TW201225841A

TW201225841A - Pest control composition

Info

Publication number: TW201225841A
Application number: TW100136704A
Authority: TW
Inventors: Katsuya Natsuhara; Yasutaka Shimokawatoko
Original assignee: Sumitomo Chemical Co
Priority date: 2010-10-20
Filing date: 2011-10-11
Publication date: 2012-07-01
Also published as: WO2012053658A2; JP2012106994A; WO2012053658A3; AR083489A1

Abstract

Disclosed is a pest control composition having an excellent controlling effect on pests, which comprises pyriproxyfen and a compound represented by formula (I): wherein, R1 is a hydrogen atom or a methyl group, R2 is a hydrogen atom, a C1-C4 alkyl group, a C1-C4 haloalkyl group, or a (C1-C4 alkyl)carbonyl group, R3 is a hydrogen atom, a C1-C4 alkyl group, a C1-C4 haloalkyl group, or a (C1-C4 alkyl)carbonyl group, R4 is a hydrogen atom, a C1-C4 alkyl group, a C1-C4 haloalkyl group, or a (C1-C4 alkyl)carbonyl group, R5 is a hydrogen atom, a C1-C4 alkyl group, or a C1-C4 alkylamino group, R6 is a hydrogen atom or a methyl group, R7 is a methyl group or an ethyl group, R8 is an amino group, a C1-C4 alkylamino group, or a di(C1-C4 alkyl)amino group, and X1 and X2 are hydrogen atoms or X1 and X2 together represent a single bond.

Description

201225841 六、發明說明：【發明所屬之技術領域】本發明申請案主張日本專利公開號第2010-235520號之優先權，其整體内容於此併入本文作為參考。本發明係關於有害生物防治組成物及有害生物防治方法。【先前技術】為達防治有害生物之目的，迄今已有多種化合物被發現及發展，且包括該化合物作為有效成分之有害生物防治劑用於實務操作。百利普芬[化學名：4-苯氧基苯基2-(2-吼啶氧基）丙基醚]係習知作為有害生物防治劑之活性成分（例如，參照專利文獻1)。又，下式（I)表示之化合物為習知作為有害生物防治劑之活性成分（例如，參照專利文獻2及3):。。。。。。。。。。。。。。。。。。。。。。。。。。。。。。。。。。。。。。。。。。 The present invention relates to pest control compositions and methods for controlling pests. [Prior Art] In order to achieve the purpose of controlling pests, various compounds have been discovered and developed to date, and pesticidal agents including the compound as an active ingredient are used for practical operations. Bilpefene [chemical name: 4-phenoxyphenyl 2-(2-acridinyloxy) propyl ether] is conventionally used as an active ingredient of a pest control agent (for example, refer to Patent Document 1). Further, the compound represented by the following formula (I) is an active ingredient conventionally used as a pest control agent (for example, refer to Patent Documents 2 and 3):

式中， R1為氫原子或曱基， R2為氫原子、C1-C4烷基、C1-C4鹵烷基、或（C1-C4 4 323554 201225841 烷基）羰基， R3為氮原子、C1-C4烷基、C1-C4鹵烷基、或（Cl-C4 烷基）羰基， R4為氳原子、C卜C4烷基、a-C4鹵烷基、或（a-C4 烷基）羰基， R5為氫原子、C1-C4烷基、或C1-C4烷基胺基， R6為氳原子或曱基， R7為曱基或乙基， R8為胺基、C1-C4烧基胺基、或二（C1_C4烧基）胺基’ 以及 X1及X2為氫原子或X1及X2共同表示單鍵。引用文獻列單專利文獻專利文獻1 : EP0128648A 專利文獻2 ·· EP375316A 專利文獻3 : W097/00265 【發明内容】技術問題本發明之目的係提供對有害生物具有優異防治效果之有害生物防治組成物及有害生物防治方法。解決問題之手段本案發明者精心研究後，結果發現組合百利普芬與下式（I)表示之化合物對有害生物具有優異防治效果。因此，完成本發明。 5 323554 201225841 本發明提供： (1)一種有害生物防治組成物，包括百利普芬及下式（I)表示之化合物：Wherein R1 is a hydrogen atom or a fluorenyl group, R2 is a hydrogen atom, a C1-C4 alkyl group, a C1-C4 haloalkyl group, or a (C1-C4 4 323554 201225841 alkyl)carbonyl group, and R3 is a nitrogen atom, C1-C4 An alkyl group, a C1-C4 haloalkyl group, or a (Cl-C4 alkyl)carbonyl group, R4 is a halogen atom, a C-C4 alkyl group, an a-C4 haloalkyl group, or an (a-C4 alkyl)carbonyl group, R5 is a hydrogen atom, a C1-C4 alkyl group, or a C1-C4 alkylamino group, R6 is a halogen atom or a fluorenyl group, R7 is a fluorenyl group or an ethyl group, R8 is an amine group, a C1-C4 alkylamino group, or a The C1_C4 alkyl group "amino group" and X1 and X2 are a hydrogen atom or X1 and X2 together represent a single bond. CITATION LIST Patent Literature Patent Literature 1: EP0128648A Patent Document 2: EP375316A Patent Document 3: W097/00265 [Technical Problem] An object of the present invention is to provide a pest control composition having excellent control effects against harmful organisms and Pest control methods. Means for Solving the Problem After careful study by the inventors of the present invention, it was found that the combination of bailipfen and the compound represented by the following formula (I) has an excellent control effect against harmful organisms. Therefore, the present invention has been completed. 5 323554 201225841 The present invention provides: (1) A pest control composition comprising balixifene and a compound represented by the following formula (I):

式中， R1為氫原子或甲基， R2為氫原子、C1-C4烷基、C1-C4鹵烷基、或（C1-C4 烷基）羰基， R3為氩原子、n-C4烷基、C1-C4鹵烷基、或（C1-C4 烷基）羰基， R4為氫原子、C1-C4烷基、H-C4鹵烷基、或（C1-C4 烷基）羰基， R5為氫原子、C1-C4烷基、或n-C4烷基胺基， R6為氩原子或曱基， R7為曱基或乙基， R8為胺基、C1-C4烷基胺基、或二（n-C4烷基）胺基，以及 X1及X2為氫原子或X1及X2共同表示單鍵； (2)根據上述（1)之有害生物防治組成物，其中，該百利普 6 323554 201225841 芬與式（I)表示之化合物之重量比係介於5000 : 1至1 : ' 5000 ； (3) 根據上述（1)或（2)之有害生物防治組成物，其中，該式 (I)表示之化合物為賜諾殺（spinosad)或多殺菌素 (spinetoram); (4) 一種有害生物防治方法，其包括將有效總量之百利普芬與下式（I)表示之化合物施用於有害生物或有害生物棲息處：In the formula, R1 is a hydrogen atom or a methyl group, R2 is a hydrogen atom, a C1-C4 alkyl group, a C1-C4 haloalkyl group, or a (C1-C4 alkyl)carbonyl group, and R3 is an argon atom or an n-C4 alkyl group. a C1-C4 haloalkyl group or a (C1-C4 alkyl)carbonyl group, R4 is a hydrogen atom, a C1-C4 alkyl group, an H-C4 haloalkyl group, or a (C1-C4 alkyl)carbonyl group, and R5 is a hydrogen atom, a C1-C4 alkyl group, or an n-C4 alkylamino group, R6 is an argon atom or a fluorenyl group, R7 is a fluorenyl group or an ethyl group, and R8 is an amine group, a C1-C4 alkylamino group, or a di(n-C4) group. Alkylamino group, and X1 and X2 are a hydrogen atom or X1 and X2 collectively represent a single bond; (2) A pest control composition according to the above (1), wherein the Phillips 6 323554 201225841 The weight ratio of the compound represented by the formula (I) is 5,000:1 to 1:5000; (3) The pest control composition according to the above (1) or (2), wherein the compound represented by the formula (I) is Spinosad or spinetoram; (4) A pest control method comprising applying an effective total amount of bafilfen and a compound represented by the following formula (I) to a pest or a pest Perch:

式中， R1為氩原子或甲基， R2為氫原子、C卜C4烷基、（n-C4鹵烷基、或（n-C4 *烧基）幾基， R3為氫原子、n-C4烷基、C卜C4鹵烷基、或（a-C4 烷基）羰基， R4為氫原子、C1-C4烷基、a-C4鹵烷基、或（(n-C4 烷基）羰基， R5為氫原子、C1-C4烷基、或C1-C4烷基胺基， R6為氫原子或曱基， 7 323554 201225841 C1〜C4烷基胺基 '或 R7為甲基或乙基， R8為胺基、 '或二（a-C4烷基）胺基，以及 χ1及χ2為氫原子或χΐ及χ2Wherein R1 is an argon atom or a methyl group, and R2 is a hydrogen atom, a C-C4 alkyl group, (n-C4 haloalkyl group, or (n-C4*alkyl) group, R3 is a hydrogen atom, n-C4 An alkyl group, a C-C4 haloalkyl group, or an (a-C4 alkyl)carbonyl group, R4 is a hydrogen atom, a C1-C4 alkyl group, an a-C4 haloalkyl group, or ((n-C4 alkyl)carbonyl group, R5 Is a hydrogen atom, a C1-C4 alkyl group, or a C1-C4 alkylamino group, R6 is a hydrogen atom or a fluorenyl group, 7 323554 201225841 C1 to C4 alkylamino group ' or R7 is a methyl group or an ethyl group, and R8 is an amine. a base, a or a (a-C4 alkyl) amine group, and χ1 and χ2 are hydrogen atoms or ruthenium and osmium 2

灸X共同表示單鍵；分防治方法，其中，該百利普芬量比係介於5000: 1至1: 5000 ; ⑹根據上述⑷或(5)之有害4 表示之化合物為賜諾殺或多殺害生物防治方法，其中，該式（D ，殺菌素。本發明之效果根據本發明，可提供對有害生物具有優異防治效果之有害生物防治組成物及有害生物防治方法。【實施方式】本發明之有害生物防治組成物含有百利普芬與上述式 (I)表示之化合物。百利普芬可經由EP0128648A中所述方法來製備。式（I)表示之化合物，例如已描述於EP375316A及W097 /00265，且可經其中所述方法來製備。在式（1)中，尺2、尺3、^、1^5及1^表示之取代基之實例係如下列者。 R2、R3、R4、或R5表示之“C1-C4院基”之實例包含曱基、乙基、丙基、丁基、1-曱基乙基及1，1-二甲基乙基。 R2、R3或R4表示之“C1-C4鹵烧基”之實例包含2 2 二氟乙基。至於本文所用術語“鹵（halo)”意指氟、氣、 323554 8 201225841 溴或碘。 R2、R3或R4表示之“（C1-C4烷基）羰基”之實例包含曱基羰基、乙基羰基、丙基羰基、及丁基羰基。 R5或R8表示之“C1-C4烷基胺基”之實例包含甲基胺基、乙基胺基、丙基胺基、及丁基胺基。 R8表示之“二（C1-C4烷基）胺基”之實例包含二曱基胺基、二乙基胺基、曱基乙基胺基、及二丙基胺基。其中X1及X2共同表示單鍵之式（I)表示之化合物特別為式（I-a)表示之化合物：Moxibustion X collectively represents a single bond; a method for controlling the same, wherein the ratio of the Bollipfin is between 5000:1 and 1:5000; (6) the compound represented by the harmful 4 of the above (4) or (5) is a spinosad or A multi-killing biological control method, wherein the formula (D, bactericidal effect) According to the present invention, a pest control composition and a pest control method which have an excellent control effect against harmful organisms can be provided. The pest control composition of the invention contains bollipfen and a compound represented by the above formula (I). Billipfen can be produced by the method described in EP 0128648 A. The compound represented by the formula (I), for example, has been described in EP 375316A and W097 / 00265, and can be prepared by the method described therein. In the formula (1), examples of the substituent represented by the ruler 2, the ruler 3, the ^, the 1^5 and the 1^ are as follows. R2, R3, Examples of the "C1-C4 yard group" represented by R4 or R5 include an anthracenyl group, an ethyl group, a propyl group, a butyl group, a 1-mercaptoethyl group, and a 1,1-dimethylethyl group. R2, R3 or R4 An example of a "C1-C4 haloalkyl group" is represented by 2 2 difluoroethyl. As used herein, "Halo" means fluorine, gas, 323554 8 201225841 bromine or iodine. Examples of "(C1-C4 alkyl)carbonyl" represented by R2, R3 or R4 include mercaptocarbonyl, ethylcarbonyl, propylcarbonyl And butylcarbonyl. Examples of the "C1-C4 alkylamino group" represented by R5 or R8 include a methylamino group, an ethylamino group, a propylamino group, and a butylamino group. R8 represents "two ( Examples of the C1-C4 alkyl)amino group include a dinonylamino group, a diethylamino group, a mercaptoethylamino group, and a dipropylamino group. wherein X1 and X2 together represent a single bond (I) The compound represented by the formula is specifically a compound represented by the formula (Ia):

