TW200716982A - Measuring thrombin activity in whole blood - Google Patents

Measuring thrombin activity in whole blood

Info

Publication number: TW200716982A
Authority: TW; Taiwan
Prior art keywords: sample; thrombin; layer; whole blood; thrombin activity
Prior art date: 2005-04-29

Application number

TW095115377A

Other languages

English (en)

Inventor

Hendrik Coenraad Hemker

Suzette Beguin

Raed Al-Dieri

Robert Wagenvoord

Sebastiaan Nijhuis

Peter Giesen

Original Assignee

Synapse Bv

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2005-04-29

Filing date

2006-04-28

Publication date

2007-05-01

2006-04-28 Application filed by Synapse Bv filed Critical Synapse Bv

2007-05-01 Publication of TW200716982A publication Critical patent/TW200716982A/zh

Links

108090000190 Thrombin Proteins 0.000 title abstract 6
229960004072 thrombin Drugs 0.000 title abstract 6
239000008280 blood Substances 0.000 title abstract 2
210000004369 blood Anatomy 0.000 title abstract 2
230000000694 effects Effects 0.000 title abstract 2
239000007850 fluorescent dye Substances 0.000 abstract 3
UPSFMJHZUCSEHU-JYGUBCOQSA-N n-[(2s,3r,4r,5s,6r)-2-[(2r,3s,4r,5r,6s)-5-acetamido-4-hydroxy-2-(hydroxymethyl)-6-(4-methyl-2-oxochromen-7-yl)oxyoxan-3-yl]oxy-4,5-dihydroxy-6-(hydroxymethyl)oxan-3-yl]acetamide Chemical compound CC(=O)N[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1O[C@H]1[C@H](O)[C@@H](NC(C)=O)[C@H](OC=2C=C3OC(=O)C=C(C)C3=CC=2)O[C@@H]1CO UPSFMJHZUCSEHU-JYGUBCOQSA-N 0.000 abstract 3
230000002255 enzymatic effect Effects 0.000 abstract 1
238000000338 in vitro Methods 0.000 abstract 1
238000000034 method Methods 0.000 abstract 1

Classifications

- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/86—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving blood coagulating time or factors, or their receptors
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/56—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving blood clotting factors, e.g. involving thrombin, thromboplastin, fibrinogen
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/90—Enzymes; Proenzymes
- G01N2333/914—Hydrolases (3)
- G01N2333/948—Hydrolases (3) acting on peptide bonds (3.4)
- G01N2333/974—Thrombin

Landscapes

Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Organic Chemistry (AREA)
Engineering & Computer Science (AREA)
Zoology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Wood Science & Technology (AREA)
Hematology (AREA)
Immunology (AREA)
Molecular Biology (AREA)
Biochemistry (AREA)
General Health & Medical Sciences (AREA)
Physics & Mathematics (AREA)
Biotechnology (AREA)
Microbiology (AREA)
Analytical Chemistry (AREA)
Bioinformatics & Cheminformatics (AREA)
Neurosurgery (AREA)
General Engineering & Computer Science (AREA)
Biophysics (AREA)
Genetics & Genomics (AREA)
Urology & Nephrology (AREA)
Biomedical Technology (AREA)
Cell Biology (AREA)
Food Science & Technology (AREA)
Medicinal Chemistry (AREA)
General Physics & Mathematics (AREA)
Pathology (AREA)
Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Investigating Or Analysing Biological Materials (AREA)
Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)

TW095115377A 2005-04-29 2006-04-28 Measuring thrombin activity in whole blood TW200716982A (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
EP05290952A EP1717588A1 (en)	2005-04-29	2005-04-29	Measuring thrombin activity in whole blood

Publications (1)

Publication Number	Publication Date
TW200716982A true TW200716982A (en)	2007-05-01

Family

ID=34978991

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
TW095115377A TW200716982A (en)	2005-04-29	2006-04-28	Measuring thrombin activity in whole blood

Country Status (16)

Country	Link
US (1)	US8916356B2 (zh)
EP (2)	EP1717588A1 (zh)
JP (1)	JP4897794B2 (zh)
KR (1)	KR20080025043A (zh)
CN (1)	CN101171519A (zh)
AR (1)	AR053371A1 (zh)
AT (1)	ATE483984T1 (zh)
AU (1)	AU2006243283B2 (zh)
BR (1)	BRPI0612967B8 (zh)
CA (1)	CA2606906C (zh)
DE (1)	DE602006017350D1 (zh)
ES (1)	ES2354086T3 (zh)
MX (1)	MX2007013497A (zh)
RU (1)	RU2422835C2 (zh)
TW (1)	TW200716982A (zh)
WO (1)	WO2006117246A1 (zh)

