TW200716616A - Modulators of CCR-5 activity - Google Patents

Modulators of CCR-5 activity

Info

Publication number
TW200716616A
TW200716616A TW095118810A TW95118810A TW200716616A TW 200716616 A TW200716616 A TW 200716616A TW 095118810 A TW095118810 A TW 095118810A TW 95118810 A TW95118810 A TW 95118810A TW 200716616 A TW200716616 A TW 200716616A
Authority
TW
Taiwan
Prior art keywords
ccr
modulators
activity
compounds
compositions
Prior art date
Application number
TW095118810A
Other languages
Chinese (zh)
Inventor
Erik Boman
Russell Dahl
Nancy G J Delaet
Justin Ernst
Christopher Lum
Lubomir Sebo
Jan Urban
Original Assignee
Kemia Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kemia Inc filed Critical Kemia Inc
Publication of TW200716616A publication Critical patent/TW200716616A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/22—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with hetero atoms directly attached to ring nitrogen atoms
    • C07D295/28—Nitrogen atoms
    • C07D295/32—Nitrogen atoms acylated with carboxylic or carbonic acids, or their nitrogen or sulfur analogues
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
    • C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/08—Bridged systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Ths present invention relates to low molecular weight compounds, including compounds of Formulas I and II as defined herein, and pharmaceutical compositions thereof, useful as modulators of CCR-5 activity. The invention further relates to the use of such compounds and compositions in treating disorders mediated by CCR-5 such as viral infections and inflammatory diseases.
TW095118810A 2005-05-27 2006-05-26 Modulators of CCR-5 activity TW200716616A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US68514705P 2005-05-27 2005-05-27
US78509006P 2006-03-22 2006-03-22

Publications (1)

Publication Number Publication Date
TW200716616A true TW200716616A (en) 2007-05-01

Family

ID=37482161

Family Applications (1)

Application Number Title Priority Date Filing Date
TW095118810A TW200716616A (en) 2005-05-27 2006-05-26 Modulators of CCR-5 activity

Country Status (2)

Country Link
TW (1) TW200716616A (en)
WO (1) WO2006130426A2 (en)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB201017345D0 (en) 2010-10-14 2010-11-24 Proximagen Ltd Receptor antagonists
WO2014102594A2 (en) * 2012-12-27 2014-07-03 Purdue Pharma L.P. Substituted benzimidazole-type piperidine compounds and uses thereof
GB201321748D0 (en) * 2013-12-09 2014-01-22 Ucb Pharma Sa Therapeutic agents
WO2015135091A1 (en) * 2014-03-10 2015-09-17 Merck Sharp & Dohme Corp. Piperazine derivatives as hiv protease inhibitors
US10138255B2 (en) 2014-03-10 2018-11-27 Merck Sharp & Dohme Corp. Piperazine derivatives as HIV protease inhibitors
CA2944069C (en) * 2014-04-01 2022-03-08 William Hawkins Sigma-2 receptor ligand drug conjugates as antitumor compounds, methods of synthesis and uses thereof
CN104083386B (en) * 2014-07-08 2016-07-06 滨州医学院 Amprenavir application in the medicine of preparation prevention or treatment acute lung injury/acute respiratory distress syndrome and pulmonary fibrosis
CN104387379B (en) * 2014-11-26 2017-01-11 扬州氟药科技有限公司 Difluoro methylene piperidine carboxamide derivative as well as preparation method and application thereof
JP6927882B2 (en) 2015-04-02 2021-09-01 プロキシマジェン，リミティド ライアビリティ カンパニー New treatment for cancer
CN118526500B (en) * 2024-07-02 2025-11-14 中国药科大学 New pharmaceutical uses for rilpivirine

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU4143300A (en) * 1999-04-28 2000-11-17 Takeda Chemical Industries Ltd. Cyclic amide compounds, process for the preparation of the same and uses thereof
AR025884A1 (en) * 1999-10-01 2002-12-18 Takeda Pharmaceutical CYCLINE AMINE COMPOUNDS, ITS PRODUCTION AND USE

Also Published As

Publication number Publication date
WO2006130426A3 (en) 2007-06-21
WO2006130426A2 (en) 2006-12-07

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