(I-a) 此處，表述“X1及X2共同表示單鍵”意為碳原子分別地接附至X1及X2以形成一個雙鍵（c=c)部分之情況，如式 (I-a)所示。式（I)表示之化合物之實例包含下列化合物。式（I)表示之化合物： 9 323554 201225841(I-a) Here, the expression "X1 and X2 collectively represent a single bond" means a case where carbon atoms are attached to X1 and X2, respectively, to form a double bond (c=c) moiety, as shown in the formula (I-a). Examples of the compound represented by the formula (I) include the following compounds. Compound represented by formula (I): 9 323554 201225841

其中，R1、R2、R3、R4、R5、R6、R7、R8、X1 及 X2 表示表 1 中所顯示之任何組合。 10 323554 201225841 表1 編破 R1 R2 R3 R4 -一一 R6 ........... R6 R7 R8 X1 X2 1 Η CHa CHs CHs H CH3 CHaCHa N(CHa)2 單鍵 2 Η CHs CHa ch3 H CH3 CHaCHa NH(CH3> 單鍵 3 Η ch3 ch3 CHs H ch3 CH2CH3 nh2 單鍵 4 CH3 CHa CHa CH3 H CH3 CHzCHa N(CH3)2 單鍵 5 Η CH3 CHa CHa H CH3 CHa N(CH3)2 單鍵 6 Η ch3 ch3 CHs H H CH2CH3 NCCH3)2 單鍵 7 Η H CHa CHa H CHa CHzCHa N(CHs)z 單鍵 8 Η CHa H CH3 H CH3 CH2CH3 N(CH〇2 單鍵 9 Η CHs ch3 H H CHs CHsCHa N(CH3)2 單鍵 10 CHa CHa H CH3 H CHs CHaCHa N(CH3)z 單鍵 11 Η CHa H CH3 H CHa CH2CH3 NH(CH〇單鍵 12 CH3 ch3 H CHa H CH3 CHaCHs NH(CH3) 單鍵 13 CHs CHa ch3 H H CH3 CH2CH3 N(CH3)2 單鍵 14 Η CHs H H H CHs CH2CH3 NCCHOa 單鍵 15 CHa H CHa CHs H CHa CHaCHa N(CH3)2 單鍵 16 Η H CHs CHs H CHs CH2CH3 NHCCHs) 單鍵 17 Η H CHa CHs H — 一· CH3 CHaCHs n(ch〇2 單鍵 18 Η H H CHs H — CHs CH2CH3 N(CH3)2 單鍵 19 Η H CHs H H CHs CHiCHa N(CH3)2 單鍵 20 CHs H CH3 H H CHs CH2CH3 N(CH3)i 單鍵 21 ch3 CHa H H H --一一 CHa CH2CH3 ncch3)2 單鍵 22 Η CHa CHa H H CHa CHs N(CH3)2 單鍵 23 Η CH3 CH2CH3 CHs JU- CH3 CH2CHs N(CH3)2 Η Η 24 CHs CHa CHjCHs CH3 H CHa CH2CH3 N(CH3>2 單鍵在表1中，化合物編號1又稱為賜諾司A(Spin〇Syn A)、化合物編號4又稱兔晛处η Λ , , 冉马賜諾司D、化合物編號23又稱為 323554 11 201225841 賜諾特J(spinetoram J)、以及化合物編號24又稱為賜諾特L 0 在表1中，“單鍵意為C=C部分（m〇iety)，其中C 原子分別地接附至X1及X2。化合物編號1(賜諾司A)與化合物編號4(賜諾司D)之混合物已知學名為賜謹殺（spinosad)，且已知為殺蟲劑之活性成分。化合物編號23(賜諾特j)與化合物編號24(賜諾特L)之混合物已知學名為賜諾特，·且已知為殺蟲劑之活性成分。亦可將賜諾殺或賜諾特用於本發明中。在賜諾殺中，賜諾司A與賜諾司d之混合重量比通常從50 : 50至95 : 5，較佳從70 : 2〇至95 : 5。可藉由例如 EP375316A所述方法製備賜諾殺。在賜諾特中，賜諾特J與賜諾特L之混合重量比通常從50:50至95:10，較佳從7〇:3〇至9〇:1〇。可藉由例如W097/00265所述方法製備賜諾特。在本發明之有害生物防治組成物中，百利普芬與式⑴ 表示之化合物之重量比通常從丨〇〇〇〇 : 1至1 · 1〇〇〇〇，較佳從 5000 : 1 至 1 : 5000。本發明之有害生物防治組成物可為百利普芬與式（〇表示之化合物之單純混合物。然而，本發明之有害生物防治組成物通常藉由將百利普芬及式（1)表示之化合物與惰性載劑混合，且若需要，加人界面活性劑及其他調配添加物’接著將該混合物調配成下列劑型（d〇sage f〇rm) :如油性溶液、可乳化濃縮物、懸浮濃縮物、可溼性粉末、水分 323554 12 201225841 散粒劑、粉劑、或粒劑。本發明之有害生物防治組成物包含百利普芬及式（I) 表示之化合物之總量通常為0. 01至90重量％，較佳0. 1至 80重量％。惰性載劑之實例包含固體載劑、液體載劑及氣體載劑。固體載劑之實例包含下列者之細粉末及顆粒：礦物質 (例如高嶺土、鎂質膨土（attapulgite)、微晶高嶺石 (montmori 1 Ionite)、酸性白黏土、葉躐石（pyrophyl ite)、滑石、矽藻土、及方解石）；天然有機物質（例如玉米芯粉、及核桃殼粉）：合成之有機物質（例如尿素、及尿素曱醛樹脂）；鹽類（例如碳酸鈣、及硫酸銨）；合成之無機物質（例如合成之水合氧化梦）。液體載體之實例包含芳香烴（例如二甲苯、烷基苯、及曱基萘）；醇類（例如2-丙醇、乙二醇、丙二醇、及乙二醇單乙醚）；闕類（例如丙酮、環己酮、及異佛爾酮 (isophorone));蔬菜油（例如大豆油、及棉籽油）；以石油為基質的脂肪烴類；酯類；二曱亞砜；乙腈；及水。氣體載體之實例包含氟碳、丁烷氣體、液化石油氣 (LPG)、二曱醚、及二氧化碳氣體。界面活性劑之實例包含陰離子性界面活性劑（例如烷基硫酸酯鹽、烷基芳基磺酸鹽、磺琥珀酸二烷酯鹽、聚氧乙烯烷基芳基醚磷酸酯鹽、木質素磺酸鹽、萘磺酸鹽曱醛縮聚物、苯乙烯-丙烯酸共聚物、及曱基油醯基牛磺酸鈉鹽）；非離子性界面活性劑（例如聚氧乙烯烷基芳基醚、聚 13 323554 201225841 氧乙稀烧基聚氧丙烯嵌段共聚物、及山梨醇酐脂肪酸酯）；以及陽離子性界面活性劑（例如燒基三甲基錄鹽）。調配添加物之實例包含水溶性聚合物（例如聚乙烯醇、及聚乙稀咐^各烧嗣）；多醣類（例如阿拉伯膠、海蕩酸及其鹽類、CMC(叛曱基纖維素）、及黃原膠）；無機物質（例如矽酸鎂鋁、蒙脫石、及氧化鋁·•溶膠）；防腐劑（例如5一氣-2-甲基-4-異噻唑啉-3-酮、1,2-苯并噻唑啉_3__酮、及 2-漠-2-硝基丙烧-1，3-二醇）；著色劑、及安定劑（例如pAp (酸性磷酸異丙酯）、及BHT(2, 6-二-第三丁基_4—甲基盼））。本發明之有害生物防治組成物可對其展現防治效果之有害生物的實例包括：節肢動物，諸如昆蟲及蟎，以及線蟲蠕蟲門（nemathelminths) ’諸如線蟲，如下文所列舉之。半翅目（Hemiptera): 飛蝨科（Delphacidae) ’ 諸如斑飛蝨（La〇delphax striatellus)、褐飛蝨（Nilaparvata lugens)、及白背飛兹（Sogatella furcifera);浮塵子科 (Deltocephalidae) ’ 諸如黑尾葉蟬（Neph〇tettix cincticeps)、及二點黑尾葉蟬（Nephotettix virescens);蚜科（Aphididae)，諸如棉蚜（Aphis gossypii)、桃蚜（Myzuspersicae)、甘藍蚜（Brevicoryne brassicae)、馬鈴薯蚜（Macrosiphum euphorbiae)、茄溝無網财（Aulacorthum solani)、禾榖溢管蚜 (Rhopalosiphumpadi)、及桔蚜（Toxopteracitricidus); 椿科（Pentatomidae)，諸如稻綠椿象（Nezara 14 323554 201225841 antennata)、點蜂緣椿象（Riptortus clavetus)、中華稻緣蜂（Leptocorisa chinensis)、白星蝽（Eysarcoris parvus)、大綠椿（Halyomorpha mista) ' 及變色盲椿（Lygus lineolaris);粉兹科（Aleyrodidae)，諸‘溫室粉兹 (Trialeurodes vaporariorum)、終草粉兹（Bemisia 士8匕&(^)、銀葉粉盘（86111丨3丨3 3犷运€111；丨{〇1丨丨）、及黑刺粉蟲 (Aleurocanthus spiniferus);軟介殼蟲科（Coccidae)，諸如紅圓介殼蟲（Aonidiella aurantii)、梨圓介殼蟲 (Comstockaspis perniciosa)、桔矢尖介殼蟲（Unaspis citri)，紅臘介殼蟲（Ceroplastes rubens)、吹綿介殼蟲 (Icerya purchasi)、及桑介殼蟲（Pseudaulacaspis pentagona);軍配蟲科（Tingidae);木蝨科（Psyllidae); 等。鱗翅目（Lepidoptera): 螟蛾科（Pyralidae)，諸如二化填蛾（Chilo suppressalis)、三化模蛾（Tryporyza incertulas)、稻縱捲葉野填蛾（Cnaphalocrocis medinalis)、棉捲葉野埃 (Notarcha derogata)、印度穀粉螟蛾（Plodia interpunctella)、亞洲玉米模（Ostrinia furnacalis)、歐洲玉米填（Ostrinia nubilaris)、菜心野模蛾（Hellula undalis)、及早熟禾草填（Pediasia teterrellus);夜蛾科（Noctuidae)，諸如斜紋夜蛾（Spodoptera litura)、甜菜葉蛾（Spodoptera exigua)、東方黏蟲（Pseudaletia separata)、甘藍夜蛾（Mamestra brassicae)、球菜夜蛾 15 323554 201225841 (八厓1*〇1：丨3丨？811〇11)、黑點銀紋夜蛾（？11^41^21^31§阳）、夜蛾屬（Thoricoplusia spp.)、棉鈴蟲屬（Heliothis spp.)、及葉蛾屬（Helicoverpa spp.);粉蝶科 (Pieridae)，諸如紋白蝶（pieris rapae);捲蛾科 (Tortricidae) ’ 諸如小捲葉蛾屬（Adoxophyes spp.)、梨小食心蟲(^以？11〇1^&111〇16313)、豆捲葉螟〇^8111^11“〇1*& glycinivorella)、立小捲葉蛾（Matsumuraeses azukivora)、小角紋捲葉蛾（Adoxophyes orana fasciata)、茶小捲葉蛾屬（Adoxophyes spp.)、茶長捲葉蛾（Homona magnanima)、亂紋蘋果捲葉蛾（Archips fuscocupreanus)、及蘋果蠹蛾（Cydia pomonella);細蛾科（Gracillariidae)，諸如茶細蛾（Caloptilia 让6卜0犷&)、及潛葉蛾（？1^11〇11〇^(^61'1411舀01^6118);果蛀蛾科（Carposinidae)，諸如桃小食心蟲（carposina niponensis)，潛蛾科（Lyonetiidae)，諸如潛蛾屬 (Lyonetia spp.);毒蛾科（Lymantriidae)，諸如毒蛾屬 (Lymantria spp.)、及毛蟲屬（Euproctis sPp.);巢蛾科 (Yponomeutidae) ’ 諸如小菜蛾（Plutella xylostella); 麥蛾科（Gelechiidae)，诸如棉紅铃蟲（PeCtin〇phora gossypiella)、及馬龄薯塊莖蛾（phthorimaea operculella);燈蛾科（Arctiidae)，諸如美國白娥 (Hyphantria cunea);谷蛾科（Tineidae)，諸如衣蛾（Tinea translucens)、及衣蟑（Tineola bisselliella);等。纓翅目（Thysanoptera): 16 323554 201225841 魚1J馬科（Thripidae) ’诸如西方花莉馬（Frankliniella occidentalis)、瓜薊馬（Thrips palmi)、小黃薊馬 (Scirtothrips dorsalis)、蔥薊馬（Thrips tabaci)、黑腹薊馬（Frankliniella intonsa)、及煙草,15 馬 (Frankliniella fusca);等。雙翅目（Diptera): 家蠅（Musca domestica)、淡色庫蚊（Culex pipiens pallens)、it(Tabanus trigonus)、葱種繩（Hylemya antiqua)、玉米種繩（Hylemya platura)、中華按蚊 (Anopheles sinensis)、日本稻潛繩（Agromyza oryzae)、稻潛葉繩（Hydrellia griseola)、稻稈潛繩（Chlorops oryzae);潛繩科（Agromyzidae)，諸如非洲菊斑潛繩 (Liriomyza trifolii);瓜實蠅（Dacus cucurbitae)、地中海實繩（Ceratitis capitata);等。勒翅目（Coleoptera) ·· 茄二十八星瓢蟲（Epilachna vigintioctopunctata)、黃守瓜（Aulacophora femoralis)、黃條葉蛋（Phyllotreta striolata)、稻負泥蟲（Oulema oryzae)、稻象曱（Echinocn6mus squameus)、稻水象曱（Lissorhoptrus oryzophilus)、棉鈴象鼻蟲 (Anthonomus grandis)、四紋夏蠟梅（Callosobruchus chinensis)、黑楔象鼻蟲（Sphenophorus venatus)、曰本豆金龜（Popillia japonica)、金銅金龜（Anomala cuprea)、玉米根蟲屬（Diabrotica spp.)、煙草甲 17 323554 201225841 (Lasioderma serricorne)、小圓花皮蠹（Anthrenus verbasci)、赤擬谷盜（Tribolium castaneum)、褐粉蠹 (Lyctus brunneus)、星天牛（Anoplophora malasiaca)、縱坑切梢小蠹（Tomicus piniperda);等。直翅目（Orthoptera): 東亞飛竣（Locusta migratoria)、非洲螻姑 (Gryllotalpa africana)、條斑紫菜稻幢（Oxya yezoensis)、中華稻粳（Oxya japonica);等。膜翅目（Hymenoptera): 黃翅菜葉蜂（Athalia rosae)、尖蟻屬（Acromyrmex spp.)、紅火蛾屬（Solenopsis spp.);等。蜚蠊目（Blattodea): 德國小嫌（Blattella germanica)、黑胸大蠊 (Periplaneta fuliginosa)、美洲大蠊（Periplaneta americana)、褐大蠊（Periplaneta brunneg)、東方蜚蠊 (Blatta orientalis);等。蜱蜗目（Acarine): 葉蟎科（Tetranychidae) ’ 諸如二斑葉蟎（Tetranychus urticae)、掛#组虫知蛛（Panonychus citri)、葉蜗屬 (Oligonychus spp.);節碑科（Eriophydae)，諸如皮氏刺皮瘿蟎（八(：111〇?3?6161^33丨）；細蟎科（丁&^01^111丨(1&6)，諸如茶細蟎（Polyphagotarsonemus latus)擬葉蟎科 (Tenuipalpidae);杜克葉蟎科（Tuckerellidae);粉蟎科 (Acaridae) ’ 諸如腐食酷·瞒（Tyrophagus 18 323554 201225841 putrescentiae);塵蜗科（Pyroglyphidae)，諸如塵瞒 (Dermatophagoides farinae)、及屋塵蜗 (Dermatophagoides ptrenyssnus) ·，肉食蜗科 (Cheyletidae)，諸如普通肉食蟎（Cheyletus eruditus)、馬六曱（Cheyletus malaccensis)、及莫瑞肉食蜗 (Cheyletus moorei);等。線蟲綱（Nematoda): 水稻幹尖線蟲（Aphelenchoides besseyi)、草每不正莖線蟲（Nothotylenchus acris)、等。本發明之有害生物防治方法包括將有效總量之百利普芬與式（I)表示之化合物施用於有害生物或有害生物棲息處。有害生物棲息處之實例包括作物及生長作物之土壤。本發明之有害生物防治方法可經由將本發明之有害生物防治組成物施用予有害生物或該有害生物之棲息處來進行本發明之有害生物防治方法亦可經由分別將百利普芬與式（I)表示之化合物施用予有害生物或有害生物棲息處來進行。一在本發明之有害生物防治方法中，百利普芬與式（I) 表不之化合物的重量比通常係在10000: 1至1 : 10000之. 範圍内，較佳為500〇:1至1:5〇〇〇。與式（I)表示不之化合物之古dWherein R1, R2, R3, R4, R5, R6, R7, R8, X1 and X2 represent any combination shown in Table 1. 10 323554 201225841 Table 1 R1 R2 R3 R4 - One R6 ........... R6 R7 R8 X1 X2 1 Η CHa CHs CHs H CH3 CHaCHa N(CHa)2 One-touch 2 Η CHs CHa Ch3 H CH3 CHaCHa NH(CH3> Single bond 3 Η ch3 ch3 CHs H ch3 CH2CH3 nh2 Single bond 4 CH3 CHa CHa CH3 H CH3 CHzCHa N(CH3)2 Single bond 5 Η CH3 CHa CHa H CH3 CHa N(CH3)2 Single Key 6 Η ch3 ch3 CHs HH CH2CH3 NCCH3)2 Single key 7 Η H CHa CHa H CHa CHzCHa N(CHs)z Single key 8 Η CHa H CH3 H CH3 CH2CH3 N(CH〇2 Single key 9 Η CHs ch3 HH CHs CHsCHa N(CH3)2 single bond 10 CHa CHa H CH3 H CHs CHaCHa N(CH3)z single bond 11 Η CHa H CH3 H CHa CH2CH3 NH(CH〇 single bond 12 CH3 ch3 H CHa H CH3 CHaCHs NH(CH3) single bond 13 CHs CHa ch3 HH CH3 CH2CH3 N(CH3)2 Single bond 14 Η CHs HHH CHs CH2CH3 NCCHOa Single bond 15 CHa H CHa CHs H CHa CHaCHa N(CH3)2 One-button 16 Η H CHs CHs H CHs CH2CH3 NHCCHs) One-touch 17 Η H CHa CHs H — I· CH3 CHaCHs n(ch〇2 single bond 18 Η HH CHs H — CHs CH2CH3 N(CH3)2 single button 19 Η H CHs HH CHs CHiCHa N(CH3)2 single button 20 CHs H CH3 HH CHs CH2CH3 N(CH3)i One button 21 ch3 CHa HHH - one CHa CH2CH3 ncch3)2 single bond 22 Η CHa CHa HH CHa CHs N(CH3)2 single bond 23 Η CH3 CH2CH3 CHs JU- CH3 CH2CHs N(CH3)2 Η Η 24 CHs CHa CHjCHs CH3 H CHa CH2CH3 N (CH3>2 single bond in Table 1, compound number 1 is also known as spinosyn A (Spin 〇Syn A), compound number 4 is also known as 晛晛 η , , , 冉赐诺司 D, compound No. 23 is also known as 323554 11 201225841 Spinetoram J, and