435 hydrogen atom Chemical group [H]* 0.000 description 5
239000000047 product Substances 0.000 description 5
238000000926 separation method Methods 0.000 description 5
238000003756 stirring Methods 0.000 description 5
125000000954 2-hydroxyethyl group Chemical group [H]C([*])([H])C([H])([H])O[H] 0.000 description 4
GWEVSGVZZGPLCZ-UHFFFAOYSA-N Titan oxide Chemical compound O=[Ti]=O GWEVSGVZZGPLCZ-UHFFFAOYSA-N 0.000 description 4
125000002091 cationic group Chemical group 0.000 description 4
239000003795 chemical substances by application Substances 0.000 description 4
235000014113 dietary fatty acids Nutrition 0.000 description 4
239000004205 dimethyl polysiloxane Substances 0.000 description 4
235000013870 dimethyl polysiloxane Nutrition 0.000 description 4
REZZEXDLIUJMMS-UHFFFAOYSA-M dimethyldioctadecylammonium chloride Chemical compound [Cl-].CCCCCCCCCCCCCCCCCC[N+](C)(C)CCCCCCCCCCCCCCCCCC REZZEXDLIUJMMS-UHFFFAOYSA-M 0.000 description 4
238000004945 emulsification Methods 0.000 description 4
238000011156 evaluation Methods 0.000 description 4
239000000194 fatty acid Substances 0.000 description 4
229930195729 fatty acid Natural products 0.000 description 4
239000007788 liquid Substances 0.000 description 4
229920000435 poly(dimethylsiloxane) Polymers 0.000 description 4
RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 3
DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 description 3
230000006750 UV protection Effects 0.000 description 3
150000007513 acids Chemical class 0.000 description 3
125000003342 alkenyl group Chemical group 0.000 description 3
150000001412 amines Chemical class 0.000 description 3
230000000052 comparative effect Effects 0.000 description 3
229960000735 docosanol Drugs 0.000 description 3
239000004403 ethyl p-hydroxybenzoate Substances 0.000 description 3
235000010228 ethyl p-hydroxybenzoate Nutrition 0.000 description 3
229940043351 ethyl-p-hydroxybenzoate Drugs 0.000 description 3
NUVBSKCKDOMJSU-UHFFFAOYSA-N ethylparaben Chemical compound CCOC(=O)C1=CC=C(O)C=C1 NUVBSKCKDOMJSU-UHFFFAOYSA-N 0.000 description 3
238000007654 immersion Methods 0.000 description 3
230000003020 moisturizing effect Effects 0.000 description 3
JXTPJDDICSTXJX-UHFFFAOYSA-N n-Triacontane Natural products CCCCCCCCCCCCCCCCCCCCCCCCCCCCCC JXTPJDDICSTXJX-UHFFFAOYSA-N 0.000 description 3
230000037311 normal skin Effects 0.000 description 3
229940032094 squalane Drugs 0.000 description 3
238000012360 testing method Methods 0.000 description 3
239000002023 wood Substances 0.000 description 3
PUPZLCDOIYMWBV-UHFFFAOYSA-N (+/-)-1,3-Butanediol Chemical compound CC(O)CCO PUPZLCDOIYMWBV-UHFFFAOYSA-N 0.000 description 2
BJDAUCLANVMIOB-UHFFFAOYSA-N (3-decanoyloxy-2,2-dimethylpropyl) decanoate Chemical compound CCCCCCCCCC(=O)OCC(C)(C)COC(=O)CCCCCCCCC BJDAUCLANVMIOB-UHFFFAOYSA-N 0.000 description 2
HZAXFHJVJLSVMW-UHFFFAOYSA-N 2-Aminoethan-1-ol Chemical compound NCCO HZAXFHJVJLSVMW-UHFFFAOYSA-N 0.000 description 2
QGZKDVFQNNGYKY-UHFFFAOYSA-N Ammonia Chemical compound N QGZKDVFQNNGYKY-UHFFFAOYSA-N 0.000 description 2
AJLPPLKPZTZMCJ-UHFFFAOYSA-N C(CCCCCCCCCCCCCCC(C)C)C(O)(C(O)CO)CCCCCCCCCCCCCC Chemical compound C(CCCCCCCCCCCCCCC(C)C)C(O)(C(O)CO)CCCCCCCCCCCCCC AJLPPLKPZTZMCJ-UHFFFAOYSA-N 0.000 description 2
