TW219332B - - Google Patents

Info

Publication number

TW219332B

TW219332B TW80108795A TW80108795A TW219332B TW 219332 B TW219332 B TW 219332B TW 80108795 A TW80108795 A TW 80108795A TW 80108795 A TW80108795 A TW 80108795A TW 219332 B TW219332 B TW 219332B

Authority

TW

Taiwan

Prior art keywords

acid

ear

layer

drug

sister

Prior art date

1990-06-14

Links

• Espacenet
• Global Dossier
• Discuss

• 239000003814 drug Substances 0.000 claims description 118
• 241001465754 Metazoa Species 0.000 claims description 97
• 229940079593 drug Drugs 0.000 claims description 75
• 239000011159 matrix material Substances 0.000 claims description 49
• 239000007787 solid Substances 0.000 claims description 40
• 229960005309 estradiol Drugs 0.000 claims description 27
• 239000000203 mixture Substances 0.000 claims description 27
• VOXZDWNPVJITMN-ZBRFXRBCSA-N 17β-estradiol Chemical compound OC1=CC=C2[C@H]3CC[C@](C)([C@H](CC4)O)[C@@H]4[C@@H]3CCC2=C1 VOXZDWNPVJITMN-ZBRFXRBCSA-N 0.000 claims description 24
• 229930182833 estradiol Natural products 0.000 claims description 24
• 239000002250 absorbent Substances 0.000 claims description 20
• 230000002745 absorbent Effects 0.000 claims description 20
• 210000004246 corpus luteum Anatomy 0.000 claims description 20
• 239000000825 pharmaceutical preparation Substances 0.000 claims description 20
• 238000012360 testing method Methods 0.000 claims description 19
• 239000003921 oil Substances 0.000 claims description 18
• 229940127557 pharmaceutical product Drugs 0.000 claims description 18
• -1 corpus luteum Chemical compound 0.000 claims description 17
• 230000009975 flexible effect Effects 0.000 claims description 17
• 210000003027 ear inner Anatomy 0.000 claims description 14
• 210000000883 ear external Anatomy 0.000 claims description 13
• MUMGGOZAMZWBJJ-DYKIIFRCSA-N Testostosterone Chemical compound O=C1CC[C@]2(C)[C@H]3CC[C@](C)([C@H](CC4)O)[C@@H]4[C@@H]3CCC2=C1 MUMGGOZAMZWBJJ-DYKIIFRCSA-N 0.000 claims description 12
• 239000007788 liquid Substances 0.000 claims description 12
• 239000000463 material Substances 0.000 claims description 12
• 241000282414 Homo sapiens Species 0.000 claims description 11
• 235000014113 dietary fatty acids Nutrition 0.000 claims description 10
• 229930195729 fatty acid Natural products 0.000 claims description 10
• 239000000194 fatty acid Substances 0.000 claims description 10
• 239000002253 acid Substances 0.000 claims description 9
• 150000004665 fatty acids Chemical class 0.000 claims description 9
• 229940127554 medical product Drugs 0.000 claims description 9
• 239000000262 estrogen Substances 0.000 claims description 8
• VKOBVWXKNCXXDE-UHFFFAOYSA-N icosanoic acid Chemical compound CCCCCCCCCCCCCCCCCCCC(O)=O VKOBVWXKNCXXDE-UHFFFAOYSA-N 0.000 claims description 8
• 230000037317 transdermal delivery Effects 0.000 claims description 8
• QTBSBXVTEAMEQO-UHFFFAOYSA-M Acetate Chemical compound CC([O-])=O QTBSBXVTEAMEQO-UHFFFAOYSA-M 0.000 claims description 7
• ZQPPMHVWECSIRJ-UHFFFAOYSA-N Oleic acid Natural products CCCCCCCCC=CCCCCCCCC(O)=O ZQPPMHVWECSIRJ-UHFFFAOYSA-N 0.000 claims description 7
• DTOSIQBPPRVQHS-PDBXOOCHSA-N alpha-linolenic acid Chemical compound CC\C=C/C\C=C/C\C=C/CCCCCCCC(O)=O DTOSIQBPPRVQHS-PDBXOOCHSA-N 0.000 claims description 7
• ZQPPMHVWECSIRJ-MDZDMXLPSA-N elaidic acid Chemical compound CCCCCCCC\C=C\CCCCCCCC(O)=O ZQPPMHVWECSIRJ-MDZDMXLPSA-N 0.000 claims description 7
• 150000002148 esters Chemical class 0.000 claims description 7
• 239000003925 fat Substances 0.000 claims description 7
• 235000019197 fats Nutrition 0.000 claims description 7
• QXJSBBXBKPUZAA-UHFFFAOYSA-N isooleic acid Natural products CCCCCCCC=CCCCCCCCCC(O)=O QXJSBBXBKPUZAA-UHFFFAOYSA-N 0.000 claims description 7
• 229960004488 linolenic acid Drugs 0.000 claims description 7
• 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 7
• KAESVJOAVNADME-UHFFFAOYSA-N Pyrrole Chemical compound C=1C=CNC=1 KAESVJOAVNADME-UHFFFAOYSA-N 0.000 claims description 6
• 238000010521 absorption reaction Methods 0.000 claims description 6
• 229940011871 estrogen Drugs 0.000 claims description 6
• 150000002430 hydrocarbons Chemical class 0.000 claims description 6
• 239000000126 substance Substances 0.000 claims description 6
• 229960003604 testosterone Drugs 0.000 claims description 6
• WRIDQFICGBMAFQ-UHFFFAOYSA-N (E)-8-Octadecenoic acid Natural products CCCCCCCCCC=CCCCCCCC(O)=O WRIDQFICGBMAFQ-UHFFFAOYSA-N 0.000 claims description 5
• LQJBNNIYVWPHFW-UHFFFAOYSA-N 20:1omega9c fatty acid Natural products CCCCCCCCCCC=CCCCCCCCC(O)=O LQJBNNIYVWPHFW-UHFFFAOYSA-N 0.000 claims description 5
• QSBYPNXLFMSGKH-UHFFFAOYSA-N 9-Heptadecensaeure Natural products CCCCCCCC=CCCCCCCCC(O)=O QSBYPNXLFMSGKH-UHFFFAOYSA-N 0.000 claims description 5
