TW202440549A - 檢查點激酶１（ｃｈｋ１）抑制劑及其用途 - Google Patents

檢查點激酶１（ｃｈｋ１）抑制劑及其用途 Download PDF

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Publication number: TW202440549A
Authority: TW; Taiwan
Prior art keywords: alkyl; compound; cycloalkyl; pharmaceutically acceptable; heterocycloalkyl
Prior art date: 2022-11-29

Application number

TW112146049A

Other languages

English (en)

Chinese (zh)

Inventor

安東尼Ｂ平克頓

史蒂芬陶德梅爾

Original Assignee

美商無界生物公司

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2022-11-29

Filing date

2023-11-28

Publication date

2024-10-16

2023-11-28 Application filed by 美商無界生物公司 filed Critical 美商無界生物公司

2024-10-16 Publication of TW202440549A publication Critical patent/TW202440549A/zh

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Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents

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Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

TW112146049A 2022-11-29 2023-11-28 檢查點激酶１（ｃｈｋ１）抑制劑及其用途 TW202440549A (zh)

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CA3219348A1 (fr)	2021-05-27	2022-12-01	Anthony B. Pinkerton	Inhibiteurs de la checkpoint kinase 1 (chk1) et leurs utilisations
WO2025217307A1 (fr)	2024-04-09	2025-10-16	Revolution Medicines, Inc.	Procédés de prédiction de la réponse à un inhibiteur de ras(on) et polythérapies
WO2025240847A1 (fr)	2024-05-17	2025-11-20	Revolution Medicines, Inc.	Inhibiteurs de ras
US20250375445A1 (en)	2024-06-07	2025-12-11	Revolution Medicines, Inc.	Methods of treating a ras protein-related disease or disorder
WO2025265060A1 (fr)	2024-06-21	2025-12-26	Revolution Medicines, Inc.	Compositions thérapeutiques et procédés de gestion d'effets liés au traitement
WO2026006747A1 (fr)	2024-06-28	2026-01-02	Revolution Medicines, Inc.	Inhibiteurs de ras
WO2026015801A1 (fr)	2024-07-12	2026-01-15	Revolution Medicines, Inc.	Méthodes de traitement d'une maladie ou d'un trouble liés à ras
WO2026015796A1 (fr)	2024-07-12	2026-01-15	Revolution Medicines, Inc.	Méthodes de traitement d'une maladie ou d'un trouble lié à ras
WO2026015825A1 (fr)	2024-07-12	2026-01-15	Revolution Medicines, Inc.	Utilisation d'un inhibiteur de ras pour traiter le cancer du pancréas
WO2026015790A1 (fr)	2024-07-12	2026-01-15	Revolution Medicines, Inc.	Méthodes de traitement d'une maladie ou d'un trouble lié à ras
WO2026050446A1 (fr)	2024-08-29	2026-03-05	Revolution Medicines, Inc.	Inhibiteurs de ras
WO2026072904A2 (fr)	2024-09-26	2026-04-02	Revolution Medicines, Inc.	Compositions et méthodes de traitement du cancer du poumon

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GB201402277D0 (en) *	2014-02-10	2014-03-26	Sentinel Oncology Ltd	Pharmaceutical compounds
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AU2021389190A1 (en) *	2020-11-30	2023-06-29	Sumitomo Pharma Co., Ltd.	5-heteroaryl-1h-pyrazol-3-amine derivative
CA3219348A1 (fr) *	2021-05-27	2022-12-01	Anthony B. Pinkerton	Inhibiteurs de la checkpoint kinase 1 (chk1) et leurs utilisations
CN119255990A (zh) *	2022-05-25	2025-01-03	曙方医药	作为检查点激酶1抑制剂的含氮五元杂环衍生物及其用途

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WO2024118564A1 (fr)	2024-06-06

Publication	Publication Date	Title
TW202440549A (zh)	2024-10-16	檢查點激酶１（ｃｈｋ１）抑制劑及其用途
US11707462B2 (en)	2023-07-25	Checkpoint kinase 1 (CHK1) inhibitors and uses thereof
TW202411217A (zh)	2024-03-16	吡啶檢測點激酶1（chk1）抑制劑及其用途
JP6404717B2 (ja)	2018-10-17	アミドスピロ環状アミド及びスルホンアミド誘導体
JP7680619B2 (ja)	2025-05-20	Ｐａｒｐ１阻害薬及びその使用
JP5961628B2 (ja)	2016-08-02	ＦＡＫ／Ｐｙｋ２阻害剤である２，４−ジアミノ−６，７−ジヒドロ−５Ｈ−ピロロ［２，３］ピリミジン誘導体
JP2021502388A (ja)	2021-01-28	Ａｓｈ１ｌ阻害剤及びそれを用いた治療方法
WO2013170770A1 (fr)	2013-11-21	Dérivés d'acétylène ayant une activité antitumorale
CA2921208A1 (fr)	2015-02-19	Compose pyrimidine fusionne ou sel dudit compose
JP2024534420A (ja)	2024-09-20	環状スルホンアミドリボヌクレオチドレダクターゼ（ｒｎｒ）阻害剤およびその使用
CN118488945A (zh)	2024-08-13	磺酰胺核糖核苷酸还原酶(rnr)抑制剂及其用途
WO2024118596A1 (fr)	2024-06-06	Combinaisons d'inhibiteurs de la checkpoint kinase 1 (chk1) et leurs utilisations
EA051928B1 (ru)	2025-12-22	Пиридиновые ингибиторы киназы 1 контрольной точки (chk1) и их применение
BR122025009667A2 (pt)	2025-06-17	Inibidores de parp1, composições que os compreendem, e usos dos mesmos
BR112024014920B1 (pt)	2025-08-05	Inibidores de parp1, composições que os compreendem, e usos dos mesmos
EA051378B1 (ru)	2025-10-30	Ингибиторы parp1 и их применение
BR112017026085B1 (pt)	2023-07-18	Métodos e composições para a inibição da interação da menin com proteínas da mll