TW201225962A - Composition for oral use - Google Patents
Composition for oral use Download PDFInfo
- Publication number
- TW201225962A TW201225962A TW100133446A TW100133446A TW201225962A TW 201225962 A TW201225962 A TW 201225962A TW 100133446 A TW100133446 A TW 100133446A TW 100133446 A TW100133446 A TW 100133446A TW 201225962 A TW201225962 A TW 201225962A
- Authority
- TW
- Taiwan
- Prior art keywords
- bean
- biofilm
- formation
- inhibiting
- oral composition
- Prior art date
Links
- 239000000203 mixture Substances 0.000 title claims abstract description 26
- 239000003242 anti bacterial agent Substances 0.000 claims abstract description 27
- 239000002532 enzyme inhibitor Substances 0.000 claims abstract description 12
- 239000000284 extract Substances 0.000 claims description 19
- 230000002401 inhibitory effect Effects 0.000 claims description 13
- 244000046052 Phaseolus vulgaris Species 0.000 claims description 11
- 230000015572 biosynthetic process Effects 0.000 claims description 11
- 240000001417 Vigna umbellata Species 0.000 claims description 10
- 235000011453 Vigna umbellata Nutrition 0.000 claims description 10
- 235000010627 Phaseolus vulgaris Nutrition 0.000 claims description 9
- 241000194019 Streptococcus mutans Species 0.000 claims description 9
- 230000003115 biocidal effect Effects 0.000 claims description 8
- 229940125532 enzyme inhibitor Drugs 0.000 claims description 8
- 229940069765 bean extract Drugs 0.000 claims description 7
- 239000000126 substance Substances 0.000 claims description 5
- 241000199361 Villosa perpurpurea Species 0.000 claims description 4
- 230000006698 induction Effects 0.000 claims description 4
- 244000066764 Ailanthus triphysa Species 0.000 claims description 3
- 241000219977 Vigna Species 0.000 claims description 3
- 235000010726 Vigna sinensis Nutrition 0.000 claims description 3
- 238000002156 mixing Methods 0.000 claims description 2
- 101710082261 Competence-stimulating peptide Proteins 0.000 claims 2
- PCHJSUWPFVWCPO-UHFFFAOYSA-N gold Chemical compound [Au] PCHJSUWPFVWCPO-UHFFFAOYSA-N 0.000 claims 1
- 239000010931 gold Substances 0.000 claims 1
- 229910052737 gold Inorganic materials 0.000 claims 1
- 230000032770 biofilm formation Effects 0.000 abstract description 23
- 208000002925 dental caries Diseases 0.000 abstract description 22
- 241000894006 Bacteria Species 0.000 abstract description 14
- 238000000034 method Methods 0.000 abstract description 13
- 229940088710 antibiotic agent Drugs 0.000 abstract description 7
- 230000002265 prevention Effects 0.000 abstract description 5
- 230000000694 effects Effects 0.000 abstract description 4
- 150000004676 glycans Chemical class 0.000 abstract description 4
- 229920001282 polysaccharide Polymers 0.000 abstract description 4
- 239000005017 polysaccharide Substances 0.000 abstract description 4
- 230000035515 penetration Effects 0.000 abstract description 3
- 230000001939 inductive effect Effects 0.000 abstract 1
- 230000018612 quorum sensing Effects 0.000 abstract 1
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 19