• 239000005642 Oleic acid Substances 0.000 claims description 5
• 235000020661 alpha-linolenic acid Nutrition 0.000 claims description 5
• 229930195733 hydrocarbon Natural products 0.000 claims description 5
• 239000002917 insecticide Substances 0.000 claims description 5
• WWZKQHOCKIZLMA-UHFFFAOYSA-N octanoic acid Chemical compound CCCCCCCC(O)=O WWZKQHOCKIZLMA-UHFFFAOYSA-N 0.000 claims description 5
• 230000035515 penetration Effects 0.000 claims description 5
• 229940121363 anti-inflammatory agent Drugs 0.000 claims description 4
• 239000002260 anti-inflammatory agent Substances 0.000 claims description 4
• UKMSUNONTOPOIO-UHFFFAOYSA-N docosanoic acid Chemical compound CCCCCCCCCCCCCCCCCCCCCC(O)=O UKMSUNONTOPOIO-UHFFFAOYSA-N 0.000 claims description 4
• POULHZVOKOAJMA-UHFFFAOYSA-N dodecanoic acid Chemical compound CCCCCCCCCCCC(O)=O POULHZVOKOAJMA-UHFFFAOYSA-N 0.000 claims description 4
• 238000001647 drug administration Methods 0.000 claims description 4
• 238000005538 encapsulation Methods 0.000 claims description 4
• 239000007952 growth promoter Substances 0.000 claims description 4
• 210000003128 head Anatomy 0.000 claims description 4
• IPCSVZSSVZVIGE-UHFFFAOYSA-N hexadecanoic acid Chemical compound CCCCCCCCCCCCCCCC(O)=O IPCSVZSSVZVIGE-UHFFFAOYSA-N 0.000 claims description 4
• CGIGDMFJXJATDK-UHFFFAOYSA-N indomethacin Chemical compound CC1=C(CC(O)=O)C2=CC(OC)=CC=C2N1C(=O)C1=CC=C(Cl)C=C1 CGIGDMFJXJATDK-UHFFFAOYSA-N 0.000 claims description 4
• 239000004615 ingredient Substances 0.000 claims description 4
• 239000011785 micronutrient Substances 0.000 claims description 4
• 235000013369 micronutrients Nutrition 0.000 claims description 4
• XLEAQAXJBGJJHT-QVNBCSSZSA-N CC(O)=O.C1CC2=CC(=O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC(C)[C@H](C(C)=O)[C@@]1(C)CC2 Chemical compound CC(O)=O.C1CC2=CC(=O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC(C)[C@H](C(C)=O)[C@@]1(C)CC2 XLEAQAXJBGJJHT-QVNBCSSZSA-N 0.000 claims description 3
• 230000033228 biological regulation Effects 0.000 claims description 3
• 230000005540 biological transmission Effects 0.000 claims description 3
• 229940124630 bronchodilator Drugs 0.000 claims description 3
• 229960005135 eicosapentaenoic acid Drugs 0.000 claims description 3
• KQQKGWQCNNTQJW-UHFFFAOYSA-N linolenic acid Natural products CC=CCCC=CCC=CCCCCCCCC(O)=O KQQKGWQCNNTQJW-UHFFFAOYSA-N 0.000 claims description 3
• 235000012149 noodles Nutrition 0.000 claims description 3
• 230000000590 parasiticidal effect Effects 0.000 claims description 3
• 235000020777 polyunsaturated fatty acids Nutrition 0.000 claims description 3
• XSXIVVZCUAHUJO-AVQMFFATSA-N (11e,14e)-icosa-11,14-dienoic acid Chemical compound CCCCC\C=C\C\C=C\CCCCCCCCCC(O)=O XSXIVVZCUAHUJO-AVQMFFATSA-N 0.000 claims description 2
• 235000021357 Behenic acid Nutrition 0.000 claims description 2
• DPUOLQHDNGRHBS-UHFFFAOYSA-N Brassidinsaeure Natural products CCCCCCCCC=CCCCCCCCCCCCC(O)=O DPUOLQHDNGRHBS-UHFFFAOYSA-N 0.000 claims description 2
• 239000005635 Caprylic acid (CAS 124-07-2) Substances 0.000 claims description 2
• TWFZGCMQGLPBSX-UHFFFAOYSA-N Carbendazim Natural products C1=CC=C2NC(NC(=O)OC)=NC2=C1 TWFZGCMQGLPBSX-UHFFFAOYSA-N 0.000 claims description 2
• 229930186147 Cephalosporin Natural products 0.000 claims description 2
• 229920002307 Dextran Polymers 0.000 claims description 2
• URXZXNYJPAJJOQ-UHFFFAOYSA-N Erucic acid Natural products CCCCCCC=CCCCCCCCCCCCC(O)=O URXZXNYJPAJJOQ-UHFFFAOYSA-N 0.000 claims description 2
• XSXIVVZCUAHUJO-UHFFFAOYSA-N Homo-gamma-linoleic acid Natural products CCCCCC=CCC=CCCCCCCCCCC(O)=O XSXIVVZCUAHUJO-UHFFFAOYSA-N 0.000 claims description 2
• 239000005639 Lauric acid Substances 0.000 claims description 2
• 235000021353 Lignoceric acid Nutrition 0.000 claims description 2
• CQXMAMUUWHYSIY-UHFFFAOYSA-N Lignoceric acid Natural products CCCCCCCCCCCCCCCCCCCCCCCC(=O)OCCC1=CC=C(O)C=C1 CQXMAMUUWHYSIY-UHFFFAOYSA-N 0.000 claims description 2
• 235000021314 Palmitic acid Nutrition 0.000 claims description 2
• 235000021355 Stearic acid Nutrition 0.000 claims description 2
• 239000004098 Tetracycline Substances 0.000 claims description 2
• 239000003242 anti bacterial agent Substances 0.000 claims description 2
• 229940088710 antibiotic agent Drugs 0.000 claims description 2
• 229940116226 behenic acid Drugs 0.000 claims description 2
• 239000000168 bronchodilator agent Substances 0.000 claims description 2
• JNPZQRQPIHJYNM-UHFFFAOYSA-N carbendazim Chemical compound C1=C[CH]C2=NC(NC(=O)OC)=NC2=C1 JNPZQRQPIHJYNM-UHFFFAOYSA-N 0.000 claims description 2
• 239000006013 carbendazim Substances 0.000 claims description 2
• 239000002327 cardiovascular agent Substances 0.000 claims description 2
• 229940125692 cardiovascular agent Drugs 0.000 claims description 2
