TW201733982A - 芳香醯胺類衍生物、其製備方法及其在醫藥上的應用 - Google Patents

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Publication number

TW201733982A

TW201733982A TW106109163A TW106109163A TW201733982A TW 201733982 A TW201733982 A TW 201733982A TW 106109163 A TW106109163 A TW 106109163A TW 106109163 A TW106109163 A TW 106109163A TW 201733982 A TW201733982 A TW 201733982A

Authority

TW

Taiwan

Prior art keywords

group

cycloalkyl

heteroaryl

alkyl

compound

Prior art date

2016-03-18

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• AQVAGHLSOGAWDM-UHFFFAOYSA-N methyl 1-cyclopropyl-2-(hydroxymethyl)indole-5-carboxylate Chemical compound COC(=O)C=1C=C2C=C(N(C2=CC=1)C1CC1)CO AQVAGHLSOGAWDM-UHFFFAOYSA-N 0.000 description 1
• CHWRAEYDRXDNPB-UHFFFAOYSA-N methyl 1-cyclopropyl-2-[[2-(trifluoromethyl)phenyl]methyl]indole-5-carboxylate Chemical compound COC(=O)C=1C=C2C=C(N(C2=CC=1)C1CC1)CC1=C(C=CC=C1)C(F)(F)F CHWRAEYDRXDNPB-UHFFFAOYSA-N 0.000 description 1
• BGFTVBGTMUQYDI-UHFFFAOYSA-N methyl 1-cyclopropyl-2-[[2-fluoro-4-(trifluoromethyl)phenyl]methyl]indole-5-carboxylate Chemical compound COC(=O)c1ccc2n(C3CC3)c(Cc3ccc(cc3F)C(F)(F)F)cc2c1 BGFTVBGTMUQYDI-UHFFFAOYSA-N 0.000 description 1
• NKUANJWLZORYEK-UHFFFAOYSA-N methyl 1-cyclopropyl-2-[[4-(trifluoromethoxy)phenyl]methyl]indole-5-carboxylate Chemical compound COC(=O)C=1C=C2C=C(N(C2=CC=1)C1CC1)CC1=CC=C(C=C1)OC(F)(F)F NKUANJWLZORYEK-UHFFFAOYSA-N 0.000 description 1
• DZJVSLPTQSKOPL-UHFFFAOYSA-N methyl 1-cyclopropyl-2-[[4-(trifluoromethyl)phenyl]methyl]indole-5-carboxylate Chemical compound COC(=O)C=1C=C2C=C(N(C2=CC=1)C1CC1)CC1=CC=C(C=C1)C(F)(F)F DZJVSLPTQSKOPL-UHFFFAOYSA-N 0.000 description 1
• XSICWKOCAFVITO-UHFFFAOYSA-N methyl 1-cyclopropyl-2-[[4-fluoro-2-(trifluoromethyl)phenyl]methyl]indole-5-carboxylate Chemical compound COC(=O)C=1C=C2C=C(N(C2=CC=1)C1CC1)CC1=C(C=C(C=C1)F)C(F)(F)F XSICWKOCAFVITO-UHFFFAOYSA-N 0.000 description 1
• OQMBMZMRRCJUCC-UHFFFAOYSA-N methyl 1-cyclopropyl-2-[[5-(trifluoromethyl)pyrazol-1-yl]methyl]indole-5-carboxylate Chemical compound COC(=O)c1ccc2n(C3CC3)c(Cn3nccc3C(F)(F)F)cc2c1 OQMBMZMRRCJUCC-UHFFFAOYSA-N 0.000 description 1
• VXMBSFZXZYIHGL-UHFFFAOYSA-N methyl 1-ethyl-2-[[2-(trifluoromethyl)phenyl]methyl]indole-5-carboxylate Chemical compound CCn1c(Cc2ccccc2C(F)(F)F)cc2cc(ccc12)C(=O)OC VXMBSFZXZYIHGL-UHFFFAOYSA-N 0.000 description 1
• PFAMEYPFSCQBGZ-UHFFFAOYSA-N methyl 1-ethyl-2-[[2-fluoro-4-(trifluoromethyl)phenyl]methyl]indole-5-carboxylate Chemical compound CCn1c(Cc2ccc(cc2F)C(F)(F)F)cc2cc(ccc12)C(=O)OC PFAMEYPFSCQBGZ-UHFFFAOYSA-N 0.000 description 1
• ZKQVECZXLLGWET-UHFFFAOYSA-N methyl 1-ethyl-2-[[4-(trifluoromethoxy)phenyl]methyl]indole-5-carboxylate Chemical compound CCn1c(Cc2ccc(OC(F)(F)F)cc2)cc2cc(ccc12)C(=O)OC ZKQVECZXLLGWET-UHFFFAOYSA-N 0.000 description 1
• MCXKKDGBTDQLNH-UHFFFAOYSA-N methyl 1-ethyl-2-[[4-(trifluoromethyl)phenyl]methyl]indole-5-carboxylate Chemical compound CCn1c(Cc2ccc(cc2)C(F)(F)F)cc2cc(ccc12)C(=O)OC MCXKKDGBTDQLNH-UHFFFAOYSA-N 0.000 description 1
• SQHTUMVTWCYRAX-UHFFFAOYSA-N methyl 1-ethyl-2-[[6-(trifluoromethyl)pyridin-3-yl]methyl]indole-5-carboxylate Chemical compound CCn1c(Cc2ccc(nc2)C(F)(F)F)cc2cc(ccc12)C(=O)OC SQHTUMVTWCYRAX-UHFFFAOYSA-N 0.000 description 1
