TW205504B - - Google Patents

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Publication number: TW205504B
Authority: TW; Taiwan
Prior art keywords: patent application; item; glyceryl; composition according; composition
Prior art date: 1991-05-03

Application number

TW80108379A

Other languages

English (en)

Chinese (zh)

Original Assignee

Mcneil Ppc Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1991-05-03

Filing date

1991-10-24

Publication date

1993-05-11

1991-10-24 Application filed by Mcneil Ppc Inc filed Critical Mcneil Ppc Inc

1993-05-11 Application granted granted Critical

1993-05-11 Publication of TW205504B publication Critical patent/TW205504B/zh

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ARIWANIATODDMH-UHFFFAOYSA-N rac-1-monolauroylglycerol Chemical compound CCCCCCCCCCCC(=O)OCC(O)CO ARIWANIATODDMH-UHFFFAOYSA-N 0.000 claims description 241
239000000203 mixture Substances 0.000 claims description 108
229940068939 glyceryl monolaurate Drugs 0.000 claims description 93
241000191967 Staphylococcus aureus Species 0.000 claims description 67
150000001875 compounds Chemical class 0.000 claims description 48
150000002148 esters Chemical class 0.000 claims description 42
PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims description 41
238000004519 manufacturing process Methods 0.000 claims description 38
235000014113 dietary fatty acids Nutrition 0.000 claims description 31
239000000194 fatty acid Substances 0.000 claims description 31
229930195729 fatty acid Natural products 0.000 claims description 31
150000004665 fatty acids Chemical class 0.000 claims description 27
206010044248 Toxic shock syndrome Diseases 0.000 claims description 26
238000011049 filling Methods 0.000 claims description 26
206010040070 Septic Shock Diseases 0.000 claims description 25
231100000650 Toxic shock syndrome Toxicity 0.000 claims description 25
DNIAPMSPPWPWGF-GSVOUGTGSA-N (R)-(-)-Propylene glycol Chemical compound C[C@@H](O)CO DNIAPMSPPWPWGF-GSVOUGTGSA-N 0.000 claims description 21
150000005690 diesters Chemical class 0.000 claims description 20
239000002253 acid Substances 0.000 claims description 18
235000011187 glycerol Nutrition 0.000 claims description 17
239000000052 vinegar Substances 0.000 claims description 17
235000021419 vinegar Nutrition 0.000 claims description 17
125000002887 hydroxy group Chemical group [H]O* 0.000 claims description 15
241000894006 Bacteria Species 0.000 claims description 13
POULHZVOKOAJMA-UHFFFAOYSA-N dodecanoic acid Chemical compound CCCCCCCCCCCC(O)=O POULHZVOKOAJMA-UHFFFAOYSA-N 0.000 claims description 12
125000003976 glyceryl group Chemical group [H]C([*])([H])C(O[H])([H])C(O[H])([H])[H] 0.000 claims description 11
VBICKXHEKHSIBG-UHFFFAOYSA-N 1-monostearoylglycerol Chemical compound CCCCCCCCCCCCCCCCCC(=O)OCC(O)CO VBICKXHEKHSIBG-UHFFFAOYSA-N 0.000 claims description 10
108010006464 Hemolysin Proteins Proteins 0.000 claims description 10
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239000003228 hemolysin Substances 0.000 claims description 10
239000007788 liquid Substances 0.000 claims description 8
OQQOAWVKVDAJOI-UHFFFAOYSA-N (2-dodecanoyloxy-3-hydroxypropyl) dodecanoate Chemical compound CCCCCCCCCCCC(=O)OCC(CO)OC(=O)CCCCCCCCCCC OQQOAWVKVDAJOI-UHFFFAOYSA-N 0.000 claims description 7
239000005639 Lauric acid Substances 0.000 claims description 7
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GHBFNMLVSPCDGN-UHFFFAOYSA-N rac-1-monooctanoylglycerol Chemical compound CCCCCCCC(=O)OCC(O)CO GHBFNMLVSPCDGN-UHFFFAOYSA-N 0.000 claims description 7
229940074049 glyceryl dilaurate Drugs 0.000 claims description 6
