TW200720656A - Prediction of prognosis of liver disease associated with hepatitis c virus infection - Google Patents
Prediction of prognosis of liver disease associated with hepatitis c virus infectionInfo
- Publication number
- TW200720656A TW200720656A TW095114055A TW95114055A TW200720656A TW 200720656 A TW200720656 A TW 200720656A TW 095114055 A TW095114055 A TW 095114055A TW 95114055 A TW95114055 A TW 95114055A TW 200720656 A TW200720656 A TW 200720656A
- Authority
- TW
- Taiwan
- Prior art keywords
- hepatitis
- amino acid
- peptide
- prediction
- liver disease
- Prior art date
Links
- 208000019423 liver disease Diseases 0.000 title abstract 3
- 208000010710 hepatitis C virus infection Diseases 0.000 title abstract 2
- 238000004393 prognosis Methods 0.000 title abstract 2
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 4
- 108700039791 Hepatitis C virus nucleocapsid Proteins 0.000 abstract 3
- 125000003275 alpha amino acid group Chemical group 0.000 abstract 2
- 125000000539 amino acid group Chemical group 0.000 abstract 2
- 150000001413 amino acids Chemical class 0.000 abstract 2
- 238000000034 method Methods 0.000 abstract 2
- 241000711549 Hepacivirus C Species 0.000 abstract 1
- 239000008280 blood Substances 0.000 abstract 1
- 210000004369 blood Anatomy 0.000 abstract 1
- 208000015181 infectious disease Diseases 0.000 abstract 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/576—Immunoassay; Biospecific binding assay; Materials therefor for hepatitis
- G01N33/5767—Immunoassay; Biospecific binding assay; Materials therefor for hepatitis non-A, non-B hepatitis
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Molecular Biology (AREA)
- Urology & Nephrology (AREA)
- Biomedical Technology (AREA)
- Chemical & Material Sciences (AREA)
- Hematology (AREA)
- Food Science & Technology (AREA)
- Analytical Chemistry (AREA)
- Microbiology (AREA)
- Cell Biology (AREA)
- Biotechnology (AREA)
- Medicinal Chemistry (AREA)
- Physics & Mathematics (AREA)
- Communicable Diseases (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Peptides Or Proteins (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Abstract
Disclosed is a method for the prediction of progress of a liver disease associated with HCV infection, the method comprising determining the antibody titer of an antibody against a peptide comprising an amino acid sequence composed of contiguous 8 or more amino acid residues containing amino acid Gly 32 of a hepatitis C virus core protein in the blood of a subject. Further, the antibody titer against NS5A-2132 peptide of hepatitis C virus and the antibody titer against C33 or C35 peptide of a hepatitis C virus core protein are also determined. Based on the combination of these results, it becomes possible to predict the prognosis with higher reliability. Also disclosed is a kit for use in the prediction of the progress of a liver disease associated with hepatitis C virus infection, the kit comprising a peptide which can be recognized by an anti-HCV antibody capable of binding to a peptide comprising an amino acid sequence composed of contiguous 8 or more amino acid residues containing amino acid Gly 32 of a hepatitis C virus core protein.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2005121293 | 2005-04-19 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| TW200720656A true TW200720656A (en) | 2007-06-01 |
Family
ID=37115194
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| TW095114055A TW200720656A (en) | 2005-04-19 | 2006-04-19 | Prediction of prognosis of liver disease associated with hepatitis c virus infection |
Country Status (3)
| Country | Link |
|---|---|
| JP (1) | JP4615567B2 (en) |
| TW (1) | TW200720656A (en) |
| WO (1) | WO2006112482A1 (en) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP4890254B2 (en) | 2003-10-27 | 2012-03-07 | バーテックス ファーマシューティカルズ インコーポレイテッド | HCVNS3-NS4A protease resistant mutant |
| US7705138B2 (en) | 2005-11-11 | 2010-04-27 | Vertex Pharmaceuticals Incorporated | Hepatitis C virus variants |
| AU2006315438A1 (en) * | 2005-11-11 | 2007-05-24 | Vertex Pharmaceuticals Incorporated | Hepatitis C virus variants |
| RU2336526C1 (en) * | 2007-06-07 | 2008-10-20 | Государственное учреждение "УФИМСКИЙ НАУЧНО-ИССЛЕДОВАТЕЛЬСКИЙ ИНСТИТУТ ГЛАЗНЫХ БОЛЕЗНЕЙ" Академии наук Республики Башкортостан (УфНИИ ГБ АН РБ) | Method of prediction of children capillary haemangioma development |
| WO2010050181A1 (en) * | 2008-10-27 | 2010-05-06 | 株式会社グリーンペプタイド | Vaccine for preventing onset and recurrence of liver cancer induced by hepatitis c virus |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP3055793B2 (en) * | 1990-09-07 | 2000-06-26 | 財団法人化学及血清療法研究所 | Non-A non-B hepatitis virus fusion peptide and method for producing the same |
| DE4240980A1 (en) * | 1992-08-07 | 1994-02-10 | Boehringer Mannheim Gmbh | HCV peptide antigens and method for the determination of HCV |
| KR20060087574A (en) * | 2003-09-22 | 2006-08-02 | 가부시키가이샤 그린 펩티드 | Hepatitis C virus-derived peptide |
-
2006
- 2006-04-19 JP JP2007528175A patent/JP4615567B2/en not_active Expired - Fee Related
- 2006-04-19 WO PCT/JP2006/308233 patent/WO2006112482A1/en not_active Ceased
- 2006-04-19 TW TW095114055A patent/TW200720656A/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| JP4615567B2 (en) | 2011-01-19 |
| JPWO2006112482A1 (en) | 2008-12-11 |
| WO2006112482A1 (en) | 2006-10-26 |
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