compound number 24 is also known as Snort L 0. In Table 1, "a single bond means C = C part (m〇iety), where The C atoms are attached to X1 and X2, respectively. A mixture of Compound No. 1 (Zenos A) and Compound No. 4 (Zornos D) is known as spinosad and is known as the active ingredient of insecticides. A mixture of Compound No. 23 (Zenot j) and Compound No. 24 (Nornote L) is known by the name of Sinop and is known as an active ingredient of insecticides. It is also possible to use the promise or the sinote in the present invention. In the promise of sin, the weight ratio of the sinus A to the sinus d is usually from 50:50 to 95:5, preferably from 70:2 to 95:5. The spinosad can be prepared by the method described, for example, in EP 375 316 A. In Schnauzer, the weight ratio of Snort J to Snort L is usually from 50:50 to 95:10, preferably from 7:3 to 9:1. The snort can be prepared by the method described, for example, in W097/00265. In the pest control composition of the present invention, the weight ratio of baprifene to the compound represented by the formula (1) is usually from 丨〇〇〇〇: 1 to 1 · 1 Torr, preferably from 5000 : 1 to 1 : 5000. The pest control composition of the present invention may be a simple mixture of balixifene and a compound of the formula (〇). However, the pest control composition of the present invention is usually represented by the method of expressing bailipfen and formula (1). The compound is mixed with an inert carrier and, if necessary, a surfactant and other formulation additives are added. The mixture is then formulated into the following dosage forms (d〇sage f〇rm): such as oily solutions, emulsifiable concentrates, suspension concentrates And the total amount of the compound represented by the formula (I) is usually 0.10. The total amount of the compound represented by the formula (I) is usually 0.10. To 90% by weight, preferably 0.1 to 80% by weight. Examples of inert carriers include solid carriers, liquid carriers, and gaseous carriers. Examples of solid carriers include fine powders and granules of the following: minerals ( For example, kaolin, attapulgite, montmori 1 Ionite, acid white clay, pyrophyl ite, talc, diatomaceous earth, and calcite; natural organic matter (eg Corn cob powder, and walnut shell powder): synthetic organic substances (such as urea, and urea furfural resin); salts (such as calcium carbonate, and ammonium sulfate); synthetic inorganic substances (such as synthetic hydration oxidized dream). Examples of the liquid carrier include aromatic hydrocarbons (e.g., xylene, alkylbenzene, and mercaptophthalene); alcohols (e.g., 2-propanol, ethylene glycol, propylene glycol, and ethylene glycol monoethyl ether); anthracene (e.g., acetone) , cyclohexanone, and isophorone); vegetable oils (eg, soybean oil, and cottonseed oil); petroleum-based aliphatic hydrocarbons; esters; disulfoxide; acetonitrile; and water. Examples of the carrier include fluorocarbon, butane gas, liquefied petroleum gas (LPG), dioxane, and carbon dioxide gas. Examples of the surfactant include an anionic surfactant (for example, an alkyl sulfate, an alkyl aryl sulfonate) Acid salt, sulfosuccinate dialkyl ester salt, polyoxyethylene alkyl aryl ether phosphate salt, lignosulfonate, naphthalene sulfonate furfural polycondensate, styrene-acrylic acid copolymer, and sulfhydryl hydrazine Sodium taurate sodium salt); nonionic Surfactant (eg, polyoxyethylene alkyl aryl ether, poly 13 323554 201225841 oxyethylene dialkyl polyoxypropylene block copolymer, and sorbitan fatty acid ester); and cationic surfactant (eg, alkyl) Trimethyl salt.) Examples of blending additives include water-soluble polymers (such as polyvinyl alcohol, and polyethylene sulphate); polysaccharides (such as gum arabic, tartaric acid and its salts, CMC (rebel cellulose), and xanthan gum; inorganic substances (such as magnesium aluminum silicate, montmorillonite, and alumina sol); preservatives (such as 5-gas-2-methyl-4- Isothiazolin-3-one, 1,2-benzothiazoline_3_-one, and 2-di-2-nitropropane-1,3-diol); colorants, and stabilizers (eg, pAp) (Acid isopropyl phosphate), and BHT (2,6-di-t-butyl-4-methyl-). Examples of pests to which the pest control composition of the present invention can exhibit a controlling effect include: arthropods such as insects and mites, and nematohelminths such as nematodes, as exemplified below. Hemiptera: Delphacidae 'such as La〇delphax striatellus, Nilaparvata lugens, and Sogatella furcifera; Deltocephalidae' such as black tail Neph〇tettix cincticeps, and Nephotettix virescens; Aphididae, such as Aphis gossypii, Myzuspersicae, Brevicoryne brassicae, potato mash (Macrosiphum euphorbiae), Aulacorthum solani, Rhopalosiphumpadi, and Toxopteracitricidus; Pentatomidae, such as the rice green elephant (Nezara 14 323554 201225841 antennata), point Riptortus clavetus, Leptocorisa chinensis, Eysarcoris parvus, Halyomorpha mista, and Lygus lineolaris; Aleyrodidae, Trialeurodes vaporariorum, end grass powder (Bemisia 8 匕 & (^), silver leaf powder plate (86111丨3丨3 3犷) €111;丨{〇1丨丨), and Aleurocanthus spiniferus; Coccidae, such as Aonidiella aurantii, Comstockaspis perniciosa, orange Unaspis citri, Ceroplastes rubens, Icerya purchasi, and Pseudaulacaspis pentagona; Tingidae; Psyllidae; Lepidoptera: Pyralidae, such as Chilo suppressalis, Tryporyza incertulas, Cnaphalocrocis medinalis, laps (Notarcha derogata), Plodia interpunctella, Ostrinia furnacalis, Ostrinia nubilaris, Hellula undalis, and Pediasia teterrellus; Noctuidae, such as Spodoptera litura, Spodoptera exigua, Pseudaletia separata, Cabbage Mamestra brassicae), vegetables armyworm ball 15 323,554,201,225,841 (eight Cliff 1 * 〇1: 3 Shu Shu? 811〇11), Black Spotted Spodoptera litura (?11^41^21^31§yang), Noctuidae (Thoricoplusia spp.), Helicoverpa armigera (Heliothis spp.), and Helicoverpa spp. Pieridae, such as Pieris rapae; Tortricidae', such as Adoxophyes spp., P. sinensis (^11〇1^&111〇16313), Bean leaf 螟〇 ^8111^11 "〇1*& glycinivorella", Matsumuraeses azukivora, Adoxophyes orana fasciata, Adoxophyes spp., Homona Magnanima), Archips fuscocupreanus, and Cydia pomonella; Gracillariidae, such as the tea moth (Caloptilia 6b0&), and the leaf miner (?1) ^11〇11〇^(^61'1411舀01^6118); Carposinidae, such as carposina niponensis, Lyonetiidae, such as Lyonetia spp. Lymantriidae, such as Lymantria spp., and Caterpillar (E) Uproctis sPp.); Yponomeutidae 'such as Plutella xylostella; Gelechiidae, such as Helicoverpa armigera (PeCtin〇phora gossypiella), and horsorimaea operculella; Arctiidae, such as Hyphantria cunea; Tineidae, such as Tinea translucens, and Tineola bisselliella; etc. Thysanoptera: 16 323554 201225841 Fish 1J Thripidae 'such as Frankliniella occidentalis, Thrips palmi, Scirthothrips dorsalis, Thrips tabaci, Frankliniella Intonsa), and tobacco, 15 horses (Frankliniella fusca); Diptera: Musca domestica, Culex pipiens pallens, it (Tabanus trigonus), Hylemya antiqua, Hylemya platura, Anopheles Sinensis), Agromyza oryzae, Hydrellia griseola, Chlorops oryzae; Agromyzidae, such as Liriomyza trifolii; Fly (Dacus cucurbitae), Mediterranean solid rope (Ceratitis capitata); Coleoptera · Epilachna vigintioctopunctata, Aulacophora femoralis, Phyllotreta striolata, Oulema oryzae, rice 曱Echinocn6mus squameus), Lissorhoptrus oryzophilus, Anthonomus grandis, Callosobruchus chinensis, Sphenophorus venatus, Popillia japonica , Anomala cuprea, Diabrotica spp., Tobacco A 17 323554 201225841 (Lasioderma serricorne), Anthrenus verbasci, Tribolium castaneum, brown meal (Lyctus brunneus), Anoplophora malasiaca, Longitus piniperda; Orthoptera: Locusta migratoria, Gryllotalpa africana, Oxya yezoensis, Oxya japonica, etc. Hymenoptera: Athalia rosae, Acromyrmex spp., Solenopsis spp., etc. Blattodea: Blattella germanica, Periplaneta fuliginosa, Periplaneta americana, Periplaneta brunneg, Blatta orientalis; Acarine: Tetranychidae ' such as Tetranychus urticae, Panonychus citri, Oligonychus spp.; Eriophydae Such as Pei's thorn skin 八 (eight (: 111 〇? 3? 6161 ^ 33 丨); 螨螨 (丁 & ^ 01 ^ 111 丨 (1 & 6), such as tea fine 螨 (Polyphagotarsonemus latus) Tenuipalpidae; Tuckerellidae; Acaridae' such as Tyrophagus 18 323554 201225841 putrescentiae; Pyroglyphidae, such as Drosophila (Dermatophagoides farinae) And Dermatophagoides ptrenyssnus · Cheyletidae, such as Cheyletus eruditus, Cheyletus malaccensis, and Cheyletus moorei; etc. Nematoda): Aphelenchoides besseyi, Nothotylenchus acris, etc. The pest control method of the present invention comprises an effective total amount of baclofen and a compound represented by the formula (I) Applied to pests or pest habitats Examples of pest habitats include crops and soils for growing crops. The pest control method of the present invention can be applied to a pest or the pest by applying the pest control composition of the present invention. The pest control method for carrying out the present invention can also be carried out by separately administering the compound represented by the formula (I) and the compound represented by the formula (I) to a pest or a pest habitat. In the range of 10,000:1 to 1:10000, the weight ratio of the compound of the formula (I) is usually in the range of 10,000:1 to 1:5 Å. (I) indicates the ancient d of the compound

