TW200738656A - N-oxides as prodrugs of piperazine and piperidine derivatives - Google Patents
N-oxides as prodrugs of piperazine and piperidine derivativesInfo
- Publication number
- TW200738656A TW200738656A TW095130407A TW95130407A TW200738656A TW 200738656 A TW200738656 A TW 200738656A TW 095130407 A TW095130407 A TW 095130407A TW 95130407 A TW95130407 A TW 95130407A TW 200738656 A TW200738656 A TW 200738656A
- Authority
- TW
- Taiwan
- Prior art keywords
- art
- relates
- disease
- manufacture
- disclosed
- Prior art date
Links
- GLUUGHFHXGJENI-UHFFFAOYSA-N Piperazine Chemical compound C1CNCCN1 GLUUGHFHXGJENI-UHFFFAOYSA-N 0.000 title abstract 4
- 150000001204 N-oxides Chemical class 0.000 title abstract 2
- 150000003053 piperidines Chemical class 0.000 title abstract 2
- 229940002612 prodrug Drugs 0.000 title 1
- 239000000651 prodrug Substances 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 5
- 239000003814 drug Substances 0.000 abstract 3
- 238000004519 manufacturing process Methods 0.000 abstract 3
- 230000009286 beneficial effect Effects 0.000 abstract 2
- 201000010099 disease Diseases 0.000 abstract 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 2
- 208000019901 Anxiety disease Diseases 0.000 abstract 1
- 206010003805 Autism Diseases 0.000 abstract 1
- 208000020706 Autistic disease Diseases 0.000 abstract 1
- 206010012335 Dependence Diseases 0.000 abstract 1
- 208000011688 Generalised anxiety disease Diseases 0.000 abstract 1
- 208000021384 Obsessive-Compulsive disease Diseases 0.000 abstract 1
- 208000018737 Parkinson disease Diseases 0.000 abstract 1
- 208000020114 Schizophrenia and other psychotic disease Diseases 0.000 abstract 1
- 208000012886 Vertigo Diseases 0.000 abstract 1
- 230000016571 aggressive behavior Effects 0.000 abstract 1
- 208000015114 central nervous system disease Diseases 0.000 abstract 1
- 230000019771 cognition Effects 0.000 abstract 1
- 235000019788 craving Nutrition 0.000 abstract 1
- 208000029364 generalized anxiety disease Diseases 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 208000019906 panic disease Diseases 0.000 abstract 1
- 231100000889 vertigo Toxicity 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
- C07D263/52—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings condensed with carbocyclic rings or ring systems
- C07D263/54—Benzoxazoles; Hydrogenated benzoxazoles
- C07D263/58—Benzoxazoles; Hydrogenated benzoxazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
The present invention relates to N-oxides of certain piperazine and piperidine derivatives and to methods for the preparation of these compounds. The invention also relates to the use of compounds disclosed herein for the manufacture of a medicament giving a beneficial effect. A beneficial effect is disclosed herein or apparent to a person skilled in the art from the specification and general knowledge in the art. The invention also relates to the use of a compound of the invention for the manufacture of a medicament for treating or preventing a disease or condition. More particularly, the invention relates to a new use for the treatment of a disease or condition disclosed herein or apparent to a person skilled in the art from the specification and general knowledge in the art. In embodiments of the invention specific compounds disclosed herein are used for the manufacture of a medicament useful in the treatment of CNS-disorders, in particular the treatment of anxiety disorders, including generalized anxiety disorder and panic disorder, obsessive compulsive disorder, aggression, addiction (including craving), depression, autism, vertigo, schizophrenia and other psychotic disorders, Parkinson's disease and disturbances of cognition and memory. The compounds have the general formula (1), wherein the symbols have the meanings given in the specification.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP05107671 | 2005-08-22 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| TW200738656A true TW200738656A (en) | 2007-10-16 |
Family
ID=35502590
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| TW095130407A TW200738656A (en) | 2005-08-22 | 2006-08-18 | N-oxides as prodrugs of piperazine and piperidine derivatives |
Country Status (6)
| Country | Link |
|---|---|
| CN (1) | CN101248053B (en) |
| AR (1) | AR058022A1 (en) |
| BR (1) | BRPI0614843A2 (en) |
| TW (1) | TW200738656A (en) |
| UA (1) | UA94718C2 (en) |
| ZA (1) | ZA200800741B (en) |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BE503170A (en) * | 1975-09-02 | |||
| AU708053B2 (en) * | 1996-03-29 | 1999-07-29 | Duphar International Research B.V. | Piperazine and piperidine compounds |
| UA71590C2 (en) * | 1998-11-13 | 2004-12-15 | Duphar Int Res | Piperazine and piperidine derivatives |
| US6911448B2 (en) * | 2000-05-12 | 2005-06-28 | Solvay Pharmaceuticals B.V. | Piperazine and piperidine compounds |
| RU2301806C2 (en) * | 2002-01-16 | 2007-06-27 | Янссен Фармацевтика Н.В. | Prucaloprid n-oxide |
-
2006
- 2006-08-17 AR ARP060103590 patent/AR058022A1/en not_active Application Discontinuation
- 2006-08-18 TW TW095130407A patent/TW200738656A/en unknown
- 2006-08-21 BR BRPI0614843-3A patent/BRPI0614843A2/en not_active IP Right Cessation
- 2006-08-21 UA UAA200803586A patent/UA94718C2/en unknown
- 2006-08-21 CN CN2006800306608A patent/CN101248053B/en not_active Expired - Fee Related
-
2008
- 2008-01-24 ZA ZA200800741A patent/ZA200800741B/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CN101248053B (en) | 2011-06-01 |
| HK1120261A1 (en) | 2009-03-27 |
| BRPI0614843A2 (en) | 2012-12-04 |
| AR058022A1 (en) | 2008-01-23 |
| UA94718C2 (en) | 2011-06-10 |
| CN101248053A (en) | 2008-08-20 |
| ZA200800741B (en) | 2009-01-28 |
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