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 14
- 229940112822 chewing gum Drugs 0.000 description 6
- 235000015218 chewing gum Nutrition 0.000 description 6
- 235000013305 food Nutrition 0.000 description 6
- 210000000214 mouth Anatomy 0.000 description 6
- 241000196324 Embryophyta Species 0.000 description 5
- 238000000605 extraction Methods 0.000 description 5
- 244000005700 microbiome Species 0.000 description 5
- 238000004220 aggregation Methods 0.000 description 4
- 230000002776 aggregation Effects 0.000 description 4
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- 230000014509 gene expression Effects 0.000 description 4
- 229940034610 toothpaste Drugs 0.000 description 4
- 239000000606 toothpaste Substances 0.000 description 4
- 238000005406 washing Methods 0.000 description 4
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 description 3
- 244000124209 Crocus sativus Species 0.000 description 3
- 235000015655 Crocus sativus Nutrition 0.000 description 3
- XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 description 3
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 3
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 description 3
- 230000001580 bacterial effect Effects 0.000 description 3
- 239000003814 drug Substances 0.000 description 3
- 229940079593 drug Drugs 0.000 description 3
- 238000000338 in vitro Methods 0.000 description 3
- 239000003960 organic solvent Substances 0.000 description 3
- 230000001717 pathogenic effect Effects 0.000 description 3
- 239000000047 product Substances 0.000 description 3
- 239000004248 saffron Substances 0.000 description 3
- 235000013974 saffron Nutrition 0.000 description 3
- 239000000243 solution Substances 0.000 description 3
- 239000002904 solvent Substances 0.000 description 3
- GHXZTYHSJHQHIJ-UHFFFAOYSA-N Chlorhexidine Chemical compound C=1C=C(Cl)C=CC=1NC(N)=NC(N)=NCCCCCCN=C(N)N=C(N)NC1=CC=C(Cl)C=C1 GHXZTYHSJHQHIJ-UHFFFAOYSA-N 0.000 description 2
- HEDRZPFGACZZDS-UHFFFAOYSA-N Chloroform Chemical compound ClC(Cl)Cl HEDRZPFGACZZDS-UHFFFAOYSA-N 0.000 description 2
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 2
- 108090000790 Enzymes Proteins 0.000 description 2
- 102000004190 Enzymes Human genes 0.000 description 2
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 2
- LRHPLDYGYMQRHN-UHFFFAOYSA-N N-Butanol Chemical compound CCCCO LRHPLDYGYMQRHN-UHFFFAOYSA-N 0.000 description 2
- 230000001680 brushing effect Effects 0.000 description 2
- 239000003518 caustics Substances 0.000 description 2
- 229960003260 chlorhexidine Drugs 0.000 description 2
- 239000000551 dentifrice Substances 0.000 description 2
- 230000001419 dependent effect Effects 0.000 description 2
- 235000013399 edible fruits Nutrition 0.000 description 2
- 238000009472 formulation Methods 0.000 description 2
- 208000015181 infectious disease Diseases 0.000 description 2
- 230000005764 inhibitory process Effects 0.000 description 2
- 238000004519 manufacturing process Methods 0.000 description 2
- 230000000813 microbial effect Effects 0.000 description 2
