TW200732308A - Substituted 4-aminoquinazoline derivatives, preparation thereof and therapeutic application thereof - Google Patents

Substituted 4-aminoquinazoline derivatives, preparation thereof and therapeutic application thereof

Info

Publication number: TW200732308A
Authority: TW; Taiwan
Prior art keywords: alkylene; alkyl; aryl; optionally substituted; nrarb
Prior art date: 2005-10-12

Application number

TW095137552A

Other languages

English (en)

Chinese (zh)

Inventor

Jean Michel Augereau

Gilles Courtemanche

Pierre Despeyroux

Michel Geslin

Anne Thomas

Original Assignee

Sanofi Aventis

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2005-10-12

Filing date

2006-10-12

Publication date

2007-09-01

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=36645639&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=TW200732308(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

2006-10-12 Application filed by Sanofi Aventis filed Critical Sanofi Aventis

2007-09-01 Publication of TW200732308A publication Critical patent/TW200732308A/zh

Links

DRYRBWIFRVMRPV-UHFFFAOYSA-N quinazolin-4-amine Chemical class C1=CC=C2C(N)=NC=NC2=C1 DRYRBWIFRVMRPV-UHFFFAOYSA-N 0.000 title abstract 2
230000001225 therapeutic effect Effects 0.000 title 1
125000006273 (C1-C3) alkyl group Chemical group 0.000 abstract 11
229910003827 NRaRb Inorganic materials 0.000 abstract 7
125000006527 (C1-C5) alkyl group Chemical group 0.000 abstract 4
125000003118 aryl group Chemical group 0.000 abstract 4
125000001072 heteroaryl group Chemical group 0.000 abstract 4
229910052736 halogen Inorganic materials 0.000 abstract 2
150000002367 halogens Chemical class 0.000 abstract 2
125000005913 (C3-C6) cycloalkyl group Chemical group 0.000 abstract 1
125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 1
-1 cycloprop-1,1-diyl Chemical group 0.000 abstract 1
125000000623 heterocyclic group Chemical group 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
239000012453 solvate Substances 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/10—Drugs for disorders of the urinary system of the bladder
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Bioinformatics & Cheminformatics (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Engineering & Computer Science (AREA)
Diabetes (AREA)
Obesity (AREA)
Neurosurgery (AREA)
Neurology (AREA)
Biomedical Technology (AREA)
Hematology (AREA)
Endocrinology (AREA)
Child & Adolescent Psychology (AREA)
Cardiology (AREA)
Emergency Medicine (AREA)
Heart & Thoracic Surgery (AREA)
Pain & Pain Management (AREA)
Psychiatry (AREA)
Urology & Nephrology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)

TW095137552A 2005-10-12 2006-10-12 Substituted 4-aminoquinazoline derivatives, preparation thereof and therapeutic application thereof TW200732308A (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
FR0510409A FR2891829A1 (fr)	2005-10-12	2005-10-12	Derives de la 4-amino-quinazoline, leur preparation et leur application en therapeutique

Publications (1)

Publication Number	Publication Date
TW200732308A true TW200732308A (en)	2007-09-01

Family

ID=36645639

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
TW095137552A TW200732308A (en)	2005-10-12	2006-10-12	Substituted 4-aminoquinazoline derivatives, preparation thereof and therapeutic application thereof

Country Status (5)