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JP5461175B2 (ja) *	2006-06-06	2014-04-02	トロームビノスコープベスローテンフェンノートシャップ	生体媒質中で酵素活性を決定する方法
DE602007011661D1 (de) *	2006-11-02	2011-02-10	Thrombinoscope B V	Verfahren zur messung der konzentration transienter proteolytischer aktivität in zellen enthaltenden zusammengesetzten biologischen medien
EP2088435B1 (en)	2008-02-07	2011-07-13	Synapse B.V.	Time-course measurement of enzymatic activity corrected for impacts of disturbances relating to the reaction of the enzyme with a substrate
FR2933496B1 (fr) *	2008-07-02	2012-10-05	Lfb Biotechnologies	Procede de mesure du taux de facteur vii active dans un echantillon
CN102124346B (zh) *	2008-07-16	2014-01-15	雷迪奥米特医学公司	凝血酶底物和测定样本中生物活性凝血酶水平的测定法
EP2313785B1 (en)	2008-08-05	2016-02-17	Synapse B.V.	A method and assembly for measuring thrombin generation in plasma
JP5582745B2 (ja) *	2009-09-09	2014-09-03	メタウォーター株式会社	化学発光反応の時間計測による被検出物質の濃度を測定する方法およびそれに使用するキット
US8293493B2 (en) *	2010-01-27	2012-10-23	Adventist Health System/Sunbelt, Inc.	Thrombin generation determination method
CN102798598A (zh) *	2011-05-25	2012-11-28	兆科药业（合肥）有限公司	一种检测磷脂依赖性凝血因子x激活物酶活性的方法
RU2518247C2 (ru) *	2011-07-26	2014-06-10	Общество с ограниченной ответственностью "ГемаКор Лабс" (ООО "ГемаКор Лабс")	Способ определения пространственно-временного распределения активности протеолитического фермента в гетерогенной системе, устройство для реализации указанного способа и способ диагностики нарушений системы гемостаза по изменению пространственно-временного распределения активности протеолитического фермента в гетерогенной системе
JP6491880B2 (ja)	2011-08-23	2019-03-27	シナプス・ビー．ブイ．ＳｙｎａｐｓｅＢ．Ｖ．	異物表面との接触による血液凝固系の活性化の熱安定性阻害剤
WO2013101836A1 (en) *	2011-12-31	2013-07-04	The University Of Vermont And State Agriculture College	Methods for dynamic visualization of clinical parameters over time
KR101383333B1 (ko) *	2012-01-13	2014-04-10	연세대학교 산학협력단	트롬빈 생성 측정 방법
EP2677037B1 (en)	2012-06-21	2016-04-13	Synapse B.V.	Simultaneous measurement of thrombin generation and clot strength in plasma and whole blood
WO2014098056A1 (ja)	2012-12-18	2014-06-26	第一三共株式会社	トロンビン産生の測定方法
CN103185710B (zh) *	2013-02-04	2015-01-07	中国医学科学院输血研究所	人静脉注射免疫球蛋白中活化凝血因子ⅺ检测方法
CN104977259A (zh) *	2014-04-04	2015-10-14	天津药物研究院	一种基于高通量检测的血小板聚集测定方法及在药物筛选中的应用
US9986941B2 (en)	2014-06-26	2018-06-05	The Board Of Trustees Of The Leland Stanford Junior University	Methods and apparatus for rapid monitoring of hemostatic state
CN104459165B (zh) *	2014-12-10	2016-07-06	中国医学科学院输血研究所	一种检测人凝血酶原复合物抗凝能力的方法
US10633645B2 (en) *	2015-12-30	2020-04-28	General Electric Company	Calcium controlled activation of platelets via electrical stimulation
EP3388838B1 (en)	2016-01-29	2022-02-16	Sony Group Corporation	Blood coagulation analysis
EP3363912B1 (en)	2017-02-17	2020-10-28	Synapse B.V.	Self-calibrated assay for determining proteolytic enzyme generation, dedicated means and uses thereof
CN107102125B (zh) *	2017-04-17	2019-07-09	中国科学院苏州生物医学工程技术研究所	血栓弹力图仪的校准方法
RU2709341C1 (ru) *	2019-04-19	2019-12-17	федеральное государственное бюджетное учреждение "Национальный медицинский исследовательский центр профилактической медицины" Министерства здравоохранения Российской Федерации (ФГБУ "НМИЦ ПМ" Минздрава России)	Определение циркулирующего тромбина в тесте активации системы комплемента
US12522855B2 (en)	2019-07-31	2026-01-13	Tel Hashomer Medical Research Infrastructure And Services Ltd.	Methods and kits for identifying thrombus origin and optimizing post-ischemic event treatment
CN110412001B (zh) *	2019-08-01	2022-02-11	武汉塞力斯生物技术有限公司	一种动态监测凝血酶生成能力的试剂盒
US20220275421A1 (en) *	2019-08-07	2022-09-01	Tokyo Dental College	Determination method, fluorescence measurement device, and test agent
CN110568117B (zh) *	2019-09-19	2022-03-22	青岛海洋生物医药研究院股份有限公司	一种多靶点抗血栓活性物质的液相色谱-质谱筛选方法
WO2022137002A1 (en)	2020-12-21	2022-06-30	Ethicon, Inc.	Bleeding detection method