- 239000000419 plant extract Substances 0.000 description 2
- 108090000765 processed proteins & peptides Proteins 0.000 description 2
- BDERNNFJNOPAEC-UHFFFAOYSA-N propan-1-ol Chemical compound CCCO BDERNNFJNOPAEC-UHFFFAOYSA-N 0.000 description 2
- 230000008054 signal transmission Effects 0.000 description 2
- 239000006228 supernatant Substances 0.000 description 2
- 230000001629 suppression Effects 0.000 description 2
- 239000000725 suspension Substances 0.000 description 2
- 241000251468 Actinopterygii Species 0.000 description 1
- 235000017166 Bambusa arundinacea Nutrition 0.000 description 1
- 235000017491 Bambusa tulda Nutrition 0.000 description 1
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 1
- 102000000340 Glucosyltransferases Human genes 0.000 description 1
- 108010055629 Glucosyltransferases Proteins 0.000 description 1
- 208000025157 Oral disease Diseases 0.000 description 1
- 229910019142 PO4 Inorganic materials 0.000 description 1
- 244000082204 Phyllostachys viridis Species 0.000 description 1
- 235000015334 Phyllostachys viridis Nutrition 0.000 description 1
- 229930006000 Sucrose Natural products 0.000 description 1
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 description 1
- 238000002835 absorbance Methods 0.000 description 1
- DPXJVFZANSGRMM-UHFFFAOYSA-N acetic acid;2,3,4,5,6-pentahydroxyhexanal;sodium Chemical compound [Na].CC(O)=O.OCC(O)C(O)C(O)C(O)C=O DPXJVFZANSGRMM-UHFFFAOYSA-N 0.000 description 1
- 239000004480 active ingredient Substances 0.000 description 1
- 239000013543 active substance Substances 0.000 description 1
- 239000000853 adhesive Substances 0.000 description 1
- 230000001070 adhesive effect Effects 0.000 description 1
- 230000000844 anti-bacterial effect Effects 0.000 description 1
- 244000052616 bacterial pathogen Species 0.000 description 1
- 239000011425 bamboo Substances 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 235000013361 beverage Nutrition 0.000 description 1
- 235000015895 biscuits Nutrition 0.000 description 1
- 210000004556 brain Anatomy 0.000 description 1
- 235000008429 bread Nutrition 0.000 description 1
- UOAITRWPAYGGAM-UHFFFAOYSA-L calcium;propane-1,2,3-triol;carbonate Chemical compound [Ca+2].[O-]C([O-])=O.OCC(O)CO UOAITRWPAYGGAM-UHFFFAOYSA-L 0.000 description 1
- 239000002775 capsule Substances 0.000 description 1
- 229920003123 carboxymethyl cellulose sodium Polymers 0.000 description 1
- 229940063834 carboxymethylcellulose sodium Drugs 0.000 description 1
- 238000004113 cell culture Methods 0.000 description 1
- 238000005119 centrifugation Methods 0.000 description 1
- 235000019219 chocolate Nutrition 0.000 description 1
- 238000004587 chromatography analysis Methods 0.000 description 1
- 239000013065 commercial product Substances 0.000 description 1
- 238000011109 contamination Methods 0.000 description 1
- 235000013365 dairy product Nutrition 0.000 description 1
- 230000001877 deodorizing effect Effects 0.000 description 1
- 235000011850 desserts Nutrition 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- -1 ether 'chloroform Chemical compound 0.000 description 1
