TW200716565A - Tetrahydronaphthalene derivatives, process for their production and their use as anti-inflammatory agents - Google Patents

Tetrahydronaphthalene derivatives, process for their production and their use as anti-inflammatory agents

Info

Publication number
TW200716565A
TW200716565A TW095113518A TW95113518A TW200716565A TW 200716565 A TW200716565 A TW 200716565A TW 095113518 A TW095113518 A TW 095113518A TW 95113518 A TW95113518 A TW 95113518A TW 200716565 A TW200716565 A TW 200716565A
Authority
TW
Taiwan
Prior art keywords
production
inflammatory agents
tetrahydronaphthalene derivatives
tetrahydronaphthalene
derivatives
Prior art date
Application number
TW095113518A
Other languages
Chinese (zh)
Inventor
Anne Mengel
Konrad Krolikiewicz
Stefan Baurle
Heike Schacke
Original Assignee
Schering Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Ag filed Critical Schering Ag
Publication of TW200716565A publication Critical patent/TW200716565A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/32—One oxygen, sulfur or nitrogen atom
    • C07D239/42—One nitrogen atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C215/00—Compounds containing amino and hydroxy groups bound to the same carbon skeleton
    • C07C215/42—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having amino groups or hydroxy groups bound to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
    • C07C215/44—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having amino groups or hydroxy groups bound to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton bound to carbon atoms of the same ring or condensed ring system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/38—Nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2602/00—Systems containing two condensed rings
    • C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
    • C07C2602/04—One of the condensed rings being a six-membered aromatic ring
    • C07C2602/10—One of the condensed rings being a six-membered aromatic ring the other ring being six-membered, e.g. tetraline

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pain & Pain Management (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Rheumatology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

The invention relates to polysubstituted tetrahydronaphthalene derivatives of formula(I), process for their production and their use as anti-inflammatory agents.
TW095113518A 2005-04-14 2006-04-14 Tetrahydronaphthalene derivatives, process for their production and their use as anti-inflammatory agents TW200716565A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE102005017316A DE102005017316A1 (en) 2005-04-14 2005-04-14 Tetrahydronaphthalene derivatives, process for their preparation and their use as anti-inflammatory agents

Publications (1)

Publication Number Publication Date
TW200716565A true TW200716565A (en) 2007-05-01

Family

ID=36889239

Family Applications (1)

Application Number Title Priority Date Filing Date
TW095113518A TW200716565A (en) 2005-04-14 2006-04-14 Tetrahydronaphthalene derivatives, process for their production and their use as anti-inflammatory agents

Country Status (8)

Country Link
AR (1) AR053582A1 (en)
DE (1) DE102005017316A1 (en)
DO (1) DOP2006000089A (en)
GT (1) GT200600152A (en)
PE (1) PE20061360A1 (en)
TW (1) TW200716565A (en)
UY (1) UY29482A1 (en)
WO (1) WO2006108713A2 (en)

Family Cites Families (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS63220242A (en) * 1987-03-10 1988-09-13 Fuji Photo Film Co Ltd Photoresist composition
JPH02501737A (en) * 1987-05-15 1990-06-14 シェリング・コーポレーション Aryl-substituted naphthalenes, benzoxepines, benzazepines, benzocycloheptene derivatives
EP0370056A1 (en) * 1987-07-16 1990-05-30 Byk Gulden Lomberg Chemische Fabrik Gmbh New diazols
US5059609A (en) * 1987-10-19 1991-10-22 Pfizer Inc. Substituted tetralins, chromans and related compounds in the treatment of asthma, arthritis and related diseases
JPH0641038A (en) * 1992-07-17 1994-02-15 Mitsubishi Kasei Corp Carboxylic acid derivative
US5489584A (en) * 1994-12-29 1996-02-06 Allergan, Inc. Acetylenes disubstituted with a 5-amino or substituted 5-amino substituted tetrahydronaphthyl group and with an aryl or heteroaryl group having retinoid-like biological activity
WO1999004778A1 (en) * 1997-07-22 1999-02-04 Eli Lilly And Company Pharmaceutical compounds
GB9716244D0 (en) * 1997-07-31 1997-10-08 Electrophoretics International Pharmaceutical compounds
US6333337B1 (en) * 1998-01-27 2001-12-25 Icagen, Inc. Potassium channel inhibitors
US6013830A (en) * 1998-03-30 2000-01-11 Sepracor Inc. Asymmetric grignard synthesis with cyclic 1,2 aminoalcohols
WO2000010977A1 (en) * 1998-08-21 2000-03-02 The Scripps Research Institute Catalytic asymmetric aminohydroxylation with amino-substituted heterocycles
JP2000256255A (en) * 1999-03-10 2000-09-19 Kuraray Co Ltd Optical resolution method of (±) -trans-permetholinic acid
SE9903930D0 (en) * 1999-10-29 1999-10-29 Astra Pharma Inc Novel compounds and a novel process for their preparation
ES2193839B1 (en) * 2001-06-22 2005-02-16 Almirall Prodesfarma, S.A. NEW DERIVATIVES OF 6-PHENYLDIHYDROPIRROLPIRIMIDINDIONA.
KR20040053130A (en) * 2001-09-21 2004-06-23 일라이 릴리 앤드 캄파니 Muscarinic Agonists
PE20030547A1 (en) * 2001-09-24 2003-08-18 Bayer Corp IMIDAZOLE DERIVATIVES FOR THE TREATMENT OF OBESITY
DE60234269D1 (en) * 2001-11-21 2009-12-17 Pharmacia & Upjohn Co Llc SUBSTITUTED ARYL 1,4-PYRAZINE DERIVATIVES
US6875866B2 (en) * 2002-02-21 2005-04-05 Schering Corporation Process for synthesis of D1 receptor antagonists
WO2004020375A1 (en) * 2002-08-26 2004-03-11 Merck Patent Gmbh Cyclopenta[b]naphthalene derivatives
WO2005021682A1 (en) * 2003-08-22 2005-03-10 Merck Patent Gmbh Cyclopenta[a]naphthaline derivatives
CN1239441C (en) * 2003-09-12 2006-02-01 中国科学院上海有机化学研究所 Method for processing asymmetric hydroxylamination and dihydroxylation reaction by use of supported bi-cinchoni alkaloid ligand

Also Published As

Publication number Publication date
WO2006108713A3 (en) 2006-12-14
WO2006108713A2 (en) 2006-10-19
AR053582A1 (en) 2007-05-09
DOP2006000089A (en) 2006-11-15
UY29482A1 (en) 2006-10-31
GT200600152A (en) 2007-03-19
PE20061360A1 (en) 2007-01-26
DE102005017316A1 (en) 2006-10-19

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