TW200734333A - Pure and stable tiotropium bromide - Google Patents

Pure and stable tiotropium bromide

Info

Publication number
TW200734333A
TW200734333A TW095147753A TW95147753A TW200734333A TW 200734333 A TW200734333 A TW 200734333A TW 095147753 A TW095147753 A TW 095147753A TW 95147753 A TW95147753 A TW 95147753A TW 200734333 A TW200734333 A TW 200734333A
Authority
TW
Taiwan
Prior art keywords
tiotropium bromide
pure
solvates
stable tiotropium
stable
Prior art date
Application number
TW095147753A
Other languages
English (en)
Chinese (zh)
Inventor
Roberta Volonte
Nicola Diulgheroff
Francesca Scarpitta
Alessandro Pontiroli
Roberto Casalone
Original Assignee
Sicor Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sicor Inc filed Critical Sicor Inc
Publication of TW200734333A publication Critical patent/TW200734333A/zh

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
    • C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
    • C07D451/06—Oxygen atoms
    • C07D451/10—Oxygen atoms acylated by aliphatic or araliphatic carboxylic acids, e.g. atropine, scopolamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/46—8-Azabicyclo [3.2.1] octane; Derivatives thereof, e.g. atropine, cocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pulmonology (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Emergency Medicine (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
TW095147753A 2005-12-19 2006-12-19 Pure and stable tiotropium bromide TW200734333A (en)

Applications Claiming Priority (12)

Application Number Priority Date Filing Date Title
US75267205P 2005-12-19 2005-12-19
US75453005P 2005-12-27 2005-12-27
US76143706P 2006-01-23 2006-01-23
US77405106P 2006-02-15 2006-02-15
US78031006P 2006-03-07 2006-03-07
US83023106P 2006-07-10 2006-07-10
US83218906P 2006-07-20 2006-07-20
US83520106P 2006-08-03 2006-08-03
US83520006P 2006-08-03 2006-08-03
US83603706P 2006-08-07 2006-08-07
US85122306P 2006-10-12 2006-10-12
US85274006P 2006-10-18 2006-10-18

Publications (1)

Publication Number Publication Date
TW200734333A true TW200734333A (en) 2007-09-16

Family

ID=38105786

Family Applications (1)

Application Number Title Priority Date Filing Date
TW095147753A TW200734333A (en) 2005-12-19 2006-12-19 Pure and stable tiotropium bromide

Country Status (9)

Country Link
EP (1) EP1966196A2 (fr)
JP (1) JP2008530251A (fr)
KR (1) KR20080079586A (fr)
CN (1) CN101360744A (fr)
CA (1) CA2620142A1 (fr)
IL (1) IL188178A0 (fr)
MX (1) MX2007009987A (fr)
TW (1) TW200734333A (fr)
WO (1) WO2007075838A2 (fr)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2768553C (fr) 2009-08-07 2016-08-02 Generics [Uk] Limited Anhydrate de bromure de tiotropium
WO2011015883A1 (fr) * 2009-08-07 2011-02-10 Generics [Uk] Limited Solvate de dichlorométhane du bromure de tiotropium et son utilisation
WO2011095800A2 (fr) * 2010-02-02 2011-08-11 Generics [Uk] Limited Procédés analytiques
CN101863885B (zh) * 2010-06-03 2012-05-30 南京金丹呈医药技术有限公司 一种噻托溴铵的制备方法
TR201101897A2 (tr) * 2011-02-28 2012-09-21 Bi̇lgi̇ç Mahmut Tiotropyum bromür içeren kristal madde
CZ304368B6 (cs) 2011-11-28 2014-04-02 Zentiva, K.S. Směsný solvát tiotropium bromidu a způsob jeho přípravy
CN103130798B (zh) * 2011-11-30 2015-12-02 连云港润众制药有限公司 噻托溴铵的结晶
PT106142B (pt) * 2012-02-10 2014-07-18 Hovione Farmaci Ncia S A Processo para a preparação de brometo de tiotrópio
EP2789611A1 (fr) * 2013-04-08 2014-10-15 Cerbios-Pharma S.A. Formules cristallines de bromure de tiotropium

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AP1712A (en) * 2000-10-12 2007-01-24 Boehringer Ingelheim Pharma Novel tiotropium-containing inhalation powder
AU2002214996B2 (en) * 2000-10-12 2007-03-15 Boehringer Ingelheim Pharma Gmbh & Co. Kg Crystalline monohydrate, method for producing the same and the use thereof in the production of a medicament
DE10064816A1 (de) * 2000-12-22 2002-06-27 Boehringer Ingelheim Pharma Verfahren zur Herstellung eines Anticholinergikums
DK1682543T3 (da) * 2003-11-03 2010-12-13 Boehringer Ingelheim Int Fremgangsmåde til fremstilling af nye tiotropiumsalte
KR20080012932A (ko) * 2005-05-02 2008-02-12 베링거 인겔하임 인터내셔날 게엠베하 티오트로퓸 브로마이드의 신규한 결정형
EP1879888A2 (fr) * 2005-05-02 2008-01-23 Boehringer Ingelheim International GmbH Formes cristallines de bromure de tiotropium

Also Published As

Publication number Publication date
MX2007009987A (es) 2007-10-02
IL188178A0 (en) 2008-03-20
EP1966196A2 (fr) 2008-09-10
CN101360744A (zh) 2009-02-04
CA2620142A1 (fr) 2007-07-05
KR20080079586A (ko) 2008-09-01
WO2007075838A3 (fr) 2007-08-16
JP2008530251A (ja) 2008-08-07
WO2007075838A2 (fr) 2007-07-05

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