• 229940124587 cephalosporin Drugs 0.000 claims description 2
• 150000001780 cephalosporins Chemical class 0.000 claims description 2
• DPUOLQHDNGRHBS-KTKRTIGZSA-N erucic acid Chemical compound CCCCCCCC\C=C/CCCCCCCCCCCC(O)=O DPUOLQHDNGRHBS-KTKRTIGZSA-N 0.000 claims description 2
• 150000007857 hydrazones Chemical class 0.000 claims description 2
• 229960000905 indomethacin Drugs 0.000 claims description 2
• 238000003780 insertion Methods 0.000 claims description 2
• 230000037431 insertion Effects 0.000 claims description 2
• WQEPLUUGTLDZJY-UHFFFAOYSA-N n-Pentadecanoic acid Natural products CCCCCCCCCCCCCCC(O)=O WQEPLUUGTLDZJY-UHFFFAOYSA-N 0.000 claims description 2
• JVDHPAUNFBGCFT-UHFFFAOYSA-N octadeca-12,15-dienoic acid Chemical compound CCC=CCC=CCCCCCCCCCCC(O)=O JVDHPAUNFBGCFT-UHFFFAOYSA-N 0.000 claims description 2
• QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 claims description 2
• OQCDKBAXFALNLD-UHFFFAOYSA-N octadecanoic acid Natural products CCCCCCCC(C)CCCCCCCCC(O)=O OQCDKBAXFALNLD-UHFFFAOYSA-N 0.000 claims description 2
• 229960002446 octanoic acid Drugs 0.000 claims description 2
• 235000021313 oleic acid Nutrition 0.000 claims description 2
• 239000012188 paraffin wax Substances 0.000 claims description 2
• 239000002297 parasiticide Substances 0.000 claims description 2
• 230000001850 reproductive effect Effects 0.000 claims description 2
• 150000003839 salts Chemical class 0.000 claims description 2
• 238000007789 sealing Methods 0.000 claims description 2
• 239000008117 stearic acid Substances 0.000 claims description 2
• IMCGHZIGRANKHV-AJNGGQMLSA-N tert-butyl (3s,5s)-2-oxo-5-[(2s,4s)-5-oxo-4-propan-2-yloxolan-2-yl]-3-propan-2-ylpyrrolidine-1-carboxylate Chemical compound O1C(=O)[C@H](C(C)C)C[C@H]1[C@H]1N(C(=O)OC(C)(C)C)C(=O)[C@H](C(C)C)C1 IMCGHZIGRANKHV-AJNGGQMLSA-N 0.000 claims description 2
• QZZGJDVWLFXDLK-UHFFFAOYSA-N tetracosanoic acid Chemical compound CCCCCCCCCCCCCCCCCCCCCCCC(O)=O QZZGJDVWLFXDLK-UHFFFAOYSA-N 0.000 claims description 2
• 229960002180 tetracycline Drugs 0.000 claims description 2
• 229930101283 tetracycline Natural products 0.000 claims description 2
• 235000019364 tetracycline Nutrition 0.000 claims description 2
• 150000003522 tetracyclines Chemical class 0.000 claims description 2
• 150000003626 triacylglycerols Chemical class 0.000 claims description 2
• YZXBAPSDXZZRGB-DOFZRALJSA-N arachidonic acid Chemical compound CCCCC\C=C/C\C=C/C\C=C/C\C=C/CCCC(O)=O YZXBAPSDXZZRGB-DOFZRALJSA-N 0.000 claims 2
• 239000002131 composite material Substances 0.000 claims 2
• 238000003475 lamination Methods 0.000 claims 2
• BITHHVVYSMSWAG-KTKRTIGZSA-N (11Z)-icos-11-enoic acid Chemical compound CCCCCCCC\C=C/CCCCCCCCCC(O)=O BITHHVVYSMSWAG-KTKRTIGZSA-N 0.000 claims 1
• GWHCXVQVJPWHRF-KTKRTIGZSA-N (15Z)-tetracosenoic acid Chemical class CCCCCCCC\C=C/CCCCCCCCCCCCCC(O)=O GWHCXVQVJPWHRF-KTKRTIGZSA-N 0.000 claims 1
• YPYBVYAVVFLHDN-UHFFFAOYSA-N 1,10-phenanthrolin-2-amine Chemical compound C1=CN=C2C3=NC(N)=CC=C3C=CC2=C1 YPYBVYAVVFLHDN-UHFFFAOYSA-N 0.000 claims 1
• GYSCBCSGKXNZRH-UHFFFAOYSA-N 1-benzothiophene-2-carboxamide Chemical compound C1=CC=C2SC(C(=O)N)=CC2=C1 GYSCBCSGKXNZRH-UHFFFAOYSA-N 0.000 claims 1
• NENBAISIHCWPKP-UHFFFAOYSA-N Clofenamide Chemical compound NS(=O)(=O)C1=CC=C(Cl)C(S(N)(=O)=O)=C1 NENBAISIHCWPKP-UHFFFAOYSA-N 0.000 claims 1
• GHVNFZFCNZKVNT-UHFFFAOYSA-N Decanoic acid Natural products CCCCCCCCCC(O)=O GHVNFZFCNZKVNT-UHFFFAOYSA-N 0.000 claims 1
• 240000000220 Panda oleosa Species 0.000 claims 1
• 235000016496 Panda oleosa Nutrition 0.000 claims 1
• 229930182555 Penicillin Natural products 0.000 claims 1
• JGSARLDLIJGVTE-MBNYWOFBSA-N Penicillin G Chemical compound N([C@H]1[C@H]2SC([C@@H](N2C1=O)C(O)=O)(C)C)C(=O)CC1=CC=CC=C1 JGSARLDLIJGVTE-MBNYWOFBSA-N 0.000 claims 1
• 244000269722 Thea sinensis Species 0.000 claims 1
• KSZVHVUMUSIKTC-UHFFFAOYSA-N acetic acid;propan-2-one Chemical compound CC(C)=O.CC(O)=O KSZVHVUMUSIKTC-UHFFFAOYSA-N 0.000 claims 1
• 230000001464 adherent effect Effects 0.000 claims 1
• HXHWSAZORRCQMX-UHFFFAOYSA-N albendazole Chemical compound CCCSC1=CC=C2NC(NC(=O)OC)=NC2=C1 HXHWSAZORRCQMX-UHFFFAOYSA-N 0.000 claims 1
• 229960002669 albendazole Drugs 0.000 claims 1
• AHANXAKGNAKFSK-PDBXOOCHSA-N all-cis-icosa-11,14,17-trienoic acid Chemical compound CC\C=C/C\C=C/C\C=C/CCCCCCCCCC(O)=O AHANXAKGNAKFSK-PDBXOOCHSA-N 0.000 claims 1
• 230000002421 anti-septic effect Effects 0.000 claims 1
• 229940114079 arachidonic acid Drugs 0.000 claims 1
• 235000021342 arachidonic acid Nutrition 0.000 claims 1
• 235000015278 beef Nutrition 0.000 claims 1
• 229960002883 clofenamide Drugs 0.000 claims 1
• 230000032798 delamination Effects 0.000 claims 1
• 229940126534 drug product Drugs 0.000 claims 1
