TW200946221A - Microreactor assembly incorporating intrconnect backbone - Google Patents

Microreactor assembly incorporating intrconnect backbone Download PDF

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Publication number
TW200946221A
TW200946221A TW097149983A TW97149983A TW200946221A TW 200946221 A TW200946221 A TW 200946221A TW 097149983 A TW097149983 A TW 097149983A TW 97149983 A TW97149983 A TW 97149983A TW 200946221 A TW200946221 A TW 200946221A
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TW
Taiwan
Prior art keywords
fluid
interconnect
glass
microchannel
backbone
Prior art date
Application number
TW097149983A
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English (en)
Inventor
Stephane Poissy
Ronan Tanguy
Original Assignee
Corning Inc
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Application filed by Corning Inc filed Critical Corning Inc
Publication of TW200946221A publication Critical patent/TW200946221A/zh

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    • B01J19/0093—Microreactors, e.g. miniaturised or microfabricated reactors
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    • B01L3/502715—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by interfacing components, e.g. fluidic, electrical, optical or mechanical interfaces
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Description

200946221 九、發明說明： 【發明所屬乏技術領域】 本發贱w概魏ϋ猶。微反 結構反應器’微通道反應器，或微流體裝置。不管使用何種 名稱，微反應器就是一種將移動或靜止目標樣本限制在其 中來接受處理和/或分析的裝置。在—些情況中，此處理牵 涉到化學反應的分析。在其他情況中，此處理是使用兩個 ❹ 相異反應物之製造處理的一部分。不管是哪-瓣礼限 制大小都在大約1公細敎。微猶是這類限制 的最典型开)式，而相較於批式反應器來說，微反應器通常是 連續流動反應器。微通道降低的内部尺寸，在質量和熱轉 移速率上提供了大大的改進。此外微反應器提供很多超 越傳統規模反絲_點，包括大大增進能翻^率，反應速 度’反應產能，安全性，可靠性，擴充性等等。
【先前技術J Q 微反應器通常用來將兩個分開的反應物引進共同的微 通道網狀結構中。通常，微通道網狀結構和用來將反應物 引導到網狀結構内適當微通道的結合元件都相當複雜，而 且需要配置成在高溫和高壓下運作。因此，傳統的微反應 器構造例如在已出版之國際專利申請w〇_2007_0365i3中所 提到的，應用各種流體管，配件，轉接器，〇_環，爽子，和其他 種類的連接元件將微反應器構造中的各種微結構互連。每 一個這些元件都會增加系統的複雜度，而且成為系統内滲 漏或其他誤差的潛在來源。 200946221 【發明内容】 本發明大致上是關於微反應器組合的設計，降低了很 多刚面提到之元件的使用，因此解決了這些設計問題。 根據本發明的一個實施例提供了一微反應器組合，其 包含流體互連骨幹和多個流體微結構。這些流體微結構由 各自的部分流體互連骨幹來支撐。此微反應器組合包含多 個非聚合物互連密封，跟互連輸入和輸出埠聯繫。流體互 〇 連骨幹的互連輸入埠在其中一個非聚合物互連密封處，跟 第一流體微結構的微通道輸出埠形成介面。流體互連骨幹 的互連輸出埠在另一個非聚合物互連密封處跟第二流體微 結構的微通道輸入埠形成介面。互連微通道完全由流體互 連骨幹界定出，配置成使它從第一流體微結構之微通道輸 出埠的非聚合物互連密封處一直延伸到第二流體微結構之 微通道輸入埠的非聚合物互連密封處，中間沒有其他密封 介面的干擾。 〇 【實施方式】 參考圖1和2,其顯示了根據本發明一個實施例的微反 - 應器組件麗。