• MAWMIWRQOXGCAC-UHFFFAOYSA-N methyl 1-methyl-2-[[4-(trifluoromethoxy)phenyl]methyl]indole-5-carboxylate Chemical compound COC(=O)C=1C=C2C=C(N(C2=CC=1)C)CC1=CC=C(C=C1)OC(F)(F)F MAWMIWRQOXGCAC-UHFFFAOYSA-N 0.000 description 1
• LEPIQEIUDFAVKV-UHFFFAOYSA-N methyl 1-propan-2-yl-2-[[2-(trifluoromethoxy)phenyl]methyl]indole-5-carboxylate Chemical compound COC(=O)c1ccc2n(C(C)C)c(Cc3ccccc3OC(F)(F)F)cc2c1 LEPIQEIUDFAVKV-UHFFFAOYSA-N 0.000 description 1
• LKOBCRBZIPNCNC-UHFFFAOYSA-N methyl 1-propan-2-yl-2-[[2-(trifluoromethyl)phenyl]methyl]indole-5-carboxylate Chemical compound COC(=O)c1ccc2n(C(C)C)c(Cc3ccccc3C(F)(F)F)cc2c1 LKOBCRBZIPNCNC-UHFFFAOYSA-N 0.000 description 1
• LUJVYTLWPMOFBN-UHFFFAOYSA-N methyl 1-propan-2-yl-2-[[4-(trifluoromethyl)phenyl]methyl]indole-5-carboxylate Chemical compound COC(=O)C=1C=C2C=C(N(C2=CC=1)C(C)C)CC1=CC=C(C=C1)C(F)(F)F LUJVYTLWPMOFBN-UHFFFAOYSA-N 0.000 description 1
• DRYBMFJLYYEOBZ-UHFFFAOYSA-N methyl 1h-indole-5-carboxylate Chemical compound COC(=O)C1=CC=C2NC=CC2=C1 DRYBMFJLYYEOBZ-UHFFFAOYSA-N 0.000 description 1
• MCHWHPPAJXHNED-UHFFFAOYSA-N methyl 2-[(2-methoxyphenyl)methyl]-1-propan-2-ylindole-5-carboxylate Chemical compound COC(=O)c1ccc2n(C(C)C)c(Cc3ccccc3OC)cc2c1 MCHWHPPAJXHNED-UHFFFAOYSA-N 0.000 description 1
• RHQIVGVRIPFZMI-UHFFFAOYSA-N methyl 2-[(2-methoxyphenyl)methyl]-1H-indole-5-carboxylate Chemical compound COC(=O)C=1C=C2C=C(NC2=CC=1)CC1=C(C=CC=C1)OC RHQIVGVRIPFZMI-UHFFFAOYSA-N 0.000 description 1
• ZGPDJPIOUJOLRQ-UHFFFAOYSA-N methyl 2-[[2-(trifluoromethoxy)phenyl]methyl]-1H-indole-5-carboxylate Chemical compound COC(=O)C=1C=C2C=C(NC2=CC=1)CC1=C(C=CC=C1)OC(F)(F)F ZGPDJPIOUJOLRQ-UHFFFAOYSA-N 0.000 description 1
• PVWBBYMRQHXTLH-UHFFFAOYSA-N methyl 2-[[2-chloro-4-(trifluoromethyl)phenyl]methyl]-1-propan-2-ylindole-5-carboxylate Chemical compound COC(=O)C=1C=C2C=C(N(C2=CC=1)C(C)C)CC1=C(C=C(C=C1)C(F)(F)F)Cl PVWBBYMRQHXTLH-UHFFFAOYSA-N 0.000 description 1
• GTTLDGCUIKEDDB-UHFFFAOYSA-N methyl 2-[[2-chloro-4-(trifluoromethyl)phenyl]methyl]-1H-indole-5-carboxylate Chemical compound COC(=O)C=1C=C2C=C(NC2=CC=1)CC1=C(C=C(C=C1)C(F)(F)F)Cl GTTLDGCUIKEDDB-UHFFFAOYSA-N 0.000 description 1
• KBSQIXRDVXOTSB-UHFFFAOYSA-N methyl 2-[[2-fluoro-4-(trifluoromethyl)phenyl]methyl]-1-propan-2-ylindole-5-carboxylate Chemical compound COC(=O)C=1C=C2C=C(N(C2=CC=1)C(C)C)CC1=C(C=C(C=C1)C(F)(F)F)F KBSQIXRDVXOTSB-UHFFFAOYSA-N 0.000 description 1
• FTOLHNZSBYXTQC-UHFFFAOYSA-N methyl 2-[[2-fluoro-4-(trifluoromethyl)phenyl]methyl]-1H-indole-5-carboxylate Chemical compound COC(=O)C=1C=C2C=C(NC2=CC=1)CC1=C(C=C(C=C1)C(F)(F)F)F FTOLHNZSBYXTQC-UHFFFAOYSA-N 0.000 description 1
• SYXVOGQZDRIROF-UHFFFAOYSA-N methyl 2-[[3-(trifluoromethyl)phenyl]methyl]-1H-indole-5-carboxylate Chemical compound COC(=O)C=1C=C2C=C(NC2=CC=1)CC1=CC(=CC=C1)C(F)(F)F SYXVOGQZDRIROF-UHFFFAOYSA-N 0.000 description 1
• VWEBAPJWOZUBRA-UHFFFAOYSA-N methyl 2-[[4-(trifluoromethoxy)phenyl]methyl]-1H-indole-5-carboxylate Chemical compound COC(=O)C=1C=C2C=C(NC2=CC=1)CC1=CC=C(C=C1)OC(F)(F)F VWEBAPJWOZUBRA-UHFFFAOYSA-N 0.000 description 1
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