TW201613564A - Process for the preparation of sustained-release microparticles having a controllable release profile - Google Patents

Process for the preparation of sustained-release microparticles having a controllable release profile

Info

Publication number
TW201613564A
TW201613564A TW104125559A TW104125559A TW201613564A TW 201613564 A TW201613564 A TW 201613564A TW 104125559 A TW104125559 A TW 104125559A TW 104125559 A TW104125559 A TW 104125559A TW 201613564 A TW201613564 A TW 201613564A
Authority
TW
Taiwan
Prior art keywords
microparticles
release
preparation
sustained
controllable
Prior art date
Application number
TW104125559A
Other languages
Chinese (zh)
Inventor
Yu-Fang Hu
Shih-Hwa Tsai
Cheng-Wei Cheng
Chan-Jung Li
Shih-Feng Peng
Original Assignee
Tty Biopharm Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Tty Biopharm Co Ltd filed Critical Tty Biopharm Co Ltd
Publication of TW201613564A publication Critical patent/TW201613564A/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1682—Processes
    • A61K9/1694—Processes resulting in granules or microspheres of the matrix type containing more than 5% of excipient
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1635—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1641—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
    • A61K9/1647—Polyesters, e.g. poly(lactide-co-glycolide)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia

Landscapes

  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Psychiatry (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Preparation (AREA)

Abstract

Disclosed is a method for preparing biocompatible, biodegradable microparticles having a controllable release profile for release of a biologically active agent contained in the microparticles. By adjusting the time period of treating the microparticles with a conditioning solvent during the preparation of the microparticles, the release profile for release of the biologically active agent can be controlled.
TW104125559A 2014-08-06 2015-08-05 Process for the preparation of sustained-release microparticles having a controllable release profile TW201613564A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201462033670P 2014-08-06 2014-08-06

Publications (1)

Publication Number Publication Date
TW201613564A true TW201613564A (en) 2016-04-16

Family

ID=55263167

Family Applications (1)

Application Number Title Priority Date Filing Date
TW104125559A TW201613564A (en) 2014-08-06 2015-08-05 Process for the preparation of sustained-release microparticles having a controllable release profile

Country Status (2)

Country Link
TW (1) TW201613564A (en)
WO (1) WO2016019881A1 (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN113230989A (en) * 2021-04-23 2021-08-10 浙江圣兆药物科技股份有限公司 Microsphere preparation system capable of simultaneously adjusting particle size and release of microspheres

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3348268A4 (en) * 2015-09-07 2019-04-10 Nipro Corporation Risperidone-containing microcapsule, method for manufacturing same and release control method
EP4125823A1 (en) 2020-03-30 2023-02-08 Biological E Limited Risperidone microspheres, process for their prepartion and uses thereof
CN111973561B (en) * 2020-08-31 2022-06-07 常州药物研究所有限公司 Method for removing organic solvent residue in polymer microsphere solvent

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1074923C (en) * 1993-11-19 2001-11-21 詹森药业有限公司 Microencapsulated 3-piperidinyl-substituted 1,2-benzisoxazoles and 1,2-benzisothiazoles

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN113230989A (en) * 2021-04-23 2021-08-10 浙江圣兆药物科技股份有限公司 Microsphere preparation system capable of simultaneously adjusting particle size and release of microspheres

Also Published As

Publication number Publication date
WO2016019881A1 (en) 2016-02-11

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