- 238000011156 evaluation Methods 0.000 description 1
- 230000003631 expected effect Effects 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 235000013332 fish product Nutrition 0.000 description 1
- 239000003205 fragrance Substances 0.000 description 1
- 239000008103 glucose Substances 0.000 description 1
- 235000011187 glycerol Nutrition 0.000 description 1
- 235000015243 ice cream Nutrition 0.000 description 1
- 235000015094 jam Nutrition 0.000 description 1
- 235000021332 kidney beans Nutrition 0.000 description 1
- 235000021374 legumes Nutrition 0.000 description 1
- 230000003902 lesion Effects 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 235000013372 meat Nutrition 0.000 description 1
- 208000030194 mouth disease Diseases 0.000 description 1
- 239000002324 mouth wash Substances 0.000 description 1
- 229940051866 mouthwash Drugs 0.000 description 1
- 244000052769 pathogen Species 0.000 description 1
- 230000008506 pathogenesis Effects 0.000 description 1
- 239000002304 perfume Substances 0.000 description 1
- 208000028169 periodontal disease Diseases 0.000 description 1
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 description 1
- 239000010452 phosphate Substances 0.000 description 1
- 239000002504 physiological saline solution Substances 0.000 description 1
- 230000007505 plaque formation Effects 0.000 description 1
- 238000006116 polymerization reaction Methods 0.000 description 1
- 229920001184 polypeptide Polymers 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 102000004196 processed proteins & peptides Human genes 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 235000011962 puddings Nutrition 0.000 description 1
- 238000010298 pulverizing process Methods 0.000 description 1
- 235000013580 sausages Nutrition 0.000 description 1
- 230000001953 sensory effect Effects 0.000 description 1
- 235000013570 smoothie Nutrition 0.000 description 1
- 235000011888 snacks Nutrition 0.000 description 1
- 235000019333 sodium laurylsulphate Nutrition 0.000 description 1
- 238000000638 solvent extraction Methods 0.000 description 1
- 235000014347 soups Nutrition 0.000 description 1
- 239000007921 spray Substances 0.000 description 1
- 230000004936 stimulating effect Effects 0.000 description 1
- 239000005720 sucrose Substances 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23G—COCOA; COCOA PRODUCTS, e.g. CHOCOLATE; SUBSTITUTES FOR COCOA OR COCOA PRODUCTS; CONFECTIONERY; CHEWING GUM; ICE-CREAM; PREPARATION THEREOF
- A23G3/00—Sweetmeats; Confectionery; Marzipan; Coated or filled products
- A23G3/34—Sweetmeats, confectionery or marzipan; Processes for the preparation thereof
- A23G3/36—Sweetmeats, confectionery or marzipan; Processes for the preparation thereof characterised by the composition containing organic or inorganic compounds
- A23G3/364—Sweetmeats, confectionery or marzipan; Processes for the preparation thereof characterised by the composition containing organic or inorganic compounds containing microorganisms or enzymes; containing paramedical or dietetical agents, e.g. vitamins