• BITHHVVYSMSWAG-UHFFFAOYSA-N eicosenoic acid Natural products CCCCCCCCC=CCCCCCCCCCC(O)=O BITHHVVYSMSWAG-UHFFFAOYSA-N 0.000 claims 1
• 230000002996 emotional effect Effects 0.000 claims 1
• 239000000796 flavoring agent Substances 0.000 claims 1
• 238000003682 fluorination reaction Methods 0.000 claims 1
• 125000004383 glucosinolate group Chemical group 0.000 claims 1
• 235000021299 gondoic acid Nutrition 0.000 claims 1
• 235000012680 lutein Nutrition 0.000 claims 1
• KBPHJBAIARWVSC-RGZFRNHPSA-N lutein Chemical compound C([C@H](O)CC=1C)C(C)(C)C=1\C=C\C(\C)=C\C=C\C(\C)=C\C=C\C=C(/C)\C=C\C=C(/C)\C=C\[C@H]1C(C)=C[C@H](O)CC1(C)C KBPHJBAIARWVSC-RGZFRNHPSA-N 0.000 claims 1
• 229960005375 lutein Drugs 0.000 claims 1
• ORAKUVXRZWMARG-WZLJTJAWSA-N lutein Natural products CC(=C/C=C/C=C(C)/C=C/C=C(C)/C=C/C1=C(C)CCCC1(C)C)C=CC=C(/C)C=CC2C(=CC(O)CC2(C)C)C ORAKUVXRZWMARG-WZLJTJAWSA-N 0.000 claims 1
• 239000001656 lutein Substances 0.000 claims 1
• 230000000149 penetrating effect Effects 0.000 claims 1
• 229940049954 penicillin Drugs 0.000 claims 1
• 230000035699 permeability Effects 0.000 claims 1
• 229910000338 selenium disulfide Inorganic materials 0.000 claims 1
• JNMWHTHYDQTDQZ-UHFFFAOYSA-N selenium sulfide Chemical compound S=[Se]=S JNMWHTHYDQTDQZ-UHFFFAOYSA-N 0.000 claims 1
• 229960005265 selenium sulfide Drugs 0.000 claims 1
• 208000003265 stomatitis Diseases 0.000 claims 1
• DHCDFWKWKRSZHF-UHFFFAOYSA-N sulfurothioic S-acid Chemical compound OS(O)(=O)=S DHCDFWKWKRSZHF-UHFFFAOYSA-N 0.000 claims 1
• KBPHJBAIARWVSC-XQIHNALSSA-N trans-lutein Natural products CC(=C/C=C/C=C(C)/C=C/C=C(C)/C=C/C1=C(C)CC(O)CC1(C)C)C=CC=C(/C)C=CC2C(=CC(O)CC2(C)C)C KBPHJBAIARWVSC-XQIHNALSSA-N 0.000 claims 1
• FJHBOVDFOQMZRV-XQIHNALSSA-N xanthophyll Natural products CC(=C/C=C/C=C(C)/C=C/C=C(C)/C=C/C1=C(C)CC(O)CC1(C)C)C=CC=C(/C)C=CC2C=C(C)C(O)CC2(C)C FJHBOVDFOQMZRV-XQIHNALSSA-N 0.000 claims 1
• 210000004369 blood Anatomy 0.000 description 69
• 239000008280 blood Substances 0.000 description 69
• 239000010410 layer Substances 0.000 description 59
• RJKFOVLPORLFTN-LEKSSAKUSA-N Progesterone Chemical compound C1CC2=CC(=O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H](C(=O)C)[C@@]1(C)CC2 RJKFOVLPORLFTN-LEKSSAKUSA-N 0.000 description 39
• 210000002966 serum Anatomy 0.000 description 39
• 241001494479 Pecora Species 0.000 description 33
• 238000000034 method Methods 0.000 description 29
• 239000000758 substrate Substances 0.000 description 29
• 239000002552 dosage form Substances 0.000 description 28
• 238000002474 experimental method Methods 0.000 description 27
• 235000019687 Lamb Nutrition 0.000 description 26
• 239000003549 soybean oil Substances 0.000 description 25
• 235000012424 soybean oil Nutrition 0.000 description 24
• 210000005069 ears Anatomy 0.000 description 21
• 239000003795 chemical substances by application Substances 0.000 description 20
• 239000000186 progesterone Substances 0.000 description 20
• 229960003387 progesterone Drugs 0.000 description 20
• HLFSDGLLUJUHTE-SNVBAGLBSA-N Levamisole Chemical compound C1([C@H]2CN3CCSC3=N2)=CC=CC=C1 HLFSDGLLUJUHTE-SNVBAGLBSA-N 0.000 description 18
• 229960001614 levamisole Drugs 0.000 description 18
• DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 description 15
• 235000019198 oils Nutrition 0.000 description 15
• 241000283690 Bos taurus Species 0.000 description 14
• PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 14
• 244000309466 calf Species 0.000 description 14
• 241000283903 Ovis aries Species 0.000 description 13
• 150000001875 compounds Chemical class 0.000 description 11
• 230000000694 effects Effects 0.000 description 10
• 238000010586 diagram Methods 0.000 description 9
• 238000002360 preparation method Methods 0.000 description 9
• 241000282412 Homo Species 0.000 description 8
• 210000004731 jugular vein Anatomy 0.000 description 8
• 244000309464 bull Species 0.000 description 7
• 238000001514 detection method Methods 0.000 description 7
• 229940110456 cocoa butter Drugs 0.000 description 6
• 235000019868 cocoa butter Nutrition 0.000 description 6
• 235000011187 glycerol Nutrition 0.000 description 6
• 238000004519 manufacturing process Methods 0.000 description 6
• 239000004033 plastic Substances 0.000 description 6
• 229920003023 plastic Polymers 0.000 description 6
• 238000011160 research Methods 0.000 description 6
• SPBDXSGPUHCETR-JFUDTMANSA-N 8883yp2r6d Chemical compound O1[C@@H](C)[C@H](O)[C@@H](OC)C[C@@H]1O[C@@H]1[C@@H](OC)C[C@H](O[C@@H]2C(=C/C[C@@H]3C[C@@H](C[C@@]4(O[C@@H]([C@@H](C)CC4)C(C)C)O3)OC(=O)[C@@H]3C=C(C)[C@@H](O)[C@H]4OC\C([C@@]34O)=C/C=C/[C@@H]2C)/C)O[C@H]1C.C1C[C@H](C)[C@@H]([C@@H](C)CC)O[C@@]21O[C@H](C\C=C(C)\[C@@H](O[C@@H]1O[C@@H](C)[C@H](O[C@@H]3O[C@@H](C)[C@H](O)[C@@H](OC)C3)[C@@H](OC)C1)[C@@H](C)\C=C\C=C/1[C@]3([C@H](C(=O)O4)C=C(C)[C@@H](O)[C@H]3OC\1)O)C[C@H]4C2 SPBDXSGPUHCETR-JFUDTMANSA-N 0.000 description 5
