TW201716067A - 含有環狀二胜肽之抗肥胖用組成物 - Google Patents

含有環狀二胜肽之抗肥胖用組成物 Download PDF

Info

Publication number: TW201716067A
Authority: TW; Taiwan
Prior art keywords: cyclo; gly; cycloglycine; pro; obesity
Prior art date: 2015-07-17

Application number

TW105122441A

Other languages

English (en)

Chinese (zh)

Inventor

Norimasa Kanegawa

Kenji Yamamoto

Hitoshi Onuki

Shota Nonaka

Original Assignee

Suntory Holdings Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2015-07-17

Filing date

2016-07-15

Publication date

2017-05-16

2016-07-15 Application filed by Suntory Holdings Ltd filed Critical Suntory Holdings Ltd

2017-05-16 Publication of TW201716067A publication Critical patent/TW201716067A/zh

Links

125000004122 cyclic group Chemical group 0.000 title claims abstract description 115
108010016626 Dipeptides Proteins 0.000 title claims abstract description 107
239000000203 mixture Substances 0.000 title claims abstract description 91
230000003579 anti-obesity Effects 0.000 title claims abstract description 75
208000008589 Obesity Diseases 0.000 claims abstract description 61
235000020824 obesity Nutrition 0.000 claims abstract description 61
150000003839 salts Chemical class 0.000 claims abstract description 60
230000000694 effects Effects 0.000 claims abstract description 44
238000009825 accumulation Methods 0.000 claims abstract description 33
210000000577 adipose tissue Anatomy 0.000 claims abstract description 30
238000000034 method Methods 0.000 claims abstract description 30
230000001737 promoting effect Effects 0.000 claims abstract description 20
238000000354 decomposition reaction Methods 0.000 claims abstract description 18
210000001596 intra-abdominal fat Anatomy 0.000 claims abstract description 18
238000005265 energy consumption Methods 0.000 claims abstract description 17
235000019786 weight gain Nutrition 0.000 claims abstract description 15
239000002253 acid Substances 0.000 claims description 46
239000004475 Arginine Substances 0.000 claims description 39
ODKSFYDXXFIFQN-UHFFFAOYSA-N arginine Natural products OC(=O)C(N)CCCNC(N)=N ODKSFYDXXFIFQN-UHFFFAOYSA-N 0.000 claims description 39
WHUUTDBJXJRKMK-UHFFFAOYSA-N Glutamic acid Natural products OC(=O)C(N)CCC(O)=O WHUUTDBJXJRKMK-UHFFFAOYSA-N 0.000 claims description 35
235000013922 glutamic acid Nutrition 0.000 claims description 33
239000004220 glutamic acid Substances 0.000 claims description 33
BKASXWPLSXFART-UHFFFAOYSA-N 1,2,3,5a,6,7,8,10a-octahydrodipyrrolo[1,2-c:1',2'-f]pyrazine-5,10-dione Chemical compound O=C1C2CCCN2C(=O)C2CCCN12 BKASXWPLSXFART-UHFFFAOYSA-N 0.000 claims description 30
CWERGRDVMFNCDR-UHFFFAOYSA-N thioglycolic acid Chemical compound OC(=O)CS CWERGRDVMFNCDR-UHFFFAOYSA-N 0.000 claims description 30
WSLYCILIEOFQPK-UHFFFAOYSA-N 3-methyl-2,3,6,7,8,8a-hexahydropyrrolo[1,2-a]pyrazine-1,4-dione Chemical compound O=C1C(C)NC(=O)C2CCCN21 WSLYCILIEOFQPK-UHFFFAOYSA-N 0.000 claims description 28
-1 Cyclopropylamine-Alanine Chemical compound 0.000 claims description 27
230000002401 inhibitory effect Effects 0.000 claims description 25
VPZXBVLAVMBEQI-VKHMYHEASA-N Glycyl-alanine Chemical compound OC(=O)[C@H](C)NC(=O)CN VPZXBVLAVMBEQI-VKHMYHEASA-N 0.000 claims description 22
KDXKERNSBIXSRK-UHFFFAOYSA-N Lysine Natural products NCCCCC(N)C(O)=O KDXKERNSBIXSRK-UHFFFAOYSA-N 0.000 claims description 19
239000004472 Lysine Substances 0.000 claims description 19
235000001014 amino acid Nutrition 0.000 claims description 19
ZJQXGJBINIMBOY-UHNVWZDZSA-N Gly-Hyp Chemical compound NCC(=O)N1C[C@H](O)C[C@H]1C(O)=O ZJQXGJBINIMBOY-UHNVWZDZSA-N 0.000 claims description 17
108010079596 glycyl-4-hydroxyproline Proteins 0.000 claims description 17
HTJDQJBWANPRPF-UHFFFAOYSA-N Cyclopropylamine Chemical compound NC1CC1 HTJDQJBWANPRPF-UHFFFAOYSA-N 0.000 claims description 16
239000004480 active ingredient Substances 0.000 claims description 16
150000003573 thiols Chemical class 0.000 claims description 16
FYFJTCMGWLBLPG-LURJTMIESA-N (3s)-3-(1h-imidazol-5-ylmethyl)piperazine-2,5-dione Chemical compound N1C(=O)CNC(=O)[C@@H]1CC1=CN=CN1 FYFJTCMGWLBLPG-LURJTMIESA-N 0.000 claims description 15
OWOHLURDBZHNGG-YFKPBYRVSA-N (8ar)-hexahydropyrrolo[1,2-a]pyrazine-1,4-dione Chemical compound O=C1CNC(=O)[C@@H]2CCCN12 OWOHLURDBZHNGG-YFKPBYRVSA-N 0.000 claims description 15
150000001413 amino acids Chemical class 0.000 claims description 15
108010001140 cyclo(glycylprolyl) Proteins 0.000 claims description 15
108010023968 cyclo(prolylprolyl) Proteins 0.000 claims description 15
VQFHWKRNHGHZTK-LURJTMIESA-N (3s)-3-(2-methylpropyl)piperazine-2,5-dione Chemical compound CC(C)C[C@@H]1NC(=O)CNC1=O VQFHWKRNHGHZTK-LURJTMIESA-N 0.000 claims description 14
QHLSAVHDWSYPEP-VIFPVBQESA-N (3s)-3-[(4-hydroxyphenyl)methyl]piperazine-2,5-dione Chemical compound C1=CC(O)=CC=C1C[C@H]1C(=O)NCC(=O)N1 QHLSAVHDWSYPEP-VIFPVBQESA-N 0.000 claims description 14
UZOJHXFWJFSFAI-VIFPVBQESA-N (3s)-3-benzylpiperazine-2,5-dione Chemical compound N1C(=O)CNC(=O)[C@@H]1CC1=CC=CC=C1 UZOJHXFWJFSFAI-VIFPVBQESA-N 0.000 claims description 14
STTIAONCINEOLF-VKHMYHEASA-N 2-[(2s)-3,6-dioxopiperazin-2-yl]acetic acid Chemical compound OC(=O)C[C@@H]1NC(=O)CNC1=O STTIAONCINEOLF-VKHMYHEASA-N 0.000 claims description 14
SITWEMZOJNKJCH-WDSKDSINSA-N Ala-Arg Chemical compound C[C@H](N)C(=O)N[C@H](C(O)=O)CCCN=C(N)N SITWEMZOJNKJCH-WDSKDSINSA-N 0.000 claims description 14
JZDHUJAFXGNDSB-WHFBIAKZSA-N Glu-Ala Chemical compound OC(=O)[C@H](C)NC(=O)[C@@H](N)CCC(O)=O JZDHUJAFXGNDSB-WHFBIAKZSA-N 0.000 claims description 14
SITWEMZOJNKJCH-UHFFFAOYSA-N L-alanine-L-arginine Natural products CC(N)C(=O)NC(C(O)=O)CCCNC(N)=N SITWEMZOJNKJCH-UHFFFAOYSA-N 0.000 claims description 14