在本發明之有害生物防治方法中，進行施用百利普芬例如：將百利普芬與式（I) 葉上、將百利普芬與式（I) 19 323554 201225841 表示之化合物灌溉在生長作物之土壤上、或以百利普芬與式（I)表示之化合物處理作物之種子。於本文中，“有效總量”意為百利普芬及式（I)表示之化合物之總量，其中兩種化合物之施用量可使得有害生物經控制。當將百利普芬與式（I)表示之化合物施用予作物之群葉或生長作物之土壤，雖然施用量可取決於保護免於有害生物之作物種類、目標有害生物之種類、目標有害生物之族群大小、調配物之類型、施用期間、及氣候條件而有所不同’就百利普芬及式（I)表示之化合物而言’其施用率通电為每10000平方米（m2)〇. 1至1000克（g)，較佳為每1〇〇〇〇平方米1至200克。當百利普芬與式（I)表示之化合物被調配成可乳化的 /農维物、可濕性粉劑或懸浮性濃縮物時，這些調配物通常係以水稀釋後再喷灑。在此種情況下，該調配物係經稀釋，、使得百利普务與式（I)表示之化合物之總濃度通常稀釋戍1至10000 ppm，較佳為5至5〇〇 ppra。 ;當將百利普芬與式（I)表示之化合物調配成粉塵或顆教時’該調配物通常以其本身被施用而未加以稀釋。當以百利普芬與式（I)表示之化合物處理作物之種子发、就百利普芬與式⑴表示之化合物的總量而言，處理率為每公斤種子通常為0.001至20克，較佳為0.01至10克。本發明之有害生物防治組成物包括，例如，下列具體實例： 323554 20 201225841 包含以10000 : 1至1 : 10000之重量比（百利普芬：式 (I)表示之化合物）之百利普芬與式（I)表示之化合物之組成物；包含以5000: 1至1 : 5000之重量比（百利普芬：式（I) 表示之化合物）之百利普芬與式（I)表示之化合物之組成物；包含以5000 : 1至1 : 500之重量比（百利普芬：式（I) 表示之化合物）之百利普芬與式（I)表示之化合物之組成物；包含以10000 : 1至1 : 10000之重量比（百利普芬：多殺菌素）之百利普芬與多殺菌素之組成物；包含以5000 : 1至1 : 5000之重量比（百利普芬：多殺菌素）之百利普芬與多殺菌素之組成物；包含以5000 : 1至1 : 500之重量比（百利普芬：多殺菌素）之百利普芬與多殺菌素之組成物。本發明之有害生物防制組成物可用於防治植物之有害生物，包含（但不限於）用於防治下列示之“作物”之有害生物。 “作物”：農作物：玉米、小麥、大麥、黑麥、燕麥、高粱、棉花、大豆、稻、花生、騫麥、甜菜、油菜、向曰葵、甘蔑、煙草、等；蔬菜·· ％科蔬菜（Sol anaceae vegetables)(祐子、蕃茄、青椒、紅辣椒、馬鈴薯等）、葫蘆科蔬菜（Cucurbitaceae 21 323554 201225841 vegetables)(黃瓜、南瓜、西葫蘆、西瓜、甜瓜等）、十字花科蔬菜（Cruciferae vegetables)(日本蘿蔔、蕪菁、辣根、球莖甘藍（kohlrabi)、中國甘藍菜、甘藍菜、黑芬（brown mustard)、青花菜、花椰菜等）、菊科蔬菜（Compositae vegetables)(牛蒡、茼蒿、朝鮮薊、萵苣等）、百合科蔬菜 (Liliaceae vegetables)(蔥、洋蔥、蒜、蘆筍等）、繳形花科蔬菜（Umbelliferae vegetables)(胡蘿蔔、歐芽、芽菜、防風草（parsnip)等）、藜科蔬菜（Chenopodiaceae vegetables)(菠菜、甜菜等）、薄荷科蔬菜（Labiatae vegetables)(曰本羅勒、薄荷、九層塔等）、草莓、蕃薯、山藥、芋（aroid)等；化及觀貝植物.老鼠籍、牵牛花、杜鸦、输球花、海葵竹節、櫻茅（rhodohypoxisbaurii)、海葵、玉竹、孤挺 ί匕、鳶尾、阿利瑟姆、海石竹（armeria)、藍目菊 (arctot is)、中國翠韌、食用花卉、茜草屬植物（Bauera rubioides)、古巴百合、山地玉簪（H〇sta montana)、墨西哥翠菊、紫茉莉、貫葉連翹、東方罌粟、龍膽、金邊山地玉簪（Hosta aureomarginata)、日本鳶尾、威靈仙蘚、勳章菊、白色香水百合、康乃馨、鮮豔百合、非洲菊、長壽花、蒲包、咖哩草、卡羅來州茉莉、美人蕉、.菊花、曼陀羅t、百波斯軔、大蕉百合、秋海棠（j(imjongi 1 ja)、茶樹 (Manuka)、金盞花、香桃木、金蓮花、劍蘭、暹羅鬱金香、威靈仙、雞冠花、蝦花、中午花、大波斯菊、玉簪天女、牽牛花賛、玉簪寒河江、月見草、紅花、丹參、仙客來、 323554 22 201225841 台才田祿考、与藥、銀蓮如甜茶、白芨、甜碗豆、山谷百合、雪花、馬齒莧、紫羅蘭、木堇、西洋蓍草、石竹、蔥蘭、天竺葵、大根草、澤弗百合、大麗花、菊科、鬱金香、巧克力波斯菊、大長春花、綿棗兒、霜絨毛番石榴、德國鳶尾、西番蓮、石竹、油菜花、馬達加斯加長春花、軟白頭翁、喜林草屬、娜麗花（Nerine)、沼澤菊花（北極）、曰本水鳶尾（iris ensata var. spontanea)、馬鞭草、扶桑、約瑟的綵衣（Joseph’ coat)、珊瑚花、日本水鳶尾（Iris ensata)、東方紫荊花、紫星花、波形葉海薰衣草、加州罌粟一色堇維吉尼亞务羅蘭、雛菊、虞美人（C〇r n p〇ppy)、喜馬拉雅爬虎耳草、向日葵、風信子、紫薇、天竺葵、倒掛金鐘、小蒼蘭、報春、鳳仙花、地面櫻花、牡丹、油點草（Tricyrtis)、瑪格麗特、金盖花、六月菊（Gymnaster savatieri)、麥桿菊、葡萄風信子、日本紫膠、百合、毛茛、馬纓丹、龍膽、羽扇豆、半邊蓮、等；觀葉植物：常春藤、香蒲、粗肋草、鐵線蕨、蘆筍、鐵角、疲蘿、金脈單藥（apheiandra)、海芋、火鹤花、印度橡膠樹、豬籠草、蜻蜓鳳梨、口紅花（aeschynanthus)、喜蔭花（episcia)、大鹤望蘭、吊蘭、中國榕樹、木棉、花葉、斑馬竹芋、紫絨藤（紫背天葵.）、迷你兵馬俑 (Guzumania)、錦竹芋（ctenanthe)、楓香樹、玉樹、巴豆、海芋、七里香、咖啡樹、龍血樹、針葉樹、彩葉草、朱蕉、金魚花、虎尾蘭、虎尾蘭、中國仙丹、鶴掌、青紫葛、莎草、蘆葦、絲綢茉莉、合果芋、天堂鳥、白鶴芋、千里光、 23 323554 201225841 吊竹梅、日本西谷椰子、鐵蘭、多蕊木、珊瑚樹、孔雀木、萬年青、杜蘭塔、酒瓶椰子、龍血樹、紫露草、彩葉鳳梨、腎蕨、心藤、朱槿、夾竹桃、圭亞那栗（發財樹）、馬尾辮、鹿角蕨、冷水麻、熊掌木、薜荔、蔓綠絨、九重葛、鳳凰木、白網紋草、鳳尾、新娘面紗、驚歌鳳梨、香茶菜、海棠、椒草、褐尾蕉、白棬、一品紅、黃金葛、四角毽蘭、竹芋、萬年竹、綠玉樹、雞蛋花、龜背竹、棕櫚、絲蘭、馬纓丹、等；果樹；仁果類（蘋果、普通梨木、日本梨、木瓜、榲梓 (quince)等）、核果類（桃、李、油桃、日本李、樓桃、杏、乾果李等）、掛橘類植物（蜜柑（Satsuma mandarin)、柳撥、檸檬、萊姆、葡萄袖等）、堅果類（栗、胡桃、榛果、杏仁、開心果、腰果、澳洲胡桃等）、漿果類（藍莓、蔓越莓、黑莓、覆盆子等）、葡萄、柿、橄欖、枇杷、香蕉、咖啡 '棗、椰子等；除了果樹以外之樹種：茶樹、桑樹、觀花樹木與灌木、行道樹（搏樹、樺樹、山茱萸、尤加利（eucaiyptus)、銀杏、紫丁香、楓樹、橡樹、白揚樹、紫荊、楓香、梧桐、櫸樹、曰本側柏、冷杉、日本鐵杉、杜松、松樹、雲杉、紫杉）等。前述“作物”包含藉由典型育種方法或遺傳工程技術等而對除草劑具有抗性之植物者，且該除草劑包含：4_經苯基丙酮酸雙加氧酶抑制劑（諸如異噚唑草酮 (isoxaflutole))、乙醯乳酸合成酶（後文中簡稱為“ALS”） 323554 24 201225841 抑制劑（諸如咪草煙（imazethapyr)、及°塞吩續隆-曱基 (thifensulfuron-methyl))、5-烯醇-丙酮酸-莽草酸-3-填酸酯合成酶（5-enol-pyruivylshikimate-3-phosphate) (後文中簡稱為“ EPSP ” ）抑制劑（諸如草甘膦 (glyphosate))、麩醯胺合成酶抑制劑（諸如固殺草 (glufosinate))、生長素類除草劑（諸如2, 4-D、及麥草畏 (dicamba)、及溴苯腈（bromoxynil)。經由典型育種方法所賦予之抗性的“作物”之實例包含對咪唑啉酮型 ALS抑制性劑（諸如咪草煙 (imazethapyr))，且其已上市的商品名為克利爾 (Clearfield)(註冊商標））具抗性之玉米或油菜；對磺醯脲型ALS抑制劑（諸如噻吩磺隆-曱基）具有抗性之STS大豆；以及對乙酿輔酶A叛化酶抑制劑（例如三酮肪（k丨〇ne X丨me ) 型除草劑及芳氧苯氧丙酸（aryloxy phenoxypropionic acid)型除草劑）具有抗性之SR玉米。舉例言之，對乙醢輔酶A缓化酶抑制劑具有抗性之作物係見於Proc. Natl.In the pest control method of the present invention, administration of balixifan, for example, irrigate the compound represented by the formula (I) on the leaf of the formula (I), and the compound represented by the formula (I) 19 323554 201225841 The seeds of the crop are treated on the soil of the crop, or with the compound represented by the formula (I). As used herein, "effective total amount" means the total amount of a compound represented by balippren and formula (I), wherein the application amount of the two compounds allows the pest to be controlled. When the compound represented by the formula (I) and the compound represented by the formula (I) are applied to the soil of the foliage of the crop or the soil of the growing crop, although the application amount may depend on the species of the crop protected from the pest, the species of the target pest, and the target pest. The size of the ethnic group, the type of formulation, the period of application, and the climatic conditions vary. 'In the case of the compound represented by the formula (I), the application rate is 10,000 square meters (m2). 1 to 1000 g (g), preferably 1 to 200 g per 1 m2. When the compound represented by the formula (I) and the compound represented by the formula (I) are formulated into an emulsifiable/agricultural, wettable or suspension concentrate, these formulations are usually diluted with water and then sprayed. In this case, the formulation is diluted such that the total concentration of the compound represented by the formula (I) is usually 戍1 to 10,000 ppm, preferably 5 to 5 〇〇 ppra. When the compound represented by the formula (I) is formulated into dust or a composition, the formulation is usually applied as it is without being diluted. When the seed of the crop is treated with the compound represented by the formula (I), the treatment rate is usually 0.001 to 20 g per kg of the seed, in terms of the total amount of the compound represented by the formula (1). It is preferably from 0.01 to 10 g. The pest control composition of the present invention includes, for example, the following specific examples: 323554 20 201225841 Included in a weight ratio of 10000:1 to 1:10000 (Bellipfen: a compound represented by the formula (I)) a composition of the compound represented by the formula (I); and a solution containing the weight ratio of 5,000:1 to 1:5000 (Billipsen: a compound represented by the formula (I)) and the formula (I) a composition of a compound; a composition comprising a compound represented by the formula (I) in a weight ratio of 5,000:1 to 1:500 (Billipsen: a compound represented by the formula (I)); 10000 : 1 to 1: weight ratio of 10,000 (Bellipfen: spinosyn) to the composition of baclifen and spinosyn; weight ratio of 5000 : 1 to 1: 5000 (Balifen : spinosyn and a composition of spinosad; comprising baclifen and spinosyn at a weight ratio of 5000:1 to 1:500 (Bellipfen: spinosyn) Composition. The pest control composition of the present invention can be used for controlling pests of plants, including, but not limited to, pests for controlling the "crops" shown below. "Crops": Crops: corn, wheat, barley, rye, oats, sorghum, cotton, soybeans, rice, peanuts, buckwheat, beets, canola, geranium, kansui, tobacco, etc.; vegetables · · · Vegetables (Solanaceae vegetables) (youzi, tomato, green pepper, red pepper, potato, etc.), Cucurbitaceae vegetables (Cucurbitaceae 21 323554 201225841 vegetables) (cucumber, pumpkin, zucchini, watermelon, melon, etc.), cruciferae vegetables (Cruciferae vegetables) ) (Japanese radish, turnip, horseradish, kohlrabi, Chinese cabbage, kale, brown mustard, broccoli, broccoli, etc.), Compositae vegetables (Arctium, Artemisia, North Korea)蓟, lettuce, etc.), Liliaceae vegetables (onions, onions, garlic, asparagus, etc.), Umbelliferae vegetables (carrots, buds, sprouts, parsnips, etc.), Chenopodiaceae vegetables (spinach, beets, etc.), Labiatae vegetables (Sakamoto basil, mint, nine layers) Tower, etc., strawberry, sweet potato, yam, aroid, etc.; chemical and ornamental plants. mouse, morning glory, crow, stalk flower, sea anemone bamboo, rhododendron (rhodohypoxisbaurii), anemone, Polygonatum, sturdy, scorpion, Alice, sea carnation, armotot is, Chinese sylvestris, edible flowers, Bauera rubioides, Cuban lily, mountain scorpion (H 〇sta montana), Mexican aster, purple jasmine, St. John's wort, oriental poppy, gentian, Hosta aureomarginata, Japanese iris, Clematis, medallion, white perfume lily, carnation, bright lily, Gerbera, longevity flower, pouch, curry grass, jasmine of carolina, canna, chrysanthemum, mandala t, hundred persian, plantain lily, begonia (j (imjongi 1 ja), tea tree (Manuka), calendula, incense Peach, Golden Lotus, Gladiolus, Siam Tulip, Clematis, Cockscomb, Shrimp Flower, Noon Flower, Cosmos, Hosta, Morning Glory, Jade, River, Evening Primrose, Safflower, Salvia, Cyclamen, 32355 4 22 201225841 Taicai Tianluo, medicine, Yinlian, such as sweet tea, white peony, sweet bowl of beans, lily of the valley, snowflake, purslane, violet, hibiscus, yarrow, dianthus, onion, geranium, radix, zea Lily, Dahlia, Compositae, Tulip, Chocolate Cosmos, Great Periwinkle, Mianzao, Frosted Carou, German Iris, Passionflower, Dianthus, Rape, Madagascar Periwinkle, Soft Pulsatilla, Hibiscus , Nerine, Marsh Chrysanthemum (Arctic), Iris ensata var. spontanea, Verbena, Fuso, Joseph's coat, Coral flower, Japanese water iris (Iris ensata) ), Oriental Bauhinia, Purple Star Flower, Waved Leaf Sea Lavender, California Poppy Color, Virginia Violet, Daisy, Corn Poppy (C〇rnp〇ppy), Himalayan Tiger Sagittarius, Sunflower, Hyacinth, Crape Myrtle , geranium, fuchsia, freesia, primula, impatiens, ground cherry, peony, Tricyrtis, Margaret, Golden Cover, Junenaster savatieri, Mai Rhizome, grape hyacinth, Japanese shellac, lily, buttercup, lantana, gentian, lupin, lobelia, etc.; foliage plants: ivy, cattail, lentia, maidenhair, asparagus, iron Horn, spirulina, apheiandra, sea bream, flamingo flower, Indian rubber tree, pitcher plant, pineapple, aeschynanthus, episcia, big crane, orchid, spider plant, China Eucalyptus, kapok, flower leaf, zebra bamboo bud, purple velvet vine (Zibei Tiankui.), mini terracotta warrior (Guzumania), jinzhu 芋 (ctenanthe), sweet gum tree, eucalyptus, croton, sea bream, thyme, coffee tree , Dragon Blood Tree, Coniferous Tree, Coleus, Zhu Jiao, Goldfish Flower, Tigertail Orchid, Tigertail Orchid, Chinese Elixir, Crane Palm, Cyanopsis, Sedge, Reed, Silk Jasmine, Hessian, Bird of Paradise, White Crane, Senecio, 23 323554 201225841 Hang bamboo plum, Japanese sago palm, Tillandsia, Dollywood, coral tree, peacock wood, evergreen, Duranta, bottle coconut, dragon blood tree, purple grass, colorful leaf pineapple, kidney fern, Heart vine, cinnabar, oleander, Guyana Chestnut (fat tree), ponytail, staghorn fern, cold water hemp, bear paw wood, dragonfly, vine green cashmere, bougainvillea, phoenix wood, white netted grass, phoenix tail, bridal veil, sing song pineapple, fragrant tea , sea bream, pepper grass, brown plant, white peony, poinsettia, golden georgette, four-horned cypress, bamboo bud, Wannian bamboo, green eucalyptus, plumeria, monstera, palm, yucca, lantana, etc.; Pome fruit (apple, common pear wood, Japanese pear, papaya, quince, etc.), stone fruit (peach, plum, nectarine, Japanese plum, building peach, apricot, dried fruit plum, etc.), hanging orange plants (Satsuma mandarin, willow, lemon, lime, grape sleeves, etc.), nuts (chestnuts, walnuts, hazelnuts, almonds, pistachios, cashews, macadamia, etc.), berries (blueberries, cranberries) , blackberries, raspberries, etc.), grapes, persimmons, olives, alfalfa, bananas, coffee 'jujube, coconut, etc.; except for fruit trees: tea trees, mulberry trees, trees and shrubs, street trees (Borrow trees, birches, hawthorns) , eucaiyptus, ginkgo, lilac Maple, oak, poplar trees, redbud, sweetgum, sycamore, beech, said this arborvitae, fir, Japanese hemlock, juniper, pine, spruce, yew) and the like. The aforementioned "crop" comprises a plant resistant to a herbicide by a typical breeding method or genetic engineering technique, and the herbicide comprises: a 4-phenylpyruvate dioxygenase inhibitor (such as isoxazole) Isoxaflutole), acetamidine lactate synthase (hereinafter referred to as "ALS") 323554 24 201225841 Inhibitors (such as imazethapyr, and thifensulfuron-methyl) , 5-enol-pyruvylshikimate-3-phosphate (hereinafter referred to as "EPSP") inhibitor (such as glyphosate) , branamide synthetase inhibitors (such as glufosinate), auxin herbicides (such as 2, 4-D, and dicamba, and bromoxynil). Examples of the "crop" to which the resistance is imparted include an imidazolinone type ALS inhibitor (such as imazethapyr), and its market name is Clearfield (registered trademark). Resistant corn or canola; for sulfonylurea-type ALS inhibitors For example, thifensulfuron-sulfonate-resistant STS soybeans; and beta-enzyme A-removal enzyme inhibitors (eg, triketon-type (K丨〇ne X丨me) type herbicides and aryloxyphenoxypropionic acid) (aryloxy phenoxypropionic acid) herbicide (SR-resistant corn). For example, a crop line resistant to an acetoin A-lowering enzyme inhibitor is found in Proc. Natl.

