TW200718423A - Heteroatom-interrupted analogs of 15-hydroxyeicosatetraenoic acid and pharmaceutical composition thereof - Google Patents
Heteroatom-interrupted analogs of 15-hydroxyeicosatetraenoic acid and pharmaceutical composition thereofInfo
- Publication number
- TW200718423A TW200718423A TW095131568A TW95131568A TW200718423A TW 200718423 A TW200718423 A TW 200718423A TW 095131568 A TW095131568 A TW 095131568A TW 95131568 A TW95131568 A TW 95131568A TW 200718423 A TW200718423 A TW 200718423A
- Authority
- TW
- Taiwan
- Prior art keywords
- heteroatom
- interrupted
- analogs
- pharmaceutical composition
- hydroxyeicosatetraenoic acid
- Prior art date
Links
- JSFATNQSLKRBCI-UHFFFAOYSA-N 15-Hydroxyeicosatetraenoic acid Chemical compound CCCCCC(O)C=CC=CCC=CCC=CCCCC(O)=O JSFATNQSLKRBCI-UHFFFAOYSA-N 0.000 title 1
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- 208000003556 Dry Eye Syndromes Diseases 0.000 abstract 1
- 206010013774 Dry eye Diseases 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/655—Azo (—N=N—), diazo (=N2), azoxy (>N—O—N< or N(=O)—N<), azido (—N3) or diazoamino (—N=N—N<) compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
- A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
- A61K31/23—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin of acids having a carboxyl group bound to a chain of seven or more carbon atoms
- A61K31/232—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin of acids having a carboxyl group bound to a chain of seven or more carbon atoms having three or more double bonds, e.g. etretinate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/557—Eicosanoids, e.g. leukotrienes or prostaglandins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/04—Artificial tears; Irrigation solutions
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C233/00—Carboxylic acid amides
- C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C233/16—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms
- C07C233/17—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom
- C07C233/18—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom having the carbon atom of the carboxamide group bound to a hydrogen atom or to a carbon atom of an acyclic saturated carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
- C07C271/06—Esters of carbamic acids
- C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
- C07C271/10—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C271/16—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of hydrocarbon radicals substituted by singly-bound oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
- C07C323/50—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
- C07C323/51—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
- C07C323/54—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and unsaturated
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Ophthalmology & Optometry (AREA)
- Emergency Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US16438399P | 1999-11-09 | 1999-11-09 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| TW200718423A true TW200718423A (en) | 2007-05-16 |
Family
ID=22594245
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| TW095131568A TW200718423A (en) | 1999-11-09 | 2000-11-08 | Heteroatom-interrupted analogs of 15-hydroxyeicosatetraenoic acid and pharmaceutical composition thereof |