• 238000009472 formulation Methods 0.000 description 5
• 229940126601 medicinal product Drugs 0.000 description 5
• 238000013271 transdermal drug delivery Methods 0.000 description 5
• XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 5
• VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 4
• 241000244206 Nematoda Species 0.000 description 4
• 230000002079 cooperative effect Effects 0.000 description 4
• 201000010099 disease Diseases 0.000 description 4
• 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 4
• 244000309465 heifer Species 0.000 description 4
• 229940088597 hormone Drugs 0.000 description 4
• 239000005556 hormone Substances 0.000 description 4
• 238000002347 injection Methods 0.000 description 4
• 239000007924 injection Substances 0.000 description 4
• 230000027758 ovulation cycle Effects 0.000 description 4
• 239000008188 pellet Substances 0.000 description 4
• 230000035935 pregnancy Effects 0.000 description 4
• 238000003127 radioimmunoassay Methods 0.000 description 4
• 230000008961 swelling Effects 0.000 description 4
• AZSNMRSAGSSBNP-UHFFFAOYSA-N 22,23-dihydroavermectin B1a Natural products C1CC(C)C(C(C)CC)OC21OC(CC=C(C)C(OC1OC(C)C(OC3OC(C)C(O)C(OC)C3)C(OC)C1)C(C)C=CC=C1C3(C(C(=O)O4)C=C(C)C(O)C3OC1)O)CC4C2 AZSNMRSAGSSBNP-UHFFFAOYSA-N 0.000 description 3
• WSFSSNUMVMOOMR-UHFFFAOYSA-N Formaldehyde Chemical compound O=C WSFSSNUMVMOOMR-UHFFFAOYSA-N 0.000 description 3
• 239000005662 Paraffin oil Substances 0.000 description 3
• 208000035415 Reinfection Diseases 0.000 description 3
• 240000008042 Zea mays Species 0.000 description 3
• 235000002017 Zea mays subsp mays Nutrition 0.000 description 3
• 239000013543 active substance Substances 0.000 description 3
• 239000012790 adhesive layer Substances 0.000 description 3
• 150000001412 amines Chemical class 0.000 description 3
• 238000004458 analytical method Methods 0.000 description 3
• 239000003098 androgen Substances 0.000 description 3
• 230000008901 benefit Effects 0.000 description 3
• 238000009395 breeding Methods 0.000 description 3
• 230000001488 breeding effect Effects 0.000 description 3
• 239000003153 chemical reaction reagent Substances 0.000 description 3
• 238000005516 engineering process Methods 0.000 description 3
• 230000012173 estrus Effects 0.000 description 3
• RAXXELZNTBOGNW-UHFFFAOYSA-N imidazole Natural products C1=CNC=N1 RAXXELZNTBOGNW-UHFFFAOYSA-N 0.000 description 3
• 238000010255 intramuscular injection Methods 0.000 description 3
• 239000007927 intramuscular injection Substances 0.000 description 3
• 229960002418 ivermectin Drugs 0.000 description 3
• 230000000670 limiting effect Effects 0.000 description 3
• 230000000938 luteal effect Effects 0.000 description 3
• 206010063344 microscopic polyangiitis Diseases 0.000 description 3
• 235000015067 sauces Nutrition 0.000 description 3
• 239000011669 selenium Substances 0.000 description 3
• 229910052711 selenium Inorganic materials 0.000 description 3
• 239000007790 solid phase Substances 0.000 description 3
• 238000001228 spectrum Methods 0.000 description 3
• 238000002560 therapeutic procedure Methods 0.000 description 3
• 238000005303 weighing Methods 0.000 description 3
• HIQIXEFWDLTDED-UHFFFAOYSA-N 4-hydroxy-1-piperidin-4-ylpyrrolidin-2-one Chemical compound O=C1CC(O)CN1C1CCNCC1 HIQIXEFWDLTDED-UHFFFAOYSA-N 0.000 description 2
• 235000019489 Almond oil Nutrition 0.000 description 2
• 244000144725 Amygdalus communis Species 0.000 description 2
• CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 description 2
• WDPFQABQVGJEBZ-MAKOZQESSA-N Bothermon Chemical compound OC1=CC=C2[C@H]3CC[C@](C)([C@H](CC4)O)[C@@H]4[C@@H]3CCC2=C1.O=C1CC[C@]2(C)[C@H]3CC[C@](C)([C@H](CC4)O)[C@@H]4[C@@H]3CCC2=C1 WDPFQABQVGJEBZ-MAKOZQESSA-N 0.000 description 2
• GJSURZIOUXUGAL-UHFFFAOYSA-N Clonidine Chemical compound ClC1=CC=CC(Cl)=C1NC1=NCCN1 GJSURZIOUXUGAL-UHFFFAOYSA-N 0.000 description 2
• BWGNESOTFCXPMA-UHFFFAOYSA-N Dihydrogen disulfide Chemical compound SS BWGNESOTFCXPMA-UHFFFAOYSA-N 0.000 description 2
• WZUVPPKBWHMQCE-UHFFFAOYSA-N Haematoxylin Chemical compound C12=CC(O)=C(O)C=C2CC2(O)C1C1=CC=C(O)C(O)=C1OC2 WZUVPPKBWHMQCE-UHFFFAOYSA-N 0.000 description 2
• 206010061218 Inflammation Diseases 0.000 description 2
• UFWIBTONFRDIAS-UHFFFAOYSA-N Naphthalene Chemical compound C1=CC=CC2=CC=CC=C21 UFWIBTONFRDIAS-UHFFFAOYSA-N 0.000 description 2
• 241001111421 Pannus Species 0.000 description 2
• 235000019483 Peanut oil Nutrition 0.000 description 2
• 239000004698 Polyethylene Substances 0.000 description 2
• 235000019484 Rapeseed oil Nutrition 0.000 description 2
• FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 2
• 241001050678 Stachys byzantina Species 0.000 description 2