Acad. Sci. USA 1990，87，ρ7Π5-7179。經由遺傳工程技術而賦予之抗性的“作物，，之實例包含對嘉磷塞（glyph〇sate)及固殺草（gluf〇sinate)具有抗陡之玉米、大豆及棉知*，其已上市的商品名為RoundupReady (注冊商標）、LibertyLink(註冊商標）和Optimum GAT(註冊商標）。已知有對乙醯輔酶A緩化酶抑制劑具有抗性之突變乙醯輔酶A羧化酶，例如，見於Weed Science 53: p. 728-746， s 323554 25 201225841 ()田，、’呈由遺傳工程技術將編碼突變乙醯輔酶a叛化因導入作物時或是將提供抗性相關之突變導入作物中編碼獅A緩化酶之基因中時，可製得對乙醯輔酶. A叛化酶抑制具有抗性之植物。料，錄導入驗基取代突變之核酸可經由嵌合修復術（chimerapiasty)導入植物細胞内（參見.a T·，Repairing the Genome，sAcad. Sci. USA 1990, 87, ρ7Π5-7179. "Crops, which are endowed with resistance by genetic engineering techniques, include anti-steep corn, soybeans, and cotton* for glyph〇sate and gluf〇sinate, which are on the market. The trade names are RoundupReady (registered trademark), LibertyLink (registered trademark), and Optimum GAT (registered trademark). It is known that there is a mutant acetamyl coenzyme A carboxylase which is resistant to an acetoin A-lowering enzyme inhibitor, for example. , in Weed Science 53: p. 728-746, s 323554 25 201225841 () Tian,, 'is genetically engineered to introduce mutations in the mutation of acetaminophen coenzyme a into the crop or to provide resistance-related mutations When the crop encodes the gene of the lion A-lowering enzyme, a plant resistant to the inhibition of the acetaminophen coenzyme A can be obtained. The nucleic acid into which the substitution-substitution mutation is introduced can be chimerapiasty. ) Introduction into plant cells (see .a T·, Repairing the Genome, s

