TW201903149A - 抑制apcs之表現的核酸 - Google Patents

抑制apcs之表現的核酸 Download PDF

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Publication number: TW201903149A
Authority: TW; Taiwan
Prior art keywords: nucleic acid; double; stranded; apcs; antisense strand
Prior art date: 2017-05-31

Application number

TW107118805A

Other languages

English (en)

Chinese (zh)

Inventor

有山博之

村上拓也

今枝隆

宮澤達也

Original Assignee

日商協和醱酵麒麟有限公司

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2017-05-31

Filing date

2018-05-31

Publication date

2019-01-16

2018-05-31 Application filed by 日商協和醱酵麒麟有限公司 filed Critical 日商協和醱酵麒麟有限公司

2019-01-16 Publication of TW201903149A publication Critical patent/TW201903149A/zh

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230000001177 retroviral effect Effects 0.000 description 1
PYWVYCXTNDRMGF-UHFFFAOYSA-N rhodamine B Chemical compound [Cl-].C=12C=CC(=[N+](CC)CC)C=C2OC2=CC(N(CC)CC)=CC=C2C=1C1=CC=CC=C1C(O)=O PYWVYCXTNDRMGF-UHFFFAOYSA-N 0.000 description 1
125000000548 ribosyl group Chemical group C1([C@H](O)[C@H](O)[C@H](O1)CO)* 0.000 description 1
229920002477 rna polymer Polymers 0.000 description 1
239000012266 salt solution Substances 0.000 description 1
210000002966 serum Anatomy 0.000 description 1
239000003381 stabilizer Substances 0.000 description 1
239000012128 staining reagent Substances 0.000 description 1
239000012089 stop solution Substances 0.000 description 1
238000006467 substitution reaction Methods 0.000 description 1
150000008163 sugars Chemical class 0.000 description 1
229910052717 sulfur Inorganic materials 0.000 description 1
125000004434 sulfur atom Chemical group 0.000 description 1
239000000829 suppository Substances 0.000 description 1
208000024891 symptom Diseases 0.000 description 1
239000013076 target substance Substances 0.000 description 1
RYYWUUFWQRZTIU-UHFFFAOYSA-K thiophosphate Chemical compound [O-]P([O-])([O-])=S RYYWUUFWQRZTIU-UHFFFAOYSA-K 0.000 description 1
229940104230 thymidine Drugs 0.000 description 1
210000001519 tissue Anatomy 0.000 description 1
238000001890 transfection Methods 0.000 description 1
239000012096 transfection reagent Substances 0.000 description 1
QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 description 1

Classifications

- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7088—Compounds having three or more nucleosides or nucleotides
- A61K31/7105—Natural ribonucleic acids, i.e. containing only riboses attached to adenine, guanine, cytosine or uracil and having 3'-5' phosphodiester links
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7088—Compounds having three or more nucleosides or nucleotides
- A61K31/713—Double-stranded nucleic acids or oligonucleotides
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/10—Type of nucleic acid
- C12N2310/11—Antisense
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/10—Type of nucleic acid
- C12N2310/14—Type of nucleic acid interfering nucleic acids [NA]
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/32—Chemical structure of the sugar
- C12N2310/321—2'-O-R Modification

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Genetics & Genomics (AREA)
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Microbiology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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Chemical Kinetics & Catalysis (AREA)
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Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

TW107118805A 2017-05-31 2018-05-31 抑制apcs之表現的核酸 TW201903149A (zh)

Applications Claiming Priority (2)

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JP2017108502		2017-05-31
JP2017-108502		2017-05-31

Publications (1)

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TW201903149A true TW201903149A (zh)	2019-01-16

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TW107118805A TW201903149A (zh)	2017-05-31	2018-05-31	抑制apcs之表現的核酸

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US (1)	US11466272B2 (de)
EP (1)	EP3633037A4 (de)
JP (1)	JPWO2018221649A1 (de)
KR (1)	KR20200014320A (de)
CN (1)	CN110832078A (de)
AU (1)	AU2018277476A1 (de)
CA (1)	CA3065149A1 (de)
TW (1)	TW201903149A (de)
WO (1)	WO2018221649A1 (de)