• 235000005824 Zea mays ssp. parviglumis Nutrition 0.000 description 2
• QTBSBXVTEAMEQO-UHFFFAOYSA-N acetic acid Substances CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 2
• 239000000654 additive Substances 0.000 description 2
• 239000000853 adhesive Substances 0.000 description 2
• 239000008168 almond oil Substances 0.000 description 2
• 238000010171 animal model Methods 0.000 description 2
• 230000009286 beneficial effect Effects 0.000 description 2
• UREBDLICKHMUKA-DVTGEIKXSA-N betamethasone Chemical compound C1CC2=CC(=O)C=C[C@]2(C)[C@]2(F)[C@@H]1[C@@H]1C[C@H](C)[C@@](C(=O)CO)(O)[C@@]1(C)C[C@@H]2O UREBDLICKHMUKA-DVTGEIKXSA-N 0.000 description 2
• 229960002537 betamethasone Drugs 0.000 description 2
• 238000001574 biopsy Methods 0.000 description 2
• 239000000969 carrier Substances 0.000 description 2
• 229960002896 clonidine Drugs 0.000 description 2
• 238000013270 controlled release Methods 0.000 description 2
• 235000005822 corn Nutrition 0.000 description 2
• 235000013365 dairy product Nutrition 0.000 description 2
• 239000003937 drug carrier Substances 0.000 description 2
• YQGOJNYOYNNSMM-UHFFFAOYSA-N eosin Chemical compound [Na+].OC(=O)C1=CC=CC=C1C1=C2C=C(Br)C(=O)C(Br)=C2OC2=C(Br)C(O)=C(Br)C=C21 YQGOJNYOYNNSMM-UHFFFAOYSA-N 0.000 description 2
• 239000004744 fabric Substances 0.000 description 2
• 244000144992 flock Species 0.000 description 2
• 239000003676 hair preparation Substances 0.000 description 2
• 230000036571 hydration Effects 0.000 description 2
• 238000006703 hydration reaction Methods 0.000 description 2
• 125000002887 hydroxy group Chemical group [H]O* 0.000 description 2
• 230000002519 immonomodulatory effect Effects 0.000 description 2
• 238000005470 impregnation Methods 0.000 description 2
• 230000006872 improvement Effects 0.000 description 2
• 230000004054 inflammatory process Effects 0.000 description 2
• 238000001802 infusion Methods 0.000 description 2
• 239000007972 injectable composition Substances 0.000 description 2
• 238000007689 inspection Methods 0.000 description 2
• 238000007918 intramuscular administration Methods 0.000 description 2
• 238000011835 investigation Methods 0.000 description 2
• 229940007210 ivomec Drugs 0.000 description 2
• 239000000944 linseed oil Substances 0.000 description 2
• 235000021388 linseed oil Nutrition 0.000 description 2
• 244000144972 livestock Species 0.000 description 2
• 235000016709 nutrition Nutrition 0.000 description 2
• 238000012856 packing Methods 0.000 description 2
• 239000000312 peanut oil Substances 0.000 description 2
• 239000003961 penetration enhancing agent Substances 0.000 description 2
• 235000019271 petrolatum Nutrition 0.000 description 2
• 239000012071 phase Substances 0.000 description 2
• 229920000573 polyethylene Polymers 0.000 description 2
• 229920000642 polymer Polymers 0.000 description 2
• 238000002203 pretreatment Methods 0.000 description 2
• 238000000926 separation method Methods 0.000 description 2
• 230000001568 sexual effect Effects 0.000 description 2
• 239000011780 sodium chloride Substances 0.000 description 2
• 239000000243 solution Substances 0.000 description 2
• 238000010254 subcutaneous injection Methods 0.000 description 2
• 239000007929 subcutaneous injection Substances 0.000 description 2
• 230000002459 sustained effect Effects 0.000 description 2
• 230000009885 systemic effect Effects 0.000 description 2
• 230000035922 thirst Effects 0.000 description 2
• 239000006211 transdermal dosage form Substances 0.000 description 2
• 210000002700 urine Anatomy 0.000 description 2
• 235000015112 vegetable and seed oil Nutrition 0.000 description 2
• 239000008158 vegetable oil Substances 0.000 description 2
• 210000003462 vein Anatomy 0.000 description 2
• 125000000391 vinyl group Chemical group [H]C([*])=C([H])[H] 0.000 description 2
• 229920002554 vinyl polymer Polymers 0.000 description 2
• NOOLISFMXDJSKH-UTLUCORTSA-N (+)-Neomenthol Chemical compound CC(C)[C@@H]1CC[C@@H](C)C[C@@H]1O NOOLISFMXDJSKH-UTLUCORTSA-N 0.000 description 1
• XFWGKJZCFAREHL-UHFFFAOYSA-M 1,2,2,6,6-pentamethyl-1-azoniabicyclo[2.2.2]octane;iodide Chemical compound [I-].C1C[N+]2(C)C(C)(C)CC1CC2(C)C XFWGKJZCFAREHL-UHFFFAOYSA-M 0.000 description 1
• LDVVTQMJQSCDMK-UHFFFAOYSA-N 1,3-dihydroxypropan-2-yl formate Chemical compound OCC(CO)OC=O LDVVTQMJQSCDMK-UHFFFAOYSA-N 0.000 description 1
• ZKFNOUUKULVDOB-UHFFFAOYSA-N 1-amino-1-phenylmethyl phosphonic acid Chemical compound OP(=O)(O)C(N)C1=CC=CC=C1 ZKFNOUUKULVDOB-UHFFFAOYSA-N 0.000 description 1
• NVEPPWDVLBMNMB-SNAWJCMRSA-N 1-methyl-2-[(e)-2-(3-methylthiophen-2-yl)ethenyl]-5,6-dihydro-4h-pyrimidine Chemical compound CN1CCCN=C1\C=C\C1=C(C)C=CS1 NVEPPWDVLBMNMB-SNAWJCMRSA-N 0.000 description 1