- A23G3/368—Sweetmeats, confectionery or marzipan; Processes for the preparation thereof characterised by the composition containing organic or inorganic compounds containing microorganisms or enzymes; containing paramedical or dietetical agents, e.g. vitamins containing vitamins, antibiotics
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23G—COCOA; COCOA PRODUCTS, e.g. CHOCOLATE; SUBSTITUTES FOR COCOA OR COCOA PRODUCTS; CONFECTIONERY; CHEWING GUM; ICE-CREAM; PREPARATION THEREOF
- A23G3/00—Sweetmeats; Confectionery; Marzipan; Coated or filled products
- A23G3/34—Sweetmeats, confectionery or marzipan; Processes for the preparation thereof
- A23G3/36—Sweetmeats, confectionery or marzipan; Processes for the preparation thereof characterised by the composition containing organic or inorganic compounds
- A23G3/48—Sweetmeats, confectionery or marzipan; Processes for the preparation thereof characterised by the composition containing organic or inorganic compounds containing plants or parts thereof, e.g. fruits, seeds, extracts
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23G—COCOA; COCOA PRODUCTS, e.g. CHOCOLATE; SUBSTITUTES FOR COCOA OR COCOA PRODUCTS; CONFECTIONERY; CHEWING GUM; ICE-CREAM; PREPARATION THEREOF
- A23G4/00—Chewing gum
- A23G4/06—Chewing gum characterised by the composition containing organic or inorganic compounds
- A23G4/068—Chewing gum characterised by the composition containing organic or inorganic compounds containing plants or parts thereof, e.g. fruits, seeds, extracts
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23G—COCOA; COCOA PRODUCTS, e.g. CHOCOLATE; SUBSTITUTES FOR COCOA OR COCOA PRODUCTS; CONFECTIONERY; CHEWING GUM; ICE-CREAM; PREPARATION THEREOF
- A23G4/00—Chewing gum
- A23G4/06—Chewing gum characterised by the composition containing organic or inorganic compounds
- A23G4/12—Chewing gum characterised by the composition containing organic or inorganic compounds containing microorganisms or enzymes; containing paramedical or dietetical agents, e.g. vitamins
- A23G4/126—Chewing gum characterised by the composition containing organic or inorganic compounds containing microorganisms or enzymes; containing paramedical or dietetical agents, e.g. vitamins containing vitamins, antibiotics
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/105—Plant extracts, their artificial duplicates or their derivatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9789—Magnoliopsida [dicotyledons]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/19—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2200/00—Function of food ingredients
- A23V2200/30—Foods, ingredients or supplements having a functional effect on health
- A23V2200/312—Foods, ingredients or supplements having a functional effect on health having an effect on dental health
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Botany (AREA)
- Food Science & Technology (AREA)
- Polymers & Plastics (AREA)
- Microbiology (AREA)
- Inorganic Chemistry (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Nutrition Science (AREA)