微反應器組件100包含流體互連骨幹10,和 多個流體微結構20, 30,40。雖然本發明並不局限於使用特 疋類型的流體微結橡但是在顯示的實施例中，反應物A和B 首先被引導過各別的熱交換微結構20來幫忙調節反應物的 溫度。然後第一反應物A被配送過反應物分散微結構30,在 其中反應物A的流體流動路徑分佈橫過多個反應物流動路 徑31。每個反應物流動路徑31接下來都導向混合微結構40 200946221 讓反應物Α和Β反應。 如上面所提到的，圖1顯示的特定流體微結構構造不應 該用來限制本發明的範圍。而是，圖i所選用的微結構可以 達到一般目的，用來說明根據本發明的微反應器組件可以 利用流體互連骨幹1G來支撐並在運作上讓各個&體微結$ 100互連，包含但不局限於圖丨所顯示的那些。 Ο Ο 同時參考圖1和2,細流體微結構20, 30,40包含多個 流體微通道25, 35,45,其包含各自的微通道輸入槔22,32， 42’和微通道輸出埠24,34,44。同樣的流體互連骨幹仞包 15’ 含互連輸人埠12和互連 輸出埠14。微反應器組件1〇〇也包含多個跟互連輸入和輸 出埠12,14聯繫的非聚合物互連密封。 如圖2清楚顯示的，流體互連骨幹的互連輸入璋12，在 其中個非t合物互連密封5〇處跟第一流體微結構2〇的微 通道輸出埠24形成介面。同樣的流體互連骨幹1〇的互連 輸出痒14在另-個非聚合物互連密封5〇處跟第二流體微結 構30的微通道輸入埠32形成介面。互連微通道π完全由满 體互連月幹1〇界疋出，要配置成使它從第一流體微結構之 微通道輸出埠24的非聚合物互連密封5〇處一直延伸到第二 二體微結構30之微通道輸入埠32的非聚合物互連密封物邠 處，中間沒有其他密封介面的干擾。結果，微反應器組合 100利用—10來提供流體微結構之間的高效能連接 在化予抗f生’和運作壓力和溫度方面。互連骨幹10也大 大降低微結構之間的外部連接數目，以及結合的安姊密 200946221 .封硬體，因而簡化了微反應器組件100。 此外，互連骨幹10可以增進微反應器組件的處理控制， 因為它也合併了熱互連微通道16 〇更具體地說，同時參考 圖1和2,流體微結構20, 30,40每個都可以包含熱流體微通 道26,46用來在流體微通道25,35,45中的反應物流體和熱 流體微通道26,46中的熱流體之間作熱交換。同樣的，互連 - 微通道15可以透過對應的非聚合物互連密封包含作為流體 φ 微結構2〇, 30,40之熱流體微通道26,46的熱互連微通道。 如圖2所示，流體互連骨幹10被配置成多層歧管，其包 含跨層開口 18和層内阻隔19用來將多層歧管的各別層分離 成多個獨立的互連微通道。因此，流體互連骨幹1〇可以經 過配置跟各種不同複雜度的流體微結構配對。跨層開口 Μ 的各別位置可以經過選擇，<吏得互連輸入和輸出埠12,14可 以跟各種微流體結構的標準1/〇(輸W輸出)樣式，或是相 當獨特之應用的定制1/0樣式相配對。 ❹ 如那些熟悉微反應器技術的人所瞭解的，這裡所示之 複雜度可以作廣泛的變動，在圖丄 - 和2中’、尺以相i簡單的簡圖开》式來作說明。為了描述並 界疋出本七明，要注意的是前面提到的互連和反應物微通 道^5, 25,35,45是用來將兩個或更多反應物A，B引導到微反 應為組件1〇〇的一個或多個共同部分來協助反應以產生一 個^多個反應絲c。熱趟微通道16,26,46 _熱流體Η =裒來控制微反應器組件1〇〇的溫度，及其中不同的流體循 環。在本發明的特定實施例中，可以考慮讓輸入熱流體Η, 200946221 的溫度在預定值之間變動，以協助在不同模式或不同條件 τ運作。—… ——........ 選擇為非聚合物料錢魏50可明it在相當高或 相田低·度下的效能，也就是聚合物密封會損壞或劣化的 服度在操作本發明時，非聚合物互連密封5〇能夠以很多 方式來建構。例如，一個或多個非聚合物互連密封物50可 - 以包3由流體微結構20,30,40其中一個的材料，流體互連 〇 骨210的材料，和插入的非聚合物枯合材料共同形成的密 封"面。或者，一個或多個非聚合物互連密封5〇可以包含 玻璃/玻璃密封介面，由流體微結構20, 30,40其中-個的玻 璃，和流體互連骨幹50的玻璃共同形成。根據本發明的另 一個實施例，一個或多個非聚合物互連密封5〇可以包含玻 璃/玻璃料/玻璃密封介面，由流體微結構2〇, 4〇其中一 侧賴，流體互連骨幹 同形成。在另一個可考慮的實施例中，一個或多個非聚合 ❹ 物互連密封5〇可以包含玻璃/陶瓷密封介面，由流體微結構 20, 30,40其中一個的玻璃或陶瓷，和流體互連骨幹1〇的玻 璃或陶瓷共同形成。在又另一個實施例中，一個或多個非 聚合物互連密封50可以包含陶曼/陶瓷密封介面，由流體微 結構20,30,40其中一個的陶曼，和流體互連骨幹1 〇的陶究 共同形成。在又另一個實施例中，一個或多個非聚合物互 連密封50可以包含玻璃/玻璃，玻璃/陶瓷或陶竟/陶瓷密 封介面，和插入的非聚合物粘合材料。 要注意，這裡陳述將本發明的元件以特定方式來"配置 200946221 的陳述3而^生貝’或以特定方式來作用’這些都是結構上 ”配置^不1途上的陳述。具體地說，這裡所提到元件 、方式，疋指出此元件現有的實體狀礼因此應該視 為此兀件之結構特性的明確陳述。 >^詳略述本發明並參考特殊實施例之後，我們可以 f修改和變動是可能的，但是都不讎申請專利範 圍斤界疋出本發明的細。具體的說，雖然本發明的一些 Ο 項目在讀被標識為較好，或特別有利，但是本發明不-定 要局限在本發日月這些較好的方面。 【圖式簡單說明】 底下詳細描述本發明的特定實施例，可以配合底下的 附圖得到最佳的瞭解，其中相似的結構以相似的參考數字 來表示，其中： 圖1為依據本發明一項實施例微反應器組件之示意圖。 圖2為顯示於圖1部份微反應器組件詳細示意圖。 〇 【主要元件符號說明】 流體互連骨幹10;互連輸入埠12;互連輸出埠14;互 . 連微通道15;熱互連微通道16;跨層開口 18;層内阻隔 19;流體微結構2〇, 3〇, 4〇;微通道輸入埠22, 32,42;微通 道輸出埠24,34,44;流體微通道25,35,45;熱流體微通道 26,46;反應物流動路徑31;非聚合物互連密封50;微反 應器組件1〇〇。 第10 頁