Spelling Mistakes, Science vol. 285, p. 316-318(1999)) 以誘心除草劑目標之植物基因（例如基因編碼乙醯辅酶A 叛化酶或基因編蜗ALS)之定點（Site-directed)胺基酸突變，並藉此製得對除草劑具有抗性之植物。對麥草畏（dicamba)具抗性之植物可藉由將麥草畏降解S# (諸如藉由嗜麥芽假單胞菌（pseud〇m〇nas maltophilia)分離之麥草畏單加氧酶）引入植物中來製造 (參見 Behrens 等人.，2007 Dicamba Resistance : Enlarging and Preserving Biotechnology-Based WeedSpelling Mistakes, Science vol. 285, p. 316-318 (1999)) Site-directed plant genes (eg, genes encoding acetaminophen A-recarbase or gene-splitting ALS) with a herbicidal herbicide target The amino acid is mutated, and thereby a plant resistant to the herbicide is obtained. Plants resistant to dicamba can be introduced into plants by degrading dicamba, S#, such as dicamba monooxygenase isolated by Pseudo〇m〇nas maltophilia Made in China (see Behrens et al., 2007 Dicamba Resistance: Enlarging and Preserving Biotechnology-Based Weed

Management Strategies. Science 316: 1185-1188)。經由將編碼芳氧基鏈烷酸雙加氧酶基因導入植物可製造對下列兩者具抗性之植物：苯氧酸型除草劑（諸如 2, 4-D、MCPA、2, 4-滴丙酸（dichloprop)、及 2, 4-滴丁酸 (mecoprop));及芳氧基苯氧基丙酸酯型除草劑（諸如精喹禾靈（quizalofop)、蓋草能（haloxyfop)、精比氟禾草靈 (fluazifop)、禾草靈（diclofop)、精°惡σ坐禾草靈 (fenoxaprop)、β惡唾醯草胺（metamifop)、及氰氟草酯 (cyhalofop))(參見 W02005/107437、W02007/053482、及 26 323554 201225841 W02008/141154)。前述“作物”亦包含經由遺傳工程技術而有能力產生殺蟲毒素之植物者，該殺蟲毒素為例如由芽孢桿菌 (Bacillus)所產生之選擇性毒素。由此等遺傳工程改造植物所產生的殺蟲毒素之實例包含：由仙人掌桿菌（Bacillus cereus)及多枯芽孢桿菌 (Bacillus popilliae)衍生之殺蟲蛋白；由蘇力菌 (Bacillus thuringiensis)衍生之 d-内毒素（諸如Management Strategies. Science 316: 1185-1188). A plant resistant to the following two can be produced by introducing a gene encoding an aryloxyalkanoic acid dioxygenase into a plant: a phenoxy acid type herbicide (such as 2, 4-D, MCPA, 2, 4-D-propyl) Acid (dichloprop), and 2,4-D-butyric acid (mecoprop); and aryloxyphenoxypropionate-type herbicides (such as quizalofop, haloxyfop, fine ratio Fluazifop, diclofop, fenoxaprop, betaamifop, and cyhalofop (see W02005/) 107437, W02007/053482, and 26 323554 201225841 W02008/141154). The aforementioned "crop" also includes a plant capable of producing a pesticidal toxin by genetic engineering techniques, such as a selective toxin produced by Bacillus. Examples of insecticidal toxins produced by genetically engineered plants include: insecticidal proteins derived from Bacillus cereus and Bacillus popilliae; and d derived from Bacillus thuringiensis - endotoxin (such as

CrylAb、CrylAc、CrylF、CrylFa2、Cry2Ab、Cry3A、Cry3Bbl 及 Cry9C)、VIP 1、VIP 2、VIP 3 及 VIP 3A ;由線蟲衍生之殺蟲蛋白；由動物產生之毒素，例如蠍毒素、缺^朱毒素、蜂毒素及昆蟲專一性神經毒素；真菌毒素；植物凝集素 (lectin)，减集素（agglutinin);蛋白酶抑制劑，例如騰蛋白酶抑制劑、絲胺酸蛋白酶抑制劑、馬鈐薯塊莖儲藏蛋白（patatin)、半胱胺酸蛋白酶抑制劑（cystatin)、及木瓜酵素（papain)抑制劑；核醣體去活性蛋白（RIp)，例如蓖麻毒素、玉米-RIP、相思子素（abrin)、絲瓜籽蛋白（luffin) 皂草毒素蛋白（saporin)、及瀉根素（bri〇din);類固醇代謝酵素，例如3,基類固醇氧化酶'蜆皮類固醇_脈_葡萄糖基轉移酶（ecdysteroid-UDP- gluC〇Syltransferase)、及膽固醇氧化酶；规皮激素抑制劑；HMG-C〇A還原酶；離子通道抑制劑，外如納離子通道抑制劑及娜子通道抑制劑；f春激素㈣；利尿激素受體’一苯乙烯口成酶’聯苄基合成酶；幾丁質酶；及葡聚CrylAb, CrylAc, CrylF, CrylFa2, Cry2Ab, Cry3A, Cry3Bbl and Cry9C), VIP 1, VIP 2, VIP 3 and VIP 3A; insecticidal proteins derived from nematodes; toxins produced by animals, such as scorpion toxin, deficiency ^ Zhu Toxins, melittin and insect-specific neurotoxins; mycotoxins; lectins, agglutinins; protease inhibitors such as transcriptase inhibitors, serine protease inhibitors, horseshoe tuber storage Protein (patatin), cystatin, and papain inhibitor; ribosome deactivated protein (RIp), such as ricin, corn-RIP, abrin, Loofah protein (luffin) saporin toxin (sporin), and puerarin (bri〇din); steroid metabolism enzymes, such as 3, steroid oxidase 'ecdysteroid _ _ glucosyltransferase (ecdysteroid-UDP) - gluC〇Syltransferase), and cholesterol oxidase; cutaneous hormone inhibitor; HMG-C〇A reductase; ion channel inhibitor, external nano-channel inhibitor and nano-channel inhibitor; (d); diuretic hormone receptor '-styrene-forming enzyme' bi-benzyl synthase; chitinase; and

323554 S 27 201225841 膽酶。由此等遺傳工程改造植物所產生的毒素亦包含：殺蟲蛋白之雜合毒素、部分缺失毒素及經修飾毒素，例如d-内毒素蛋白（諸如 CrylAb、CrylAc、CrylF、CrylFa2、Cry2Ab、 Cry3A、Cry3Bbl 及 Cry9C)、VIP 1、VIP 2、VIP 3 及 VIP 3A。雜合毒素係經由遺傳工程技術組合殺蟲蛋白之不同功能區 (domain)所製得。部分缺失毒素之實例包含CrylAb，其中已刪除部分胺基酸。經修飾毒素之實例包含已取代天然毒素中的一個或多個胺基酸之毒素。該殺蟲毒素及有能力產生殺蟲毒素之遺傳工程改造植物之實例描述於，例如，ΕΡ-Α-α 374 753、W0 93/07278、 W0 95/34656 、 ΕΡ-Α-0 427 529 、 ΕΡ-Α-451878 、或 W0 03/ 052073 。有能力產生殺蟲毒素之遺傳工程改造植物對於鞘翅目有害生物、雙翅目有害生物及鱗翅目有害生物的攻擊特別具有抗性。亦知具有一種或多種殺蟲性有害生物抗性基因並因而能產生-冑或多種毒素之遺傳工程改造植物，且該等遺傳工程改造植物中有些為市售可得者。此等遺傳工程改造植物之實例=含：YieldGard (註冊商標）（表現㈣Ab毒素 <玉米培月。„種）、YleldGard此。切_(註冊商標）（表現 CrySBbl毒素之玉米培育品種）、…⑽咖pius(註冊商標）（表現CrylAb及Cry3Bbl毒素之玉米培育品種）、 HecuiexK註冊商標）（表現⑽㈣毒素及彻菌素N—乙 323554 28 201225841 醯基轉移酶（phosphinothricin N-acetyltransferase (PAT))而對草丁膦（g 1 uphosinate)具有抗性之玉米培育品種）、NuCOTN33B(註冊商標）（表現cryiAc毒素之棉花培育品種）、Bollgard I(註冊商標）（表現CrylAc毒素之棉花培育品種）、Bollgard II(註冊商標）（表現CrylAc及Cry2Ab 毒素之棉花培育品種）、VIPC0T(註冊商標表現VIP毒素之棉花培育品種）、NewLeaf(註冊商標）（表現Cry3A毒素之馬鈴薯品種）、NatureGard(註冊商標）Agr丨sure (註冊商標） GT(註冊商標）Advantage(註冊商標）（GA21抗草甘膦特性 (GA21 glyphosate-resistance character)) 、 Agrisure (註冊商標）CB Advantage (Btll玉米螟蟲（CB)特性）、及 Protecta(註冊商標）。前述“作物，，之實例包含其中導入Ragl基因（抗蚜蟲基因1)而賦予對蚜蟲之抗性的植物。刖述作物”亦包含經由遺傳工程技術而賦予產生抗病原菌物質之能力之植物。323554 S 27 201225841 Biliase. The toxins produced by genetically engineered plants also include: hybrid toxins of insecticidal proteins, partially deleted toxins, and modified toxins, such as d-endotoxin proteins (such as CrylAb, CrylAc, CrylF, CrylFa2, Cry2Ab, Cry3A, Cry3Bbl and Cry9C), VIP 1, VIP 2, VIP 3 and VIP 3A. Hybrid toxins are produced by genetic engineering techniques combining different domains of the insecticidal protein. An example of a partially deleted toxin comprises a CrylAb in which a portion of the amino acid has been deleted. Examples of modified toxins include toxins that have replaced one or more of the amino acids in the natural toxin. Examples of the insecticidal toxin and genetically engineered plants capable of producing insecticidal toxins are described, for example, in ΕΡ-Α-α 374 753, W0 93/07278, W0 95/34656, ΕΡ-Α-0 427 529, ΕΡ -Α-451878, or W0 03/ 052073. Genetically engineered plants capable of producing insecticidal toxins are particularly resistant to attack by coleopteran pests, dipteran pests, and lepidopteran pests. Genetically engineered plants having one or more insecticidal pest resistance genes and thus producing - or multiple toxins are also known, and some of these genetically engineered plants are commercially available. Examples of such genetically engineered plants = containing: YieldGard (registered trademark) (performance (4) Ab toxin < corn cultivating month. „ species), YleldGard this. Cut _ (registered trademark) (CrySBbl toxin corn cultivar),... (10) coffee pius (registered trademark) (a maize cultivar showing CrylAb and Cry3Bbl toxin), HecuiexK registered trademark) (performance (10) (four) toxin and gramin N-B 323554 28 201225841 phosphinothricin N-acetyltransferase (PAT) a corn cultivar resistant to g 1 uphosinate, NuCOTN33B (registered trademark) (a cotton cultivar showing the cryiAc toxin), Bollgard I (registered trademark) (a cotton cultivar showing a CrylAc toxin), Bollgard II (registered trademark) (cotton cultivar showing CrylAc and Cry2Ab toxins), VIPC0T (registered trademark of cotton cultivar showing VIP toxin), NewLeaf (registered trademark) (potato variety showing Cry3A toxin), NatureGard (registered trademark) Agr丨sure (registered trademark) GT (registered trademark) Advantage (registered trademark) (GA21 glyphosate resistant (GA21 glyphosate-resistance character), Agrisure (registered trademark) CB Advantage (Btll corn borer (CB) characteristics), and Protecta (registered trademark). The aforementioned "crop, examples include the introduction of Ragl gene (anti-aphid gene) 1) A plant that confers resistance to aphids. The crops also include plants that are genetically engineered to confer the ability to produce pathogenic bacteria.

