TW200916443A - 5-aryl-4,5-dihydro-(1H)-pyrazolines as cannabinoid CB1 receptor agonists - Google Patents

5-aryl-4,5-dihydro-(1H)-pyrazolines as cannabinoid CB1 receptor agonists Download PDF

Info

Publication number: TW200916443A
Authority: TW; Taiwan
Prior art keywords: group; compound; ethyl; alkyl; phenyl
Prior art date: 2007-09-20

Application number

TW97135608A

Other languages

English (en)

Chinese (zh)

Inventor

Josephus H M Lange

Hicham Zilaout

Vliet Bernard J Van

Original Assignee

Solvay Pharm Bv

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2007-09-20

Filing date

2008-09-17

Publication date

2009-04-16

2008-09-17 Application filed by Solvay Pharm Bv filed Critical Solvay Pharm Bv

2009-04-16 Publication of TW200916443A publication Critical patent/TW200916443A/zh

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229930003827 cannabinoid Natural products 0.000 title abstract description 21
239000003557 cannabinoid Substances 0.000 title abstract description 21
229940044601 receptor agonist Drugs 0.000 title abstract description 7
239000000018 receptor agonist Substances 0.000 title abstract description 7
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108010073366 CB1 Cannabinoid Receptor Proteins 0.000 title abstract description 4
150000001875 compounds Chemical class 0.000 claims abstract description 178
238000000034 method Methods 0.000 claims abstract description 30
239000008194 pharmaceutical composition Substances 0.000 claims abstract description 20
-1 trifluorosulfonyl Chemical group 0.000 claims description 120
125000001424 substituent group Chemical group 0.000 claims description 56
125000000217 alkyl group Chemical group 0.000 claims description 47
150000003839 salts Chemical class 0.000 claims description 47
125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims description 37
125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 27
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 26
125000001153 fluoro group Chemical group F* 0.000 claims description 23
238000011282 treatment Methods 0.000 claims description 22
125000003118 aryl group Chemical group 0.000 claims description 20
125000001072 heteroaryl group Chemical group 0.000 claims description 16
125000004435 hydrogen atom Chemical group [H]* 0.000 claims description 16
239000004480 active ingredient Substances 0.000 claims description 15
239000003814 drug Substances 0.000 claims description 14
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125000003983 fluorenyl group Chemical group C1(=CC=CC=2C3=CC=CC=C3CC12)* 0.000 claims description 9
229910052736 halogen Inorganic materials 0.000 claims description 9
150000002367 halogens Chemical class 0.000 claims description 9
125000003545 alkoxy group Chemical group 0.000 claims description 8
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125000005842 heteroatom Chemical group 0.000 claims description 7
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QFCGOOYWGNZMKP-UHFFFAOYSA-N 1-amino-1-cyanoguanidine Chemical compound N#CN(N)C(N)=N QFCGOOYWGNZMKP-UHFFFAOYSA-N 0.000 claims description 2
125000004206 2,2,2-trifluoroethyl group Chemical group [H]C([H])(*)C(F)(F)F 0.000 claims description 2
125000000579 2,2-diphenylethyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])(C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])* 0.000 claims description 2
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TW97135608A 2007-09-20 2008-09-17 5-aryl-4,5-dihydro-(1H)-pyrazolines as cannabinoid CB1 receptor agonists TW200916443A (en)

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JP (1)	JP2010539214A (pt)
CN (1)	CN101801934A (pt)
BR (1)	BRPI0816950A2 (pt)
EA (1)	EA201070381A1 (pt)
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TW (1)	TW200916443A (pt)

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CN114805208A (zh) *	2022-05-05	2022-07-29	台州学院	一种4-三氟甲基-4,5-二氢吡唑衍生物及其制备方法

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MX2010003059A (es)	2010-06-30
BRPI0816950A2 (pt)	2015-03-24
CN101801934A (zh)	2010-08-11
JP2010539214A (ja)	2010-12-16
EA201070381A1 (ru)	2010-12-30

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