TW200730202A - Solid dosage form - Google Patents

Solid dosage form

Info

Publication number
TW200730202A
TW200730202A TW095122887A TW95122887A TW200730202A TW 200730202 A TW200730202 A TW 200730202A TW 095122887 A TW095122887 A TW 095122887A TW 95122887 A TW95122887 A TW 95122887A TW 200730202 A TW200730202 A TW 200730202A
Authority
TW
Taiwan
Prior art keywords
dosage form
solid dosage
angiotensin
formulated
active ingredients
Prior art date
Application number
TW095122887A
Other languages
Chinese (zh)
Other versions
TWI388345B (en
Inventor
Takeshi Hamaura
Mitsuru Kanno
Original Assignee
Sankyo Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sankyo Co filed Critical Sankyo Co
Publication of TW200730202A publication Critical patent/TW200730202A/en
Application granted granted Critical
Publication of TWI388345B publication Critical patent/TWI388345B/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4178—1,3-Diazoles not condensed 1,3-diazoles and containing further heterocyclic rings, e.g. pilocarpine, nitrofurantoin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4422—1,4-Dihydropyridines, e.g. nifedipine, nicardipine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
    • A61K9/2086—Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat
    • A61K9/209—Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat containing drug in at least two layers or in the core and in at least one outer layer
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5073—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5084—Mixtures of one or more drugs in different galenical forms, at least one of which being granules, microcapsules or (coated) microparticles according to A61K9/16 or A61K9/50, e.g. for obtaining a specific release pattern or for combining different drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/10—Antioedematous agents; Diuretics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

The invention relates to a solid dosage form comprising an angiotensin II receptor antagonist and a calcium channel blocker, wherein the active ingredients are formulated such that they are not intimately mixed in said solid dosage form. The solid dosage form demonstrates improved dissolution properties.
TW095122887A 2005-06-27 2006-06-26 Solid dosage form comprising angiotensin iireceptor antagonist and calcium channel blocker for prophylaxis or treatment of hypertension TWI388345B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP2005187214 2005-06-27

Publications (2)

Publication Number Publication Date
TW200730202A true TW200730202A (en) 2007-08-16
TWI388345B TWI388345B (en) 2013-03-11

Family

ID=37460221

Family Applications (1)

Application Number Title Priority Date Filing Date
TW095122887A TWI388345B (en) 2005-06-27 2006-06-26 Solid dosage form comprising angiotensin iireceptor antagonist and calcium channel blocker for prophylaxis or treatment of hypertension

Country Status (3)

Country Link
JP (2) JP5110697B2 (en)
TW (1) TWI388345B (en)
WO (1) WO2007001067A2 (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103127110A (en) * 2013-03-18 2013-06-05 吉林省博大伟业制药有限公司 Compound preparation containing angiotensin II receptor antagonist and calcium channel blocker
TWI586353B (en) * 2012-10-12 2017-06-11 Ea Pharma Co Ltd Pharmaceutical preparations containing calcium antagonists and angiotensin II receptor antagonists

