TW202602853A - ｐＨ—敏感性陽離子脂質、包含其之脂質奈米顆粒及傳遞核酸之方法 - Google Patents

ｐＨ—敏感性陽離子脂質、包含其之脂質奈米顆粒及傳遞核酸之方法

Info

Publication number
TW202602853A
TW202602853A TW114110513A TW114110513A TW202602853A TW 202602853 A TW202602853 A TW 202602853A TW 114110513 A TW114110513 A TW 114110513A TW 114110513 A TW114110513 A TW 114110513A TW 202602853 A TW202602853 A TW 202602853A
Authority
TW
Taiwan
Prior art keywords
compound
group
lipid nanoparticles
lipid
heterocyclic group
Prior art date
Application number
TW114110513A
Other languages
English (en)
Chinese (zh)
Inventor
田口将光
Original Assignee
日商日東電工股份有限公司
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 日商日東電工股份有限公司 filed Critical 日商日東電工股份有限公司
Publication of TW202602853A publication Critical patent/TW202602853A/zh

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/51—Nanocapsules; Nanoparticles
    • A61K9/5107—Excipients; Inactive ingredients
    • A61K9/5123—Organic compounds, e.g. fats, sugars
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
    • A61K9/1271—Non-conventional liposomes, e.g. PEGylated liposomes or liposomes coated or grafted with polymers
    • A61K9/1272—Non-conventional liposomes, e.g. PEGylated liposomes or liposomes coated or grafted with polymers comprising non-phosphatidyl surfactants as bilayer-forming substances, e.g. cationic lipids or non-phosphatidyl liposomes coated or grafted with polymers

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Molecular Biology (AREA)
  • Physics & Mathematics (AREA)
  • Dispersion Chemistry (AREA)
  • Biophysics (AREA)
  • Biomedical Technology (AREA)
  • Nanotechnology (AREA)
  • Optics & Photonics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
TW114110513A 2024-03-21 2025-03-20 ｐＨ—敏感性陽離子脂質、包含其之脂質奈米顆粒及傳遞核酸之方法 TW202602853A (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US202463568218P 2024-03-21 2024-03-21
US63/568,218 2024-03-21

Publications (1)

Publication Number Publication Date
TW202602853A true TW202602853A (zh) 2026-01-16

Family

ID=97140220

Family Applications (1)

Application Number Title Priority Date Filing Date
TW114110513A TW202602853A (zh) 2024-03-21 2025-03-20 ｐＨ—敏感性陽離子脂質、包含其之脂質奈米顆粒及傳遞核酸之方法

Country Status (2)

Country Link
TW (1) TW202602853A (fr)
WO (1) WO2025199302A1 (fr)

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10125092B2 (en) * 2014-09-05 2018-11-13 Novartis Ag Lipids and lipid compositions for the delivery of active agents
KR102676927B1 (ko) * 2017-06-15 2024-06-24 국립대학법인 홋가이도 다이가쿠 siRNA 세포 내 송달을 위한 지질막 구조체
AU2021355199A1 (en) * 2020-10-02 2023-05-25 National University Corporation Hokkaido University Lipid nanoparticle

Also Published As

Publication number Publication date
WO2025199302A1 (fr) 2025-09-25

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