TW201733607A - 神經性疾病之預防用組成物 - Google Patents

神經性疾病之預防用組成物 Download PDF

Info

Publication number: TW201733607A
Authority: TW; Taiwan
Prior art keywords: peptide; animal; composition; neurological disease; preventive
Prior art date: 2016-01-08

Application number

TW106100494A

Other languages

English (en)

Chinese (zh)

Inventor

Hiroshi Watanabe

Toshihide Suzuki

Mitsuhiro Zeida

Masafumi Ito

Yasunori Fujita

Kyojiro Kawakami

Original Assignee

Suntory Holdings Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2016-01-08

Filing date

2017-01-06

Publication date

2017-10-01

2017-01-06 Application filed by Suntory Holdings Ltd filed Critical Suntory Holdings Ltd

2017-10-01 Publication of TW201733607A publication Critical patent/TW201733607A/zh

Links

208000012902 Nervous system disease Diseases 0.000 title claims abstract description 86
208000025966 Neurological disease Diseases 0.000 title claims abstract description 86
239000000203 mixture Substances 0.000 title claims abstract description 70
108090000765 processed proteins & peptides Proteins 0.000 claims abstract description 174
241001465754 Metazoa Species 0.000 claims abstract description 95
238000000034 method Methods 0.000 claims abstract description 26
208000024827 Alzheimer disease Diseases 0.000 claims abstract description 17
201000000980 schizophrenia Diseases 0.000 claims abstract description 17
206010012289 Dementia Diseases 0.000 claims abstract description 15
206010002026 amyotrophic lateral sclerosis Diseases 0.000 claims abstract description 13
239000000463 material Substances 0.000 claims abstract description 10
241000196324 Embryophyta Species 0.000 claims description 67
108010046377 Whey Proteins Proteins 0.000 claims description 44
230000003449 preventive effect Effects 0.000 claims description 44
102000007544 Whey Proteins Human genes 0.000 claims description 43
239000005862 Whey Substances 0.000 claims description 40
235000010469 Glycine max Nutrition 0.000 claims description 39
244000068988 Glycine max Species 0.000 claims description 38
MWUXSHHQAYIFBG-UHFFFAOYSA-N Nitric oxide Chemical compound O=[N] MWUXSHHQAYIFBG-UHFFFAOYSA-N 0.000 claims description 33
230000000694 effects Effects 0.000 claims description 19
210000000274 microglia Anatomy 0.000 claims description 18
230000002265 prevention Effects 0.000 claims description 17
235000013311 vegetables Nutrition 0.000 claims description 17
239000004480 active ingredient Substances 0.000 claims description 13
102000004196 processed proteins & peptides Human genes 0.000 claims description 12
210000002569 neuron Anatomy 0.000 claims description 11
230000002401 inhibitory effect Effects 0.000 claims description 10
208000018737 Parkinson disease Diseases 0.000 claims description 8
230000004913 activation Effects 0.000 claims description 8
239000000126 substance Substances 0.000 claims description 5
239000003795 chemical substances by application Substances 0.000 claims description 4
201000010099 disease Diseases 0.000 claims description 4
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 4
230000028327 secretion Effects 0.000 claims description 4
230000009471 action Effects 0.000 claims description 3
230000002718 inhibitory effect on inflammation Effects 0.000 claims 1
206010034010 Parkinsonism Diseases 0.000 abstract description 9
238000010438 heat treatment Methods 0.000 description 62
239000000047 product Substances 0.000 description 50
238000011282 treatment Methods 0.000 description 41
108010016626 Dipeptides Proteins 0.000 description 31
125000004122 cyclic group Chemical group 0.000 description 30
150000003839 salts Chemical class 0.000 description 23
238000000354 decomposition reaction Methods 0.000 description 17
239000007788 liquid Substances 0.000 description 14
210000004027 cell Anatomy 0.000 description 13
235000013305 food Nutrition 0.000 description 12
235000018102 proteins Nutrition 0.000 description 12
102000004169 proteins and genes Human genes 0.000 description 12
108090000623 proteins and genes Proteins 0.000 description 12
230000002025 microglial effect Effects 0.000 description 10