| TW089123629A TWI268776B (en) | 1999-11-09 | 2000-11-08 | Heteroatom-interrupted analogs of 15-hydroxyeicosatetraenoic acid and pharmaceutical composition thereof |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| TW089123629A TWI268776B (en) | 1999-11-09 | 2000-11-08 | Heteroatom-interrupted analogs of 15-hydroxyeicosatetraenoic acid and pharmaceutical composition thereof |
Country Status (20)
| Country | Link |
|---|---|
| US (3) | US6331566B1 (zh) |
| EP (1) | EP1227809B1 (zh) |
| JP (1) | JP2003513910A (zh) |
| KR (1) | KR20020040848A (zh) |
| CN (1) | CN1382046A (zh) |
| AR (1) | AR031536A1 (zh) |
| AT (1) | ATE292464T1 (zh) |
| AU (1) | AU776258B2 (zh) |
| BR (1) | BR0015423A (zh) |
| CA (1) | CA2386623A1 (zh) |
| DE (1) | DE60019322T2 (zh) |
| ES (1) | ES2235966T3 (zh) |
| HK (1) | HK1045260B (zh) |
| MX (1) | MXPA02004702A (zh) |
| PL (1) | PL356092A1 (zh) |
| PT (1) | PT1227809E (zh) |
| TR (1) | TR200201249T2 (zh) |
| TW (2) | TW200718423A (zh) |
| WO (1) | WO2001034129A2 (zh) |
| ZA (1) | ZA200202278B (zh) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TWI823922B (zh) * | 2018-04-04 | 2023-12-01 | 德商巴斯夫歐洲公司 | 用於製造半導體基板的方法中的可裂解添加劑 |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2003030892A1 (en) * | 2001-10-11 | 2003-04-17 | Alcon, Inc. | Methods for treating dry eye |
| US20030109508A1 (en) * | 2001-10-11 | 2003-06-12 | Alcon, Inc. | Methods for treating dry eye |
| US20030232858A1 (en) * | 2002-06-14 | 2003-12-18 | Barker Ronnie C. | Use of hydroxyeicosatetraenoic acid compounds to treat dry mouth |
| WO2003105824A1 (en) * | 2002-06-14 | 2003-12-24 | Alcon, Inc. | Topical use of hydroxyeicosatetraenoic acid compounds to treat psoriasis |
| WO2003105831A1 (en) * | 2002-06-14 | 2003-12-24 | Alcon, Inc. | Use of hydroxyeicosatetraenoic acid compounds to treat ophthalmic inflammatory disorders |
| CA2497977A1 (en) * | 2002-09-20 | 2004-04-01 | Alcon, Inc. | Use of cytokine synthesis inhibitors for the treatment of dry eye disorders |
| EP2073810B1 (en) * | 2006-09-13 | 2011-08-31 | Takeda Pharmaceutical Company Limited | Use of 2-6-(3-amino-piperidin-1-yl)-3-methyl-2,4-dioxo-3,4-dihydro-2h-pyrimidin-1-ylmethyl-4-fluoro-benzonitrile for treating diabetes, cancer, autoimmune disorders and hiv infection |
| US8324383B2 (en) | 2006-09-13 | 2012-12-04 | Takeda Pharmaceutical Company Limited | Methods of making polymorphs of benzoate salt of 2-[[6-[(3R)-3-amino-1-piperidinyl]-3,4-dihydro-3-methyl-2,4-dioxo-1(2H)-pyrimidinyl]methyl]-benzonitrile |
| ITUB20153104A1 (it) * | 2015-08-13 | 2017-02-13 | Sooft Italia S P A Contrada Molino 17 68333 Montegiorgio Fm | Composizione ed uso di collirio a base di inositolo per migliorare l'accomodazione visiva dei pazienti |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| US3991759A (en) | 1975-10-28 | 1976-11-16 | Alza Corporation | Method and therapeutic system for treating aqueous deficient dry eye |
| US4131651A (en) | 1977-10-25 | 1978-12-26 | Barnes-Hind Pharmaceuticals, Inc. | Treatment of dry eye |
| US4409205A (en) | 1979-03-05 | 1983-10-11 | Cooper Laboratories, Inc. | Ophthalmic solution |
| US4370325A (en) | 1979-03-30 | 1983-01-25 | Dermik Laboratories | Pharmaceutical compositions and method of treatment |
| AU546872B2 (en) | 1982-06-16 | 1985-09-26 | Unilever Plc | Skin treatment compositions containing a fatty acid or ester |
| US4421748A (en) | 1982-07-13 | 1983-12-20 | Trager Seymour F | Artificial tear aid |
