TW201114765A - Use of aminodihydrothiazines for the treatment or prevention of diabetes - Google Patents

Use of aminodihydrothiazines for the treatment or prevention of diabetes Download PDF

Info

Publication number: TW201114765A
Authority: TW; Taiwan
Prior art keywords: group; phenyl; alkyl; compound; ethyl
Prior art date: 2009-09-11

Application number

TW099130754A

Other languages

English (en)

Chinese (zh)

Inventor

Jeremy Beauchamp

Agnes Benardeau

Hans Hilpert

Cristiano Migliorini

William Riboulet

Hai-Yan Wang

Original Assignee

Hoffmann La Roche

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2009-09-11

Filing date

2010-09-10

Publication date

2011-05-01

2010-09-10 Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche

2011-05-01 Publication of TW201114765A publication Critical patent/TW201114765A/zh

Links

238000011282 treatment Methods 0.000 title claims abstract description 51
206010012601 diabetes mellitus Diseases 0.000 title claims abstract description 27
230000002265 prevention Effects 0.000 title claims abstract description 20
VNTNANCAPVJRJP-UHFFFAOYSA-N 3,4-dihydrothiazin-2-amine Chemical class NN1CCC=CS1 VNTNANCAPVJRJP-UHFFFAOYSA-N 0.000 title abstract 2
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208000001072 type 2 diabetes mellitus Diseases 0.000 claims abstract description 32
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BDAGIHXWWSANSR-UHFFFAOYSA-N formic acid Substances OC=O BDAGIHXWWSANSR-UHFFFAOYSA-N 0.000 claims description 67
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229910052736 halogen Inorganic materials 0.000 claims description 35
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Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
- A61K31/541—Non-condensed thiazines containing further heterocyclic rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D279/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one sulfur atom as the only ring hetero atoms
- C07D279/04—1,3-Thiazines; Hydrogenated 1,3-thiazines
- C07D279/06—1,3-Thiazines; Hydrogenated 1,3-thiazines not condensed with other rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Epidemiology (AREA)
Diabetes (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Hematology (AREA)
Emergency Medicine (AREA)
Obesity (AREA)
Endocrinology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Plural Heterocyclic Compounds (AREA)

TW099130754A 2009-09-11 2010-09-10 Use of aminodihydrothiazines for the treatment or prevention of diabetes TW201114765A (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
EP09170126		2009-09-11
EP09172068		2009-10-02

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TW201114765A true TW201114765A (en)	2011-05-01

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TW099130754A TW201114765A (en)	2009-09-11	2010-09-10	Use of aminodihydrothiazines for the treatment or prevention of diabetes

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Country	Link
US (3)	US20110065695A1 (2)
EP (1)	EP2475658A1 (2)
JP (1)	JP2013503838A (2)
CN (1)	CN102482268B (2)
AR (1)	AR078163A1 (2)
CA (1)	CA2771374A1 (2)
IN (1)	IN2012DN01233A (2)
SG (1)	SG179034A1 (2)
TW (1)	TW201114765A (2)
WO (1)	WO2011029803A1 (2)