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 9
206010061218 Inflammation Diseases 0.000 description 7
230000004054 inflammatory process Effects 0.000 description 7
238000004519 manufacturing process Methods 0.000 description 7
XWYXUMDVQIOAPR-UHFFFAOYSA-N (3S,6S)-3,6-Diisobutyl-2,5-dioxohexahydropyrazine Natural products CC(C)CC1NC(=O)C(CC(C)C)NC1=O XWYXUMDVQIOAPR-UHFFFAOYSA-N 0.000 description 6
QPDMOMIYLJMOQJ-UHFFFAOYSA-N Cyclo-L-leu-L-phe Natural products N1C(=O)C(CC(C)C)NC(=O)C1CC1=CC=CC=C1 QPDMOMIYLJMOQJ-UHFFFAOYSA-N 0.000 description 6
235000019658 bitter taste Nutrition 0.000 description 6
XWYXUMDVQIOAPR-UWVGGRQHSA-N cyclo(L-leucyl-L-leucyl) Chemical compound CC(C)C[C@@H]1NC(=O)[C@H](CC(C)C)NC1=O XWYXUMDVQIOAPR-UWVGGRQHSA-N 0.000 description 6
QPDMOMIYLJMOQJ-STQMWFEESA-N cyclo(L-phenylalanyl-L-leucyl) Chemical compound N1C(=O)[C@H](CC(C)C)NC(=O)[C@@H]1CC1=CC=CC=C1 QPDMOMIYLJMOQJ-STQMWFEESA-N 0.000 description 6
108010048344 cyclo(leucyl-phenylalanyl) Proteins 0.000 description 6
239000012153 distilled water Substances 0.000 description 6
230000002757 inflammatory effect Effects 0.000 description 6
238000002360 preparation method Methods 0.000 description 6
BZUNCDPEEKFTCX-GJZGRUSLSA-N (3s,6s)-3-(1h-indol-3-ylmethyl)-6-(2-methylpropyl)piperazine-2,5-dione Chemical compound N1C(=O)[C@H](CC(C)C)NC(=O)[C@@H]1CC1=CNC2=CC=CC=C12 BZUNCDPEEKFTCX-GJZGRUSLSA-N 0.000 description 5
QZBUWPVZSXDWSB-UHFFFAOYSA-N 3-benzyl-2,3,6,7,8,8a-hexahydropyrrolo[1,2-a]pyrazine-1,4-dione Chemical compound O=C1N2CCCC2C(=O)NC1CC1=CC=CC=C1 QZBUWPVZSXDWSB-UHFFFAOYSA-N 0.000 description 5
102000004190 Enzymes Human genes 0.000 description 5
108090000790 Enzymes Proteins 0.000 description 5
210000004556 brain Anatomy 0.000 description 5
108010027501 cyclo(leucyl-prolyl) Proteins 0.000 description 5
108010038252 cyclo(phenylalanyl-prolyl) Proteins 0.000 description 5
229940088598 enzyme Drugs 0.000 description 5
238000000605 extraction Methods 0.000 description 5
230000001225 therapeutic effect Effects 0.000 description 5
SZJNCZMRZAUNQT-UHFFFAOYSA-N (3R,8aS)-hexahydro-3-(2-methylpropyl)pyrrolo[1,2-a]pyrazine-1,4-dione Natural products O=C1C(CC(C)C)NC(=O)C2CCCN21 SZJNCZMRZAUNQT-UHFFFAOYSA-N 0.000 description 4
CHYMARRIVIIBNV-UWVGGRQHSA-N (3S,6S)-3-(4-Hydroxybenzyl)-6-(hydroxymethyl)-2,5-piperazinedione Chemical compound N1C(=O)[C@H](CO)NC(=O)[C@@H]1CC1=CC=C(O)C=C1 CHYMARRIVIIBNV-UWVGGRQHSA-N 0.000 description 4
IFQZEERDQXQTLJ-NSHDSACASA-N Cyclo(glycyltryptophyl) Chemical compound N1C(=O)CNC(=O)[C@@H]1CC1=CNC2=CC=CC=C12 IFQZEERDQXQTLJ-NSHDSACASA-N 0.000 description 4
102000004127 Cytokines Human genes 0.000 description 4
108090000695 Cytokines Proteins 0.000 description 4
LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 4
239000002253 acid Substances 0.000 description 4
SZJNCZMRZAUNQT-IUCAKERBSA-N cyclo(L-Leu-L-Pro) Chemical compound O=C1[C@H](CC(C)C)NC(=O)[C@@H]2CCCN21 SZJNCZMRZAUNQT-IUCAKERBSA-N 0.000 description 4
108010012664 cyclo(seryltyrosyl) Proteins 0.000 description 4
-1 placenta Proteins 0.000 description 4
239000002994 raw material Substances 0.000 description 4
239000002904 solvent Substances 0.000 description 4
235000013343 vitamin Nutrition 0.000 description 4
239000011782 vitamin Substances 0.000 description 4
229940088594 vitamin Drugs 0.000 description 4
229930003231 vitamin Natural products 0.000 description 4
235000021119 whey protein Nutrition 0.000 description 4
UBLWFFBGMBRBMC-VQVTYTSYSA-N (3S,8aS)-3-[(1R)-1-hydroxyethyl]-2,3,6,7,8,8a-hexahydropyrrolo[1,2-a]pyrazine-1,4-dione Chemical compound O=C1[C@H]([C@H](O)C)NC(=O)[C@@H]2CCCN21 UBLWFFBGMBRBMC-VQVTYTSYSA-N 0.000 description 3
241000209094 Oryza Species 0.000 description 3
244000000231 Sesamum indicum Species 0.000 description 3
235000003434 Sesamum indicum Nutrition 0.000 description 3
239000000654 additive Substances 0.000 description 3
150000001413 amino acids Chemical class 0.000 description 3
230000037396 body weight Effects 0.000 description 3
239000005018 casein Substances 0.000 description 3