RVQDZELMXZRSSI-IUCAKERBSA-N Pro-Lys Chemical compound NCCCC[C@@H](C(O)=O)NC(=O)[C@@H]1CCCN1 RVQDZELMXZRSSI-IUCAKERBSA-N 0.000 claims description 14
UZOJHXFWJFSFAI-SECBINFHSA-N cyclic glycylphenylalanine Natural products N1C(=O)CNC(=O)[C@H]1CC1=CC=CC=C1 UZOJHXFWJFSFAI-SECBINFHSA-N 0.000 claims description 14
108010021250 cyclo(leucylglycine) Proteins 0.000 claims description 14
QHLSAVHDWSYPEP-UHFFFAOYSA-N cyclo-Gly-L-Tyr Natural products C1=CC(O)=CC=C1CC1C(=O)NCC(=O)N1 QHLSAVHDWSYPEP-UHFFFAOYSA-N 0.000 claims description 14
108010049041 glutamylalanine Proteins 0.000 claims description 14
108010037850 glycylvaline Proteins 0.000 claims description 14
STKYPAFSDFAEPH-LURJTMIESA-N glycylvaline Chemical compound CC(C)[C@@H](C(O)=O)NC(=O)CN STKYPAFSDFAEPH-LURJTMIESA-N 0.000 claims description 14
230000005764 inhibitory process Effects 0.000 claims description 14
BXRNXXXXHLBUKK-UHFFFAOYSA-N piperazine-2,5-dione Chemical compound O=C1CNC(=O)CN1 BXRNXXXXHLBUKK-UHFFFAOYSA-N 0.000 claims description 14
MOWMPSYJSYTSSM-VKHMYHEASA-N (3s)-3-(hydroxymethyl)piperazine-2,5-dione Chemical compound OC[C@@H]1NC(=O)CNC1=O MOWMPSYJSYTSSM-VKHMYHEASA-N 0.000 claims description 13
WFLSPLQAZRBQJX-BYPYZUCNSA-N 3-[(2s)-3,6-dioxopiperazin-2-yl]propanoic acid Chemical compound OC(=O)CC[C@@H]1NC(=O)CNC1=O WFLSPLQAZRBQJX-BYPYZUCNSA-N 0.000 claims description 13
NDCKGUDRHBPJAQ-WDSKDSINSA-N 3-[(2s,5s)-5-(2-carboxyethyl)-3,6-dioxopiperazin-2-yl]propanoic acid Chemical compound OC(=O)CC[C@@H]1NC(=O)[C@H](CCC(O)=O)NC1=O NDCKGUDRHBPJAQ-WDSKDSINSA-N 0.000 claims description 13
DAQIJMOLTMGJLO-YUMQZZPRSA-N Arg-Val Chemical compound CC(C)[C@@H](C(O)=O)NC(=O)[C@@H](N)CCCNC(N)=N DAQIJMOLTMGJLO-YUMQZZPRSA-N 0.000 claims description 13
IKAIKUBBJHFNBZ-LURJTMIESA-N Gly-Lys Chemical compound NCCCC[C@@H](C(O)=O)NC(=O)CN IKAIKUBBJHFNBZ-LURJTMIESA-N 0.000 claims description 13
PFMUCCYYAAFKTH-YFKPBYRVSA-N Gly-Met Chemical compound CSCC[C@@H](C(O)=O)NC(=O)CN PFMUCCYYAAFKTH-YFKPBYRVSA-N 0.000 claims description 13
QLROSWPKSBORFJ-BQBZGAKWSA-N L-Prolyl-L-glutamic acid Chemical compound OC(=O)CC[C@@H](C(O)=O)NC(=O)[C@@H]1CCCN1 QLROSWPKSBORFJ-BQBZGAKWSA-N 0.000 claims description 13
108010079364 N-glycylalanine Proteins 0.000 claims description 13
108010036533 arginylvaline Proteins 0.000 claims description 13
108010014087 cyclo(prolylarginyl) Proteins 0.000 claims description 13
VPZXBVLAVMBEQI-UHFFFAOYSA-N glycyl-DL-alpha-alanine Natural products OC(=O)C(C)NC(=O)CN VPZXBVLAVMBEQI-UHFFFAOYSA-N 0.000 claims description 13
108010015792 glycyllysine Proteins 0.000 claims description 13
108010070643 prolylglutamic acid Proteins 0.000 claims description 13
WWISPHBAYBECQZ-IMJSIDKUSA-N (3s,6s)-3,6-dimethylpiperazine-2,5-dione Chemical compound C[C@@H]1NC(=O)[C@H](C)NC1=O WWISPHBAYBECQZ-IMJSIDKUSA-N 0.000 claims description 12
KGVHCTWYMPWEGN-FSPLSTOPSA-N Gly-Ile Chemical compound CC[C@H](C)[C@@H](C(O)=O)NC(=O)CN KGVHCTWYMPWEGN-FSPLSTOPSA-N 0.000 claims description 12
OLIFSFOFKGKIRH-WUJLRWPWSA-N Gly-Thr Chemical compound C[C@@H](O)[C@@H](C(O)=O)NC(=O)CN OLIFSFOFKGKIRH-WUJLRWPWSA-N 0.000 claims description 12
108010015607 cyclo(alanylalanyl) Proteins 0.000 claims description 12
WWISPHBAYBECQZ-UHFFFAOYSA-N cyclo-L-Ala-L-Ala Natural products CC1NC(=O)C(C)NC1=O WWISPHBAYBECQZ-UHFFFAOYSA-N 0.000 claims description 12
230000014509 gene expression Effects 0.000 claims description 12
108010089804 glycyl-threonine Proteins 0.000 claims description 12
230000006872 improvement Effects 0.000 claims description 12
230000002265 prevention Effects 0.000 claims description 12
DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 claims description 11
COLNVLDHVKWLRT-QMMMGPOBSA-N L-phenylalanine Chemical compound OC(=O)[C@@H](N)CC1=CC=CC=C1 COLNVLDHVKWLRT-QMMMGPOBSA-N 0.000 claims description 11
ONPXCLZMBSJLSP-CSMHCCOUSA-N Pro-Hyp Chemical compound C1[C@H](O)C[C@@H](C(O)=O)N1C(=O)[C@H]1NCCC1 ONPXCLZMBSJLSP-CSMHCCOUSA-N 0.000 claims description 11
COLNVLDHVKWLRT-UHFFFAOYSA-N phenylalanine Natural products OC(=O)C(N)CC1=CC=CC=C1 COLNVLDHVKWLRT-UHFFFAOYSA-N 0.000 claims description 11
125000003396 thiol group Chemical group [H]S* 0.000 claims description 11
239000000470 constituent Substances 0.000 claims description 10
WGYKZJWCGVVSQN-UHFFFAOYSA-N propylamine Chemical compound CCCN WGYKZJWCGVVSQN-UHFFFAOYSA-N 0.000 claims description 10
230000004584 weight gain Effects 0.000 claims description 10
PMMYEEVYMWASQN-DMTCNVIQSA-N Hydroxyproline Chemical compound O[C@H]1CN[C@H](C(O)=O)C1 PMMYEEVYMWASQN-DMTCNVIQSA-N 0.000 claims description 9
102000004316 Oxidoreductases Human genes 0.000 claims description 8
108090000854 Oxidoreductases Proteins 0.000 claims description 8
229960004397 cyclophosphamide Drugs 0.000 claims description 8
PMMYEEVYMWASQN-UHFFFAOYSA-N dl-hydroxyproline Natural products OC1C[NH2+]C(C([O-])=O)C1 PMMYEEVYMWASQN-UHFFFAOYSA-N 0.000 claims description 8
229960002591 hydroxyproline Drugs 0.000 claims description 8
PFNFFQXMRSDOHW-UHFFFAOYSA-N spermine Chemical compound NCCCNCCCCNCCCN PFNFFQXMRSDOHW-UHFFFAOYSA-N 0.000 claims description 8
FGMPLJWBKKVCDB-UHFFFAOYSA-N trans-L-hydroxy-proline Natural products ON1CCCC1C(O)=O FGMPLJWBKKVCDB-UHFFFAOYSA-N 0.000 claims description 8
239000004471 Glycine Substances 0.000 claims description 7
PHIQHXFUZVPYII-ZCFIWIBFSA-N (R)-carnitine Chemical compound C[N+](C)(C)C[C@H](O)CC([O-])=O PHIQHXFUZVPYII-ZCFIWIBFSA-N 0.000 claims description 6
SFZULDYEOVSIKM-UHFFFAOYSA-N chembl321317 Chemical compound C1=CC(C(=N)NO)=CC=C1C1=CC=C(C=2C=CC(=CC=2)C(=N)NO)O1 SFZULDYEOVSIKM-UHFFFAOYSA-N 0.000 claims description 6
TXGVDTJWMZUNMP-UHFFFAOYSA-N cyclodecanamine Chemical compound NC1CCCCCCCCC1 TXGVDTJWMZUNMP-UHFFFAOYSA-N 0.000 claims description 6
