TW201425312A - 經取代１，６－□啶 - Google Patents

經取代１，６－□啶 Download PDF

Info

Publication number: TW201425312A
Authority: TW; Taiwan
Prior art keywords: carboxamide; pyridyl; pyridin; chlorophenyl; phenyl
Prior art date: 2012-11-20

Application number

TW102141946A

Other languages

English (en)

Chinese (zh)

Inventor

Simona M Ceccarelli

Ravi Jagasia

Roland Jakob-Roetne

Rainer E Martin

Jens-Uwe Peters

Juergen Wichmann

Original Assignee

Hoffmann La Roche

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2012-11-20

Filing date

2013-11-18

Publication date

2014-07-01

2013-11-18 Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche

2014-07-01 Publication of TW201425312A publication Critical patent/TW201425312A/zh

Links

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Classifications

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- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
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- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/4375—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having nitrogen as a ring heteroatom, e.g. quinolizines, naphthyridines, berberine, vincamine
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- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/444—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
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- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
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- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
- A—HUMAN NECESSITIES
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Animal Behavior & Ethology (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
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Pharmacology & Pharmacy (AREA)
Organic Chemistry (AREA)
Epidemiology (AREA)
Bioinformatics & Cheminformatics (AREA)
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Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
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TW102141946A 2012-11-20 2013-11-18 經取代１，６－□啶 TW201425312A (zh)

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US (1)	US9657014B2 (2)
EP (1)	EP2922540A1 (2)
JP (1)	JP2016505534A (2)
KR (1)	KR20150085538A (2)
CN (1)	CN104812387A (2)
AR (1)	AR093519A1 (2)
BR (1)	BR112015011094A2 (2)
CA (1)	CA2890685A1 (2)
HK (1)	HK1207317A1 (2)
MX (1)	MX2015006364A (2)
RU (1)	RU2015120217A (2)
TW (1)	TW201425312A (2)
WO (1)	WO2014079787A1 (2)

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EP3256217A1 (en) *	2015-02-11	2017-12-20	Basilea Pharmaceutica International AG	Substituted mono- and polyazanaphthalene derivatives and their use
AU2016236669B2 (en)	2015-03-24	2018-11-08	Shanghai Yingli Pharmaceutical Co., Ltd	Condensed ring derivative, and preparation method, intermediate, pharmaceutical composition and use thereof
BR112018008630A2 (pt) *	2015-11-06	2018-10-30	Neurocrine Biosciences Inc	derivados de n-[2-(1-benzilpiperidin-4-il)etil]-4-(pirazin-2-il)-piperazina-1-carboxamida, seus usos, composição farmacêutica
EA039638B1 (ru) *	2016-01-06	2022-02-21	Нейрокрин Байосайенсиз, Инк.	Антагонисты мускаринового рецептора 4 и способы их применения
EP3591040A4 (en)	2017-03-03	2020-11-11	Kyoto University	METHOD OF PRODUCTION OF PANCREATIC PROGENITOR CELLS
BR112021012950A2 (pt)	2019-01-03	2021-09-14	University Of Pittsburgh - Of The Commonwealth System Of Higher Education	Métodos e materiais para aumentar os níveis de polipeptídeo do fator de transcrição eb
US12486250B2 (en)	2019-12-06	2025-12-02	Neurocrine Biosciences, Inc.	Muscarinic receptor 4 antagonists and methods of use
JP2024508761A (ja) *	2020-12-18	2024-02-28	ザスクリプスリサーチインスティテュート	神経変性、変性及び代謝性障害の処置のための化合物並びにその使用
WO2025252732A1 (en) *	2024-06-04	2025-12-11	Syngenta Crop Protection Ag	Nitrogen-containing 6-membered bicyclic derivatives with microbiocidal activity

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CN1283995A (zh) *	1997-12-11	2001-02-14	生化制药有限公司	抗病毒化合物
AU2002218902A1 (en)	2000-12-27	2002-07-08	Shire Biochem Inc.	Macrocyclic anti-viral compounds
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2013
- 2013-11-18 CN CN201380060294.0A patent/CN104812387A/zh active Pending
- 2013-11-18 TW TW102141946A patent/TW201425312A/zh unknown
- 2013-11-18 KR KR1020157016208A patent/KR20150085538A/ko not_active Ceased
- 2013-11-18 MX MX2015006364A patent/MX2015006364A/es unknown
- 2013-11-18 CA CA2890685A patent/CA2890685A1/en not_active Abandoned
- 2013-11-18 EP EP13795705.6A patent/EP2922540A1/en not_active Withdrawn
- 2013-11-18 RU RU2015120217A patent/RU2015120217A/ru not_active Application Discontinuation
- 2013-11-18 BR BR112015011094A patent/BR112015011094A2/pt not_active IP Right Cessation
- 2013-11-18 JP JP2015543399A patent/JP2016505534A/ja active Pending
- 2013-11-18 WO PCT/EP2013/074012 patent/WO2014079787A1/en not_active Ceased
- 2013-11-18 HK HK15108069.2A patent/HK1207317A1/xx unknown
- 2013-11-18 AR ARP130104234A patent/AR093519A1/es unknown
2015
- 2015-05-20 US US14/717,109 patent/US9657014B2/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
CA2890685A1 (en)	2014-05-30
US9657014B2 (en)	2017-05-23
JP2016505534A (ja)	2016-02-25
AR093519A1 (es)	2015-06-10
US20150252044A1 (en)	2015-09-10
RU2015120217A (ru)	2017-01-10
KR20150085538A (ko)	2015-07-23
MX2015006364A (es)	2015-10-05
CN104812387A (zh)	2015-07-29
WO2014079787A1 (en)	2014-05-30
EP2922540A1 (en)	2015-09-30
BR112015011094A2 (pt)	2017-07-11
HK1207317A1 (en)	2016-01-29

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