BECPQYXYKAMYBN-UHFFFAOYSA-N casein, tech. Chemical compound NCCCCC(C(O)=O)N=C(O)C(CC(O)=O)N=C(O)C(CCC(O)=N)N=C(O)C(CC(C)C)N=C(O)C(CCC(O)=O)N=C(O)C(CC(O)=O)N=C(O)C(CCC(O)=O)N=C(O)C(C(C)O)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=O)N=C(O)C(CCC(O)=O)N=C(O)C(COP(O)(O)=O)N=C(O)C(CCC(O)=N)N=C(O)C(N)CC1=CC=CC=C1 BECPQYXYKAMYBN-UHFFFAOYSA-N 0.000 description 3
235000021240 caseins Nutrition 0.000 description 3
235000015872 dietary supplement Nutrition 0.000 description 3
239000003814 drug Substances 0.000 description 3
230000037406 food intake Effects 0.000 description 3
230000005764 inhibitory process Effects 0.000 description 3
239000000843 powder Substances 0.000 description 3
238000007670 refining Methods 0.000 description 3
238000000926 separation method Methods 0.000 description 3
230000000638 stimulation Effects 0.000 description 3
208000024891 symptom Diseases 0.000 description 3
OQQPOHUVAQPSHJ-UHFFFAOYSA-N (3S,6S)-3-(1-methylethyl)-6-(phenylmethyl)piperazine-2,5-dione Natural products N1C(=O)C(C(C)C)NC(=O)C1CC1=CC=CC=C1 OQQPOHUVAQPSHJ-UHFFFAOYSA-N 0.000 description 2
QGMAWEIDGADSAC-YUMQZZPRSA-N (3s,6s)-3,6-di(propan-2-yl)piperazine-2,5-dione Chemical compound CC(C)[C@@H]1NC(=O)[C@H](C(C)C)NC1=O QGMAWEIDGADSAC-YUMQZZPRSA-N 0.000 description 2
WWISPHBAYBECQZ-IMJSIDKUSA-N (3s,6s)-3,6-dimethylpiperazine-2,5-dione Chemical compound C[C@@H]1NC(=O)[C@H](C)NC1=O WWISPHBAYBECQZ-IMJSIDKUSA-N 0.000 description 2
CWFHBXSYJWIDIY-UWVGGRQHSA-N (3s,6s)-3-(4-aminobutyl)-6-(2-methylpropyl)piperazine-2,5-dione Chemical compound CC(C)C[C@@H]1NC(=O)[C@H](CCCCN)NC1=O CWFHBXSYJWIDIY-UWVGGRQHSA-N 0.000 description 2
ZJDMXAAEAVGGSK-ROUUACIJSA-N (3s,6s)-3-[(4-hydroxyphenyl)methyl]-6-(1h-indol-3-ylmethyl)piperazine-2,5-dione Chemical compound C1=CC(O)=CC=C1C[C@H]1C(=O)N[C@@H](CC=2C3=CC=CC=C3NC=2)C(=O)N1 ZJDMXAAEAVGGSK-ROUUACIJSA-N 0.000 description 2
OQQPOHUVAQPSHJ-RYUDHWBXSA-N (3s,6s)-3-benzyl-6-propan-2-ylpiperazine-2,5-dione Chemical compound N1C(=O)[C@H](C(C)C)NC(=O)[C@@H]1CC1=CC=CC=C1 OQQPOHUVAQPSHJ-RYUDHWBXSA-N 0.000 description 2
DBJPZCJQDRPOME-BQBZGAKWSA-N (3s,6s)-3-methyl-6-(2-methylpropyl)piperazine-2,5-dione Chemical compound CC(C)C[C@@H]1NC(=O)[C@H](C)NC1=O DBJPZCJQDRPOME-BQBZGAKWSA-N 0.000 description 2
ZDACRNZBFJOLTC-CIUDSAMLSA-N (3s,8as)-3-[(2s)-butan-2-yl]-2,3,6,7,8,8a-hexahydropyrrolo[1,2-a]pyrazine-1,4-dione Chemical compound O=C1[C@H]([C@@H](C)CC)NC(=O)[C@@H]2CCCN21 ZDACRNZBFJOLTC-CIUDSAMLSA-N 0.000 description 2
PNSKRAHOHQWAAN-WHFBIAKZSA-N 3-[(2s,5s)-5-methyl-3,6-dioxopiperazin-2-yl]propanamide Chemical compound C[C@@H]1NC(=O)[C@H](CCC(N)=O)NC1=O PNSKRAHOHQWAAN-WHFBIAKZSA-N 0.000 description 2
WYBVBIHNJWOLCJ-IUCAKERBSA-N Arg-Leu Chemical compound CC(C)C[C@@H](C(O)=O)NC(=O)[C@@H](N)CCCNC(N)=N WYBVBIHNJWOLCJ-IUCAKERBSA-N 0.000 description 2
CKAJHWFHHFSCDT-WHFBIAKZSA-N Asp-Glu Chemical compound OC(=O)C[C@H](N)C(=O)N[C@H](C(O)=O)CCC(O)=O CKAJHWFHHFSCDT-WHFBIAKZSA-N 0.000 description 2
IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 2
102000008186 Collagen Human genes 0.000 description 2
108010035532 Collagen Proteins 0.000 description 2
DBJPZCJQDRPOME-UHFFFAOYSA-N DL-alanyl-leucyl anhydride Natural products CC(C)CC1NC(=O)C(C)NC1=O DBJPZCJQDRPOME-UHFFFAOYSA-N 0.000 description 2
YBTCBQBIJKGSJP-BQBZGAKWSA-N Glu-Pro Chemical compound OC(=O)CC[C@H](N)C(=O)N1CCC[C@H]1C(O)=O YBTCBQBIJKGSJP-BQBZGAKWSA-N 0.000 description 2
OAKJQQAXSVQMHS-UHFFFAOYSA-N Hydrazine Chemical compound NN OAKJQQAXSVQMHS-UHFFFAOYSA-N 0.000 description 2
QGMAWEIDGADSAC-UHFFFAOYSA-N L-Valyl-L-valine anhydride Natural products CC(C)C1NC(=O)C(C(C)C)NC1=O QGMAWEIDGADSAC-UHFFFAOYSA-N 0.000 description 2
WYBVBIHNJWOLCJ-UHFFFAOYSA-N N-L-arginyl-L-leucine Natural products CC(C)CC(C(O)=O)NC(=O)C(N)CCCN=C(N)N WYBVBIHNJWOLCJ-UHFFFAOYSA-N 0.000 description 2
GXCLVBGFBYZDAG-UHFFFAOYSA-N N-[2-(1H-indol-3-yl)ethyl]-N-methylprop-2-en-1-amine Chemical compound CN(CCC1=CNC2=C1C=CC=C2)CC=C GXCLVBGFBYZDAG-UHFFFAOYSA-N 0.000 description 2
108091005804 Peptidases Proteins 0.000 description 2
244000046052 Phaseolus vulgaris Species 0.000 description 2
235000010627 Phaseolus vulgaris Nutrition 0.000 description 2