• USSIQXCVUWKGNF-UHFFFAOYSA-N 6-(dimethylamino)-4,4-diphenylheptan-3-one Chemical compound C=1C=CC=CC=1C(CC(C)N(C)C)(C(=O)CC)C1=CC=CC=C1 USSIQXCVUWKGNF-UHFFFAOYSA-N 0.000 description 1
• 208000037853 Abnormal uterine bleeding Diseases 0.000 description 1
• 206010000349 Acanthosis Diseases 0.000 description 1
• 206010063409 Acarodermatitis Diseases 0.000 description 1
• GUBGYTABKSRVRQ-XLOQQCSPSA-N Alpha-Lactose Chemical compound O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](CO)O[C@H](O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-XLOQQCSPSA-N 0.000 description 1
• 229920000856 Amylose Polymers 0.000 description 1
• 241001465677 Ancylostomatoidea Species 0.000 description 1
• 241000252073 Anguilliformes Species 0.000 description 1
• 244000105624 Arachis hypogaea Species 0.000 description 1
• 241000834695 Auchenoglanis occidentalis Species 0.000 description 1
• 102000040350 B family Human genes 0.000 description 1
• 108091072128 B family Proteins 0.000 description 1
• 240000002791 Brassica napus Species 0.000 description 1
• 235000004977 Brassica sinapistrum Nutrition 0.000 description 1
• 241000244203 Caenorhabditis elegans Species 0.000 description 1
• 241000282461 Canis lupus Species 0.000 description 1
• 241000283707 Capra Species 0.000 description 1
• 239000004215 Carbon black (E152) Substances 0.000 description 1
• 240000006162 Chenopodium quinoa Species 0.000 description 1
• 244000260524 Chrysanthemum balsamita Species 0.000 description 1
• 235000005633 Chrysanthemum balsamita Nutrition 0.000 description 1
• RYGMFSIKBFXOCR-UHFFFAOYSA-N Copper Chemical compound [Cu] RYGMFSIKBFXOCR-UHFFFAOYSA-N 0.000 description 1
• ZZZCUOFIHGPKAK-UHFFFAOYSA-N D-erythro-ascorbic acid Natural products OCC1OC(=O)C(O)=C1O ZZZCUOFIHGPKAK-UHFFFAOYSA-N 0.000 description 1
• NOOLISFMXDJSKH-UHFFFAOYSA-N DL-menthol Natural products CC(C)C1CCC(C)CC1O NOOLISFMXDJSKH-UHFFFAOYSA-N 0.000 description 1
• 206010012735 Diarrhoea Diseases 0.000 description 1
• 206010014733 Endometrial cancer Diseases 0.000 description 1
• 206010014759 Endometrial neoplasm Diseases 0.000 description 1
• 102000004190 Enzymes Human genes 0.000 description 1
• 108090000790 Enzymes Proteins 0.000 description 1
• 241000283086 Equidae Species 0.000 description 1
• VTLYFUHAOXGGBS-UHFFFAOYSA-N Fe3+ Chemical compound [Fe+3] VTLYFUHAOXGGBS-UHFFFAOYSA-N 0.000 description 1
• HMCCXLBXIJMERM-UHFFFAOYSA-N Febantel Chemical compound C1=C(NC(NC(=O)OC)=NC(=O)OC)C(NC(=O)COC)=CC(SC=2C=CC=CC=2)=C1 HMCCXLBXIJMERM-UHFFFAOYSA-N 0.000 description 1
• PNVJTZOFSHSLTO-UHFFFAOYSA-N Fenthion Chemical compound COP(=S)(OC)OC1=CC=C(SC)C(C)=C1 PNVJTZOFSHSLTO-UHFFFAOYSA-N 0.000 description 1
• JKQQZJHNUVDHKP-FQJIPJFPSA-N Flurogestone acetate Chemical compound C1CC2=CC(=O)CC[C@]2(C)[C@]2(F)[C@@H]1[C@@H]1CC[C@@](C(C)=O)(OC(=O)C)[C@@]1(C)C[C@@H]2O JKQQZJHNUVDHKP-FQJIPJFPSA-N 0.000 description 1
• BDAGIHXWWSANSR-UHFFFAOYSA-N Formic acid Chemical class OC=O BDAGIHXWWSANSR-UHFFFAOYSA-N 0.000 description 1
• 208000001613 Gambling Diseases 0.000 description 1
• 208000003098 Ganglion Cysts Diseases 0.000 description 1
• 244000068988 Glycine max Species 0.000 description 1
• 235000010469 Glycine max Nutrition 0.000 description 1
• HEFNNWSXXWATRW-UHFFFAOYSA-N Ibuprofen Chemical compound CC(C)CC1=CC=C(C(C)C(O)=O)C=C1 HEFNNWSXXWATRW-UHFFFAOYSA-N 0.000 description 1
• 241000758791 Juglandaceae Species 0.000 description 1
• 208000008839 Kidney Neoplasms Diseases 0.000 description 1
• GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 description 1
• 239000004166 Lanolin Substances 0.000 description 1
• 241000124008 Mammalia Species 0.000 description 1
• 241001503485 Mammuthus Species 0.000 description 1
• 240000000233 Melia azedarach Species 0.000 description 1
• RAOCRURYZCVHMG-UHFFFAOYSA-N N-(6-propoxy-1H-benzimidazol-2-yl)carbamic acid methyl ester Chemical compound CCCOC1=CC=C2N=C(NC(=O)OC)NC2=C1 RAOCRURYZCVHMG-UHFFFAOYSA-N 0.000 description 1
• SNIOPGDIGTZGOP-UHFFFAOYSA-N Nitroglycerin Chemical compound [O-][N+](=O)OCC(O[N+]([O-])=O)CO[N+]([O-])=O SNIOPGDIGTZGOP-UHFFFAOYSA-N 0.000 description 1
• 241001482564 Nyctereutes procyonoides Species 0.000 description 1
• 239000004677 Nylon Substances 0.000 description 1
• 241000243985 Onchocerca volvulus Species 0.000 description 1
• 241000283973 Oryctolagus cuniculus Species 0.000 description 1
• 235000002791 Panax Nutrition 0.000 description 1
• 241000208343 Panax Species 0.000 description 1
• 206010033799 Paralysis Diseases 0.000 description 1
• 235000019495 Pecan oil Nutrition 0.000 description 1
• 239000004264 Petrolatum Substances 0.000 description 1
• 241000242594 Platyhelminthes Species 0.000 description 1
• 239000002202 Polyethylene glycol Substances 0.000 description 1
• 239000004743 Polypropylene Substances 0.000 description 1