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  1. 200946221 十、申請專利範圍： 1. 一種微反應器組件，其包含流體互連 微結構，其中： f體微結構是由各自的部分流體互連骨幹來支撐； 每個流體_魏含多伽續微视包含各別的微通 迢輸入埠以及微通道輸出埠； 〇 流體互連骨幹至少包含一個互連微通道，含有互連輸入 埠和互連輸出埠； 微反應器組件包含多個非聚合物互連密封，跟互連輸入 和輸出埠聯繫； —流體互連骨幹的互連輸入埠，在其中一個非聚合物互連 密封處跟第-流體微結構的微通道輸ώ埠形成介面； 流體互連骨幹的互連輸出埠，在其中一個非聚合物互連 _跟㈣體微結構的微通道輸入埠形成介面;及 *互連微通道完全由流體互連骨幹界定出，配置成使其從 Q 第一流體微結構之微通道輸出埠的非聚合物互連密封處 一直延伸到第二流體微結構之微通道輸入埠的非聚合物互 連密封處，中間沒有其他密封介面的干擾。 2·依據申請專利麵第！項之微反應器組件，其中流體互連 骨幹包含多個獨立互連微通道以及配置成多層歧管，其包 含跨層開口以及層内阻隔之網狀結橼其配置成將多層歧 管的各別層分離成多個獨立的互連微通道。 3.依據申請專利範圍第1項之微反應器組件，其中由流體互 連骨幹所支撐之多個流體微結構包含至少一個反應物分散 第1丨頁 200946221 微結構以及至少一個混合微結構。 4. 依據申請專利範圍第3項之微反應器組件，其中流體互連 骨幹包含多個互連微通道，其配置成經由非聚合物互連密 封與相對應反應物分散之流體微通道及混合微結構形成界 面。 5. 依據申請專利範圍第3項之微反應器組件，其中多個流體 微結構更進一步包含至少一個熱交換微結構以及流體互連 骨幹包含多個互連微通道，其配置成與相對應熱交換微結 構之流體微通道形成介面。 6. 依據申請專利範圍第1項之微反應器組件，其中至少一個 流體微結構之流體微通道包含至少一個反應物微通道，其 配置成導引反應物流體由微通道輸入端埠至微通道輸出端 埠以及至少一個熱流體微通道，其配置成在反應物微通道 中反應物流體與熱流體微通道中熱流體之間作熱交換。 7. 依據申請專利範圍第6項之微反應器組件，其中： 流體互連骨幹包含多個互連微通道； 多個互連微通道之一個包含藉由非聚合物互連密封作為 流體微結構之反應物微通道的反應物互連微通道;以及 另一互連微通道包含藉由非聚合物互連密封作為流體 微結構之熱流體微通道的熱互連微通道。 8. 依據申請專利範圍第7項之微反應器組件，其中另一互連 微通道包含至少一個藉由非聚合物互連密封作為流體微結 構之額外反應物微通道的額外反應物互連微。 9. 依據申請專利範圍第1項之微反應器組件其中至少一個 第12 頁 200946221 非t合物互連密封包含密封介面，其由一個流體微結構材 料，流體互連骨幹材料，以及插入非聚合物黏接材料共同地 形成。 10.依據申請專利範圍第1項之微反應器組件，其中至少一 種非聚合物互連密封包含玻璃/玻璃密封介面。 11·依據申請專利範圍第10項之微反應器組件，其中玻璃/ 玻璃密封介面由一個流體微結構之玻璃以及流體互連骨幹 之玻璃共同地形成。 12. 依據申請專利範圍第1項之微反應器組件，其中至少— 種非聚合物互連密封包含玻璃/玻璃料/玻璃密封介面。 13. 依據申請專利範圍第1〇項之微反應器組件，其中玻璃/ 玻璃料/玻璃密封介面由一個流體微結構之玻璃，流體互連 骨幹之玻璃，以及玻璃料插入層共同地形成。 14. 依據申請專利範圍第1項之微反應器組件，其中至少一 個非聚合物互連密封包含玻璃/陶瓷密封介面。 15. 依據申請專利範圍第14項之微反應器組件，其中玻璃/ 陶兗密封介面由一個流體微結構之玻璃或陶竞以及流體互 連骨幹之玻璃或陶瓷共同地形成。 16. 依據申請專利範圍第1項之微反應器組件，其中至少一 個非聚合物互連密封包含陶瓷/陶瓷密封介面。 Π.依據申請專利範圍第16項之微反應器組件，其中陶資y 陶瓷密封介面由一個流體微結構之陶瓷以及流體互連骨幹 之陶瓷共同地形成。 18.依據申請專利範圍第1項之微反應器組件，其中： 200946221 至少一個非聚合物互連密封包含玻璃/玻璃，玻璃/陶瓷， 或陶瓷/陶瓷番封介面;以及 — 密封介面由一個流體微結構之玻璃或陶瓷，流體互連骨 幹之玻璃或陶瓷，及插入非聚合物黏接材料共同地形成。
    第14 頁
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US20050245308A1 (en) * 2004-04-29 2005-11-03 Cfph, Llc System and method for wagering based on financial market indicators