108010073771 Soybean Proteins Proteins 0.000 description 2
YKRQRPFODDJQTC-CSMHCCOUSA-N Thr-Lys Chemical compound C[C@@H](O)[C@H](N)C(=O)N[C@H](C(O)=O)CCCCN YKRQRPFODDJQTC-CSMHCCOUSA-N 0.000 description 2
235000021307 Triticum Nutrition 0.000 description 2
241000209140 Triticum Species 0.000 description 2
235000010724 Wisteria floribunda Nutrition 0.000 description 2
239000003513 alkali Substances 0.000 description 2
238000004458 analytical method Methods 0.000 description 2
108010038633 aspartylglutamate Proteins 0.000 description 2
QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 2
235000013361 beverage Nutrition 0.000 description 2
239000011230 binding agent Substances 0.000 description 2
239000000872 buffer Substances 0.000 description 2
238000005352 clarification Methods 0.000 description 2
229920001436 collagen Polymers 0.000 description 2
230000000052 comparative effect Effects 0.000 description 2
239000000470 constituent Substances 0.000 description 2
239000002537 cosmetic Substances 0.000 description 2
JUAPMRSLDANLAS-HOTGVXAUSA-N cyclo(L-phenylalanyl-L-phenylalanyl) Chemical compound C([C@@H]1NC([C@@H](NC1=O)CC=1C=CC=CC=1)=O)C1=CC=CC=C1 JUAPMRSLDANLAS-HOTGVXAUSA-N 0.000 description 2
108010041457 cyclo(alanyl-leucyl) Proteins 0.000 description 2
108010015607 cyclo(alanylalanyl) Proteins 0.000 description 2
108010046166 cyclo(glycyltryptophyl) Proteins 0.000 description 2
108010039669 cyclo(phenylalanyl-phenylalanyl) Proteins 0.000 description 2
WWISPHBAYBECQZ-UHFFFAOYSA-N cyclo-L-Ala-L-Ala Natural products CC1NC(=O)C(C)NC1=O WWISPHBAYBECQZ-UHFFFAOYSA-N 0.000 description 2
JUAPMRSLDANLAS-UHFFFAOYSA-N cyclo-L-Phe-L-Phe Natural products O=C1NC(CC=2C=CC=CC=2)C(=O)NC1CC1=CC=CC=C1 JUAPMRSLDANLAS-UHFFFAOYSA-N 0.000 description 2
ZJDMXAAEAVGGSK-UHFFFAOYSA-N cyclo-L-Trp-L-Phe Natural products C1=CC(O)=CC=C1CC1C(=O)NC(CC=2C3=CC=CC=C3NC=2)C(=O)N1 ZJDMXAAEAVGGSK-UHFFFAOYSA-N 0.000 description 2
230000006806 disease prevention Effects 0.000 description 2
238000004090 dissolution Methods 0.000 description 2
229940079593 drug Drugs 0.000 description 2
239000003995 emulsifying agent Substances 0.000 description 2
238000009472 formulation Methods 0.000 description 2
ZDXPYRJPNDTMRX-UHFFFAOYSA-N glutamine Natural products OC(=O)C(N)CCC(N)=O ZDXPYRJPNDTMRX-UHFFFAOYSA-N 0.000 description 2
235000013402 health food Nutrition 0.000 description 2
239000004615 ingredient Substances 0.000 description 2
229910052500 inorganic mineral Inorganic materials 0.000 description 2
239000011707 mineral Substances 0.000 description 2
235000010755 mineral Nutrition 0.000 description 2
210000003205 muscle Anatomy 0.000 description 2
239000001301 oxygen Substances 0.000 description 2
229910052760 oxygen Inorganic materials 0.000 description 2
210000002826 placenta Anatomy 0.000 description 2
238000012545 processing Methods 0.000 description 2
230000000069 prophylactic effect Effects 0.000 description 2
239000007787 solid Substances 0.000 description 2
235000019710 soybean protein Nutrition 0.000 description 2
210000000278 spinal cord Anatomy 0.000 description 2
239000003381 stabilizer Substances 0.000 description 2
VQFHWKRNHGHZTK-LURJTMIESA-N (3s)-3-(2-methylpropyl)piperazine-2,5-dione Chemical compound CC(C)C[C@@H]1NC(=O)CNC1=O VQFHWKRNHGHZTK-LURJTMIESA-N 0.000 description 1
UZOJHXFWJFSFAI-VIFPVBQESA-N (3s)-3-benzylpiperazine-2,5-dione Chemical compound N1C(=O)CNC(=O)[C@@H]1CC1=CC=CC=C1 UZOJHXFWJFSFAI-VIFPVBQESA-N 0.000 description 1
HLXXMJDWTBXTOR-STQMWFEESA-N (3s,6s)-3-benzyl-6-(1h-imidazol-5-ylmethyl)piperazine-2,5-dione Chemical compound C([C@@H]1NC([C@@H](NC1=O)CC=1NC=NC=1)=O)C1=CC=CC=C1 HLXXMJDWTBXTOR-STQMWFEESA-N 0.000 description 1
WIJKWEYCUNYTGY-UWVGGRQHSA-N (3s,6s)-3-benzyl-6-(hydroxymethyl)piperazine-2,5-dione Chemical compound N1C(=O)[C@H](CO)NC(=O)[C@@H]1CC1=CC=CC=C1 WIJKWEYCUNYTGY-UWVGGRQHSA-N 0.000 description 1
VFVAGPWBFWJBMN-YUMQZZPRSA-N (3s,8as)-3-(2-methylsulfanylethyl)-2,3,6,7,8,8a-hexahydropyrrolo[1,2-a]pyrazine-1,4-dione Chemical compound O=C1[C@H](CCSC)NC(=O)[C@@H]2CCCN21 VFVAGPWBFWJBMN-YUMQZZPRSA-N 0.000 description 1