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JPS55164356A (en) *	1979-06-08	1980-12-22	Fuji Photo Film Co Ltd	Multi-layer analysis sheet for liquid sample analysis
US5318899A (en) *	1989-06-16	1994-06-07	Cor Therapeutics, Inc.	Platelet aggregation inhibitors
JP3368279B2 (ja) *	1992-04-27	2003-01-20	ベックマンコールター，インコーポレイティド	血液凝固検定を行うためのテスト物品及び方法
WO2003093831A1 (en) *	2002-05-01	2003-11-13	Synapse B.V.	Diagnostic test for determining the concentration of transient proteolytic activity in composite biological media

2005
- 2005-04-29 EP EP05290952A patent/EP1717588A1/en not_active Withdrawn
2006
- 2006-04-26 AT AT06753838T patent/ATE483984T1/de not_active IP Right Cessation
- 2006-04-26 RU RU2007137972/15A patent/RU2422835C2/ru not_active IP Right Cessation
- 2006-04-26 MX MX2007013497A patent/MX2007013497A/es active IP Right Grant
- 2006-04-26 DE DE602006017350T patent/DE602006017350D1/de not_active Expired - Lifetime
- 2006-04-26 US US11/919,431 patent/US8916356B2/en active Active
- 2006-04-26 ES ES06753838T patent/ES2354086T3/es not_active Expired - Lifetime
- 2006-04-26 WO PCT/EP2006/004945 patent/WO2006117246A1/en not_active Ceased
- 2006-04-26 BR BRPI0612967A patent/BRPI0612967B8/pt active IP Right Grant
- 2006-04-26 AU AU2006243283A patent/AU2006243283B2/en not_active Ceased
- 2006-04-26 KR KR1020077027433A patent/KR20080025043A/ko not_active Abandoned
- 2006-04-26 JP JP2008508173A patent/JP4897794B2/ja not_active Expired - Lifetime
- 2006-04-26 CN CNA2006800147599A patent/CN101171519A/zh active Pending
- 2006-04-26 EP EP06753838A patent/EP1875249B1/en not_active Expired - Lifetime
- 2006-04-26 CA CA2606906A patent/CA2606906C/en not_active Expired - Fee Related
- 2006-04-28 TW TW095115377A patent/TW200716982A/zh unknown
- 2006-04-28 AR ARP060101736A patent/AR053371A1/es unknown

Also Published As

Publication number	Publication date
CN101171519A (zh)	2008-04-30
CA2606906C (en)	2013-03-19
JP4897794B2 (ja)	2012-03-14
AR053371A1 (es)	2007-05-02
MX2007013497A (es)	2008-04-04
KR20080025043A (ko)	2008-03-19
ES2354086T3 (es)	2011-03-09
BRPI0612967A2 (pt)	2010-12-14
RU2422835C2 (ru)	2011-06-27
JP2008539400A (ja)	2008-11-13
BRPI0612967B1 (pt)	2021-02-02
US20090311730A1 (en)	2009-12-17
BRPI0612967B8 (pt)	2021-07-27
EP1875249A1 (en)	2008-01-09
AU2006243283A1 (en)	2006-11-09
AU2006243283B2 (en)	2011-06-30
RU2007137972A (ru)	2009-06-10
EP1875249B1 (en)	2010-10-06
CA2606906A1 (en)	2006-11-09
ATE483984T1 (de)	2010-10-15
DE602006017350D1 (de)	2010-11-18
WO2006117246A1 (en)	2006-11-09
US8916356B2 (en)	2014-12-23
EP1717588A1 (en)	2006-11-02

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