150000002576 ketones Chemical class 0.000 claims description 6
101710088194 Dehydrogenase Proteins 0.000 claims description 5
OUYCCCASQSFEME-UHFFFAOYSA-N tyrosine Natural products OC(=O)C(N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-UHFFFAOYSA-N 0.000 claims description 5
QXGJCWSBOZXWOV-UHFFFAOYSA-N 3,4-dihydroxyphthalic acid Chemical compound OC(=O)C1=CC=C(O)C(O)=C1C(O)=O QXGJCWSBOZXWOV-UHFFFAOYSA-N 0.000 claims description 4
CMSMOCZEIVJLDB-UHFFFAOYSA-N Cyclophosphamide Chemical compound ClCCN(CCCl)P1(=O)NCCCO1 CMSMOCZEIVJLDB-UHFFFAOYSA-N 0.000 claims description 4
FFEARJCKVFRZRR-BYPYZUCNSA-N L-methionine Chemical compound CSCC[C@H](N)C(O)=O FFEARJCKVFRZRR-BYPYZUCNSA-N 0.000 claims description 4
XIGOXAVTSJEKFW-NXMISADUSA-N N[C@@H](CCCCN)C(=O)O.C1(CCCCCCCCC1)N[C@@H](CCCCN)C(=O)O Chemical compound N[C@@H](CCCCN)C(=O)O.C1(CCCCCCCCC1)N[C@@H](CCCCN)C(=O)O XIGOXAVTSJEKFW-NXMISADUSA-N 0.000 claims description 4
230000009471 action Effects 0.000 claims description 4
ZDXPYRJPNDTMRX-UHFFFAOYSA-N glutamine Natural products OC(=O)C(N)CCC(N)=O ZDXPYRJPNDTMRX-UHFFFAOYSA-N 0.000 claims description 4
125000002887 hydroxy group Chemical group [H]O* 0.000 claims description 4
229930182817 methionine Natural products 0.000 claims description 4
XNGIFLGASWRNHJ-UHFFFAOYSA-N phthalic acid Chemical compound OC(=O)C1=CC=CC=C1C(O)=O XNGIFLGASWRNHJ-UHFFFAOYSA-N 0.000 claims description 4
229940063675 spermine Drugs 0.000 claims description 4
CUQGPVWDPNMQEZ-ZDUSSCGKSA-N (2s)-2-(decylamino)pentanedioic acid Chemical compound CCCCCCCCCCN[C@H](C(O)=O)CCC(O)=O CUQGPVWDPNMQEZ-ZDUSSCGKSA-N 0.000 claims description 3
230000004060 metabolic process Effects 0.000 claims description 3
229940071127 thioglycolate Drugs 0.000 claims description 2
CWERGRDVMFNCDR-UHFFFAOYSA-M thioglycolate(1-) Chemical compound [O-]C(=O)CS CWERGRDVMFNCDR-UHFFFAOYSA-M 0.000 claims description 2
229940024606 amino acid Drugs 0.000 claims 4
MPZWMIIOPAPAKE-BQBZGAKWSA-N Glu-Arg Chemical compound OC(=O)CC[C@H](N)C(=O)N[C@H](C(O)=O)CCCNC(N)=N MPZWMIIOPAPAKE-BQBZGAKWSA-N 0.000 claims 3
KWTSXDURSIMDCE-QMMMGPOBSA-N (S)-amphetamine Chemical compound C[C@H](N)CC1=CC=CC=C1 KWTSXDURSIMDCE-QMMMGPOBSA-N 0.000 claims 1
JRHWHSJDIILJAT-UHFFFAOYSA-N 2-hydroxypentanoic acid Chemical compound CCCC(O)C(O)=O JRHWHSJDIILJAT-UHFFFAOYSA-N 0.000 claims 1
125000000217 alkyl group Chemical group 0.000 claims 1
229940025084 amphetamine Drugs 0.000 claims 1
239000000883 anti-obesity agent Substances 0.000 claims 1
229940125710 antiobesity agent Drugs 0.000 claims 1
229940009098 aspartate Drugs 0.000 claims 1
230000037396 body weight Effects 0.000 abstract description 11
239000000463 material Substances 0.000 abstract description 5
108090000765 processed proteins & peptides Proteins 0.000 description 43
241001465754 Metazoa Species 0.000 description 17
238000010438 heat treatment Methods 0.000 description 16
241000196324 Embryophyta Species 0.000 description 13
108090000623 proteins and genes Proteins 0.000 description 13
239000000047 product Substances 0.000 description 12
102000004190 Enzymes Human genes 0.000 description 11
108090000790 Enzymes Proteins 0.000 description 11
244000269722 Thea sinensis Species 0.000 description 10
235000013616 tea Nutrition 0.000 description 10
GXCLVBGFBYZDAG-UHFFFAOYSA-N N-[2-(1H-indol-3-yl)ethyl]-N-methylprop-2-en-1-amine Chemical compound CN(CCC1=CNC2=C1C=CC=C2)CC=C GXCLVBGFBYZDAG-UHFFFAOYSA-N 0.000 description 9
235000013305 food Nutrition 0.000 description 9
210000002826 placenta Anatomy 0.000 description 9
108010035532 Collagen Proteins 0.000 description 8
102000008186 Collagen Human genes 0.000 description 8
229920001436 collagen Polymers 0.000 description 8
238000007254 oxidation reaction Methods 0.000 description 8
235000018102 proteins Nutrition 0.000 description 8
102000004169 proteins and genes Human genes 0.000 description 8
102100027943 Carnitine O-palmitoyltransferase 1, liver isoform Human genes 0.000 description 7
101710120614 Carnitine O-palmitoyltransferase 1, liver isoform Proteins 0.000 description 7
239000003795 chemical substances by application Substances 0.000 description 7
230000037406 food intake Effects 0.000 description 7
CKLJMWTZIZZHCS-REOHCLBHSA-N L-aspartic acid Chemical compound OC(=O)[C@@H](N)CC(O)=O CKLJMWTZIZZHCS-REOHCLBHSA-N 0.000 description 6
150000001412 amines Chemical class 0.000 description 6
235000003704 aspartic acid Nutrition 0.000 description 6
OQFSQFPPLPISGP-UHFFFAOYSA-N beta-carboxyaspartic acid Natural products OC(=O)C(N)C(C(O)=O)C(O)=O OQFSQFPPLPISGP-UHFFFAOYSA-N 0.000 description 6
YPHMISFOHDHNIV-FSZOTQKASA-N cycloheximide Chemical compound C1[C@@H](C)C[C@H](C)C(=O)[C@@H]1[C@H](O)CC1CC(=O)NC(=O)C1 YPHMISFOHDHNIV-FSZOTQKASA-N 0.000 description 6
150000002632 lipids Chemical class 0.000 description 6
230000001225 therapeutic effect Effects 0.000 description 6
108091032973 (ribonucleotides)n+m Proteins 0.000 description 5
244000068988 Glycine max Species 0.000 description 5
235000010469 Glycine max Nutrition 0.000 description 5
OAKJQQAXSVQMHS-UHFFFAOYSA-N Hydrazine Chemical compound NN OAKJQQAXSVQMHS-UHFFFAOYSA-N 0.000 description 5
241000699670 Mus sp. Species 0.000 description 5
238000002156 mixing Methods 0.000 description 5
239000002994 raw material Substances 0.000 description 5
238000012360 testing method Methods 0.000 description 5
108010001058 Acyl-CoA Dehydrogenase Proteins 0.000 description 4
102000002735 Acyl-CoA Dehydrogenase Human genes 0.000 description 4
CURLTUGMZLYLDI-UHFFFAOYSA-N Carbon dioxide Chemical compound O=C=O CURLTUGMZLYLDI-UHFFFAOYSA-N 0.000 description 4