| GB8319073D0 (en) | 1983-07-14 | 1983-08-17 | Efamol Ltd | Fatty acid compositions |
| US4868154A (en) | 1986-02-19 | 1989-09-19 | Eye Research Institute Of Retina Foundation | Stimulation of tear secretion with melanocyte stimulating hormones |
| US4753945A (en) | 1986-02-19 | 1988-06-28 | Eye Research Institute Of Retina Foundation | Stimulation of tear secretion with phosphodiesterase inhibitors |
| US4883658A (en) | 1986-04-28 | 1989-11-28 | Holly Frank J | Ophthalmic solution for treatment of dry-eye syndrome |
| US4744980A (en) | 1986-04-28 | 1988-05-17 | Holly Frank J | Ophthalmic solution for treatment of dry eye syndrome |
| US4804539A (en) | 1986-07-28 | 1989-02-14 | Liposome Technology, Inc. | Ophthalmic liposomes |
| US4818537A (en) | 1986-10-21 | 1989-04-04 | Liposome Technology, Inc. | Liposome composition for treating dry eye |
| US4966773A (en) | 1986-11-25 | 1990-10-30 | Alcon Laboratories, Inc. | Topical ophthalmic compositions containing microfine retinoid particles |
| US5278151A (en) | 1987-04-02 | 1994-01-11 | Ocular Research Of Boston, Inc. | Dry eye treatment solution |
| US4914088A (en) | 1987-04-02 | 1990-04-03 | Thomas Glonek | Dry eye treatment solution and method |
| US4921644A (en) | 1988-02-29 | 1990-05-01 | Technology Unlimited, Inc. | Mucin directed lipsome |
| US4906467A (en) * | 1988-03-24 | 1990-03-06 | New York Medical College | Novel, long-duration treatment for glaucoma |
| US4923700A (en) | 1988-06-03 | 1990-05-08 | Kaufman Herbert E | Artificial tear suspension |
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| US5075104A (en) | 1989-03-31 | 1991-12-24 | Alcon Laboratories, Inc. | Ophthalmic carboxy vinyl polymer gel for dry eye syndrome |
| US5174988A (en) | 1989-07-27 | 1992-12-29 | Scientific Development & Research, Inc. | Phospholipid delivery system |
| WO1991012808A1 (en) | 1990-02-22 | 1991-09-05 | Macnaught Pty Limited | Artificial tears |
| US5041434A (en) | 1991-08-17 | 1991-08-20 | Virginia Lubkin | Drugs for topical application of sex steroids in the treatment of dry eye syndrome, and methods of preparation and application |
| DE69115990T2 (de) | 1990-05-29 | 1996-05-30 | Ocular Res Of Bonton Inc | Zusammensetzung zur Behandlung von Dry Eye Erkrankungen |
| ZA912797B (en) | 1990-05-29 | 1992-12-30 | Boston Ocular Res | Dry eye treatment process and solution |
| US5102670A (en) | 1990-09-14 | 1992-04-07 | Abraham Nader G | Method for treating eye disorders by reducing 12(r)-hydroxyeicosatetraenoic acid and 12(r)-dihydroxyeicosatrienoic acid levels |
| ATE141502T1 (de) | 1991-01-15 | 1996-09-15 | Alcon Lab Inc | Verwendung von karrageenan in topischen ophthalmologischen zusammensetzungen |
| ZA927277B (en) | 1991-10-02 | 1993-05-19 | Boston Ocular Res | Dry eye treatment process and solution. |
| EP0546728A3 (en) | 1991-12-13 | 1993-09-08 | Alcon Laboratories Inc | Physiological tear compositions and methods for their preparation |
| CA2133966C (en) | 1992-04-21 | 1997-09-09 | David A. Sullivan | Ocular androgen therapy in sjogren's syndrome |
| US5290572A (en) | 1992-08-06 | 1994-03-01 | Deo Corporation | Opthalmic composition for treating dry eye |
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| US5389383A (en) | 1993-06-18 | 1995-02-14 | Allergan, Inc. | Method for treating hypoxia-associated ocular complications |
| US5696166A (en) | 1995-10-31 | 1997-12-09 | Yanni; John M. | Compositions containing hydroxyeicosatetraenoic acid derivatives and methods of use in treating dry eye disorders |
