TW201121957A - Benzoimidazole compounds and uses thereof - Google Patents

Benzoimidazole compounds and uses thereof Download PDF

Info

Publication number: TW201121957A
Authority: TW; Taiwan
Prior art keywords: compound; salt; animal; formula; pharmaceutically acceptable
Prior art date: 2009-11-18

Application number

TW099139607A

Other languages

English (en)

Chinese (zh)

Inventor

Louis-David Cantin

Xuehong Luo

Miroslaw Jerzy Tomaszewski

Original Assignee

Astrazeneca Ab

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2009-11-18

Filing date

2010-11-17

Publication date

2011-07-01

2010-11-17 Application filed by Astrazeneca Ab filed Critical Astrazeneca Ab

2011-07-01 Publication of TW201121957A publication Critical patent/TW201121957A/zh

Links

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Classifications

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- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/10—Drugs for disorders of the urinary system of the bladder
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
- C07D265/28—1,4-Oxazines; Hydrogenated 1,4-oxazines
- C07D265/30—1,4-Oxazines; Hydrogenated 1,4-oxazines not condensed with other rings

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Life Sciences & Earth Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Urology & Nephrology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Pain & Pain Management (AREA)
Biomedical Technology (AREA)
Rheumatology (AREA)
Epidemiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Plural Heterocyclic Compounds (AREA)

TW099139607A 2009-11-18 2010-11-17 Benzoimidazole compounds and uses thereof TW201121957A (en)

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US26226309P	2009-11-18	2009-11-18

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US (1)	US8530467B2 (2)
EP (1)	EP2501697B1 (2)
JP (1)	JP5657018B2 (2)
KR (1)	KR20120113709A (2)
CN (1)	CN102741245B (2)
AR (1)	AR079050A1 (2)
AU (1)	AU2010322478B2 (2)
BR (1)	BR112012011518B8 (2)
CA (1)	CA2777746C (2)
ES (1)	ES2442797T3 (2)
IN (1)	IN2012DN03391A (2)
MX (1)	MX2012005329A (2)
RU (1)	RU2542582C2 (2)
TW (1)	TW201121957A (2)
UY (1)	UY33037A (2)
WO (1)	WO2011062550A1 (2)

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US10195198B2 (en)	2014-07-03	2019-02-05	Afferent Pharmaceuticals, Inc.	Methods and compositions for treating diseases and conditions
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KR102797127B1 (ko) *	2018-12-29	2025-04-21	우한 크리에이터나 사이언스 앤드 테크놀로지 컴퍼니, 리미티드	헤테로고리계 화합물, 중간체, 이의 제조 방법 및 용도
JP7578602B2 (ja) *	2019-02-25	2024-11-06	グラクソスミスクライン、インテレクチュアル、プロパティー、（ナンバー３）、リミテッド	Ｐ２ｘ３修飾薬での治療
EP4103564A4 (en) *	2020-02-14	2024-05-01	GlaxoSmithKline Intellectual Property (No.3) Limited	P2X3 MODULATORS
KR20230051209A (ko) *	2020-08-13	2023-04-17	투오지에 바이오텍 (상하이) 컴퍼니 리미티드	벤즈이미다졸 유도체, 이의 제조 방법 및 이의 의학적 용도
WO2022117062A1 (zh) *	2020-12-04	2022-06-09	上海拓界生物医药科技有限公司	含有稠合三环的化合物及其医药用途
CN114478508A (zh) *	2021-12-31	2022-05-13	淮北师范大学	一种苯并咪唑化合物的结晶形式
WO2023151660A1 (zh) *	2022-02-11	2023-08-17	江苏恒瑞医药股份有限公司	一种p2x3受体拮抗剂的结晶形式及其制备方法
WO2023151658A1 (zh) *	2022-02-11	2023-08-17	江苏恒瑞医药股份有限公司	一种p2x3受体拮抗剂的可药用盐及其制备方法

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MXPA02012903A (es)	2000-07-07	2004-07-30	Angiogene Pharm Ltd	Derivados de colquinol como inhibidores de angiogenesis.
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WO2008108958A2 (en) *	2007-03-02	2008-09-12	Schering Corporation	Benzimidazole derivatives and methods of use thereof
US20090099195A1 (en)	2007-05-08	2009-04-16	Astrazeneca Ab	Therapeutic Compounds 570
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2010
- 2010-11-17 IN IN3391DEN2012 patent/IN2012DN03391A/en unknown
- 2010-11-17 WO PCT/SE2010/051269 patent/WO2011062550A1/en not_active Ceased
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- 2010-11-17 RU RU2012124268/04A patent/RU2542582C2/ru active
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- 2010-11-17 AU AU2010322478A patent/AU2010322478B2/en active Active
- 2010-11-17 TW TW099139607A patent/TW201121957A/zh unknown
- 2010-11-17 CN CN201080061596.6A patent/CN102741245B/zh active Active
- 2010-11-17 EP EP10831876.7A patent/EP2501697B1/en active Active
- 2010-11-17 CA CA2777746A patent/CA2777746C/en active Active
- 2010-11-17 AR ARP100104240A patent/AR079050A1/es unknown
- 2010-11-17 KR KR1020127012726A patent/KR20120113709A/ko not_active Withdrawn
- 2010-11-17 ES ES10831876.7T patent/ES2442797T3/es active Active
- 2010-11-18 UY UY0001033037A patent/UY33037A/es not_active Application Discontinuation
2012
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Also Published As

Publication number	Publication date
CA2777746A1 (en)	2011-05-26
AR079050A1 (es)	2011-12-21
US8530467B2 (en)	2013-09-10
JP5657018B2 (ja)	2015-01-21
MX2012005329A (es)	2012-05-29
ES2442797T3 (es)	2014-02-13
RU2542582C2 (ru)	2015-02-20
AU2010322478B2 (en)	2013-11-14
CA2777746C (en)	2019-05-14
KR20120113709A (ko)	2012-10-15
JP2013511517A (ja)	2013-04-04
RU2012124268A (ru)	2013-12-27
EP2501697A1 (en)	2012-09-26
CN102741245A (zh)	2012-10-17
BR112012011518B8 (pt)	2023-01-10
UY33037A (es)	2011-06-30
US20120289504A1 (en)	2012-11-15
BR112012011518B1 (pt)	2020-03-10
BR112012011518A2 (pt)	2016-06-28
IN2012DN03391A (2)	2015-10-23
AU2010322478A1 (en)	2012-05-31
EP2501697A4 (en)	2013-04-24
CN102741245B (zh)	2014-11-05
EP2501697B1 (en)	2013-10-23
WO2011062550A1 (en)	2011-05-26

Publication	Publication Date	Title
TW201121957A (en)	2011-07-01	Benzoimidazole compounds and uses thereof
US9814725B2 (en)	2017-11-14	Imidazopyridine compounds and uses thereof
US20230406851A1 (en)	2023-12-21	Imidazopyridine compounds and uses thereof