OUYCCCASQSFEME-QMMMGPOBSA-N L-tyrosine Chemical compound OC(=O)[C@@H](N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-QMMMGPOBSA-N 0.000 description 4
239000002537 cosmetic Substances 0.000 description 4
238000000605 extraction Methods 0.000 description 4
235000013402 health food Nutrition 0.000 description 4
210000004185 liver Anatomy 0.000 description 4
239000002609 medium Substances 0.000 description 4
108020004999 messenger RNA Proteins 0.000 description 4
235000013336 milk Nutrition 0.000 description 4
239000008267 milk Substances 0.000 description 4
210000004080 milk Anatomy 0.000 description 4
239000000843 powder Substances 0.000 description 4
UFTFJSFQGQCHQW-UHFFFAOYSA-N triformin Chemical compound O=COCC(OC=O)COC=O UFTFJSFQGQCHQW-UHFFFAOYSA-N 0.000 description 4
240000005979 Hordeum vulgare Species 0.000 description 3
235000007340 Hordeum vulgare Nutrition 0.000 description 3
241000699666 Mus <mouse, genus> Species 0.000 description 3
125000003277 amino group Chemical group 0.000 description 3
125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 description 3
210000004027 cell Anatomy 0.000 description 3
239000003814 drug Substances 0.000 description 3
238000011156 evaluation Methods 0.000 description 3
235000021050 feed intake Nutrition 0.000 description 3
HNDVDQJCIGZPNO-UHFFFAOYSA-N histidine Natural products OC(=O)C(N)CC1=CN=CN1 HNDVDQJCIGZPNO-UHFFFAOYSA-N 0.000 description 3
230000003647 oxidation Effects 0.000 description 3
230000036284 oxygen consumption Effects 0.000 description 3
238000002360 preparation method Methods 0.000 description 3
125000002924 primary amino group Chemical group [H]N([H])* 0.000 description 3
210000002966 serum Anatomy 0.000 description 3
GVJHHUAWPYXKBD-UHFFFAOYSA-N (±)-α-Tocopherol Chemical compound OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-UHFFFAOYSA-N 0.000 description 2
CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 description 2
102000011632 Caseins Human genes 0.000 description 2
108010076119 Caseins Proteins 0.000 description 2
PMATZTZNYRCHOR-CGLBZJNRSA-N Cyclosporin A Chemical compound CC[C@@H]1NC(=O)[C@H]([C@H](O)[C@H](C)C\C=C\C)N(C)C(=O)[C@H](C(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](C(C)C)NC(=O)[C@H](CC(C)C)N(C)C(=O)CN(C)C1=O PMATZTZNYRCHOR-CGLBZJNRSA-N 0.000 description 2
229930105110 Cyclosporin A Natural products 0.000 description 2
108010036949 Cyclosporine Proteins 0.000 description 2
101150112014 Gapdh gene Proteins 0.000 description 2
ZRALSGWEFCBTJO-UHFFFAOYSA-N Guanidine Chemical compound NC(N)=N ZRALSGWEFCBTJO-UHFFFAOYSA-N 0.000 description 2
102000014171 Milk Proteins Human genes 0.000 description 2
108010011756 Milk Proteins Proteins 0.000 description 2
230000010718 Oxidation Activity Effects 0.000 description 2
108091005804 Peptidases Proteins 0.000 description 2
241000700159 Rattus Species 0.000 description 2
229930006000 Sucrose Natural products 0.000 description 2
CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 description 2
235000006468 Thea sinensis Nutrition 0.000 description 2
108010046377 Whey Proteins Proteins 0.000 description 2
102000007544 Whey Proteins Human genes 0.000 description 2
238000010521 absorption reaction Methods 0.000 description 2
239000000654 additive Substances 0.000 description 2
235000013361 beverage Nutrition 0.000 description 2
238000009395 breeding Methods 0.000 description 2
230000001488 breeding effect Effects 0.000 description 2
235000019577 caloric intake Nutrition 0.000 description 2
239000001569 carbon dioxide Substances 0.000 description 2
229910002092 carbon dioxide Inorganic materials 0.000 description 2
239000005018 casein Substances 0.000 description 2
BECPQYXYKAMYBN-UHFFFAOYSA-N casein, tech. Chemical compound NCCCCC(C(O)=O)N=C(O)C(CC(O)=O)N=C(O)C(CCC(O)=N)N=C(O)C(CC(C)C)N=C(O)C(CCC(O)=O)N=C(O)C(CC(O)=O)N=C(O)C(CCC(O)=O)N=C(O)C(C(C)O)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=O)N=C(O)C(CCC(O)=O)N=C(O)C(COP(O)(O)=O)N=C(O)C(CCC(O)=N)N=C(O)C(N)CC1=CC=CC=C1 BECPQYXYKAMYBN-UHFFFAOYSA-N 0.000 description 2
235000021240 caseins Nutrition 0.000 description 2
238000006243 chemical reaction Methods 0.000 description 2
229960001265 ciclosporin Drugs 0.000 description 2
230000000052 comparative effect Effects 0.000 description 2
239000002299 complementary DNA Substances 0.000 description 2
238000009833 condensation Methods 0.000 description 2
230000005494 condensation Effects 0.000 description 2
238000007796 conventional method Methods 0.000 description 2
229930182912 cyclosporin Natural products 0.000 description 2
TUTWLYPCGCUWQI-UHFFFAOYSA-N decanamide Chemical compound CCCCCCCCCC(N)=O TUTWLYPCGCUWQI-UHFFFAOYSA-N 0.000 description 2
125000002704 decyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 description 2
230000018044 dehydration Effects 0.000 description 2
238000006297 dehydration reaction Methods 0.000 description 2
235000005911 diet Nutrition 0.000 description 2
230000037213 diet Effects 0.000 description 2
235000014113 dietary fatty acids Nutrition 0.000 description 2
235000015872 dietary supplement Nutrition 0.000 description 2
201000010099 disease Diseases 0.000 description 2
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 2
XMOCLSLCDHWDHP-IUODEOHRSA-N epi-Gallocatechin Chemical compound C1([C@H]2OC3=CC(O)=CC(O)=C3C[C@H]2O)=CC(O)=C(O)C(O)=C1 XMOCLSLCDHWDHP-IUODEOHRSA-N 0.000 description 2
229930195729 fatty acid Natural products 0.000 description 2
239000000194 fatty acid Substances 0.000 description 2
150000004665 fatty acids Chemical group 0.000 description 2
239000000706 filtrate Substances 0.000 description 2
235000013376 functional food Nutrition 0.000 description 2
210000001035 gastrointestinal tract Anatomy 0.000 description 2