- Epidemiology (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Mycology (AREA)
- Biotechnology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Birds (AREA)
- Alternative & Traditional Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Medical Informatics (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Cosmetics (AREA)
- Medicines Containing Plant Substances (AREA)
- Confectionery (AREA)
- Coloring Foods And Improving Nutritive Qualities (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Description
201225962 六、發明說明 【發明所屬之技術領域】 本發明係關於有效的預防齲齒之抑制生物被膜形成之 口腔用組成物，尤其係關於藉由利用口腔微生物之聚量感 應，使用新穎的抑制生物被膜形成的方法之口腔用組成 物。 【先前技術】 物體表面附著的微生物並非單獨存在，而是於具有特 徵的結構中與其他微生物形成生物被膜。此生物被膜係見 於固定化微生物的利用，對人類有益的運作，另一方面， 相反地亦顯示成爲引起齲齒或食品污染的原因，近年來硏 究盛行。 口腔生物被膜係由700種類以上的細菌所構成，lmg 中存在1 〇8個以上的菌。其中佔有多數（2 0 %〜4 0 %)之 Streptococci係基於藉由口腔表面之動態的細菌間活性物 質之細菌間交流，形成生物被膜。其中Streptococcus mutans(S. mutans)產生具有黏著性之菌體外多糖，扮演形 成具有病原性生物被膜的中心角色。已知口腔生物被膜係 成爲齲齒或牙周病原因，掌握此等疾病係以S. mutans爲 首之細菌之微生物感染症。 傳統的齲齒預防係藉由殺死S · m u t a n s，或抑制葡糖 基轉移酶（glucosyltransferase)等酵素，防止牙斑的形成以 抑制齲齒的想法爲主流。然而，因爲實際的齲齒病灶係藉 201225962 由覆蓋生物被膜表層之菌體外多糖妨礙抗生素、 物質或抗生素等之滲透，多不能得到預期的效果 用抗菌劑、酵素抑制劑、抗生素等常伴隨著抗藥 現的危險性。另外，雖有藉由刷牙或洗牙等機械 抑制生物被膜的方法，但對於難以如此機械性地 生物被膜之需介護高齡者等，現在的方法難以正 口腔護理。 就此等觀點，期望開發與至今不同的發想以 被膜、預防齲齒的方法。另外，對於控制口腔生 因爲期望日常習慣地繼續實施，所以利用口香糖 牙膏等口腔組成物係有效的。 作爲候補的新的口腔生物被膜去除法，可舉 聚量感應。近年來，顯示細菌相互間訊號傳遞系 機制之聚量感應（QS;細菌密度依賴性基因發生扣 係作用於S. mutans之形成生物薄膜或發生病原1 mutans之 Q S係由感受刺激多肽（C S P，C 〇 stimulating peptide)所控制。現在，以此QS爲 制生物薄膜形成或病原性發現之硏究，期待與以 爲首之開發微生物感染病之預防方法相連繫，嘗 究，但尙未達成實用化。 例如非專利文獻1揭示稱爲S . s a 1 i v a r i u s的ί mutans形成生物薄膜之要旨、及特定基因表 expression)而可控制CSP要旨。但是，導入微生 內有安全性的問題.，並且控制基因發表大多伴隨 抑制酵素 。甚至使 耐性菌出 性去除以 控制口腔 確地實踐 去除生物 物被膜， 等食品及 例如抑制 統之分子 ]制系統） 生、或S. mpetence 標的，控 口腔疾病 試各種硏 證阻礙S. i 現（gene 物於口腔 困難。因
-6- S 201225962 此，期望開發安全性更高，而且簡便的生物被膜形成阻礙 方法。 [先前技術文獻] [非專利文獻 1 ] Or al Microbiology And Immunology, 2009 24(2):pp 1 52-6 1 【發明內容】 發明之揭示 發明所欲解決之課題 傳統以來使用某種抗菌劑、酵素抑制劑或抗生物之齲 齒抑制法，因爲口腔生物被膜之菌體外多糖阻礙抗菌劑、 酵素抑制劑、抗生素等之滲透，難以顯示目標之抑制齲齒 的效果。並且，因爲使用抗菌劑、酵素抑制劑、抗生素 等，出現抗藥耐性菌的危險性高，所以並不適宜。因此， 本發明並非進行控制齲齒原因菌，而是以提供進行控制由 齲齒原因菌形成的生物被膜，而更安全且效果高之齲齒抑 制用之口腔用組成物爲目的。 課題之解決手段 本發明者等努力硏究的結果，發現藉由控制聚量感應 之組成物而可抑制生物被膜形成，因而完成本發明。 發明之功效 藉由本發明之口腔用組成物，抑制齲齒原因菌形成生 201225962 物被膜。此等口腔用組成物係可添加於飲食品、醫藥品、 潔牙劑等，安全地使用於齲齒預防治療用。 用以實施發明之最佳型態 依據非專利文獻1所記載之傳統的硏究，可知S. mu tans之聚量感應（QS)係由特定的微生物或基因表現所 控制。然而，就摻合於口香糖等食品及潔牙劑等之口腔用 組成物，進行日常習慣地控制齲齒生物被膜之觀點，於安 全或簡便性方面有許多應解決的問題，此等中任一種QS 控制方法皆尙未達成實用化。 針對於此，本發明者等努力硏究的結果，發現 S. mutans之聚量感應爲日常中可安全攝取的特定物質所控 制，因此，實現藉由控制聚量感應以抑制齲齒生物被膜的 形成。 亦即，本發明係以藉由含豆類萃取物之口腔用組成物 抑制聚量感應關連之齲齒生物被膜形成爲特徵。 依據有關本發明的口腔用組成物，因CSP依賴性之S. mutans之生物被膜形成被抑制，所以病原性細菌不能附 著於口腔內。因此，不藉由刷牙或洗牙等機械方法而可抑 制生物被膜形成。 另外，亦不發生如傳統之使用抗菌劑、酵素抑制劑或 抗生素等之齲齒抑制法，口腔生物被膜之菌體外多糖阻礙 抗菌劑、酵素抑制劑、抗生素等之滲透而難以出現抑制齲 齒的效果之問題。