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Publication number	Priority date	Publication date	Assignee	Title
WO2019100039A1 (en) *	2017-11-20	2019-05-23	Alnylam Pharmaceuticals, Inc.	Serum amyloid p component (apcs) irna compositions and methods of use thereof
AU2019390097A1 (en) *	2018-11-30	2021-07-15	Kyowa Kirin Co., Ltd.	Nucleic acid conjugate
EP4349986A4 (de) *	2021-05-25	2025-11-19	Univ Nat Corp Tokyo Medical & Dental	Heteronukleinsäure mit scpbna oder amna

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* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB9317120D0 (en) *	1993-08-17	1993-09-29	Royal Postgrad Med School	Human serum amyloid p component
GB9711919D0 (en)	1997-06-09	1997-08-06	Ciba Geigy Ag	Oligonucleotide derivatives
ES2336887T5 (es)	2000-03-30	2019-03-06	Whitehead Inst Biomedical Res	Mediadores de interferencia por ARN específicos de secuencias de ARN
AU2003295600A1 (en) *	2002-11-14	2004-06-15	Dharmacon, Inc.	Functional and hyperfunctional sirna
CA2559955C (en)	2004-03-15	2016-02-16	City Of Hope	Methods and compositions for the specific inhibition of gene expression by double-stranded rna
WO2005116204A1 (ja)	2004-05-11	2005-12-08	Rnai Co., Ltd.	Ｒｎａ干渉を生じさせるポリヌクレオチド、および、これを用いた遺伝子発現抑制方法
US20090011003A1 (en)	2005-01-28	2009-01-08	Kyowa Hakko Kogyo Co., Ltd.	Composition for Suppressing Expression of Target Gene
JP2010505897A (ja)	2006-10-11	2010-02-25	マックス−プランク−ゲゼルシャフト・ツア・フェルデルング・デア・ヴィッセンシャフテン・エー・ファオ	インフルエンザターゲット
GB0712503D0 (en) *	2007-06-27	2007-08-08	Therapeutics Pentraxin Ltd	Use
EP2342340A1 (de)	2008-09-22	2011-07-13	Rxi Pharmaceuticals Corporation	Rna-interferenz bei hautindikationen
JP2017108502A (ja)	2015-12-08	2017-06-15	三菱自動車工業株式会社	電動機の冷却システム
WO2019100039A1 (en) *	2017-11-20	2019-05-23	Alnylam Pharmaceuticals, Inc.	Serum amyloid p component (apcs) irna compositions and methods of use thereof

2018
- 2018-05-31 KR KR1020197036566A patent/KR20200014320A/ko not_active Abandoned
- 2018-05-31 JP JP2019521298A patent/JPWO2018221649A1/ja active Pending
- 2018-05-31 CN CN201880036361.8A patent/CN110832078A/zh active Pending
- 2018-05-31 EP EP18810658.7A patent/EP3633037A4/de not_active Withdrawn
- 2018-05-31 WO PCT/JP2018/020941 patent/WO2018221649A1/ja not_active Ceased
- 2018-05-31 AU AU2018277476A patent/AU2018277476A1/en not_active Abandoned
- 2018-05-31 CA CA3065149A patent/CA3065149A1/en active Pending
- 2018-05-31 US US16/617,743 patent/US11466272B2/en active Active
- 2018-05-31 TW TW107118805A patent/TW201903149A/zh unknown

Also Published As

Publication number	Publication date
JPWO2018221649A1 (ja)	2020-04-02
US20200190514A1 (en)	2020-06-18
KR20200014320A (ko)	2020-02-10
CA3065149A1 (en)	2018-12-06
US11466272B2 (en)	2022-10-11
WO2018221649A1 (ja)	2018-12-06
CN110832078A (zh)	2020-02-21
AU2018277476A1 (en)	2020-01-02
EP3633037A1 (de)	2020-04-08
EP3633037A4 (de)	2021-03-24

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