239000004215 Carbon black (E152) Substances 0.000 description 2
UQSXHKLRYXJYBZ-UHFFFAOYSA-N Iron oxide Chemical compound [Fe]=O UQSXHKLRYXJYBZ-UHFFFAOYSA-N 0.000 description 2
239000004166 Lanolin Substances 0.000 description 2
YBGZDTIWKVFICR-JLHYYAGUSA-N Octyl 4-methoxycinnamic acid Chemical compound CCCCC(CC)COC(=O)\C=C\C1=CC=C(OC)C=C1 YBGZDTIWKVFICR-JLHYYAGUSA-N 0.000 description 2
QAOWNCQODCNURD-UHFFFAOYSA-L Sulfate Chemical compound [O-]S([O-])(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 description 2
XLOMVQKBTHCTTD-UHFFFAOYSA-N Zinc monoxide Chemical compound [Zn]=O XLOMVQKBTHCTTD-UHFFFAOYSA-N 0.000 description 2
239000006096 absorbing agent Substances 0.000 description 2
239000003945 anionic surfactant Substances 0.000 description 2
RWZYAGGXGHYGMB-UHFFFAOYSA-N anthranilic acid Chemical compound NC1=CC=CC=C1C(O)=O RWZYAGGXGHYGMB-UHFFFAOYSA-N 0.000 description 2
239000008346 aqueous phase Substances 0.000 description 2
230000004888 barrier function Effects 0.000 description 2
230000015572 biosynthetic process Effects 0.000 description 2
HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 description 2
235000012000 cholesterol Nutrition 0.000 description 2
239000011248 coating agent Substances 0.000 description 2
238000000576 coating method Methods 0.000 description 2
238000012790 confirmation Methods 0.000 description 2
125000004990 dihydroxyalkyl group Chemical group 0.000 description 2
239000002270 dispersing agent Substances 0.000 description 2
239000004664 distearyldimethylammonium chloride (DHTDMAC) Substances 0.000 description 2
239000003814 drug Substances 0.000 description 2
239000010696 ester oil Substances 0.000 description 2
150000002148 esters Chemical class 0.000 description 2
239000003205 fragrance Substances 0.000 description 2
IPCSVZSSVZVIGE-UHFFFAOYSA-N hexadecanoic acid Chemical compound CCCCCCCCCCCCCCCC(O)=O IPCSVZSSVZVIGE-UHFFFAOYSA-N 0.000 description 2
229930195733 hydrocarbon Natural products 0.000 description 2
230000007794 irritation Effects 0.000 description 2
229940119170 jojoba wax Drugs 0.000 description 2
235000019388 lanolin Nutrition 0.000 description 2
229940039717 lanolin Drugs 0.000 description 2
210000004185 liver Anatomy 0.000 description 2
VNWKTOKETHGBQD-UHFFFAOYSA-N methane Chemical compound C VNWKTOKETHGBQD-UHFFFAOYSA-N 0.000 description 2
239000004292 methyl p-hydroxybenzoate Substances 0.000 description 2
235000010270 methyl p-hydroxybenzoate Nutrition 0.000 description 2
229960002216 methylparaben Drugs 0.000 description 2
235000013336 milk Nutrition 0.000 description 2
239000008267 milk Substances 0.000 description 2
210000004080 milk Anatomy 0.000 description 2
210000005036 nerve Anatomy 0.000 description 2
239000002736 nonionic surfactant Substances 0.000 description 2
GLDOVTGHNKAZLK-UHFFFAOYSA-N octadecan-1-ol Chemical compound CCCCCCCCCCCCCCCCCCO GLDOVTGHNKAZLK-UHFFFAOYSA-N 0.000 description 2
230000003287 optical effect Effects 0.000 description 2
238000002360 preparation method Methods 0.000 description 2
239000003223 protective agent Substances 0.000 description 2
