TW201000466A - Compounds and compositions as kinase inhibitors - Google Patents

Compounds and compositions as kinase inhibitors Download PDF

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Publication number
TW201000466A
TW201000466A TW098121260A TW98121260A TW201000466A TW 201000466 A TW201000466 A TW 201000466A TW 098121260 A TW098121260 A TW 098121260A TW 98121260 A TW98121260 A TW 98121260A TW 201000466 A TW201000466 A TW 201000466A
Authority
TW
Taiwan
Prior art keywords
ylamino
gas
pyrazol
methyl
fluorenyl
Prior art date
Application number
TW098121260A
Other languages
English (en)
Chinese (zh)
Inventor
Thomas H Marsilje Iii
Wenshuo Lu
Bei Chen
Xiao-Hui He
Kun-Yong Yang
Christian Cho-Hua Lee
Song-Chun Jiang
Original Assignee
Irm Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Irm Llc filed Critical Irm Llc
Publication of TW201000466A publication Critical patent/TW201000466A/zh

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
TW098121260A 2008-06-25 2009-06-24 Compounds and compositions as kinase inhibitors TW201000466A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US7558308P 2008-06-25 2008-06-25
US15543409P 2009-02-25 2009-02-25

Publications (1)

Publication Number Publication Date
TW201000466A true TW201000466A (en) 2010-01-01

Family

ID=41349515

Family Applications (1)

Application Number Title Priority Date Filing Date
TW098121260A TW201000466A (en) 2008-06-25 2009-06-24 Compounds and compositions as kinase inhibitors

Country Status (29)

Country Link
US (2) US8519129B2 (fr)
EP (1) EP2318392A2 (fr)
JP (1) JP5508412B2 (fr)
KR (1) KR101432352B1 (fr)
CN (1) CN102112467B (fr)
AR (1) AR072787A1 (fr)
AU (1) AU2009264934B2 (fr)
BR (1) BRPI0914652A2 (fr)
CA (1) CA2729495C (fr)
CL (1) CL2009001476A1 (fr)
CO (1) CO6351787A2 (fr)
CR (1) CR20110028A (fr)
DO (1) DOP2010000397A (fr)
EA (1) EA020730B1 (fr)
EC (1) ECSP11010784A (fr)
GE (1) GEP20125564B (fr)
HN (1) HN2010002733A (fr)
IL (1) IL210124A0 (fr)
MA (1) MA32497B1 (fr)
MX (1) MX2010014039A (fr)
NI (1) NI201000219A (fr)
NZ (1) NZ590602A (fr)
PA (1) PA8834001A1 (fr)
PE (1) PE20100087A1 (fr)
SV (1) SV2010003776A (fr)
TW (1) TW201000466A (fr)
UY (1) UY31929A (fr)
WO (1) WO2010002655A2 (fr)
ZA (1) ZA201100344B (fr)

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Publication number Publication date
AR072787A1 (es) 2010-09-22
ECSP11010784A (es) 2011-02-28
CA2729495A1 (fr) 2010-01-07
AU2009264934A1 (en) 2010-01-07
ZA201100344B (en) 2012-10-31
IL210124A0 (en) 2011-02-28
CA2729495C (fr) 2013-12-17
PA8834001A1 (es) 2010-04-21
MX2010014039A (es) 2011-01-21
CN102112467A (zh) 2011-06-29
JP5508412B2 (ja) 2014-05-28
US8859574B2 (en) 2014-10-14
AU2009264934B2 (en) 2012-09-27
CN102112467B (zh) 2014-04-30
UY31929A (es) 2010-01-05
JP2011526284A (ja) 2011-10-06
BRPI0914652A2 (pt) 2017-06-06
MA32497B1 (fr) 2011-07-03
KR20110022699A (ko) 2011-03-07
HN2010002733A (es) 2013-01-28
WO2010002655A2 (fr) 2010-01-07
GEP20125564B (en) 2012-06-25
EA201100077A1 (ru) 2011-08-30
DOP2010000397A (es) 2011-01-15
KR101432352B1 (ko) 2014-08-21
EP2318392A2 (fr) 2011-05-11
PE20100087A1 (es) 2010-02-08
SV2010003776A (es) 2012-01-04
US20110112063A1 (en) 2011-05-12
NI201000219A (es) 2011-05-24
CL2009001476A1 (es) 2010-01-11
NZ590602A (en) 2011-10-28
CR20110028A (es) 2011-04-07
WO2010002655A3 (fr) 2010-04-01
CO6351787A2 (es) 2011-12-20
US8519129B2 (en) 2013-08-27
US20130310361A1 (en) 2013-11-21
EA020730B1 (ru) 2015-01-30

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