LKUNXBRZDFMZOK-UHFFFAOYSA-N rac-1-monodecanoylglycerol Chemical compound CCCCCCCCCC(=O)OCC(O)CO LKUNXBRZDFMZOK-UHFFFAOYSA-N 0.000 claims description 6
POULHZVOKOAJMA-UHFFFAOYSA-M dodecanoate Chemical compound CCCCCCCCCCCC([O-])=O POULHZVOKOAJMA-UHFFFAOYSA-M 0.000 claims description 5
239000000147 enterotoxin Substances 0.000 claims description 5
229940075507 glyceryl monostearate Drugs 0.000 claims description 5
239000001788 mono and diglycerides of fatty acids Substances 0.000 claims description 5
235000017858 Laurus nobilis Nutrition 0.000 claims description 4
QHZLMUACJMDIAE-UHFFFAOYSA-N Palmitic acid monoglyceride Natural products CCCCCCCCCCCCCCCC(=O)OCC(O)CO QHZLMUACJMDIAE-UHFFFAOYSA-N 0.000 claims description 4
235000005212 Terminalia tomentosa Nutrition 0.000 claims description 4
229940087068 glyceryl caprylate Drugs 0.000 claims description 4
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QHZLMUACJMDIAE-SFHVURJKSA-N 1-hexadecanoyl-sn-glycerol Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@@H](O)CO QHZLMUACJMDIAE-SFHVURJKSA-N 0.000 claims description 2
229940080812 glyceryl caprate Drugs 0.000 claims 4
RZRNAYUHWVFMIP-KTKRTIGZSA-N 1-oleoylglycerol Chemical compound CCCCCCCC\C=C/CCCCCCCC(=O)OCC(O)CO RZRNAYUHWVFMIP-KTKRTIGZSA-N 0.000 claims 2
PHYFQTYBJUILEZ-UHFFFAOYSA-N Trioleoylglycerol Natural products CCCCCCCCC=CCCCCCCCC(=O)OCC(OC(=O)CCCCCCCC=CCCCCCCCC)COC(=O)CCCCCCCC=CCCCCCCCC PHYFQTYBJUILEZ-UHFFFAOYSA-N 0.000 claims 2
TUNFSRHWOTWDNC-UHFFFAOYSA-N tetradecanoic acid Chemical compound CCCCCCCCCCCCCC(O)=O TUNFSRHWOTWDNC-UHFFFAOYSA-N 0.000 claims 2
TWJNQYPJQDRXPH-UHFFFAOYSA-N 2-cyanobenzohydrazide Chemical compound NNC(=O)C1=CC=CC=C1C#N TWJNQYPJQDRXPH-UHFFFAOYSA-N 0.000 claims 1
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FFRBMBIXVSCUFS-UHFFFAOYSA-N 2,4-dinitro-1-naphthol Chemical compound C1=CC=C2C(O)=C([N+]([O-])=O)C=C([N+]([O-])=O)C2=C1 FFRBMBIXVSCUFS-UHFFFAOYSA-N 0.000 description 32
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FBWNMEQMRUMQSO-UHFFFAOYSA-N tergitol NP-9 Chemical compound CCCCCCCCCC1=CC=C(OCCOCCOCCOCCOCCOCCOCCOCCOCCO)C=C1 FBWNMEQMRUMQSO-UHFFFAOYSA-N 0.000 description 9
QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 8
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WPYMKLBDIGXBTP-UHFFFAOYSA-N benzoic acid Chemical compound OC(=O)C1=CC=CC=C1 WPYMKLBDIGXBTP-UHFFFAOYSA-N 0.000 description 6
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LXCFILQKKLGQFO-UHFFFAOYSA-N methylparaben Chemical compound COC(=O)C1=CC=C(O)C=C1 LXCFILQKKLGQFO-UHFFFAOYSA-N 0.000 description 6
238000002360 preparation method Methods 0.000 description 6
QELSKZZBTMNZEB-UHFFFAOYSA-N propylparaben Chemical compound CCCOC(=O)C1=CC=C(O)C=C1 QELSKZZBTMNZEB-UHFFFAOYSA-N 0.000 description 6
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LZMSXDHGHZKXJD-VJANTYMQSA-N trypanothione disulfide Chemical compound OC(=O)[C@@H](N)CCC(=O)N[C@H]1CSSC[C@H](NC(=O)CC[C@H](N)C(O)=O)C(=O)NCC(=O)NCCCNCCCCNC(=O)CNC1=O LZMSXDHGHZKXJD-VJANTYMQSA-N 0.000 description 5
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WRIDQFICGBMAFQ-UHFFFAOYSA-N (E)-8-Octadecenoic acid Natural products CCCCCCCCCC=CCCCCCCC(O)=O WRIDQFICGBMAFQ-UHFFFAOYSA-N 0.000 description 3
ARIWANIATODDMH-AWEZNQCLSA-N 1-lauroyl-sn-glycerol Chemical compound CCCCCCCCCCCC(=O)OC[C@@H](O)CO ARIWANIATODDMH-AWEZNQCLSA-N 0.000 description 3
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Landscapes

Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

TW80108379A 1991-05-03 1991-10-24 TW205504B (de)

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US69536691A	1991-05-03	1991-05-03

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1991
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