YGSDEFSMJLZEOE-UHFFFAOYSA-N salicylic acid Chemical compound OC(=O)C1=CC=CC=C1O YGSDEFSMJLZEOE-UHFFFAOYSA-N 0.000 description 2
210000002374 sebum Anatomy 0.000 description 2
230000008591 skin barrier function Effects 0.000 description 2
210000000434 stratum corneum Anatomy 0.000 description 2
230000008719 thickening Effects 0.000 description 2
239000004408 titanium dioxide Substances 0.000 description 2
AFDXODALSZRGIH-QPJJXVBHSA-N (E)-3-(4-methoxyphenyl)prop-2-enoic acid Chemical compound COC1=CC=C(\C=C\C(O)=O)C=C1 AFDXODALSZRGIH-QPJJXVBHSA-N 0.000 description 1
OOWQBDFWEXAXPB-UHFFFAOYSA-N 1-O-palmitylglycerol Chemical compound CCCCCCCCCCCCCCCCOCC(O)CO OOWQBDFWEXAXPB-UHFFFAOYSA-N 0.000 description 1
WAYINTBTZWQNSN-UHFFFAOYSA-N 11-methyldodecyl 3,5,5-trimethylhexanoate Chemical compound CC(C)CCCCCCCCCCOC(=O)CC(C)CC(C)(C)C WAYINTBTZWQNSN-UHFFFAOYSA-N 0.000 description 1
125000004200 2-methoxyethyl group Chemical group [H]C([H])([H])OC([H])([H])C([H])([H])* 0.000 description 1
BGRXBNZMPMGLQI-UHFFFAOYSA-N 2-octyldodecyl tetradecanoate Chemical compound CCCCCCCCCCCCCC(=O)OCC(CCCCCCCC)CCCCCCCCCC BGRXBNZMPMGLQI-UHFFFAOYSA-N 0.000 description 1
JRLTTZUODKEYDH-UHFFFAOYSA-N 8-methylquinoline Chemical group C1=CN=C2C(C)=CC=CC2=C1 JRLTTZUODKEYDH-UHFFFAOYSA-N 0.000 description 1
QTBSBXVTEAMEQO-UHFFFAOYSA-M Acetate Chemical compound CC([O-])=O QTBSBXVTEAMEQO-UHFFFAOYSA-M 0.000 description 1
241000269333 Caudata Species 0.000 description 1
241000251730 Chondrichthyes Species 0.000 description 1
206010013786 Dry skin Diseases 0.000 description 1
241000196324 Embryophyta Species 0.000 description 1
VGGSQFUCUMXWEO-UHFFFAOYSA-N Ethene Chemical compound C=C VGGSQFUCUMXWEO-UHFFFAOYSA-N 0.000 description 1
239000005977 Ethylene Substances 0.000 description 1
YCKRFDGAMUMZLT-UHFFFAOYSA-N Fluorine atom Chemical compound [F] YCKRFDGAMUMZLT-UHFFFAOYSA-N 0.000 description 1
102000011782 Keratins Human genes 0.000 description 1
108010076876 Keratins Proteins 0.000 description 1
JVTAAEKCZFNVCJ-UHFFFAOYSA-N Lactic Acid Natural products CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 description 1
OFOBLEOULBTSOW-UHFFFAOYSA-N Malonic acid Chemical compound OC(=O)CC(O)=O OFOBLEOULBTSOW-UHFFFAOYSA-N 0.000 description 1
101100518501 Mus musculus Spp1 gene Proteins 0.000 description 1
235000021314 Palmitic acid Nutrition 0.000 description 1
239000004264 Petrolatum Substances 0.000 description 1
239000002202 Polyethylene glycol Substances 0.000 description 1
229920002675 Polyoxyl Polymers 0.000 description 1
239000004721 Polyphenylene oxide Substances 0.000 description 1
241001454547 Rhodotypos scandens Species 0.000 description 1
206010040880 Skin irritation Diseases 0.000 description 1
235000021355 Stearic acid Nutrition 0.000 description 1
229930182558 Sterol Natural products 0.000 description 1
PJANXHGTPQOBST-VAWYXSNFSA-N Stilbene Natural products C=1C=CC=CC=1/C=C/C1=CC=CC=C1 PJANXHGTPQOBST-VAWYXSNFSA-N 0.000 description 1
150000001335 aliphatic alkanes Chemical group 0.000 description 1
125000003368 amide group Chemical group 0.000 description 1
150000003862 amino acid derivatives Chemical class 0.000 description 1