Families Citing this family (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5940073A (en) 1996-05-03 1999-08-17 Starsight Telecast Inc. Method and system for displaying other information in a TV program guide
GT200600371A (en) * 2005-08-17 2007-03-21 SOLID DOSE FORMS OF VALSARTAN AND AMLODIPINE AND METHOD TO DO THE SAME
US9113107B2 (en) 2005-11-08 2015-08-18 Rovi Guides, Inc. Interactive advertising and program promotion in an interactive television system
TWI492747B (en) * 2006-06-27 2015-07-21 Daiichi Sankyo Co Ltd Compressed solid dosage form
US20080175872A1 (en) * 2006-09-28 2008-07-24 Osmotica Corp. Controlled Release Dosage Form Containing Lercanidipine and a Performance-enhancing Acid
US8832742B2 (en) 2006-10-06 2014-09-09 United Video Properties, Inc. Systems and methods for acquiring, categorizing and delivering media in interactive media guidance applications
KR101247583B1 (en) * 2006-12-08 2013-03-26 한미사이언스 주식회사 Pharmaceutical composition comprising amlodipine or a pharmaceutically acceptable salt thereof and losartan or a pharmaceutically acceptable salt thereof
TWI488658B (en) * 2006-12-26 2015-06-21 Daiichi Sankyo Co Ltd Method for improvement of elution
TWI402083B (en) * 2006-12-26 2013-07-21 Daiichi Sankyo Co Ltd Solid dosage form and stabilization method thereof
TWI414310B (en) * 2006-12-26 2013-11-11 Daiichi Sankyo Co Ltd Elution-improved pharmaceutical preparation
MX344778B (en) * 2008-01-25 2017-01-06 Duo-Ge COMBINATION OF ORAL MEDICINES UNITED BY A WRAP.
ES2510866T3 (en) 2008-03-13 2014-10-21 Daiichi Sankyo Company, Limited Improvement of the solubility of a preparation containing olmesartan medoxomil
AR073380A1 (en) * 2008-09-25 2010-11-03 Takeda Pharmaceutical SOLID PHARMACEUTICAL COMPOSITION. MULTI-PAD TABLET
JP5658172B2 (en) 2009-01-23 2015-01-21 ハンミ・サイエンス・カンパニー・リミテッド Solid pharmaceutical composition containing amlodipine and losartan and method for producing the same
NZ597317A (en) * 2009-06-30 2014-05-30 Sanofi Sa Solid pharmaceutical fixed dose compositions comprising irbesartan and amlodipine, their preparation and their therapeutic application
JP5886530B2 (en) * 2010-02-26 2016-03-16 第一三共株式会社 tablet
JP5421945B2 (en) * 2010-03-10 2014-02-19 大日本住友製薬株式会社 Pharmaceutical composition containing irbesartan and amlodipine or a salt thereof
JP5824222B2 (en) * 2010-03-31 2015-11-25 第一三共株式会社 Method for producing solid preparation
WO2012055941A1 (en) 2010-10-27 2012-05-03 Krka,Tovarna Zdravil, D. D., Novo Mesto Multilayer pharmaceutical composition comprising telmisartan and amlodipine
UY33772A (en) 2010-12-09 2012-07-31 Lg Life Sciences Ltd PHARMACEUTICAL COMPOSITION THAT INCLUDES LERCANIDIPINE CHLORHYDRATE AND VALSARTAN AS ACTIVE COMPONENTS AND TO A METHOD FOR THE PREPARATION OF THE SAME.
JP6041591B2 (en) * 2011-09-13 2016-12-14 大日本住友製薬株式会社 Stabilized pharmaceutical composition comprising irbesartan and amlodipine or a salt thereof
MX2013001277A (en) * 2013-01-31 2014-07-30 Miguel Ángel García Pérez Pharmaceutical composition comprising an angiotensin ii-receptor antagonist and a calcium channel blocker for the treatment of arterial hypertension.
CN103271908B (en) * 2013-05-23 2019-02-12 浙江华海药业股份有限公司 Oral tablet and preparation method thereof containing Telmisartan and Amlodipine Besylate Tablet
EP3025711B1 (en) * 2013-07-23 2020-11-18 Daiichi Sankyo Company, Limited Medicine for preventing or treating hypertension
CN103908539B (en) * 2014-05-03 2017-02-01 李全浩 Traditional Chinese medicine composition for treating hypertension as well as preparation method and application of traditional Chinese medicine composition
CN104000821B (en) * 2014-06-02 2020-06-19 浙江华海药业股份有限公司 Oral double-layer tablet containing telmisartan and amlodipine besylate and preparation method thereof
EP3244880A1 (en) * 2015-01-12 2017-11-22 Ilko Ilaç Sanayi Ve Ticaret Anonim Sirketi A stable bilayer pharmaceutical tablet compositions comprising fixed dose of irbesartan and amlodipine
EP3434284A4 (en) * 2016-03-24 2019-11-13 Daiichi Sankyo Company, Limited MEDICINE FOR TREATING RENAL DISEASE
CN109432034A (en) * 2018-12-28 2019-03-08 乐普制药科技有限公司 A kind of valsartan amlodipine tri-layer tablets and preparation method thereof
CN110237073B (en) * 2019-07-10 2022-12-02 安庆回音必制药股份有限公司 Olmesartan medoxomil amlodipine tablet and preparation method thereof
CN114712319B (en) * 2022-03-25 2024-01-09 北京诺康达医药科技股份有限公司 Felodipine and propranolol hydrochloride compound preparation and preparation method thereof
CN115227662B (en) * 2022-06-24 2023-11-24 辰欣药业股份有限公司 Valsartan amlodipine tablet and preparation method thereof
CN115944600B (en) * 2022-12-01 2024-05-28 山东齐都药业有限公司 Oral tablet containing telmisartan and amlodipine besylate and preparation method thereof

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0859470A (en) * 1994-08-29 1996-03-05 Sankyo Co Ltd Elution improving preparation of cyclopenta(alpha)pyrimidine derivative
US6395728B2 (en) * 1999-07-08 2002-05-28 Novartis Ag Method of treatment and pharmaceutical composition
HRP20040649B1 (en) * 2002-01-16 2012-12-31 Boehringer Ingelheim Pharma Bilayer pharmaceutical tablet comprising telmisartan and a diuretic and preparation thereof
JP3751287B2 (en) * 2002-03-27 2006-03-01 バイエル薬品株式会社 Miniaturized nifedipine nucleated tablets
AU2003227472A1 (en) * 2002-03-27 2003-10-08 Bayer Aktiengesellschaft Downsized core tablet containing nifedipine
EG24716A (en) * 2002-05-17 2010-06-07 Novartis Ag Combination of organic compounds
US20040198789A1 (en) * 2003-02-28 2004-10-07 Recordati Ireland Limited Lercanidipine/ARB/diuretic therapeutic combinations
JP2004300102A (en) * 2003-03-31 2004-10-28 Kissei Pharmaceut Co Ltd Condensed heterocyclic derivative, pharmaceutical composition containing the same and its pharmaceutical application
US20050209288A1 (en) * 2004-01-12 2005-09-22 Grogan Donna R Compositions comprising (S)-amlodipine malate and an angiotensin receptor blocker and methods of their use
RS53141B (en) * 2004-11-05 2014-06-30 Boehringer Ingelheim International Gmbh TWO-LAYER TABLE CONTAINING TELMISARTAN AND AMLODIPINE

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI586353B (en) * 2012-10-12 2017-06-11 Ea Pharma Co Ltd Pharmaceutical preparations containing calcium antagonists and angiotensin II receptor antagonists
CN103127110A (en) * 2013-03-18 2013-06-05 吉林省博大伟业制药有限公司 Compound preparation containing angiotensin II receptor antagonist and calcium channel blocker

Also Published As

Publication number Publication date
JP5456857B2 (en) 2014-04-02
WO2007001067A2 (en) 2007-01-04
JP5110697B2 (en) 2012-12-26
JP2008543729A (en) 2008-12-04
WO2007001067A3 (en) 2007-07-12
TWI388345B (en) 2013-03-11
JP2012236853A (en) 2012-12-06

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Legal Events

Date Code Title Description
MM4A Annulment or lapse of patent due to non-payment of fees