210000003494 hepatocyte Anatomy 0.000 description 2
230000000670 limiting effect Effects 0.000 description 2
230000037356 lipid metabolism Effects 0.000 description 2
239000007788 liquid Substances 0.000 description 2
230000007774 longterm Effects 0.000 description 2
235000004213 low-fat Nutrition 0.000 description 2
238000013227 male C57BL/6J mice Methods 0.000 description 2
235000021239 milk protein Nutrition 0.000 description 2
235000016709 nutrition Nutrition 0.000 description 2
FDPIMTJIUBPUKL-UHFFFAOYSA-N pentan-3-one Chemical compound CCC(=O)CC FDPIMTJIUBPUKL-UHFFFAOYSA-N 0.000 description 2
230000035699 permeability Effects 0.000 description 2
230000001766 physiological effect Effects 0.000 description 2
230000003169 placental effect Effects 0.000 description 2
229920000642 polymer Polymers 0.000 description 2
230000003449 preventive effect Effects 0.000 description 2
238000003753 real-time PCR Methods 0.000 description 2
230000000241 respiratory effect Effects 0.000 description 2
239000005720 sucrose Substances 0.000 description 2
208000024891 symptom Diseases 0.000 description 2
VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 description 2
MOEDDXVKEINTQF-BYPYZUCNSA-N (2s)-1-sulfanylpyrrolidine-2-carboxylic acid Chemical compound OC(=O)[C@@H]1CCCN1S MOEDDXVKEINTQF-BYPYZUCNSA-N 0.000 description 1
DVNFLGLGNLXITH-REOHCLBHSA-N (2s)-2-(diaminomethylideneamino)propanoic acid Chemical compound OC(=O)[C@H](C)N=C(N)N DVNFLGLGNLXITH-REOHCLBHSA-N 0.000 description 1
XGUXJMWPVJQIHI-YFKPBYRVSA-N (2s)-2-azaniumyl-3-cyclopropylpropanoate Chemical compound [O-]C(=O)[C@@H]([NH3+])CC1CC1 XGUXJMWPVJQIHI-YFKPBYRVSA-N 0.000 description 1
VZXTWGWHSMCWGA-UHFFFAOYSA-N 1,3,5-triazine-2,4-diamine Chemical compound NC1=NC=NC(N)=N1 VZXTWGWHSMCWGA-UHFFFAOYSA-N 0.000 description 1
SQKNIQWHYQLLMW-UHFFFAOYSA-N 1-(sulfamoylamino)decane Chemical compound CCCCCCCCCCNS(N)(=O)=O SQKNIQWHYQLLMW-UHFFFAOYSA-N 0.000 description 1
PNLUYLZSPGHNSN-YFKPBYRVSA-N 2-[3-[(2s)-3,6-dioxopiperazin-2-yl]propyl]guanidine Chemical compound NC(N)=NCCC[C@@H]1NC(=O)CNC1=O PNLUYLZSPGHNSN-YFKPBYRVSA-N 0.000 description 1
HFKJBCPRWWGPEY-UHFFFAOYSA-N 2-[[2-azaniumyl-5-(diaminomethylideneazaniumyl)pentanoyl]amino]pentanedioate Chemical compound NC(N)=NCCCC(N)C(=O)NC(CCC(O)=O)C(O)=O HFKJBCPRWWGPEY-UHFFFAOYSA-N 0.000 description 1
QTBSBXVTEAMEQO-UHFFFAOYSA-M Acetate Chemical compound CC([O-])=O QTBSBXVTEAMEQO-UHFFFAOYSA-M 0.000 description 1
102000002281 Adenylate kinase Human genes 0.000 description 1
108020000543 Adenylate kinase Proteins 0.000 description 1
QGZKDVFQNNGYKY-UHFFFAOYSA-O Ammonium Chemical compound [NH4+] QGZKDVFQNNGYKY-UHFFFAOYSA-O 0.000 description 1
206010003210 Arteriosclerosis Diseases 0.000 description 1
OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 description 1
241000700199 Cavia porcellus Species 0.000 description 1
235000009024 Ceanothus sanguineus Nutrition 0.000 description 1
241000282693 Cercopithecidae Species 0.000 description 1
KRKNYBCHXYNGOX-UHFFFAOYSA-K Citrate Chemical compound [O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O KRKNYBCHXYNGOX-UHFFFAOYSA-K 0.000 description 1
108010069514 Cyclic Peptides Proteins 0.000 description 1
102000001189 Cyclic Peptides Human genes 0.000 description 1
ZZZCUOFIHGPKAK-UHFFFAOYSA-N D-erythro-ascorbic acid Natural products OCC1OC(=O)C(O)=C1O ZZZCUOFIHGPKAK-UHFFFAOYSA-N 0.000 description 1
239000006144 Dulbecco’s modiﬁed Eagle's medium Substances 0.000 description 1
241000282326 Felis catus Species 0.000 description 1
BDAGIHXWWSANSR-UHFFFAOYSA-N Formic acid Chemical class OC=O BDAGIHXWWSANSR-UHFFFAOYSA-N 0.000 description 1
VZCYOOQTPOCHFL-OWOJBTEDSA-N Fumaric acid Chemical compound OC(=O)\C=C\C(O)=O VZCYOOQTPOCHFL-OWOJBTEDSA-N 0.000 description 1
108010068370 Glutens Proteins 0.000 description 1
BCCRXDTUTZHDEU-VKHMYHEASA-N Gly-Ser Chemical compound NCC(=O)N[C@@H](CO)C(O)=O BCCRXDTUTZHDEU-VKHMYHEASA-N 0.000 description 1
241000282412 Homo Species 0.000 description 1
VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 1
208000031226 Hyperlipidaemia Diseases 0.000 description 1
206010020772 Hypertension Diseases 0.000 description 1
XMOCLSLCDHWDHP-UHFFFAOYSA-N L-Epigallocatechin Natural products OC1CC2=C(O)C=C(O)C=C2OC1C1=CC(O)=C(O)C(O)=C1 XMOCLSLCDHWDHP-UHFFFAOYSA-N 0.000 description 1
QNAYBMKLOCPYGJ-REOHCLBHSA-N L-alanine Chemical compound C[C@H](N)C(O)=O QNAYBMKLOCPYGJ-REOHCLBHSA-N 0.000 description 1
DEFJQIDDEAULHB-IMJSIDKUSA-N L-alanyl-L-alanine Chemical compound C[C@H](N)C(=O)N[C@@H](C)C(O)=O DEFJQIDDEAULHB-IMJSIDKUSA-N 0.000 description 1
ODKSFYDXXFIFQN-BYPYZUCNSA-P L-argininium(2+) Chemical compound NC(=[NH2+])NCCC[C@H]([NH3+])C(O)=O ODKSFYDXXFIFQN-BYPYZUCNSA-P 0.000 description 1
HNDVDQJCIGZPNO-YFKPBYRVSA-N L-histidine Chemical compound OC(=O)[C@@H](N)CC1=CN=CN1 HNDVDQJCIGZPNO-YFKPBYRVSA-N 0.000 description 1
QIVBCDIJIAJPQS-VIFPVBQESA-N L-tryptophane Chemical compound C1=CC=C2C(C[C@H](N)C(O)=O)=CNC2=C1 QIVBCDIJIAJPQS-VIFPVBQESA-N 0.000 description 1
240000003553 Leptospermum scoparium Species 0.000 description 1
ROHFNLRQFUQHCH-UHFFFAOYSA-N Leucine Natural products CC(C)CC(N)C(O)=O ROHFNLRQFUQHCH-UHFFFAOYSA-N 0.000 description 1
235000015459 Lycium barbarum Nutrition 0.000 description 1
FYYHWMGAXLPEAU-UHFFFAOYSA-N Magnesium Chemical compound [Mg] FYYHWMGAXLPEAU-UHFFFAOYSA-N 0.000 description 1
CHJJGSNFBQVOTG-UHFFFAOYSA-N N-methyl-guanidine Natural products CNC(N)=N CHJJGSNFBQVOTG-UHFFFAOYSA-N 0.000 description 1
229910002651 NO3 Inorganic materials 0.000 description 1
LBRGFJHYSJHUTD-FIZIFZEPSA-N N[C@@H](CCCCN)C(=O)O.C1(CCCCC1)N[C@@H](CCCCN)C(=O)O Chemical compound N[C@@H](CCCCN)C(=O)O.C1(CCCCC1)N[C@@H](CCCCN)C(=O)O LBRGFJHYSJHUTD-FIZIFZEPSA-N 0.000 description 1