229910021529 ammonia Inorganic materials 0.000 description 1
150000008064 anhydrides Chemical class 0.000 description 1
239000010775 animal oil Substances 0.000 description 1
239000003963 antioxidant agent Substances 0.000 description 1
FLNKWZNWHZDGRT-UHFFFAOYSA-N azane;dihydrochloride Chemical compound [NH4+].[NH4+].[Cl-].[Cl-] FLNKWZNWHZDGRT-UHFFFAOYSA-N 0.000 description 1
OGBUMNBNEWYMNJ-UHFFFAOYSA-N batilol Chemical compound CCCCCCCCCCCCCCCCCCOCC(O)CO OGBUMNBNEWYMNJ-UHFFFAOYSA-N 0.000 description 1
RWCCWEUUXYIKHB-UHFFFAOYSA-N benzophenone Chemical compound C=1C=CC=CC=1C(=O)C1=CC=CC=C1 RWCCWEUUXYIKHB-UHFFFAOYSA-N 0.000 description 1
210000000941 bile Anatomy 0.000 description 1
125000000484 butyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
239000004203 carnauba wax Substances 0.000 description 1
235000013869 carnauba wax Nutrition 0.000 description 1
125000001549 ceramide group Chemical group 0.000 description 1
239000002738 chelating agent Substances 0.000 description 1
238000006243 chemical reaction Methods 0.000 description 1
150000001840 cholesterol esters Chemical class 0.000 description 1
150000001841 cholesterols Chemical class 0.000 description 1
239000000084 colloidal system Substances 0.000 description 1
238000009833 condensation Methods 0.000 description 1
230000005494 condensation Effects 0.000 description 1
125000002704 decyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 description 1
XLYOFNOQVPJJNP-DYCDLGHISA-N deuterium hydrogen oxide Chemical compound [2H]O XLYOFNOQVPJJNP-DYCDLGHISA-N 0.000 description 1
GYZLOYUZLJXAJU-UHFFFAOYSA-N diglycidyl ether Chemical compound C1OC1COCC1CO1 GYZLOYUZLJXAJU-UHFFFAOYSA-N 0.000 description 1
ZCPCLAPUXMZUCD-UHFFFAOYSA-M dihexadecyl(dimethyl)azanium;chloride Chemical compound [Cl-].CCCCCCCCCCCCCCCC[N+](C)(C)CCCCCCCCCCCCCCCC ZCPCLAPUXMZUCD-UHFFFAOYSA-M 0.000 description 1
NAPSCFZYZVSQHF-UHFFFAOYSA-N dimantine Chemical compound CCCCCCCCCCCCCCCCCCN(C)C NAPSCFZYZVSQHF-UHFFFAOYSA-N 0.000 description 1
IQDGSYLLQPDQDV-UHFFFAOYSA-N dimethylazanium;chloride Chemical compound Cl.CNC IQDGSYLLQPDQDV-UHFFFAOYSA-N 0.000 description 1
SZXQTJUDPRGNJN-UHFFFAOYSA-N dipropylene glycol Chemical compound OCCCOCCCO SZXQTJUDPRGNJN-UHFFFAOYSA-N 0.000 description 1
125000003438 dodecyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 description 1
239000002552 dosage form Substances 0.000 description 1
239000003995 emulsifying agent Substances 0.000 description 1
230000001804 emulsifying effect Effects 0.000 description 1
210000002615 epidermis Anatomy 0.000 description 1
125000004185 ester group Chemical group 0.000 description 1
238000001704 evaporation Methods 0.000 description 1
230000008020 evaporation Effects 0.000 description 1
150000004665 fatty acids Chemical class 0.000 description 1
235000020988 fatty fish Nutrition 0.000 description 1
HJUFTIJOISQSKQ-UHFFFAOYSA-N fenoxycarb Chemical compound C1=CC(OCCNC(=O)OCC)=CC=C1OC1=CC=CC=C1 HJUFTIJOISQSKQ-UHFFFAOYSA-N 0.000 description 1
239000000796 flavoring agent Substances 0.000 description 1
235000019634 flavors Nutrition 0.000 description 1
239000011737 fluorine Substances 0.000 description 1
229910052731 fluorine Inorganic materials 0.000 description 1