EP2072115A1 (en) 2007-12-21 2009-06-24 Corning Incorporated Microreactor assembly incorporating an interconnecting element
EP2077149A1 (en) * 2007-12-21 2009-07-08 Corning Incorporated Microreactor assembly incorporating an interconnecting element and diverse fluidic microstructures
US8448499B2 (en) 2008-12-23 2013-05-28 C A Casyso Ag Cartridge device for a measuring system for measuring viscoelastic characteristics of a sample liquid, a corresponding measuring system, and a corresponding method
US9599407B2 (en) * 2009-07-29 2017-03-21 Tokitae Llc System and structure for heating or sterilizing a liquid stream
US8303909B2 (en) * 2009-11-30 2012-11-06 Corning Incorporated Microfluidic assembly
EP2458358B1 (en) 2010-11-29 2017-09-27 Corning Incorporated In-line contactless pressure sensors and methods of measuring pressure
US9233372B2 (en) 2011-06-14 2016-01-12 Corning Incorporated Hybrid microfluidic assemblies
WO2013082347A1 (en) * 2011-11-30 2013-06-06 Corning Incorporated Fluidic module permanent stack assemblies and methods
CA2900215A1 (en) * 2013-03-15 2014-09-18 Illumina, Inc. System and method for generating or analyzing a biological sample
US10816559B2 (en) 2014-09-29 2020-10-27 Ca Casyso Ag Blood testing system and method
US10539579B2 (en) 2014-09-29 2020-01-21 C A Casyso Gmbh Blood testing system and method

Family Cites Families (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5387395A (en) * 1992-07-06 1995-02-07 Beckman Instruments, Inc. Fluid distribution manifold
US20050042149A1 (en) * 1994-04-01 2005-02-24 Integrated Chemical Synthesizers, Inc. Nanoscale chemical synthesis
US5856174A (en) * 1995-06-29 1999-01-05 Affymetrix, Inc. Integrated nucleic acid diagnostic device
DE19917398C2 (de) * 1999-04-16 2002-06-20 Accoris Gmbh Modulares chemisches Mikrosystem
DE19959249A1 (de) * 1999-12-08 2001-07-19 Inst Mikrotechnik Mainz Gmbh Modulares Mikroreaktionssystem
US6645432B1 (en) * 2000-05-25 2003-11-11 President & Fellows Of Harvard College Microfluidic systems including three-dimensionally arrayed channel networks
DE10036602A1 (de) * 2000-07-27 2002-02-14 Cpc Cellular Process Chemistry Mikroreaktor für Reaktionen zwischen Gasen und Flüssigkeiten
US6919046B2 (en) * 2001-06-07 2005-07-19 Nanostream, Inc. Microfluidic analytical devices and methods