NHNBFGGVMKEFGY-UHFFFAOYSA-N Nitrate Chemical compound [O-][N+]([O-])=O NHNBFGGVMKEFGY-UHFFFAOYSA-N 0.000 description 1
241000283973 Oryctolagus cuniculus Species 0.000 description 1
MUBZPKHOEPUJKR-UHFFFAOYSA-N Oxalic acid Chemical compound OC(=O)C(O)=O MUBZPKHOEPUJKR-UHFFFAOYSA-N 0.000 description 1
229910019142 PO4 Inorganic materials 0.000 description 1
102000035195 Peptidases Human genes 0.000 description 1
ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 description 1
ONIBWKKTOPOVIA-UHFFFAOYSA-N Proline Natural products OC(=O)C1CCCN1 ONIBWKKTOPOVIA-UHFFFAOYSA-N 0.000 description 1
XBDQKXXYIPTUBI-UHFFFAOYSA-M Propionate Chemical compound CCC([O-])=O XBDQKXXYIPTUBI-UHFFFAOYSA-M 0.000 description 1
239000004365 Protease Substances 0.000 description 1
102100037486 Reverse transcriptase/ribonuclease H Human genes 0.000 description 1
108010073771 Soybean Proteins Proteins 0.000 description 1
QAOWNCQODCNURD-UHFFFAOYSA-L Sulfate Chemical compound [O-]S([O-])(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 description 1
102000004357 Transferases Human genes 0.000 description 1
108090000992 Transferases Proteins 0.000 description 1
DTQVDTLACAAQTR-UHFFFAOYSA-M Trifluoroacetate Chemical compound [O-]C(=O)C(F)(F)F DTQVDTLACAAQTR-UHFFFAOYSA-M 0.000 description 1
QIVBCDIJIAJPQS-UHFFFAOYSA-N Tryptophan Natural products C1=CC=C2C(CC(N)C(O)=O)=CNC2=C1 QIVBCDIJIAJPQS-UHFFFAOYSA-N 0.000 description 1
DZGWFCGJZKJUFP-UHFFFAOYSA-N Tyramine Natural products NCCC1=CC=C(O)C=C1 DZGWFCGJZKJUFP-UHFFFAOYSA-N 0.000 description 1
229930003268 Vitamin C Natural products 0.000 description 1
229930003427 Vitamin E Natural products 0.000 description 1
239000005862 Whey Substances 0.000 description 1
230000004913 activation Effects 0.000 description 1
230000000996 additive effect Effects 0.000 description 1
235000004279 alanine Nutrition 0.000 description 1
108010056243 alanylalanine Proteins 0.000 description 1
238000010171 animal model Methods 0.000 description 1
239000003963 antioxidant agent Substances 0.000 description 1
230000003078 antioxidant effect Effects 0.000 description 1
235000006708 antioxidants Nutrition 0.000 description 1
239000002830 appetite depressant Substances 0.000 description 1
208000011775 arteriosclerosis disease Diseases 0.000 description 1
229940077388 benzenesulfonate Drugs 0.000 description 1
SRSXLGNVWSONIS-UHFFFAOYSA-M benzenesulfonate Chemical compound [O-]S(=O)(=O)C1=CC=CC=C1 SRSXLGNVWSONIS-UHFFFAOYSA-M 0.000 description 1
229940050390 benzoate Drugs 0.000 description 1
WPYMKLBDIGXBTP-UHFFFAOYSA-N benzoic acid Chemical compound OC(=O)C1=CC=CC=C1 WPYMKLBDIGXBTP-UHFFFAOYSA-N 0.000 description 1
239000011230 binding agent Substances 0.000 description 1
230000003115 biocidal effect Effects 0.000 description 1
230000033228 biological regulation Effects 0.000 description 1
230000001851 biosynthetic effect Effects 0.000 description 1
210000004369 blood Anatomy 0.000 description 1
239000008280 blood Substances 0.000 description 1
210000000481 breast Anatomy 0.000 description 1
239000006172 buffering agent Substances 0.000 description 1
210000004899 c-terminal region Anatomy 0.000 description 1
239000011575 calcium Substances 0.000 description 1
229910052791 calcium Inorganic materials 0.000 description 1
239000002775 capsule Substances 0.000 description 1
230000015556 catabolic process Effects 0.000 description 1
150000001765 catechin Chemical class 0.000 description 1
ADRVNXBAWSRFAJ-UHFFFAOYSA-N catechin Natural products OC1Cc2cc(O)cc(O)c2OC1c3ccc(O)c(O)c3 ADRVNXBAWSRFAJ-UHFFFAOYSA-N 0.000 description 1
235000005487 catechin Nutrition 0.000 description 1
238000005119 centrifugation Methods 0.000 description 1
239000000701 coagulant Substances 0.000 description 1
239000011248 coating agent Substances 0.000 description 1
239000003086 colorant Substances 0.000 description 1
150000001875 compounds Chemical class 0.000 description 1
210000002808 connective tissue Anatomy 0.000 description 1
108010052299 cyclo(arginylglycyl) Proteins 0.000 description 1
238000011161 development Methods 0.000 description 1
206010012601 diabetes mellitus Diseases 0.000 description 1
SWSQBOPZIKWTGO-UHFFFAOYSA-N dimethylaminoamidine Natural products CN(C)C(N)=N SWSQBOPZIKWTGO-UHFFFAOYSA-N 0.000 description 1
239000006185 dispersion Substances 0.000 description 1
238000004090 dissolution Methods 0.000 description 1
230000035622 drinking Effects 0.000 description 1
229940079593 drug Drugs 0.000 description 1
239000003995 emulsifying agent Substances 0.000 description 1
239000000839 emulsion Substances 0.000 description 1
DZYNKLUGCOSVKS-UHFFFAOYSA-N epigallocatechin Natural products OC1Cc2cc(O)cc(O)c2OC1c3cc(O)c(O)c(O)c3 DZYNKLUGCOSVKS-UHFFFAOYSA-N 0.000 description 1
238000000855 fermentation Methods 0.000 description 1
230000004151 fermentation Effects 0.000 description 1
238000001914 filtration Methods 0.000 description 1
239000000796 flavoring agent Substances 0.000 description 1
235000019634 flavors Nutrition 0.000 description 1
125000003983 fluorenyl group Chemical group C1(=CC=CC=2C3=CC=CC=C3CC12)* 0.000 description 1
235000013373 food additive Nutrition 0.000 description 1
239000002778 food additive Substances 0.000 description 1
235000012631 food intake Nutrition 0.000 description 1
238000009472 formulation Methods 0.000 description 1
238000004108 freeze drying Methods 0.000 description 1
WIGCFUFOHFEKBI-UHFFFAOYSA-N gamma-tocopherol Natural products CC(C)CCCC(C)CCCC(C)CCCC1CCC2C(C)C(O)C(C)C(C)C2O1 WIGCFUFOHFEKBI-UHFFFAOYSA-N 0.000 description 1
235000021312 gluten Nutrition 0.000 description 1
239000008187 granular material Substances 0.000 description 1