235000021588 free fatty acids Nutrition 0.000 description 1
239000000417 fungicide Substances 0.000 description 1
238000002309 gasification Methods 0.000 description 1
239000000499 gel Substances 0.000 description 1
150000002314 glycerols Chemical class 0.000 description 1
210000004209 hair Anatomy 0.000 description 1
150000004820 halides Chemical class 0.000 description 1
230000026030 halogenation Effects 0.000 description 1
238000005658 halogenation reaction Methods 0.000 description 1
230000003301 hydrolyzing effect Effects 0.000 description 1
230000002209 hydrophobic effect Effects 0.000 description 1
RAXXELZNTBOGNW-UHFFFAOYSA-N imidazole Substances C1=CNC=N1 RAXXELZNTBOGNW-UHFFFAOYSA-N 0.000 description 1
239000002563 ionic surfactant Substances 0.000 description 1
150000002500 ions Chemical class 0.000 description 1
229940093629 isopropyl isostearate Drugs 0.000 description 1
239000004310 lactic acid Substances 0.000 description 1
235000014655 lactic acid Nutrition 0.000 description 1
108010051201 lipid I Proteins 0.000 description 1
238000012423 maintenance Methods 0.000 description 1
229940049920 malate Drugs 0.000 description 1
BJEPYKJPYRNKOW-UHFFFAOYSA-N malic acid Chemical compound OC(=O)C(O)CC(O)=O BJEPYKJPYRNKOW-UHFFFAOYSA-N 0.000 description 1
238000005259 measurement Methods 0.000 description 1
238000002844 melting Methods 0.000 description 1
230000008018 melting Effects 0.000 description 1
LXCFILQKKLGQFO-UHFFFAOYSA-N methylparaben Chemical compound COC(=O)C1=CC=C(O)C=C1 LXCFILQKKLGQFO-UHFFFAOYSA-N 0.000 description 1
239000004200 microcrystalline wax Substances 0.000 description 1
235000019808 microcrystalline wax Nutrition 0.000 description 1
210000004400 mucous membrane Anatomy 0.000 description 1
WQEPLUUGTLDZJY-UHFFFAOYSA-N n-Pentadecanoic acid Natural products CCCCCCCCCCCCCCC(O)=O WQEPLUUGTLDZJY-UHFFFAOYSA-N 0.000 description 1
GOQYKNQRPGWPLP-UHFFFAOYSA-N n-heptadecyl alcohol Natural products CCCCCCCCCCCCCCCCCO GOQYKNQRPGWPLP-UHFFFAOYSA-N 0.000 description 1
230000001537 neural effect Effects 0.000 description 1
125000001400 nonyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 description 1
OQCDKBAXFALNLD-UHFFFAOYSA-N octadecanoic acid Natural products CCCCCCCC(C)CCCCCCCCC(O)=O OQCDKBAXFALNLD-UHFFFAOYSA-N 0.000 description 1
SFBIZPBTKROSDE-UHFFFAOYSA-N octyl 2-hydroxypropanoate Chemical compound CCCCCCCCOC(=O)C(C)O SFBIZPBTKROSDE-UHFFFAOYSA-N 0.000 description 1
125000002347 octyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
229940073665 octyldodecyl myristate Drugs 0.000 description 1
AFDXODALSZRGIH-UHFFFAOYSA-N p-coumaric acid methyl ether Natural products COC1=CC=C(C=CC(O)=O)C=C1 AFDXODALSZRGIH-UHFFFAOYSA-N 0.000 description 1
239000003002 pH adjusting agent Substances 0.000 description 1
238000010979 pH adjustment Methods 0.000 description 1
238000001139 pH measurement Methods 0.000 description 1
FJKROLUGYXJWQN-UHFFFAOYSA-N papa-hydroxy-benzoic acid Natural products OC(=O)C1=CC=C(O)C=C1 FJKROLUGYXJWQN-UHFFFAOYSA-N 0.000 description 1
239000012188 paraffin wax Substances 0.000 description 1
125000002958 pentadecyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