該抗病原菌物質之實例包含PR蛋白（PRP，揭露於 EP A 0 392 225)。此等抗病原菌物質及可產生該抗病原菌物質之遺傳工程改造植物係揭露於ΕΡ-Α-0 392 225、WO 05/33818、EP-A~〇 353 191 等中。绖由遺傳工程改造植物所產生之抗病原菌物質的實例包含]離子嗔道抑制劑，例如納離子通道抑制劑、及卿子通道抑制劑（例如經由病毒產生之κρι、κρ4、及毒素）’ 一苯乙烯合成酶；聯苄基合成酶；幾丁質酶；葡聚醣 323554 29 201225841 酶’ PR蛋白質；及由微生物產生之抗病源菌物質，例如胜狀抗生素、含雜環抗生素、及與植物病害抗性有關的蛋白質因子（稱為植物病害抗性基因，揭露於W0 03/000906中）。則述“作物”包含經由遺傳工程技術而賦予有用特性諸如經修飾之油成分之特性、及增加胺基酸含量之之植物〇兮·笼:士古t ^ 少之亞^ίΐ 例包含而厲料商標）（具有減再者，前述‘‘作物，，包含具有組合兩述典型抗除草劑牿柯七X炅多種如上基因、抗錢8物質財害生物及增=基酸含®之有益特性之多種植物品種r之特性、在本發财，可將其他有害生物防㈣蟲劑、殺蟎劑、殺線蟲劑、渚如其他殺及植物生長調節劑;增效劑=、.除草:;植物激素、 ^劑；動物飼料等與百利普芬及式⑴表示之=物= 實施例明配例及試驗例具體戈明太欠月，但本發明並不受限於該等實施例。體說明本發首先’描述調配例。名银量份。在貝施例中，術言吾“份，，係指重調配例1 將5份百利普芬、5份眼吃伤賜諾殺或多殺菌素、8份聚氣伸 323554 30 201225841 乙基苯乙烯基苯基醚、2份十二烷基苯磺酸鈣及80份二甲苯混合，獲得可乳化的濃縮物。調配例2 藉由喷射空氣磨粉機將20份百利普芬、4份賜諾殺或多殺菌素、3份十二烷基苯磺酸鈉、3份木質素磺酸鈉及 70份矽藻土之混合物磨成粉末，獲得可濕性粉末。調配例3 將1份百利普芬、0.5份賜諾殺或多殺菌素、48. 5份滑石粉、及50份黏土混合，獲得塵粉。調配例4 將1份百利普芬、4份賜諾殺或多殺菌素、5份十二烷基苯磺酸鈉、30份膨潤土、及60份黏土之混合物與適量水攪拌，以製粒機製粒，然後在流通之空氣下乾燥，獲得顆粒。調配例5 於5份聚氧乙烯苯乙烯基苯基醚硫酸鹽、20份1%黃原膠水溶液、3份蒙脫石礦物及60份水之混合物内，加入5 份百利普芬及5份賜諾殺或多殺菌素。攪拌混合物，接著以砂磨機進行濕性磨粉，獲得懸浮性濃縮物。調配例6 將0. 1份百利普芬及2份賜諾殺或多殺菌素於10份丙酮之溶液與99. 88份之動物固態飼料粉（CE-2:用於育種和繁殖之固態飼料粉，由CLEA日本公司製造）均勻混合，然後經風乾移除丙酮，獲得毒餌。 31 323554 201225841 調配例7 將0. 1份百利普芬及0. 1份賜諾殺或多殺菌素於5份二曱苯及5份三氯乙烷之溶液與89. 8份脫臭煤油混合，獲得油溶液。接著，描述根據本發明之有害生物防治的測試例。測試例1 以含有0.02體積％擴散劑（商品名：Sindain(註冊商標），由住友化學公司製造）之水稀釋含有10.0重量％百利普芬（商品名：Lano(註冊商標）可乳化的濃縮物，由住友化學公司製造）之可乳化的濃縮物，以製得濃度為lOppm之百利普芬。以含有0.02體積％擴散劑（商品名：Sindain(註冊商標），由住友化學公司製造）之水稀釋含有11.7重量％之多殺菌素（多殺菌素J :多殺菌素L之重量比=75 : 25)之懸浮性濃縮物，以製得濃度為93. 6 ppm之多殺菌素。將經水稀釋之百利普芬與特定量經水稀釋之多殺菌素混合以製備測試溶液。將甘藍菜種植在罐子（容量：860毫升），並容許其生長到第4葉期。將該甘藍菜之葉片逐一切斷。將其中一片甘藍菜葉浸沒在測試溶液中60秒。風乾後，將甘藍菜葉放在其杯底舖有濾紙之杯子（容量：500毫升）中。將10隻小菜蛾（Plutella xylostella)之三齡幼蟲釋入此杯中。此為經處理之區段。另一方面，進行未浸沒測試溶液並風乾，將一片甘藍 32 323554 201225841 菜葉放在其杯底舖有濾紙之杯子（容量：500毫升）中。將 10隻小菜蛾之三齡幼蟲釋入此杯中。此為未經處理之區段。 4天後，在經處理之區段及未經處理之區段觀察測試之幼蟲為存活或死亡。根據下列公式計算昆蟲之死亡率。昆蟲死亡率（％) = 100x(死亡昆蟲數目/測試昆蟲數目）根據下列公式修正昆蟲死亡率，以獲得經修正之昆蟲死亡率。經修正之昆蟲死亡率（％) = 100x(Mt-Mc)/(100-Mc)An example of such an anti-pathogenic material comprises a PR protein (PRP, disclosed in EP A 0 392 225). Such anti-pathogenic materials and genetically engineered plant lines capable of producing the anti-pathogenic bacteria are disclosed in ΕΡ-Α-0 392 225, WO 05/33818, EP-A~〇 353 191, and the like. Examples of anti-pathogenic bacteria produced by genetically engineered plants include] ion channel inhibitors, such as nanochannel inhibitors, and clear channel inhibitors (eg, κρι, κρ4, and toxins produced by viruses) Styrene synthase; bibenzyl synthase; chitinase; dextran 323554 29 201225841 enzyme 'PR protein; and pathogenic bacteria produced by microorganisms, such as victorious antibiotics, heterocyclic antibiotics, and A protein factor associated with plant disease resistance (referred to as a plant disease resistance gene, disclosed in WO 03/000906). The term "crop" includes plant 〇兮·cage that imparts useful properties such as the characteristics of the modified oil component and increases the amino acid content via genetic engineering techniques: Shigu t ^ 少之亚 ^ ΐ 包含(trademark) (with the subtraction, the aforementioned 'crop,' contains a combination of two typical herbicides, such as the above-mentioned genes, the above-mentioned genes, the anti-money 8 substances, and the beneficial properties of the acid-containing acid The characteristics of a variety of plant species, in the fortune, can be used to prevent other pests, insecticides, nematicides, such as other killings and plant growth regulators; synergists =, weeding:; Phytohormone, medicinal agent, animal feed, etc., and bailipfen and formula (1) = substance = examples. The examples and test examples are specifically given to the moon, but the invention is not limited to the examples. Explain that this issue first describes the formulation example. The name of silver is used. In the case of Beishi, the word "," refers to the re-adjustment of the case 1 to 5 pieces of bailipfen, 5 eyes to kill or kill Spinosad, 8 parts of polygas extension 323554 30 201225841 Ethyl styryl phenyl ether, 2 Mixing calcium dodecylbenzenesulfonate with 80 parts of xylene to obtain an emulsifiable concentrate. Formulation Example 2 20 parts of balixifene, 4 parts of spinosad or spinosad by jet air mill 3 parts of sodium dodecylbenzenesulfonate, 3 parts of sodium ligninsulfonate and 70 parts of diatomaceous earth were ground into a powder to obtain a wettable powder. Formulation Example 3 1 part of balixifene, 0.5 parts Adding noose or spinosad, 48.5 parts of talc, and 50 parts of clay to obtain dust powder. Formulation Example 4 1 part of balixifene, 4 parts of spinosad or spinosad, 5 parts of twelve A mixture of sodium alkylbenzene sulfonate, 30 parts of bentonite, and 60 parts of clay is stirred with an appropriate amount of water to granulate the granules, and then dried in a circulating air to obtain granules. Formulation 5 in 5 parts of polyoxyethylene styrene Add 5 parts of balixifene and 5 parts of spinosad or spinosad in a mixture of phenyl ether ether sulfate, 20 parts 1% xanthan gum aqueous solution, 3 parts montmorillonite mineral and 60 parts water. Stir the mixture. Then, wet grinding is carried out with a sand mill to obtain a suspension concentrate. Formulation Example 6 0.1 part of bailipfen and 2 parts of sinus or more The bactericidal solution in 10 parts of acetone and 99.88 parts of the animal solid feed powder (CE-2: solid feed powder for breeding and breeding, manufactured by CLEA Japan) are uniformly mixed, and then acetone is removed by air drying.份份。 The phlegm. 31 323554 201225841 Preparation Example 7 0. 1 part of bailipufen and 0. 1 part of the promise or spinosad in 5 parts of diphenylbenzene and 5 parts of trichloroethane solution and 89. The odorous kerosene is mixed to obtain an oil solution. Next, a test example of the pest control according to the present invention will be described. Test Example 1 Water containing 0.02% by volume of a diffusing agent (trade name: Sindain (registered trademark), manufactured by Sumitomo Chemical Co., Ltd.) The emulsifiable concentrate containing 10.0% by weight of beclofen (trade name: Lano (registered trademark) emulsifiable concentrate, manufactured by Sumitomo Chemical Co., Ltd.) was diluted to obtain baprifene at a concentration of 10 ppm. The spine containing 11.7% by weight of spinosad containing a 0.02% by volume of a diffusing agent (trade name: Sindain (registered trademark), manufactured by Sumitomo Chemical Co., Ltd.) (the spinosyn J: spinosyn L weight ratio = 75: 25 ppm的菌菌素. The suspension concentrate was obtained in a concentration of 93.6 ppm. The water-diluted bafilfen was mixed with a specific amount of water-diluted spinosyn to prepare a test solution. The cabbage was planted in a jar (capacity: 860 ml) and allowed to grow to the fourth leaf stage. The leaves of the cabbage are cut one by one. One of the cabbage leaves was immersed in the test solution for 60 seconds. After air drying, the cabbage leaves are placed in a cup (capacity: 500 ml) with a filter paper on the bottom of the cup. Ten third instar larvae of Plutella xylostella were released into the cup. This is the processed section. On the other hand, the unimmersed test solution was air-dried, and a piece of cabbage 32 323554 201225841 was placed in a cup (capacity: 500 ml) with a filter paper on the bottom of the cup. Ten third instar larvae of Plutella xylostella were released into the cup. This is an unprocessed section. After 4 days, the larvae tested in the treated and untreated sections survived or died. The mortality of insects was calculated according to the following formula. Insect mortality (%) = 100x (number of dead insects / number of tested insects) The insect mortality rate was corrected according to the following formula to obtain a corrected insect mortality rate. Modified insect mortality rate (%) = 100x (Mt-Mc) / (100-Mc)

Mt :經處理之區段中的昆蟲死亡率（°/〇)Mt : Insect mortality in treated sections (°/〇)