OWOHLURDBZHNGG-YFKPBYRVSA-N (8ar)-hexahydropyrrolo[1,2-a]pyrazine-1,4-dione Chemical compound O=C1CNC(=O)[C@@H]2CCCN12 OWOHLURDBZHNGG-YFKPBYRVSA-N 0.000 description 1
VNHJXYUDIBQDDX-UWVGGRQHSA-N 2-[(2s,5s)-5-benzyl-3,6-dioxopiperazin-2-yl]acetic acid Chemical compound N1C(=O)[C@H](CC(=O)O)NC(=O)[C@@H]1CC1=CC=CC=C1 VNHJXYUDIBQDDX-UWVGGRQHSA-N 0.000 description 1
241000238876 Acari Species 0.000 description 1
QTBSBXVTEAMEQO-UHFFFAOYSA-M Acetate Chemical compound CC([O-])=O QTBSBXVTEAMEQO-UHFFFAOYSA-M 0.000 description 1
101100381940 Acidianus ambivalens bps2 gene Proteins 0.000 description 1
WSLYCILIEOFQPK-UHFFFAOYSA-N Ala-Pro-diketopiperazine Natural products O=C1C(C)NC(=O)C2CCCN21 WSLYCILIEOFQPK-UHFFFAOYSA-N 0.000 description 1
241001107116 Castanospermum australe Species 0.000 description 1
241000700199 Cavia porcellus Species 0.000 description 1
241000282693 Cercopithecidae Species 0.000 description 1
KRKNYBCHXYNGOX-UHFFFAOYSA-K Citrate Chemical compound [O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O KRKNYBCHXYNGOX-UHFFFAOYSA-K 0.000 description 1
LSGOTAXPWMCUCK-UHFFFAOYSA-N D-prolyl-L-tyrosine anhydride Natural products C1=CC(O)=CC=C1CC1C(=O)N2CCCC2C(=O)N1 LSGOTAXPWMCUCK-UHFFFAOYSA-N 0.000 description 1
241000282326 Felis catus Species 0.000 description 1
BDAGIHXWWSANSR-UHFFFAOYSA-M Formate Chemical compound [O-]C=O BDAGIHXWWSANSR-UHFFFAOYSA-M 0.000 description 1
VZCYOOQTPOCHFL-OWOJBTEDSA-N Fumaric acid Chemical compound OC(=O)\C=C\C(O)=O VZCYOOQTPOCHFL-OWOJBTEDSA-N 0.000 description 1
108010010803 Gelatin Proteins 0.000 description 1
240000005979 Hordeum vulgare Species 0.000 description 1
235000007340 Hordeum vulgare Nutrition 0.000 description 1
VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 1
244000017020 Ipomoea batatas Species 0.000 description 1
235000002678 Ipomoea batatas Nutrition 0.000 description 1
JVTAAEKCZFNVCJ-UHFFFAOYSA-M Lactate Chemical compound CC(O)C([O-])=O JVTAAEKCZFNVCJ-UHFFFAOYSA-M 0.000 description 1
NVGBPTNZLWRQSY-UWVGGRQHSA-N Lys-Lys Chemical compound NCCCC[C@H](N)C(=O)N[C@H](C(O)=O)CCCCN NVGBPTNZLWRQSY-UWVGGRQHSA-N 0.000 description 1
QCZYYEFXOBKCNQ-STQMWFEESA-N Lys-Phe Chemical compound NCCCC[C@H](N)C(=O)N[C@H](C(O)=O)CC1=CC=CC=C1 QCZYYEFXOBKCNQ-STQMWFEESA-N 0.000 description 1
229910002651 NO3 Inorganic materials 0.000 description 1
NHNBFGGVMKEFGY-UHFFFAOYSA-N Nitrate Chemical compound [O-][N+]([O-])=O NHNBFGGVMKEFGY-UHFFFAOYSA-N 0.000 description 1
108010038807 Oligopeptides Proteins 0.000 description 1
102000015636 Oligopeptides Human genes 0.000 description 1
241000283973 Oryctolagus cuniculus Species 0.000 description 1
235000007164 Oryza sativa Nutrition 0.000 description 1
MUBZPKHOEPUJKR-UHFFFAOYSA-N Oxalic acid Chemical compound OC(=O)C(O)=O MUBZPKHOEPUJKR-UHFFFAOYSA-N 0.000 description 1
229910019142 PO4 Inorganic materials 0.000 description 1
241001494479 Pecora Species 0.000 description 1
102000035195 Peptidases Human genes 0.000 description 1
XBDQKXXYIPTUBI-UHFFFAOYSA-M Propionate Chemical compound CCC([O-])=O XBDQKXXYIPTUBI-UHFFFAOYSA-M 0.000 description 1
239000004365 Protease Substances 0.000 description 1
102100037486 Reverse transcriptase/ribonuclease H Human genes 0.000 description 1
208000034189 Sclerosis Diseases 0.000 description 1
244000061456 Solanum tuberosum Species 0.000 description 1
235000002595 Solanum tuberosum Nutrition 0.000 description 1
QAOWNCQODCNURD-UHFFFAOYSA-L Sulfate Chemical compound [O-]S([O-])(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 description 1
244000269722 Thea sinensis Species 0.000 description 1
WCRFXRIWBFRZBR-GGVZMXCHSA-N Thr-Tyr Chemical compound C[C@@H](O)[C@H](N)C(=O)N[C@H](C(O)=O)CC1=CC=C(O)C=C1 WCRFXRIWBFRZBR-GGVZMXCHSA-N 0.000 description 1
DTQVDTLACAAQTR-UHFFFAOYSA-M Trifluoroacetate Chemical compound [O-]C(=O)C(F)(F)F DTQVDTLACAAQTR-UHFFFAOYSA-M 0.000 description 1
GIAZPLMMQOERPN-YUMQZZPRSA-N Val-Pro Chemical compound CC(C)[C@H](N)C(=O)N1CCC[C@H]1C(O)=O GIAZPLMMQOERPN-YUMQZZPRSA-N 0.000 description 1
240000001417 Vigna umbellata Species 0.000 description 1
235000011453 Vigna umbellata Nutrition 0.000 description 1