S -8- 201225962 進而，因爲不使用抗菌劑、酵素抑制劑、抗生素等而 可抑制齲齒’所以可抑制對抗菌物質或抗生素之抗藥耐性 菌出現的可能性。 本發明中使用的豆類種類雖無特別的限制，但以使用 至少1種以上的豆類選自豇豆、小紅豆、紫花豆、白花 豆、黑四季豆、金時豆所萃取之萃取物爲宜。 對於本發明之得到有效成份之豆類萃取物之方法，雖 無特別限定，但藉由將前述豆類的種子或果實（豆），以適 當的粉碎方法粉碎，溶劑萃取等之方法，調製萃取物。作 爲萃取溶劑，可使用水及甲醇、乙醇、正丙醇及正丁醇等 之低級醇、醚'氯仿、乙酸乙酯、丙酮、甘油、丙二醇等 之有機溶劑中之1種或混合2種以上，但以使用熱水或親 水性有機溶劑爲宜。另外，若考慮本發明之萃取物多作爲 飲食品使用時’作爲萃取溶劑，就安全性上，以組合水及 乙醇使用爲宜。以90%以下之乙醇萃取爲宜，以60%以下 之乙醇萃取尤佳’以30%以下之乙醇萃取更好，以熱水萃 取最好。 作爲萃取條件，雖可以高溫、室溫、低溫中任—種溫 度進行萃取’但以5 0〜9 0 °C，萃取1〜5小時程度爲宜》 所得萃取物亦可過濾，餾去萃取溶劑後，於減壓下濃縮或 冷凍乾燥。並且，亦可使用將此等萃取物藉由有機溶劑、 色譜法等分離精製者。 另外’因爲本發明之口腔用組成物安全性高，所以可 摻合於例如漱口藥、牙膏、消臭噴劑等之口腔用組成物、 -9 - 201225962 或口香糖、硬糖、錠果、軟糖、巧克力、餅乾、零食等點 心、冰淇淋、冰沙、冰果等之冷果、飲料、麵包、熱餅、 乳製品、火腿、香腸等之畜肉製品類、魚板、竹輪等之魚 肉製品、熟食類、布丁、湯以及果醬等之飲食品，可日常 上使用。 作爲該摻合量，雖可依各種製造條件而改變，但相對 於口腔用組成物，以摻合豆類萃取物爲0.01重量％以上， 2.0重量％以下，進而以〇 . 〇 1重量％以上，1 · 〇重量％以下 爲宜。 因爲本發明係使用傳統以來食用物之萃取物，所以即 使口腔內或體內攝取，對於其安全性沒有問題。另外，使 口香糖等之食品或牙膏等含有而可簡便地攝取，因爲無須 如調製基因表現之複雜步驟，所以可於日常上持續而控制 生物被膜。 【實施方式】 實施例 以下係使用實施例說明關於本發明，但本發明之範圍 並不受此等實施例任何限制。 [實施例1 ] 1、調製萃取物 使用豇豆、小紅豆（大納言）、小紅豆（襟裳小紅豆）、 紫花豆、白花豆、黑四季豆、金時豆7種作爲植物樣品。
S -10- 201225962 各植物樣品係購買市售品，以粉碎機細細粉碎2 0 g 後，以200ml水，70 °C，萃取2小時。所得之萃取液係以 3 OOOrpm ’離心10分鐘，將上清液過濾後，冷凍乾燥物作 爲各植物熱水萃取物，供予實驗。 2、評估抑制生物薄膜形成之活性 2-1、形成生物薄膜 將 159 株 S. mutans UA，於 5ml 之 Brain Heart Infusi〇n(BHI)液體培養基，於37°C下嫌氣培養10小時， 以3000rpm，離心10分鐘，將所收集細菌，藉由磷酸緩 衝生理食鹽水（PBS)，調製成OD55Gnnl=0.5，將此作爲試 驗菌懸濁液。 生物被膜形成係使用96 .孔微孔細胞培養盤，進行試 驗。各孔中，添加 60μ1之植物熱水萃取物、20μ1之 CSP' 20μ1之S. mutans試驗菌懸濁液、ΙΟΟμΙ之添加 0.1%蔗糖之 Todd Hewitt Broth，於 37°C、5%C02 之條件 下’進行培養16小時，形成CSP衍生組之生物被膜。 CSP濃度係最終濃度爲1 μΜ，各樣品之熱水萃取物之濃度 係最終濃度爲lmg/ml。 比較用係不添加CSP，除此以外與前述相同條件進行 培養，形成C S P非衍生組之生物被膜。 進而，作爲對照組，對於各CSP衍生組及CSP非衍 生組，不添加樣品之熱水萃取物，除此以外與前述相同條 件進行培養。 2-2、定量生物被膜
-11 - S 201225962 對於各CSP衍生組及CSP非衍生組，去除培養後之 上清液，以PBS進行清洗各孔2次》洗淨後，於各孔中 添加0.25%之藏紅溶液，靜置15分鐘後，去除多餘的藏 紅溶液，以PBS進行清洗各孔2次。洗淨後於各孔添加 乙醇，振盪30分鐘使溶出使染色的藏紅，使用微量盤式 分析儀測定492nm的吸光度，定量生物被膜形成量。 該結果如圖1及圖2所不。 圖1係表示對於各CSP衍生組及CSP非衍生組之加 入植物萃取物進行培養組（樣品組）及對照組之生物被膜形 成量。另外，圖2係表示對於各CSP衍生組及CSP非衍 生組之以對照組之生物被膜形成量爲1 00時之樣品組之生 物被膜形成量之比例。 依據圖1，對照組中CSP衍生組亦比CSP非衍生組 之生物被膜形成量增加。認爲此增加部份係藉由以CSP 爲自誘導物（autoinducer)之聚量感應之生物被膜增加部 份。 另外，樣品組中，CSP衍生物（黑棒）的生物被膜形成 量係比對照組少，但CSP非衍生物（白棒）的生物被膜形成 量則與對照組無改變。此事亦可由圖2顯示，CSP衍生物 (黑棒）中樣品組之生物被膜形成量比對照組少（未滿 1 00%)，但C SP非衍生物（白棒）中樣品組之生物被膜形成 量則與對照組無改變（約1 00%)。由此認爲，藉由樣品組 所添加的植物萃取物，控制以 CSP爲自誘導物之S. mu tans聚量感應，生物被膜形成量未增加。
S -12- 201225962 另外，於圖1中，CSP衍生組係添加大納言小紅豆、 襟裳小紅豆、紫花豆、金時豆之熱水萃取物，進行培養時 (樣品組之cSP + )，比CSP及植物萃取物皆未添加組（對照 組之CSP-)的生物被膜形成量減少。 進而，使用實施例1調製的小紅豆萃取物，以常法調 製口香糖、硬糖、牙膏。以下係表示該配方。另外，本發 明品之範圍並不受此等任何限制。 [實施例2 ] 依據下述配方調製口香糖。 膠基材 20.0 重 砂糖 55.0 葡萄糖 15.0 水飴 9.0 香料 0.5 襟裳小紅豆熱水萃取物（實施例1) 0.5 100.0 [實施例3] 依據下述配方調製硬糖。 -13- 201225962 5 0 · 0 重量。/〇 34.0 0.5 0.5 剩餘量 100.0 5 0.0重量％ 20.0 2.0 2.0 1.0 0.1 1.0 0.01 剩餘量 100.0 砂糖 水飴 香料 大納言小紅豆熱水萃取物（實施例1 ) 水 [實施例4] 依據下述配方調製牙膏。 碳酸鈣 甘油 羧甲基纖維素 月桂基硫酸鈉 香料 糖稩 襟裳小紅豆熱水萃取物（實施例1) 雙氯苯雙胍己院（Chlorhexidine) 水 【圖式簡單說明】 [圖1]實施例1中各對照組與樣品組之csp衍生組與 CSP非衍生組之生物被膜形成量表示圖。 [圖2]實施例1中各CSP衍生組與CSP非衍生組，添 - 加植物萃取物時之生物被膜形成量變化比例表示圖。
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Claims (1)
- 201225962 七、申請專利範圍 1 · 一種用以抑制生物被膜形成之口腔用組成物，其 特徵爲摻合有控制藉由CSP(感受刺激多肽，Competence stimulating peptide)所控制之 Streptococcus mutans 之聚 量感應之物質。 2. 如申請專利範圍第1項之用以抑制生物被膜形成 之口腔用組成物，其中控制聚量感應之物質爲豆類萃取 物。 3. 如申請專利範圍第1項或第2項之用以抑制生物 被膜形成之口腔用組成物，其中豆類萃取物係至少1種以 上選自小紅豆、豇豆、白花豆、紫花豆、黑四季豆、金時 豆之豆類萃取物。 4 ·如申請專利範圍第1項或第2項之用以抑制生物 被膜形成之口腔用組成物，其中豆類萃取物係至少1種以 上選自大納言小紅豆、襟裳小紅豆、紫花豆、金時豆之豆 類萃取物。 5. 如申請專利範圍第1項或第2項之用以抑制生物 被膜形成之口腔用組成物，其係未添加抗菌劑、酵素抑制 劑及抗生素。 6. 如申請專利範圍第3項之用以抑制生物被膜形成 之口腔用組成物，其係未添加抗菌劑、酵素抑制劑及抗生 素。 7·如申請專利範圍第4項之用以抑制生物被膜形成之 口腔用組成物’其係未添加抗菌劑、酵素抑制劑及抗生素。 -15-