Me :未經處理之區段中的昆蟲死亡率（°/〇) 各處理有三重複。測試結果顯示，發現測試溶液顯現經高度修正之昆蟲死亡率。結果顯示於表2中。表2 百利普芬之濃度 (ppm) 多殺菌素之濃度 (ppm) 經修正之昆蟲死亡率 (°/〇) 6. 25 — 33 25 _ 71 — 0.00288 19 — 0.00575 29 6.25 0.00288 91 6. 25 0.00575 100 25 0.00575 100 33 323554 201225841 測試例2 以含有ο·〇2體積％擴散劑（商品名：sindain(註冊商標），由住友化學公司製造）之水稀釋含有1〇〇重量％百利普芬(商品名：Lano(註冊商標）可乳化的濃縮物，由住友化學公司製造)之可乳化的濃縮物’以製得濃度為⑽ 百利普芬。以含有0.02體積爾散劑（商品名：Sindain(註冊商標），由住友化學公司製造）之水稀釋含有117重量％之多殺菌素（多殺菌素多殺菌素[之重量比=75:25)之懸浮性濃縮物（商品t Diana(註冊商標脱，由住友化學公司製造），以製得濃度為93. 6 ppm之多殺菌素。將經水稀釋之百利普芬與特定量經水稀釋之多殺菌素混合以製備測試溶液。 μ 將甘藍菜種子種植在塑膠罐（容量：3盘司），並容許其生長到第4葉期。將該罐放入其内有許多活的於草粉益 (Bemisia tabaci)之網籠t，並靜置24小時。之後，從籠中取出罐子，並決定甘藍菜幼苗上之存活昆蟲的數目（菸草粉蝨（Bemisia tabaci),存活成蟲與幼蟲之總數目）。此為測試前之昆蟲數目。接著，將測試溶液、經水稀釋之百利普芬或經水稀釋之多殺菌素喷灑至該罐子以充分地浸潰該甘藍菜幼苗，並允許於室溫（約25°C )靜置。此為經處理之區段。處理後8 天’決定甘藍菜幼苗上之存活昆蟲的數目（菸草粉蟲 (Bemisia tabaci) ’存活成蟲與幼蟲之總數目）。此為測試 323554 34 201225841 »> 後之昆蟲數目。 -» 另一方面，除了喷灑測試溶液、經水稀釋之百利普芬或經水稀釋之多殺菌素外，在未經處理之區段中重複進行與彼等經處理之區域相同之測試程序，以決定測試前之昆蟲數目（其稱為在未經處理之區段中測試前之昆蟲數目），及決定測試後之昆蟲數目（其為在未經處理之區段中測試後之昆蟲數目）。根據下列公式，由此等結果計算經修正之密度值。經修正之密度值= (Nt-a/ Nt-b) X (U Nc-a)xl00 Nt-a ·•在經處理之區段中測試後之昆蟲數目 Nt-b :在經處理之區段中測試前之昆蟲數目 Nc-a :在未經處理之區段中測試後之昆蟲數目 Nc-b :在未經處理之區段中測試前之昆蟲數目測試結果相較於單獨使用經水稀釋之百利普芬及經水稀釋之多殺菌素之情況，測試溶液抑制昆蟲（菸草粉蝨 (Bemisia tabaci))數目之增加。結果顯示於表3中。 35 323554 201225841 表3 ------ 百利普芬之濃度 _ (PPm) 多殺菌素之濃度 (ppm) 經修正之密度值 12.5 12 —~— 0 12.5 47 0 50 12 0 50 47 0 12.5 ----- — 17 50 — 5 ~~ 12 41 — 47 ------ 27 測試例3 以含有0.02體積％擴散劑（商品名：Sindain(註冊商私），由住友化學公司製造）之水稀釋含有1〇〇重量％百利普芬（商品名：Lano(註冊商標）可乳化的濃縮物，由住友化學公司製造）之可乳化的濃縮物，以製得濃度為1〇〇ppm之百利普芬。以含有0.02體積％擴散劑（商品名：Sindain(註冊商標），由住友化學公司製造）之水稀釋含有117重量％之多殺菌素（多殺菌素J:多殺菌素L之重量比=75 : 25)之懸浮性濃縮物（商品名.D i ana (註冊商標）SC ’由住友化學公司製造）’以製得濃度為93. 6 ppm之多殺菌素。將經水稀釋之百利普芬與特定量經水稀釋之多殺菌素混合以製備測試溶液。 323554 36 201225841 # . 將甘藍菜種子種植在内有土壤之塑膠罐（容量：3盎司），並容許其生長到第3至4葉期。將該罐放入其内有許多活的終草粉蝨之網籠中，並靜置24小時。之後，從蘢中取出罐子，並計算甘藍菜幼苗上之存活昆蟲（菸草粉蝨）的數目（存活成蟲與幼蟲之總數目）。此為測試前之昆蟲數目。接著’將測試溶液、經水稀釋之百利普芬或經水稀釋之多殺菌素喷灑至該罐子以充分地浸潰該甘藍菜幼苗，並允許於室溫（約25〇C)靜置。此為經處理之區段。處理後6 天’计算甘藍菜幼苗上之存活昆蟲（終草粉為）的數目，存活成蟲與幼蟲之總數目）。此為測試後之昆蟲數目。另一方面，除了喷麗測試溶液、經水稀釋之百利普芬或經水稀釋之多殺菌素外，在未經處理之區段中重複進行與彼荨經處理之區域相同測試程序，以決定測試前之昆蟲數目（其稱為在未經處理之區段中測試前之昆蟲數目），及决疋測试後之昆蟲數目（其稱為在未經處理之區段中測試後之昆蟲數目）。根據下列公式，由此等結果計算經修正之密度值。經修正之密度值=(Nt_a/ Nt-b) X (Nc_b/ Nc_a)xi〇0Me: Insect mortality in the untreated section (°/〇) There are three replicates for each treatment. The test results showed that the test solution showed a highly corrected insect mortality rate. The results are shown in Table 2. Table 2 Concentration of bailipfen (ppm) concentration of spinosad (ppm) Modified insect mortality (°/〇) 6. 25 — 33 25 _ 71 — 0.00288 19 — 0.00575 29 6.25 0.00288 91 6. 25 0.00575 100 25 0.00575 100 33 323554 201225841 Test Example 2 Diluted with 1% by weight of bailipfen containing water containing ο·〇2% by volume of a diffusing agent (trade name: sindain (registered trademark), manufactured by Sumitomo Chemical Co., Ltd.) (trade name: Lano (registered trademark) emulsifiable concentrate, manufactured by Sumitomo Chemical Co., Ltd.) emulsifiable concentrate 'to obtain a concentration of (10) paclitaxel. Diluted with 117% by weight of spinosad (spinchanthin (weight ratio = 75:25) containing water containing 0.02 liters of powder (trade name: Sindain (registered trademark), manufactured by Sumitomo Chemical Co., Ltd.) Suspension concentrate (commercial t Diana (registered trademark, manufactured by Sumitomo Chemical Co., Ltd.) to produce a concentration of 93.6 ppm of spinosad. Diluted with water and diluted with water in a specific amount. The spinosyn is mixed to prepare a test solution. μ The cabbage seed is planted in a plastic can (capacity: 3 plates) and allowed to grow to the 4th leaf stage. The can is placed in it and there are many live grass powders. The cage of Bemisia tabaci was allowed to stand for 24 hours. After that, the jar was removed from the cage and the number of surviving insects on the cabbage seedlings (Bemisia tabaci), the total number of surviving adults and larvae was determined. This is the number of insects before the test. Next, the test solution, water-diluted baprifene or water-diluted spinosyn is sprayed onto the jar to fully impregnate the cabbage seedlings and allow Static at room temperature (about 25 ° C) This is the treated section. The number of surviving insects on the cabbage seedlings was determined 8 days after treatment (Bemisia tabaci 'the total number of surviving adults and larvae). This is the test 323554 34 201225841 »&gt The number of insects after. -» On the other hand, in addition to spraying the test solution, water-diluted bafilfen or water-diluted spinosyn, repeated with the same in the untreated section The same test procedure is used to determine the number of insects before the test (which is called the number of insects before testing in the untreated section) and the number of insects after the test (which is in the untreated area) The number of insects after the test in the segment. Calculate the corrected density value according to the following formula. The corrected density value = (Nt-a/ Nt-b) X (U Nc-a)xl00 Nt-a • Number of insects tested in the treated section Nt-b : Number of insects before testing in the treated section Nc-a : Number of insects tested in the untreated section Nc-b : Test results for the number of insects before testing in untreated sections The test solution inhibited the increase in the number of insects (Bemisia tabaci) compared to the case of water-diluted bafilfen and water-diluted spinosad alone. The results are shown in Table 3. 35 323554 201225841 Table 3 ------ Concentration of bailipfen _ (PPm) Concentration of spinosad (ppm) Modified density value 12.5 12 —~— 0 12.5 47 0 50 12 0 50 47 0 12.5 -- --- — 17 50 — 5 ~~ 12 41 — 47 ------ 27 Test Example 3 Water containing 0.02% by volume of a diffusing agent (trade name: Sindain (registered private), manufactured by Sumitomo Chemical Co., Ltd.) Dilute an emulsifiable concentrate containing 1% by weight of baclipren (trade name: Lano (registered trademark) emulsifiable concentrate, manufactured by Sumitomo Chemical Co., Ltd.) to obtain a concentration of 1 〇〇 ppm Lipfen. Dilute 117% by weight of spinosad containing water containing 0.02% by volume of a diffusing agent (trade name: Sindain (registered trademark), manufactured by Sumitomo Chemical Co., Ltd.) (Spinosyn J: spinosyn L weight ratio = 75: 25 ppm的菌菌素。 25) The suspension concentrate (trade name. D ana (registered trademark) SC 'made by Sumitomo Chemical Co., Ltd.) 'to produce a concentration of 93.6 ppm of spinosad. The water-diluted bafilfen was mixed with a specific amount of water-diluted spinosyn to prepare a test solution. 323554 36 201225841 # . Plant the cabbage seeds in a plastic tank with soil (capacity: 3 ounces) and allow them to grow to the 3rd to 4th leaf stage. The can was placed in a cage containing a lot of live grass powder and allowed to stand for 24 hours. Thereafter, the cans were taken out from the pot and the number of surviving insects (tobacco white meal) on the cabbage seedlings (the total number of surviving adults and larvae) was counted. This is the number of insects before the test. Then 'spray the test solution, water-diluted bafilfen or water-diluted spinosyn to the jar to fully impregnate the cabbage seedlings and allow to stand at room temperature (about 25 ° C) . This is the processed section. The number of surviving insects (final grass powder) on the cabbage seedlings was counted 6 days after the treatment, and the total number of adult and larvae was counted). This is the number of insects after the test. On the other hand, in addition to the spray test solution, water-diluted bafilfen or water-diluted spinosyn, the same test procedure as in the treated area is repeated in the untreated section to Determine the number of insects before the test (this is called the number of insects before testing in the untreated section), and the number of insects after the test (which is called the insect after testing in the untreated section) number). The corrected density value is calculated from the results as follows according to the following formula. Modified density value = (Nt_a / Nt-b) X (Nc_b / Nc_a) xi 〇 0

Nt-a :在經處理之區段中測試後之昆轰數目 Nt-b :在經處理之區段中測試前之昆蟲數目 Nc-a :在未經處理之區段中測試後之昆蟲數目 Nc-b :在未經處理之區段中測試前之昆蟲數目測試結果相較於單獨使用經水稀釋之百利普芬及經水稀釋之多殺菌素之情況，測試溶液抑制昆蟲（菸草粉蝨）之 323554 37 201225841 增加數目。結果顯示於表4中。 .表4 百利普芬之濃度 (ppm) 多殺菌素之濃度 (ppm) 經修正之密度值 0. 1 47 0 1 12 0 0. 1 — 48 1 — 41 — 12 28 — 47 22 【圖式簡單說明】益。【主要元件符號說明】 38 323554Nt-a : number of nucleus after testing in the treated section Nt-b : number of insects before testing in the treated section Nc-a : number of insects tested in untreated section Nc-b: Test results for the number of insects before testing in the untreated section. Test solution inhibits insects (tobacco powder) compared to the use of water-diluted balixifene and water-diluted spinosyn.虱) 323554 37 201225841 Increased number. The results are shown in Table 4. Table 4 Concentration of bailipfen (ppm) concentration of spinosad (ppm) Modified density value 0. 1 47 0 1 12 0 0. 1 — 48 1 — 41 — 12 28 — 47 22 Brief description] Benefits. [Main component symbol description] 38 323554

Claims

201225841 VII. Patent application scope: 1. A pest control composition, including balixifene and compounds represented by the following formula (I):

Wherein R1 is a hydrogen atom or a fluorenyl group, R2 is a hydrogen atom, a C-C4 alkyl group, an n-C4 haloalkyl group, or a (C1-C4 alkyl) phenyl group R3 is a hydrogen atom, H-C4 alkyl group , C1-C4 haloalkyl, or (C; l-C4 alkyl)carbonyl, R4 is a hydrogen atom, C-C4 alkyl, H-C4 haloalkyl, or ((U-C4)-based] R5 is a hydrogen atom, a C1-C4 alkyl group, or a CU-C4 alkylamino group, R6 is a hydrogen atom or a fluorenyl group, R7 is a methyl group or an ethyl group, R8 is an amine group, a C1-C4 alkylamino group, or A bis(C1_C4 alkyl)amino group, and X1 and X2 are a hydrogen atom or X1 and X2 together represent a single bond. 2. The pest control composition according to claim 1, wherein 1 323554 201225841, The weight ratio of the compound of the formula (i) to the compound of the formula (i) is from 5,000:1 to 1:5000. 3. The pest control composition according to claim 1 or 2, wherein The compound represented by the formula (I) is spinosad or spinetoram. 4. A pest control method comprising an effective total amount of baclofen and a compound represented by the following formula (I) Shi To pests or pest habitats at:

Wherein R1 is a hydrogen atom or a fluorenyl group, R2 is a hydrogen atom, an H-C4 alkyl group, a C1-C4 haloalkyl group, or a (H-C4 alkyl)carbonyl group, and R3 is a hydrogen atom, a C1-C4 alkyl group, a C1-C4 haloalkyl group, or a (C-C4 alkyl)carbonyl group, R4 is a hydrogen atom, a C1-C4 alkyl group, a C1-C4 haloalkyl group, or a ((U-C4 alkyl)carbonyl group, and R5 is a hydrogen atom. , C1-C4 alkyl, or C-C4 alkylamino, R6 is a hydrogen atom or a fluorenyl group, 2 323554 201225841 φ 4 rs ^ group, R 7 is a fluorenyl group or an ethyl group, R 8 is an amine group, C 1 -C 4 is burned The amide group or the bis(C1-C4 alkyl)amine 1 and X1 and X2 are a hydrogen atom or X1 and X2 together represent a single bond. 5. The pest control method according to claim 4, wherein The weight ratio of the compound of the formula (I) to the compound of the formula (I) is from 5,000:1 to 1:5000. 6. The method for controlling pests according to claim 4 or 5, wherein The compound represented by formula (I) is spinosad or spinosad. 3 323554 201225841 IV. Designated representative map: • (1) The representative representative of the case is: the case has no schema. (2) The symbol of the representative figure Single Description: No Fifth, if the case of formula, please disclosed invention features most indicative of the formula:

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