230000005856 abnormality Effects 0.000 description 1
230000000996 additive effect Effects 0.000 description 1
230000032683 aging Effects 0.000 description 1
125000003277 amino group Chemical group 0.000 description 1
150000003863 ammonium salts Chemical class 0.000 description 1
238000010171 animal model Methods 0.000 description 1
230000030741 antigen processing and presentation Effects 0.000 description 1
239000003963 antioxidant agent Substances 0.000 description 1
235000006708 antioxidants Nutrition 0.000 description 1
239000007864 aqueous solution Substances 0.000 description 1
235000019606 astringent taste Nutrition 0.000 description 1
239000002585 base Substances 0.000 description 1
SRSXLGNVWSONIS-UHFFFAOYSA-M benzenesulfonate Chemical compound [O-]S(=O)(=O)C1=CC=CC=C1 SRSXLGNVWSONIS-UHFFFAOYSA-M 0.000 description 1
WPYMKLBDIGXBTP-UHFFFAOYSA-N benzoic acid Chemical compound OC(=O)C1=CC=CC=C1 WPYMKLBDIGXBTP-UHFFFAOYSA-N 0.000 description 1
230000015572 biosynthetic process Effects 0.000 description 1
235000021279 black bean Nutrition 0.000 description 1
230000006931 brain damage Effects 0.000 description 1
231100000874 brain damage Toxicity 0.000 description 1
208000029028 brain injury Diseases 0.000 description 1
239000011449 brick Substances 0.000 description 1
159000000007 calcium salts Chemical class 0.000 description 1
239000002775 capsule Substances 0.000 description 1
125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 description 1
210000003169 central nervous system Anatomy 0.000 description 1
238000005119 centrifugation Methods 0.000 description 1
239000003153 chemical reaction reagent Substances 0.000 description 1
208000037976 chronic inflammation Diseases 0.000 description 1
230000006020 chronic inflammation Effects 0.000 description 1
WSLYCILIEOFQPK-WDSKDSINSA-N cis-Cyclo[L-Ala-L-Pro] Chemical compound O=C1[C@H](C)NC(=O)[C@@H]2CCCN21 WSLYCILIEOFQPK-WDSKDSINSA-N 0.000 description 1
239000000701 coagulant Substances 0.000 description 1
239000011248 coating agent Substances 0.000 description 1
239000003086 colorant Substances 0.000 description 1
230000000295 complement effect Effects 0.000 description 1
150000001875 compounds Chemical class 0.000 description 1
239000012141 concentrate Substances 0.000 description 1
238000009833 condensation Methods 0.000 description 1
230000005494 condensation Effects 0.000 description 1
239000012228 culture supernatant Substances 0.000 description 1
UZOJHXFWJFSFAI-SECBINFHSA-N cyclic glycylphenylalanine Natural products N1C(=O)CNC(=O)[C@H]1CC1=CC=CC=C1 UZOJHXFWJFSFAI-SECBINFHSA-N 0.000 description 1
NAKUGCPAQTUSBE-IUCAKERBSA-N cyclo(L-His-L-Pro) Chemical compound C([C@@H]1NC([C@@H]2CCCN2C1=O)=O)C1=CN=CN1 NAKUGCPAQTUSBE-IUCAKERBSA-N 0.000 description 1
108010048643 cyclo(aspartyl-phenylalanyl) Proteins 0.000 description 1
108010001140 cyclo(glycylprolyl) Proteins 0.000 description 1
108010021250 cyclo(leucylglycine) Proteins 0.000 description 1
WIJKWEYCUNYTGY-UHFFFAOYSA-N cyclo-L-Phe-L-Ser Natural products N1C(=O)C(CO)NC(=O)C1CC1=CC=CC=C1 WIJKWEYCUNYTGY-UHFFFAOYSA-N 0.000 description 1
239000007857 degradation product Substances 0.000 description 1
230000018044 dehydration Effects 0.000 description 1
238000006297 dehydration reaction Methods 0.000 description 1
235000005911 diet Nutrition 0.000 description 1
230000000378 dietary effect Effects 0.000 description 1
239000002270 dispersing agent Substances 0.000 description 1
239000002552 dosage form Substances 0.000 description 1
230000035622 drinking Effects 0.000 description 1
235000013399 edible fruits Nutrition 0.000 description 1
230000009982 effect on human Effects 0.000 description 1
239000000839 emulsion Substances 0.000 description 1
238000011156 evaluation Methods 0.000 description 1
238000002474 experimental method Methods 0.000 description 1
239000000706 filtrate Substances 0.000 description 1
239000000796 flavoring agent Substances 0.000 description 1
235000019634 flavors Nutrition 0.000 description 1
235000013376 functional food Nutrition 0.000 description 1