235000019271 petrolatum Nutrition 0.000 description 1
229940066842 petrolatum Drugs 0.000 description 1
239000002831 pharmacologic agent Substances 0.000 description 1
WVDDGKGOMKODPV-ZQBYOMGUSA-N phenyl(114C)methanol Chemical compound O[14CH2]C1=CC=CC=C1 WVDDGKGOMKODPV-ZQBYOMGUSA-N 0.000 description 1
NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 description 1
229940085991 phosphate ion Drugs 0.000 description 1
239000000049 pigment Substances 0.000 description 1
229930006728 pinane Natural products 0.000 description 1
XOKSLPVRUOBDEW-UHFFFAOYSA-N pinane of uncertain configuration Natural products CC1CCC2C(C)(C)C1C2 XOKSLPVRUOBDEW-UHFFFAOYSA-N 0.000 description 1
229920000570 polyether Polymers 0.000 description 1
229920001223 polyethylene glycol Polymers 0.000 description 1
229920000223 polyglycerol Polymers 0.000 description 1
229920000642 polymer Polymers 0.000 description 1
238000006116 polymerization reaction Methods 0.000 description 1
239000000843 powder Substances 0.000 description 1
239000003755 preservative agent Substances 0.000 description 1
NEOZOXKVMDBOSG-UHFFFAOYSA-N propan-2-yl 16-methylheptadecanoate Chemical compound CC(C)CCCCCCCCCCCCCCC(=O)OC(C)C NEOZOXKVMDBOSG-UHFFFAOYSA-N 0.000 description 1
239000000376 reactant Substances 0.000 description 1
238000012552 review Methods 0.000 description 1
229960004889 salicylic acid Drugs 0.000 description 1
230000001568 sexual effect Effects 0.000 description 1
229920002545 silicone oil Polymers 0.000 description 1
230000036556 skin irritation Effects 0.000 description 1
231100000475 skin irritation Toxicity 0.000 description 1
239000000344 soap Substances 0.000 description 1
230000003068 static effect Effects 0.000 description 1
239000008117 stearic acid Substances 0.000 description 1
125000004079 stearyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
235000003702 sterols Nutrition 0.000 description 1
150000003432 sterols Chemical class 0.000 description 1
235000021286 stilbenes Nutrition 0.000 description 1
125000001424 substituent group Chemical group 0.000 description 1
235000000346 sugar Nutrition 0.000 description 1
150000005846 sugar alcohols Polymers 0.000 description 1
150000008163 sugars Chemical class 0.000 description 1
229940124530 sulfonamide Drugs 0.000 description 1
210000004243 sweat Anatomy 0.000 description 1
238000003786 synthesis reaction Methods 0.000 description 1
239000002562 thickening agent Substances 0.000 description 1
125000003944 tolyl group Chemical group 0.000 description 1
230000000699 topical effect Effects 0.000 description 1
PDSVZUAJOIQXRK-UHFFFAOYSA-N trimethyl(octadecyl)azanium Chemical compound CCCCCCCCCCCCCCCCCC[N+](C)(C)C PDSVZUAJOIQXRK-UHFFFAOYSA-N 0.000 description 1
125000003258 trimethylene group Chemical group [H]C([H])([*:2])C([H])([H])C([H])([H])[*:1] 0.000 description 1
235000015112 vegetable and seed oil Nutrition 0.000 description 1
239000008158 vegetable oil Substances 0.000 description 1
239000012178 vegetable wax Substances 0.000 description 1
238000005406 washing Methods 0.000 description 1
239000001993 wax Substances 0.000 description 1
239000011787 zinc oxide Substances 0.000 description 1