238000000227 grinding Methods 0.000 description 1
238000003306 harvesting Methods 0.000 description 1
206010073071 hepatocellular carcinoma Diseases 0.000 description 1
235000003642 hunger Nutrition 0.000 description 1
230000003301 hydrolyzing effect Effects 0.000 description 1
238000001727 in vivo Methods 0.000 description 1
238000011534 incubation Methods 0.000 description 1
239000004615 ingredient Substances 0.000 description 1
238000002347 injection Methods 0.000 description 1
239000007924 injection Substances 0.000 description 1
229910052500 inorganic mineral Inorganic materials 0.000 description 1
229910017053 inorganic salt Inorganic materials 0.000 description 1
JVTAAEKCZFNVCJ-UHFFFAOYSA-N lactic acid Chemical class CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 description 1
235000019626 lipase activity Nutrition 0.000 description 1
239000000314 lubricant Substances 0.000 description 1
239000011777 magnesium Substances 0.000 description 1
229910052749 magnesium Inorganic materials 0.000 description 1
229940049920 malate Drugs 0.000 description 1
VZCYOOQTPOCHFL-UPHRSURJSA-N maleic acid Chemical compound OC(=O)\C=C/C(O)=O VZCYOOQTPOCHFL-UPHRSURJSA-N 0.000 description 1
BJEPYKJPYRNKOW-UHFFFAOYSA-N malic acid Chemical compound OC(=O)C(O)CC(O)=O BJEPYKJPYRNKOW-UHFFFAOYSA-N 0.000 description 1
210000004993 mammalian placenta Anatomy 0.000 description 1
238000004519 manufacturing process Methods 0.000 description 1
238000000968 medical method and process Methods 0.000 description 1
239000012528 membrane Substances 0.000 description 1
230000000813 microbial effect Effects 0.000 description 1
239000011707 mineral Substances 0.000 description 1
235000010755 mineral Nutrition 0.000 description 1
210000003470 mitochondria Anatomy 0.000 description 1
230000002438 mitochondrial effect Effects 0.000 description 1
229930027945 nicotinamide-adenine dinucleotide Natural products 0.000 description 1
BOPGDPNILDQYTO-NNYOXOHSSA-N nicotinamide-adenine dinucleotide Chemical compound C1=CCC(C(=O)N)=CN1[C@H]1[C@H](O)[C@H](O)[C@@H](COP(O)(=O)OP(O)(=O)OC[C@@H]2[C@H]([C@@H](O)[C@@H](O2)N2C3=NC=NC(N)=C3N=C2)O)O1 BOPGDPNILDQYTO-NNYOXOHSSA-N 0.000 description 1
235000015097 nutrients Nutrition 0.000 description 1
230000035764 nutrition Effects 0.000 description 1
235000020333 oolong tea Nutrition 0.000 description 1
239000002245 particle Substances 0.000 description 1
210000002824 peroxisome Anatomy 0.000 description 1
239000008194 pharmaceutical composition Substances 0.000 description 1
239000000546 pharmaceutical excipient Substances 0.000 description 1
NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 description 1
239000010452 phosphate Substances 0.000 description 1
229940075930 picrate Drugs 0.000 description 1
OXNIZHLAWKMVMX-UHFFFAOYSA-M picrate anion Chemical compound [O-]C1=C([N+]([O-])=O)C=C([N+]([O-])=O)C=C1[N+]([O-])=O OXNIZHLAWKMVMX-UHFFFAOYSA-M 0.000 description 1
239000011591 potassium Substances 0.000 description 1
229910052700 potassium Inorganic materials 0.000 description 1
239000003755 preservative agent Substances 0.000 description 1
230000002335 preservative effect Effects 0.000 description 1
102000004196 processed proteins & peptides Human genes 0.000 description 1
235000019833 protease Nutrition 0.000 description 1
235000019419 proteases Nutrition 0.000 description 1
238000010298 pulverizing process Methods 0.000 description 1
238000000746 purification Methods 0.000 description 1
230000009467 reduction Effects 0.000 description 1
230000002829 reductive effect Effects 0.000 description 1
230000002441 reversible effect Effects 0.000 description 1
238000012552 review Methods 0.000 description 1
210000000813 small intestine Anatomy 0.000 description 1
159000000000 sodium salts Chemical class 0.000 description 1
239000007787 solid Substances 0.000 description 1
239000000243 solution Substances 0.000 description 1
239000002904 solvent Substances 0.000 description 1
235000019710 soybean protein Nutrition 0.000 description 1
239000003381 stabilizer Substances 0.000 description 1
238000000551 statistical hypothesis test Methods 0.000 description 1
230000001954 sterilising effect Effects 0.000 description 1
239000000126 substance Substances 0.000 description 1
KDYFGRWQOYBRFD-UHFFFAOYSA-L succinate(2-) Chemical compound [O-]C(=O)CCC([O-])=O KDYFGRWQOYBRFD-UHFFFAOYSA-L 0.000 description 1
229910021653 sulphate ion Inorganic materials 0.000 description 1
239000013589 supplement Substances 0.000 description 1
239000000375 suspending agent Substances 0.000 description 1
238000003786 synthesis reaction Methods 0.000 description 1
238000002560 therapeutic procedure Methods 0.000 description 1
229960003732 tyramine Drugs 0.000 description 1
238000000108 ultra-filtration Methods 0.000 description 1
235000013311 vegetables Nutrition 0.000 description 1
229930003231 vitamin Natural products 0.000 description 1
235000013343 vitamin Nutrition 0.000 description 1
239000011782 vitamin Substances 0.000 description 1
229940088594 vitamin Drugs 0.000 description 1
235000019154 vitamin C Nutrition 0.000 description 1
239000011718 vitamin C Substances 0.000 description 1
235000019165 vitamin E Nutrition 0.000 description 1
229940046009 vitamin E Drugs 0.000 description 1
239000011709 vitamin E Substances 0.000 description 1
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
235000021119 whey protein Nutrition 0.000 description 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical & Material Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Immunology (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Epidemiology (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