229920000159 gelatin Polymers 0.000 description 1
239000008273 gelatin Substances 0.000 description 1
235000019322 gelatine Nutrition 0.000 description 1
235000011852 gelatine desserts Nutrition 0.000 description 1
239000008187 granular material Substances 0.000 description 1
210000002768 hair cell Anatomy 0.000 description 1
238000004128 high performance liquid chromatography Methods 0.000 description 1
108010017068 histidyl-proline diketopiperazine Proteins 0.000 description 1
230000007124 immune defense Effects 0.000 description 1
238000011534 incubation Methods 0.000 description 1
238000002347 injection Methods 0.000 description 1
239000007924 injection Substances 0.000 description 1
239000007951 isotonicity adjuster Substances 0.000 description 1
201000010901 lateral sclerosis Diseases 0.000 description 1
244000144972 livestock Species 0.000 description 1
230000007774 longterm Effects 0.000 description 1
239000000314 lubricant Substances 0.000 description 1
108010054155 lysyllysine Proteins 0.000 description 1
108010038320 lysylphenylalanine Proteins 0.000 description 1
LSGOTAXPWMCUCK-RYUDHWBXSA-N maculosin Chemical compound C1=CC(O)=CC=C1C[C@H]1C(=O)N2CCC[C@H]2C(=O)N1 LSGOTAXPWMCUCK-RYUDHWBXSA-N 0.000 description 1
159000000003 magnesium salts Chemical class 0.000 description 1
229940049920 malate Drugs 0.000 description 1
BJEPYKJPYRNKOW-UHFFFAOYSA-N malic acid Chemical compound OC(=O)C(O)CC(O)=O BJEPYKJPYRNKOW-UHFFFAOYSA-N 0.000 description 1
238000005259 measurement Methods 0.000 description 1
230000010534 mechanism of action Effects 0.000 description 1
230000004630 mental health Effects 0.000 description 1
230000004048 modification Effects 0.000 description 1
238000012986 modification Methods 0.000 description 1
208000005264 motor neuron disease Diseases 0.000 description 1
210000004498 neuroglial cell Anatomy 0.000 description 1
229910052757 nitrogen Inorganic materials 0.000 description 1
235000015097 nutrients Nutrition 0.000 description 1
235000016709 nutrition Nutrition 0.000 description 1
238000005580 one pot reaction Methods 0.000 description 1
239000003960 organic solvent Substances 0.000 description 1
239000002245 particle Substances 0.000 description 1
108010091748 peptide A Proteins 0.000 description 1
239000008194 pharmaceutical composition Substances 0.000 description 1
239000000546 pharmaceutical excipient Substances 0.000 description 1
239000000825 pharmaceutical preparation Substances 0.000 description 1
229940127557 pharmaceutical product Drugs 0.000 description 1
NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 description 1
239000010452 phosphate Substances 0.000 description 1
229940075930 picrate Drugs 0.000 description 1
OXNIZHLAWKMVMX-UHFFFAOYSA-M picrate anion Chemical compound [O-]C1=C([N+]([O-])=O)C=C([N+]([O-])=O)C=C1[N+]([O-])=O OXNIZHLAWKMVMX-UHFFFAOYSA-M 0.000 description 1
BXRNXXXXHLBUKK-UHFFFAOYSA-N piperazine-2,5-dione Chemical group O=C1CNC(=O)CN1 BXRNXXXXHLBUKK-UHFFFAOYSA-N 0.000 description 1
235000021118 plant-derived protein Nutrition 0.000 description 1
XAEFZNCEHLXOMS-UHFFFAOYSA-M potassium benzoate Chemical compound [K+].[O-]C(=O)C1=CC=CC=C1 XAEFZNCEHLXOMS-UHFFFAOYSA-M 0.000 description 1
239000003755 preservative agent Substances 0.000 description 1
230000017854 proteolysis Effects 0.000 description 1
229940024999 proteolytic enzymes for treatment of wounds and ulcers Drugs 0.000 description 1
239000003642 reactive oxygen metabolite Substances 0.000 description 1
238000011160 research Methods 0.000 description 1
235000009566 rice Nutrition 0.000 description 1
159000000000 sodium salts Chemical class 0.000 description 1
238000009331 sowing Methods 0.000 description 1
KDYFGRWQOYBRFD-UHFFFAOYSA-L succinate(2-) Chemical compound [O-]C(=O)CCC([O-])=O KDYFGRWQOYBRFD-UHFFFAOYSA-L 0.000 description 1
239000013589 supplement Substances 0.000 description 1
239000000725 suspension Substances 0.000 description 1
VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 description 1
235000019154 vitamin C Nutrition 0.000 description 1
239000011718 vitamin C Substances 0.000 description 1