| NZ336539A (en) | 1996-10-15 | 2000-09-29 | Liposome Co Inc | Peptide-lipid conjugates, liposomes and liposomal drug delivery |
| US5800807A (en) | 1997-01-29 | 1998-09-01 | Bausch & Lomb Incorporated | Ophthalmic compositions including glycerin and propylene glycol |
| JP2002538124A (ja) | 1999-03-01 | 2002-11-12 | ヴィスタ サイエンティフィック エルエルシー | ムチンを含む眼科用調合物 |
-
2000
- 2000-10-23 MX MXPA02004702A patent/MXPA02004702A/es active IP Right Grant
- 2000-10-23 DE DE60019322T patent/DE60019322T2/de not_active Expired - Fee Related
- 2000-10-23 CA CA002386623A patent/CA2386623A1/en not_active Abandoned
- 2000-10-23 WO PCT/US2000/029235 patent/WO2001034129A2/en not_active Ceased
- 2000-10-23 EP EP00971016A patent/EP1227809B1/en not_active Expired - Lifetime
- 2000-10-23 AT AT00971016T patent/ATE292464T1/de not_active IP Right Cessation
- 2000-10-23 PT PT00971016T patent/PT1227809E/pt unknown
- 2000-10-23 TR TR2002/01249T patent/TR200201249T2/xx unknown
- 2000-10-23 AU AU80315/00A patent/AU776258B2/en not_active Ceased
- 2000-10-23 CN CN00814647A patent/CN1382046A/zh active Pending
- 2000-10-23 HK HK02106762.1A patent/HK1045260B/zh not_active IP Right Cessation
- 2000-10-23 PL PL00356092A patent/PL356092A1/xx not_active Application Discontinuation
- 2000-10-23 BR BR0015423-7A patent/BR0015423A/pt not_active IP Right Cessation
- 2000-10-23 KR KR1020027004594A patent/KR20020040848A/ko not_active Ceased
- 2000-10-23 ES ES00971016T patent/ES2235966T3/es not_active Expired - Lifetime
- 2000-10-23 US US09/694,129 patent/US6331566B1/en not_active Expired - Fee Related
- 2000-10-23 JP JP2001536129A patent/JP2003513910A/ja not_active Withdrawn
- 2000-11-08 TW TW095131568A patent/TW200718423A/zh unknown
- 2000-11-08 TW TW089123629A patent/TWI268776B/zh not_active IP Right Cessation
- 2000-11-08 AR ARP000105867A patent/AR031536A1/es not_active Application Discontinuation
-
2001
- 2001-06-25 US US09/891,358 patent/US6441035B2/en not_active Expired - Lifetime
- 2001-06-25 US US09/891,357 patent/US6436994B2/en not_active Expired - Lifetime
-
2002
- 2002-03-20 ZA ZA200202278A patent/ZA200202278B/en unknown
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TWI823922B (zh) * | 2018-04-04 | 2023-12-01 | 德商巴斯夫歐洲公司 | 用於製造半導體基板的方法中的可裂解添加劑 |
Also Published As
| Publication number | Publication date |
|---|---|
| DE60019322T2 (de) | 2005-09-08 |
| WO2001034129A3 (en) | 2001-12-13 |
| CN1382046A (zh) | 2002-11-27 |
| HK1045260A1 (zh) | 2002-11-22 |
| US6436994B2 (en) | 2002-08-20 |
| EP1227809A2 (en) | 2002-08-07 |
| JP2003513910A (ja) | 2003-04-15 |
| US20010051648A1 (en) | 2001-12-13 |
| MXPA02004702A (es) | 2004-09-10 |
| PT1227809E (pt) | 2005-06-30 |
| ES2235966T3 (es) | 2005-07-16 |
| ZA200202278B (en) | 2003-05-28 |
| AR031536A1 (es) | 2003-09-24 |
| US20020002196A1 (en) | 2002-01-03 |
| HK1045260B (zh) | 2005-06-10 |
| TWI268776B (en) | 2006-12-21 |
| US6331566B1 (en) | 2001-12-18 |
| BR0015423A (pt) | 2002-07-09 |
| AU8031500A (en) | 2001-06-06 |
| US6441035B2 (en) | 2002-08-27 |
| ATE292464T1 (de) | 2005-04-15 |
| KR20020040848A (ko) | 2002-05-30 |
| DE60019322D1 (de) | 2005-05-12 |
| EP1227809B1 (en) | 2005-04-06 |
| CA2386623A1 (en) | 2001-05-17 |
| PL356092A1 (en) | 2004-06-14 |
| AU776258B2 (en) | 2004-09-02 |
| TR200201249T2 (tr) | 2002-09-23 |
| WO2001034129A2 (en) | 2001-05-17 |
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