Country	Link
AR (1)	AR056688A1 (fr)
FR (1)	FR2891829A1 (fr)
TW (1)	TW200732308A (fr)
UY (1)	UY29857A1 (fr)
WO (1)	WO2007042669A2 (fr)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JP2010500300A (ja)	2006-08-08	2010-01-07	サノフィ−アベンティス	アリールアミノアリール−アルキル−置換イミダゾリジン−２，４−ジオン、それらの製造法、それらの化合物を含有する薬剤、およびそれらの使用
KR20110018380A (ko) *	2008-05-22	2011-02-23	알러간, 인코포레이티드	Ｃｘｃｒ4 수용체에서 활성을 갖는 이환식 화합물
WO2010003624A2 (fr)	2008-07-09	2010-01-14	Sanofi-Aventis	Composés hétérocycliques, leurs procédés de préparation, médicaments comprenant lesdits composés et leur utilisation
WO2010068601A1 (fr)	2008-12-08	2010-06-17	Sanofi-Aventis	Hydrate de fluoroglycoside hétéroaromatique cristallin, ses procédés de fabrication, ses procédés d'utilisation et compositions pharmaceutiques le contenant
MX2012001729A (es)	2009-08-26	2012-06-13	Sanofi Sa	Nuevos hidratos cristalinos de fluoroglicosido heteroaromatico, productos farmaceuticos que comprenden estos compuestos, y su empleo.
EP2683705B1 (fr)	2011-03-08	2015-04-22	Sanofi	Dérivés oxathiazine di- et tri-substitués, procédé pour leur préparation, utilisation en tant que médicament, agent pharmaceutique contenant ces dérivés et utilisation
US8871758B2 (en)	2011-03-08	2014-10-28	Sanofi	Tetrasubstituted oxathiazine derivatives, method for producing them, their use as medicine and drug containing said derivatives and the use thereof
WO2012120052A1 (fr)	2011-03-08	2012-09-13	Sanofi	Dérivés d'oxathiazine substitués par des carbocycles ou des hétérocycles, leur procédé de préparation, médicaments contenant ces composés et leur utilisation
US8828995B2 (en)	2011-03-08	2014-09-09	Sanofi	Branched oxathiazine derivatives, method for the production thereof, use thereof as medicine and drug containing said derivatives and use thereof
EP2683699B1 (fr)	2011-03-08	2015-06-24	Sanofi	Dérivés oxathiazine di- et tri-substitués, procédé pour leur préparation, utilisation en tant que médicament, agent pharmaceutique contenant ces dérivés et utilisation
WO2016197027A1 (fr)	2015-06-04	2016-12-08	Kura Oncology, Inc.	Méthodes et compositions d'inhibition de l'interaction de la ménine avec les protéines mll
CN109640987B (zh)	2016-03-16	2022-12-02	库拉肿瘤学公司	Menin-mll的桥联双环抑制剂及使用方法
CN109152784B (zh)	2016-03-16	2021-12-28	库拉肿瘤学公司	经取代的menin-mll抑制剂及使用方法
CN110691779B (zh)	2017-03-24	2023-10-10	库拉肿瘤学公司	治疗血液系统恶性肿瘤和尤因肉瘤的方法
US11542248B2 (en)	2017-06-08	2023-01-03	Kura Oncology, Inc.	Methods and compositions for inhibiting the interaction of menin with MLL proteins
US11649251B2 (en)	2017-09-20	2023-05-16	Kura Oncology, Inc.	Substituted inhibitors of menin-MLL and methods of use
JP2024545511A (ja) *	2021-12-09	2024-12-09	バラセラピューティクス，インコーポレイテッド	メニン－ｍｌｌ相互作用の阻害剤

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP0126087A1 (fr) *	1982-09-24	1984-11-28	Beecham Group Plc	Derives d'amino-azabicycloalkyle utilises en tant qu'antagonistes de la dopamine
GB2295387A (en) *	1994-11-23	1996-05-29	Glaxo Inc	Quinazoline antagonists of alpha 1c adrenergic receptors
JP2005523237A (ja) *	2001-10-01	2005-08-04	大正製薬株式会社	Ｍｃｈ受容体アンタゴニスト
CA2488635C (fr) *	2002-06-12	2012-10-23	Abbott Laboratories	Antagonistes du recepteur de l'hormone de melano-concentration
WO2004052371A2 (fr) *	2002-12-11	2004-06-24	7Tm Pharma A/S	Composes de quinoline cycliques utilises avec des troubles lies au recepteur mch
CL2004000409A1 (es) *	2003-03-03	2005-01-07	Vertex Pharma	Compuestos derivados de 2-(cilo sustituido)-1-(amino u oxi sustituido)-quinazolina, inhibidores de canales ionicos de sodio y calcio dependientes de voltaje; composicion farmaceutica; y uso del compuesto en el tratamiento de dolor agudo, cronico, neu
JP2008526734A (ja) *	2004-12-31	2008-07-24	エスケーケミカルズカンパニーリミテッド	糖尿及び肥満治療予防に有効なキナゾリン誘導体

2005
- 2005-10-12 FR FR0510409A patent/FR2891829A1/fr not_active Withdrawn
2006
- 2006-10-11 WO PCT/FR2006/002286 patent/WO2007042669A2/fr not_active Ceased
- 2006-10-11 AR ARP060104457A patent/AR056688A1/es not_active Application Discontinuation
- 2006-10-12 UY UY29857A patent/UY29857A1/es unknown
- 2006-10-12 TW TW095137552A patent/TW200732308A/zh unknown

Also Published As

Publication number	Publication date
WO2007042669A2 (fr)	2007-04-19
UY29857A1 (es)	2007-05-31
AR056688A1 (es)	2007-10-17
WO2007042669A3 (fr)	2007-05-31
FR2891829A1 (fr)	2007-04-13

Publication	Publication Date	Title
TW200732308A (en)	2007-09-01	Substituted 4-aminoquinazoline derivatives, preparation thereof and therapeutic application thereof
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