Classifications

- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/17—Amino acids, peptides or proteins
- A23L33/18—Peptides; Protein hydrolysates
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/17—Amino acids, peptides or proteins
- A23L33/185—Vegetable proteins
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/17—Amino acids, peptides or proteins
- A23L33/19—Dairy proteins
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/20—Milk; Whey; Colostrum
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical & Material Sciences (AREA)
Engineering & Computer Science (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Mycology (AREA)
Natural Medicines & Medicinal Plants (AREA)
Public Health (AREA)
Food Science & Technology (AREA)
Polymers & Plastics (AREA)
Nutrition Science (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Epidemiology (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Biotechnology (AREA)
Immunology (AREA)
Medical Informatics (AREA)
Virology (AREA)
Developmental Biology & Embryology (AREA)
Microbiology (AREA)
Alternative & Traditional Medicine (AREA)
Biomedical Technology (AREA)
Cell Biology (AREA)
Botany (AREA)
Zoology (AREA)
Bioinformatics & Cheminformatics (AREA)
Molecular Biology (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Coloring Foods And Improving Nutritive Qualities (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Medicines Containing Plant Substances (AREA)

TW106100494A 2016-01-08 2017-01-06 神經性疾病之預防用組成物 TW201733607A (zh)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
JP2016002493		2016-01-08

Publications (1)

Publication Number	Publication Date
TW201733607A true TW201733607A (zh)	2017-10-01

Family

ID=59273726

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
TW106100494A TW201733607A (zh)	2016-01-08	2017-01-06	神經性疾病之預防用組成物

Country Status (3)

Country	Link
JP (1)	JPWO2017119476A1 (fr)
TW (1)	TW201733607A (fr)
WO (1)	WO2017119476A1 (fr)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JP7011984B2 (ja) *	2018-07-13	2022-01-27	キリンホールディングス株式会社	注意機能および判断機能向上用組成物
WO2022131026A1 (fr) *	2020-12-18	2022-06-23	Suntory Holdings Limited	Utilisation de dipeptides cycliques dans la production d'un agent pour inhiber le déclin de la fonction cognitive ou améliorer un dysfonctionnement cognitif
WO2024095906A1 (fr) *	2022-11-01	2024-05-10	サントリーホールディングス株式会社	Composition permettant de prévenir ou d'inhiber l'inflammation des cellules neurales
WO2024262349A1 (fr) *	2023-06-19	2024-12-26	サントリーホールディングス株式会社	COMPOSITION POUR SUPPRIMER OU AMÉLIORER LA DÉTÉRIORATION DE LA FONCTION COGNITIVE, ET COMPOSITION POUR INHIBER LA β-SÉCRÉTASE
KR102835798B1 (ko) *	2024-07-05	2025-07-21	주식회사 비플럭스파머	백강잠 또는 이로부터 유래한 사이클릭 펩타이드를 유효 성분으로 포함하는 근육 증진 및 개선용 그리고 근감소 관련 질환 치료 및 예방용 조성물

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
SG178213A1 (en) *	2009-12-25	2012-03-29	Suntory Holdings Ltd	Learning motivation improvers
SG11201510062VA (en) *	2013-06-10	2016-01-28	Suntory Holdings Ltd	Plant extract containing diketopiperazine and method for producing same

2017
- 2017-01-06 WO PCT/JP2017/000244 patent/WO2017119476A1/fr not_active Ceased
- 2017-01-06 JP JP2017560427A patent/JPWO2017119476A1/ja active Pending
- 2017-01-06 TW TW106100494A patent/TW201733607A/zh unknown

Also Published As

Publication number	Publication date
JPWO2017119476A1 (ja)	2018-11-01
WO2017119476A1 (fr)	2017-07-13

Publication	Publication Date	Title
JP6669750B2 (ja)	2020-03-18	環状ジペプチド含有血清カルノシン分解酵素阻害用組成物
TW201733607A (zh)	2017-10-01	神經性疾病之預防用組成物
JP6839080B2 (ja)	2021-03-03	動植物由来ペプチド含有血清カルノシン分解酵素阻害用組成物
JP6713981B2 (ja)	2020-06-24	リパーゼ阻害剤
TW201716079A (zh)	2017-05-16	Ｇｌｐ－２分泌促進用組成物
TW201716080A (zh)	2017-05-16	Ｔｒｐｖ１刺激用組成物
KR102178926B1 (ko)	2020-11-13	발효 태반 조성물을 유효성분으로 하는 면역 증강 또는 항피로 조성물과 그의 용도
WO2017119481A1 (fr)	2017-07-13	Composition contenant un dipeptide cyclique pour la prévention de maladie neurologiques
CN107922458B (zh)	2022-01-21	含有氨基酸及环状二肽的组合物
JP6671367B2 (ja)	2020-03-25	環状ジペプチド含有抗肥満用組成物
KR20140106058A (ko)	2014-09-03	수용성 연어이리 추출물 및 식물성 유산균을 포함하는 면역 증강용 조성물
JP6661597B2 (ja)	2020-03-11	α−グルコシダーゼ阻害剤
JP6770515B2 (ja)	2020-10-14	血圧降下用組成物
TW201716066A (zh)	2017-05-16	酒精吸收抑制用組成物
JP6786490B2 (ja)	2020-11-18	抗肥満用組成物
JP6687619B2 (ja)	2020-04-22	メラニン凝集ホルモン受容体拮抗用組成物
KR20210076222A (ko)	2021-06-24	누에고치 가수분해물을 포함하는 칼슘 흡수 촉진용 조성물