Landscapes

Cosmetics (AREA)

TW92126607A 2002-12-27 2003-09-26 Oil-in-water emulsion composition and manufacturing method thereof TW200416045A (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
JP2002381046		2002-12-27

Publications (2)

Publication Number	Publication Date
TW200416045A true TW200416045A (en)	2004-09-01
TWI342220B TWI342220B (de)	2011-05-21

Family

ID=34260225

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
TW92126607A TW200416045A (en)	2002-12-27	2003-09-26	Oil-in-water emulsion composition and manufacturing method thereof

Country Status (2)

Country	Link
CN (1)	CN100369600C (de)
TW (1)	TW200416045A (de)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JP4719575B2 (ja) *	2006-01-13	2011-07-06	花王株式会社	毛髪化粧料及びその製造方法
CN102727392A (zh) *	2011-03-31	2012-10-17	花王株式会社	乳化组合物
KR102485259B1 (ko) *	2018-03-27	2023-01-06	(주)아모레퍼시픽	모발 상태 개선용 액상 지질 복합 조성물
CN112680293B (zh) *	2019-10-18	2022-07-08	中国石油化工股份有限公司	乳化剂及其制备方法和应用以及碱洗塔中黄油乳化的方法

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4389418A (en) *	1981-02-25	1983-06-21	S. C. Johnson & Son, Inc.	Skin care composition
US5019376A (en) *	1989-03-13	1991-05-28	S. C. Johnson & Son, Inc.	Sparkling pearlescent personal care compositions
WO1990010429A1 (en) *	1989-03-13	1990-09-20	S.C. Johnson & Son, Inc.	Sparkling pearlescent personal care compositions
JP3333884B2 (ja) *	1990-04-27	2002-10-15	ライオン株式会社	水中油型エマルジョンの製造方法
CN1087812A (zh) *	1992-10-09	1994-06-15	花王株式会社	护发用化妆品组合物
JPH07187967A (ja) *	1993-12-28	1995-07-25	Kao Corp	毛髪洗浄料
JP2000355519A (ja) *	1999-06-14	2000-12-26	Lion Corp	乳化化粧料の製造方法
JP3715223B2 (ja) *	2000-08-04	2005-11-09	花王株式会社	水中油型乳化組成物の製造方法

2003
- 2003-09-26 TW TW92126607A patent/TW200416045A/zh not_active IP Right Cessation
- 2003-11-06 CN CNB2003101038050A patent/CN100369600C/zh not_active Expired - Fee Related

Also Published As

Publication number	Publication date
CN100369600C (zh)	2008-02-20
CN1511512A (zh)	2004-07-14
TWI342220B (de)	2011-05-21

Legal Events

Date	Code	Title	Description
2019-02-21	MM4A	Annulment or lapse of patent due to non-payment of fees

Publication	Publication Date	Title
JP4040527B2 (ja)	2008-01-30	脂質組成物およびそれを含有する皮膚外用剤
JP6377381B2 (ja)	2018-08-22	リポソーム組成物
JP2010174012A (ja)	2010-08-12	緩和された目への刺激を有するパーソナル・ケア日焼け止め剤組成物
BR102015024622B1 (pt)	2020-12-22	composições antiperspirantes
TWI516278B (zh)	2016-01-11	油中水型乳化化妝料
TW201733564A (zh)	2017-10-01	含有波紋相之組成物、α凝膠形成用組成物、以及使用該組成物的皮膚外用組成物及α凝膠組成物
CN101827578B (zh)	2012-10-31	反相囊泡组合物
JP7759687B2 (ja)	2025-10-24	皮膚状態改善剤
TWI740882B (zh)	2021-10-01	α膠形成用組成物及α膠組成物
CN102802598A (zh)	2012-11-28	囊泡组合物及用其配合的化妆品
JP3902174B2 (ja)	2007-04-04	水中油型乳化組成物の製造方法
JP2006028109A (ja)	2006-02-02	水中油型乳化組成物
JP2006036763A (ja)	2006-02-09	水中油型乳化組成物
JP2001348320A (ja)	2001-12-18	液晶構造を有する脂質組成物
JP5342736B2 (ja)	2013-11-13	水中油型エマルション及びその製造方法
JP3967292B2 (ja)	2007-08-29	油中水型乳化組成物
CN100473375C (zh)	2009-04-01	水包油型乳化化妆品
JP2005145877A (ja)	2005-06-09	水中油型乳化組成物
TW200416045A (en)	2004-09-01	Oil-in-water emulsion composition and manufacturing method thereof
JP2001048730A (ja)	2001-02-20	化粧料
JP4188149B2 (ja)	2008-11-26	皮膚外用剤
JP2005023068A (ja)	2005-01-27	水中油型乳化化粧料
JP2010013404A (ja)	2010-01-21	毛髪化粧料
JPH10194964A (ja)	1998-07-28	乳化組成物
JP5064659B2 (ja)	2012-10-31	パール剤組成物及びそれを含有する化粧料