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WO2008133273A1 (ja)	2007-04-24	2008-11-06	Shionogi & Co., Ltd.	アルツハイマー症治療用医薬組成物
TW200902526A (en) *	2007-04-24	2009-01-16	Shionogi & Amp Co Ltd	Aminodihydrothiazin derivative substituted with a cyclic group
WO2009151098A1 (ja) *	2008-06-13	2009-12-17	塩野義製薬株式会社	βセクレターゼ阻害作用を有する含硫黄複素環誘導体
JPWO2010047372A1 (ja) *	2008-10-22	2012-03-22	塩野義製薬株式会社	Ｂａｃｅ１阻害活性を有する２−アミノピリミジン−４−オンおよび２−アミノピリジン誘導体
UA108363C2 (uk)	2009-10-08	2015-04-27		Похідні імінотіадіазиндіоксиду як інгібітори bace, композиція на їх основі і їх застосування
UA110467C2 (uk)	2009-12-11	2016-01-12	Шионогі Енд Ко., Лтд.	Похідні оксазину
CN103261199A (zh)	2010-10-29	2013-08-21	盐野义制药株式会社	萘啶衍生物
EP2634188A4 (en)	2010-10-29	2014-05-07	Shionogi & Co	FUSIONED AMINODIHYDROPYRIMIDINE DERIVATIVE
WO2012138734A1 (en)	2011-04-07	2012-10-11	Merck Sharp & Dohme Corp.	C5-c6 oxacyclic-fused thiadiazine dioxide compounds as bace inhibitors, compositions, and their use
US9145426B2 (en)	2011-04-07	2015-09-29	Merck Sharp & Dohme Corp.	Pyrrolidine-fused thiadiazine dioxide compounds as BACE inhibitors, compositions, and their use
MX2013011947A (es)	2011-04-13	2014-01-16	Merck Sharp & Dohme	Iminotiazinas 5-sustituidas y sus monoxidos y dioxidos como inhibidores de la enzima que encinde la proteina precursora amiloide en el sitio beta, composiciones y su uso.
CN103596939A (zh) *	2011-04-13	2014-02-19	默沙东公司	作为bace抑制剂的5-取代的亚氨基噻嗪类及其单和二氧化物、组合物及其应用
WO2012147763A1 (ja)	2011-04-26	2012-11-01	塩野義製薬株式会社	オキサジン誘導体およびそれを含有するｂａｃｅ１阻害剤
CN103649082A (zh)	2011-04-26	2014-03-19	盐野义制药株式会社	吡啶衍生物和含有该吡啶衍生物的bace1抑制剂
US8927535B2 (en) *	2011-07-06	2015-01-06	Hoffman-La Roche Inc.	Cyclopropyl-fused-1,3-thiazepines as BACE1 and/or BACE2 inhibitors
KR20140054295A (ko)	2011-08-22	2014-05-08	머크 샤프 앤드 돔 코포레이션	Bace 억제제로서의 2-스피로-치환된 이미노티아진 및 그의 모노- 및 디옥시드, 조성물 및 그의 용도
HK1206597A1 (en)	2012-03-20	2016-01-15	艾朗制药股份有限公司	Spirocyclic dihydro-thiazine and dihydro-oxazine bace inhibitors, and compositions and uses thereof
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- 2010-09-07 CA CA2771374A patent/CA2771374A1/en not_active Abandoned
- 2010-09-07 EP EP10771367A patent/EP2475658A1/en not_active Withdrawn
- 2010-09-07 WO PCT/EP2010/063071 patent/WO2011029803A1/en not_active Ceased
- 2010-09-07 CN CN201080039905.XA patent/CN102482268B/zh not_active Expired - Fee Related
- 2010-09-07 SG SG2012016119A patent/SG179034A1/en unknown
- 2010-09-07 IN IN1233DEN2012 patent/IN2012DN01233A/en unknown
- 2010-09-07 JP JP2012527352A patent/JP2013503838A/ja active Pending
- 2010-09-09 AR ARP100103301A patent/AR078163A1/es unknown
- 2010-09-10 TW TW099130754A patent/TW201114765A/zh unknown
2012
- 2012-12-06 US US13/706,394 patent/US20130096107A1/en not_active Abandoned
2014
- 2014-04-04 US US14/245,045 patent/US20140221360A1/en not_active Abandoned

Also Published As

Publication number	Publication date
CN102482268A (zh)	2012-05-30
IN2012DN01233A (2)	2015-05-15
EP2475658A1 (en)	2012-07-18
SG179034A1 (en)	2012-04-27
CN102482268B (zh)	2014-11-26
US20140221360A1 (en)	2014-08-07
JP2013503838A (ja)	2013-02-04
AR078163A1 (es)	2011-10-19
WO2011029803A1 (en)	2011-03-17
US20110065695A1 (en)	2011-03-17
US20130096107A1 (en)	2013-04-18
CA2771374A1 (en)	2011-03-17

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