TW105122441A 2015-07-17 2016-07-15 含有環狀二胜肽之抗肥胖用組成物 TW201716067A (zh)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
JP2015142654		2015-07-17

Publications (1)

Publication Number	Publication Date
TW201716067A true TW201716067A (zh)	2017-05-16

Family

ID=57835066

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
TW105122441A TW201716067A (zh)	2015-07-17	2016-07-15	含有環狀二胜肽之抗肥胖用組成物

Country Status (3)

Country	Link
JP (1)	JP6671367B2 (fr)
TW (1)	TW201716067A (fr)
WO (1)	WO2017014153A1 (fr)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CN119837994A (zh) *	2025-01-16	2025-04-18	广州中医药大学(广州中医药研究院)	一种环状二肽在改善或治疗血脂异常相关疾病中的应用

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US11510427B2 (en) *	2016-12-21	2022-11-29	Suntory Holdings Limited	Food and beverages containing cyclo(aspartyl-glycine), glucose, and maltose
JP2024169964A (ja) *	2023-05-26	2024-12-06	国立大学法人東北大学	トリプトファンインドールリアーゼによるインドール生成の阻害剤
CN119770491B (zh) *	2024-12-20	2025-10-17	北京大学	环甘氨酸-脯氨酸在制备治疗暴食症的药物中的应用

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5418218A (en) *	1992-07-10	1995-05-23	The University Of Maryland At Baltimore	Histidyl-proline diketopiperazine (cyclo his-pro) a cns-active pharmacologic agent
EP2613786A4 (fr) *	2010-09-07	2013-10-23	Dmi Acquisition Corp	Traitement de maladies

2016
- 2016-07-14 WO PCT/JP2016/070864 patent/WO2017014153A1/fr not_active Ceased
- 2016-07-14 JP JP2017529858A patent/JP6671367B2/ja not_active Expired - Fee Related
- 2016-07-15 TW TW105122441A patent/TW201716067A/zh unknown

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CN119837994A (zh) *	2025-01-16	2025-04-18	广州中医药大学(广州中医药研究院)	一种环状二肽在改善或治疗血脂异常相关疾病中的应用

Also Published As

Publication number	Publication date
JPWO2017014153A1 (ja)	2018-04-26
WO2017014153A1 (fr)	2017-01-26
JP6671367B2 (ja)	2020-03-25

Publication	Publication Date	Title
JP5334448B2 (ja)	2013-11-06	グルタチオン産生促進剤およびグルタチオンの欠乏に起因する疾患の予防・治療剤
JP6669750B2 (ja)	2020-03-18	環状ジペプチド含有血清カルノシン分解酵素阻害用組成物
JP2019529365A (ja)	2019-10-17	持久運動能力を向上させるためおよび脂質代謝を刺激するためのコラーゲン加水分解物の使用
TW201626980A (zh)	2016-08-01	以環狀二肽作為有效成分之皮膚保濕機能改善劑
TW201716079A (zh)	2017-05-16	Ｇｌｐ－２分泌促進用組成物
JP6713981B2 (ja)	2020-06-24	リパーゼ阻害剤
TW201716067A (zh)	2017-05-16	含有環狀二胜肽之抗肥胖用組成物
TW201716080A (zh)	2017-05-16	Ｔｒｐｖ１刺激用組成物
TW201717988A (zh)	2017-06-01	含有環狀二肽及甜味料之組成物
TW201733607A (zh)	2017-10-01	神經性疾病之預防用組成物
CN107922458B (zh)	2022-01-21	含有氨基酸及环状二肽的组合物
TW201733608A (zh)	2017-10-01	含有環狀二肽之神經性疾病之預防用組成物
US10729737B2 (en)	2020-08-04	Muscle-enhancing agent
JP5980519B2 (ja)	2016-08-31	Ａｍｐｋ活性化剤
JP2006515879A (ja)	2006-06-08	哺乳類による栄養利用を向上するための方法およびその中で使用するための組成物
JP6661597B2 (ja)	2020-03-11	α−グルコシダーゼ阻害剤
TW201717985A (zh)	2017-06-01	內皮素受體拮抗用組成物
JP6786490B2 (ja)	2020-11-18	抗肥満用組成物
JP6682075B2 (ja)	2020-04-15	Ｆｇｆ２１発現促進用組成物
JP2019108364A (ja)	2019-07-04	栄養組成物
TW201717987A (zh)	2017-06-01	黑色素聚集激素受體拮抗用組成物
WO2017030160A1 (fr)	2017-02-23	Composition comestible destinée à prévenir ou améliorer un syndrome métabolique
JP7692626B2 (ja)	2025-06-16	経口組成物
JP2025096926A (ja)	2025-06-30	分枝鎖アミノ酸取り込み促進用組成物

TW201716067A - 含有環狀二胜肽之抗肥胖用組成物 - Google Patents

Info

Links

Classifications

Landscapes

Applications Claiming Priority (1)

Publications (1)

Family

ID=57835066

Family Applications (1)

Country Status (3)

Cited By (1)

Families Citing this family (3)

Family Cites Families (2)

Cited By (1)

Also Published As

Similar Documents