US20030134734A1 (en) * 2001-08-08 2003-07-17 Shiro Nishimoto Press molding method for glass and manufacturing method for glass substrate using this method
WO2003050035A2 (en) * 2001-12-06 2003-06-19 Nanostream, Inc. Adhesiveless microfluidic device fabrication
WO2004034028A2 (en) * 2002-10-09 2004-04-22 The Board Of Trustees Of The University Of Illinois Microfluidic systems and components
EP1415707A1 (en) * 2002-10-29 2004-05-06 Corning Incorporated Method and microfluidic reactor for photocatalysis
US7541007B2 (en) * 2002-12-20 2009-06-02 Lehigh University Microreactor and method of use to produce hydrogen by methanol reforming
DE112004000052T5 (de) * 2003-02-06 2005-08-11 Dai Nippon Printing Co., Ltd. Mikroreaktor und Herstellungsverfahren für diesen
DE10317451A1 (de) * 2003-04-16 2004-11-18 Degussa Ag Reaktor für heterogen katalysierte Reaktionen
US7011793B2 (en) * 2003-05-15 2006-03-14 Kionix, Inc. Reconfigurable modular microfluidic system and method of fabrication
US6994245B2 (en) * 2003-10-17 2006-02-07 James M. Pinchot Micro-reactor fabrication
JP5148267B2 (ja) * 2004-04-02 2013-02-20 エービー サイエックス エルエルシー 微小溶液の接続
US7004198B1 (en) * 2004-07-20 2006-02-28 Sandia Corporation Micro-fluidic interconnect
WO2006015308A2 (en) 2004-07-29 2006-02-09 California Institute Of Technology Modular microfluidic packaging system
KR100579831B1 (ko) * 2004-09-07 2006-05-15 삼성전자주식회사 조립 가능한 미세유동형 바이오시료 처리장치
DE102005012415B4 (de) 2005-03-17 2006-12-28 Syntics Gmbh Verfahrenstechnisches Funktionselement aus einem Folienstapel
WO2007016931A1 (en) 2005-07-25 2007-02-15 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. Chip-holder for a micro-fluidic chip
DE102005045811A1 (de) 2005-09-27 2007-04-05 Siemens Ag Modulares Mikrofluidiksystem
US7927869B2 (en) 2005-11-29 2011-04-19 Spencer Z Rosero System and method for supporting a biological chip device
WO2007131988A1 (en) 2006-05-15 2007-11-22 Corning Incorporated Sintered glass and glass-ceramic structures and methods for producing
ES2329713T3 (es) * 2006-05-15 2009-11-30 Corning Incorporated Estructuras de vitroceramica y de vidrio sinterizadas y procedimientos de produccion.
EP2072115A1 (en) 2007-12-21 2009-06-24 Corning Incorporated Microreactor assembly incorporating an interconnecting element

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