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| CN104622873B (zh) * | 2015-01-21 | 2016-08-24 | 四川大学 | 一种喹喔啉亚胺类化合物作为变异链球菌生物膜抑制剂的制备方法及应用 |
| KR101656875B1 (ko) * | 2015-11-13 | 2016-09-12 | 건국대학교 산학협력단 | 단풍나무 추출물, 당단풍나무 추출물 및 박태기나무 추출물을 이용한 그람음성세균 억제용 정족수 감지 억제제 |
| JP6293177B2 (ja) * | 2016-02-08 | 2018-03-14 | 株式会社ロッテ | 口腔用組成物 |
| GB201607518D0 (en) * | 2016-04-29 | 2016-06-15 | Andalay Technologies Ltd | Mouthwash composition |
| CN112971137A (zh) * | 2019-12-13 | 2021-06-18 | 黔东南苗族侗族自治州农业科学院 | 一种黑芸豆提取物的提取方法 |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4217341A (en) * | 1977-12-07 | 1980-08-12 | The University of Louisville | Composition and method for inhibiting the adherence of dental plaque-producing bacteria to smooth surfaces |
| JPH04124124A (ja) * | 1990-09-13 | 1992-04-24 | Morishita Jintan Kk | 口腔用組成物 |
| JP3112794B2 (ja) * | 1994-02-28 | 2000-11-27 | 明治製菓株式会社 | 歯垢形成抑制剤 |
| JP2795812B2 (ja) * | 1994-09-13 | 1998-09-10 | 敷島製パン株式会社 | 抗う蝕性剤の製造方法及び該製造方法により得られる抗う蝕剤 |
| AU3868297A (en) * | 1996-08-27 | 1998-03-19 | San-Ei Gen F.F.I., Inc. | Novel use of native gellan gum |
| US7087228B2 (en) * | 2002-07-03 | 2006-08-08 | University Of Southern California | Preventing tooth decay and infective endocarditis using natural oligopeptides |
| JP2005060297A (ja) * | 2003-08-12 | 2005-03-10 | Hiroshige Himawari | ササゲ赤褐色色素とその製造方法及びアポトーシス誘導物質 |
| JP5552725B2 (ja) * | 2007-12-27 | 2014-07-16 | ライオン株式会社 | 口腔用組成物及び口腔バイオフィルム殺菌剤 |
| JP5653002B2 (ja) * | 2008-04-07 | 2015-01-14 | 花王株式会社 | Ａｉ−２阻害剤 |
| JP2010077028A (ja) * | 2008-09-24 | 2010-04-08 | Iwate Prefecture | 齲蝕予防のための食品及び口腔ケア剤組成物 |
| WO2010050369A1 (ja) * | 2008-10-31 | 2010-05-06 | 国立大学法人岡山大学 | 虫歯予防剤 |
| JP5238557B2 (ja) | 2009-03-11 | 2013-07-17 | 三菱製紙株式会社 | 洗浄液 |
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2010
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2011
- 2011-09-07 CN CN2011800452431A patent/CN103140242A/zh active Pending
- 2011-09-07 KR KR1020137009167A patent/KR20130106837A/ko not_active Ceased
- 2011-09-07 WO PCT/JP2011/005002 patent/WO2012039101A1/ja not_active Ceased
- 2011-09-07 BR BR112013006654A patent/BR112013006654A2/pt not_active IP Right Cessation
- 2011-09-07 KR KR1020187014451A patent/KR102015237B1/ko active Active
- 2011-09-07 EP EP11826552.9A patent/EP2620160A4/en not_active Withdrawn
- 2011-09-07 PH PH1/2013/500527A patent/PH12013500527A1/en unknown
- 2011-09-07 US US13/824,364 patent/US20130189202A1/en not_active Abandoned
- 2011-09-16 TW TW100133446A patent/TW201225962A/zh unknown
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|---|---|
| EP2620160A4 (en) | 2014-05-07 |
| JP2012067018A (ja) | 2012-04-05 |
| WO2012039101A1 (ja) | 2012-03-29 |
| KR102015237B1 (ko) | 2019-08-27 |
| PH12013500527A1 (en) | 2017-08-09 |
| JP5906011B2 (ja) | 2016-04-20 |
| EP2620160A1 (en) | 2013-07-31 |
| CN103140242A (zh) | 2013-06-05 |
| US20130189202A1 (en) | 2013-07-25 |
| KR20130106837A (ko) | 2013-09-30 |
| KR20180057739A (ko) | 2018-05-30 |
| BR112013006654A2 (pt) | 2016-06-07 |
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