• 241000218206 Ranunculus Species 0.000 description 1
• 206010038389 Renal cancer Diseases 0.000 description 1
• 241000447727 Scabies Species 0.000 description 1
• 241000239226 Scorpiones Species 0.000 description 1
• BUGBHKTXTAQXES-UHFFFAOYSA-N Selenium Chemical compound [Se] BUGBHKTXTAQXES-UHFFFAOYSA-N 0.000 description 1
• 241000282887 Suidae Species 0.000 description 1
• 208000005400 Synovial Cyst Diseases 0.000 description 1
• LAZPBGZRMVRFKY-UHFFFAOYSA-N Tetramisole hydrochloride Chemical compound Cl.N1=C2SCCN2CC1C1=CC=CC=C1 LAZPBGZRMVRFKY-UHFFFAOYSA-N 0.000 description 1
• 208000025865 Ulcer Diseases 0.000 description 1
• 208000002495 Uterine Neoplasms Diseases 0.000 description 1
• 206010046798 Uterine leiomyoma Diseases 0.000 description 1
• 229930003268 Vitamin C Natural products 0.000 description 1
• 206010071212 Vulvovaginal injury Diseases 0.000 description 1
• 235000019498 Walnut oil Nutrition 0.000 description 1
• 235000016383 Zea mays subsp huehuetenangensis Nutrition 0.000 description 1
• DGEZNRSVGBDHLK-UHFFFAOYSA-N [1,10]phenanthroline Chemical compound C1=CN=C2C3=NC=CC=C3C=CC2=C1 DGEZNRSVGBDHLK-UHFFFAOYSA-N 0.000 description 1
• 230000002159 abnormal effect Effects 0.000 description 1
• 238000005299 abrasion Methods 0.000 description 1
• 230000000895 acaricidal effect Effects 0.000 description 1
• 239000000642 acaricide Substances 0.000 description 1
• 230000001133 acceleration Effects 0.000 description 1
• OTUXCLKRSRDYPV-UHFFFAOYSA-N acetylene hydrochloride Chemical compound Cl.C#C OTUXCLKRSRDYPV-UHFFFAOYSA-N 0.000 description 1
• 150000007513 acids Chemical class 0.000 description 1
• YBCVMFKXIKNREZ-UHFFFAOYSA-N acoh acetic acid Chemical compound CC(O)=O.CC(O)=O YBCVMFKXIKNREZ-UHFFFAOYSA-N 0.000 description 1
• 239000004480 active ingredient Substances 0.000 description 1
• 230000001070 adhesive effect Effects 0.000 description 1
• 239000002390 adhesive tape Substances 0.000 description 1
• 239000002671 adjuvant Substances 0.000 description 1
• 238000009098 adjuvant therapy Methods 0.000 description 1
• NDAUXUAQIAJITI-UHFFFAOYSA-N albuterol Chemical compound CC(C)(C)NCC(O)C1=CC=C(O)C(CO)=C1 NDAUXUAQIAJITI-UHFFFAOYSA-N 0.000 description 1
• 125000001931 aliphatic group Chemical group 0.000 description 1
• 235000020224 almond Nutrition 0.000 description 1
• FPQFYIAXQDXNOR-QDKLYSGJSA-N alpha-Zearalenol Chemical compound O=C1O[C@@H](C)CCC[C@H](O)CCC\C=C\C2=CC(O)=CC(O)=C21 FPQFYIAXQDXNOR-QDKLYSGJSA-N 0.000 description 1
• 229940035676 analgesics Drugs 0.000 description 1
• 239000000730 antalgic agent Substances 0.000 description 1
• 230000003110 anti-inflammatory effect Effects 0.000 description 1
• 230000002460 anti-migrenic effect Effects 0.000 description 1
• 230000002141 anti-parasite Effects 0.000 description 1
• 230000000842 anti-protozoal effect Effects 0.000 description 1
• 230000002609 anti-worm Effects 0.000 description 1
• 239000000043 antiallergic agent Substances 0.000 description 1
• 239000003963 antioxidant agent Substances 0.000 description 1
• 230000003078 antioxidant effect Effects 0.000 description 1
• 235000006708 antioxidants Nutrition 0.000 description 1
• 239000003096 antiparasitic agent Substances 0.000 description 1
• 239000003904 antiprotozoal agent Substances 0.000 description 1
• 239000007864 aqueous solution Substances 0.000 description 1
• 238000003556 assay Methods 0.000 description 1
• 239000012298 atmosphere Substances 0.000 description 1
• 239000003139 biocide Substances 0.000 description 1
• 230000015572 biosynthetic process Effects 0.000 description 1
• 229910052797 bismuth Inorganic materials 0.000 description 1
• JCXGWMGPZLAOME-UHFFFAOYSA-N bismuth atom Chemical compound [Bi] JCXGWMGPZLAOME-UHFFFAOYSA-N 0.000 description 1
• 230000000903 blocking effect Effects 0.000 description 1
• 238000009534 blood test Methods 0.000 description 1
• 230000037396 body weight Effects 0.000 description 1
• 230000000711 cancerogenic effect Effects 0.000 description 1
• 229910052799 carbon Inorganic materials 0.000 description 1
• 125000004432 carbon atom Chemical group C* 0.000 description 1
• 231100000357 carcinogen Toxicity 0.000 description 1
• 239000003183 carcinogenic agent Substances 0.000 description 1
• SOYKEARSMXGVTM-UHFFFAOYSA-N chlorphenamine Chemical compound C=1C=CC=NC=1C(CCN(C)C)C1=CC=C(Cl)C=C1 SOYKEARSMXGVTM-UHFFFAOYSA-N 0.000 description 1
• 229960003291 chlorphenamine Drugs 0.000 description 1
• 238000012790 confirmation Methods 0.000 description 1
• 238000010276 construction Methods 0.000 description 1
• 230000001276 controlling effect Effects 0.000 description 1
• 229910052802 copper Inorganic materials 0.000 description 1
• 239000010949 copper Substances 0.000 description 1
• 239000002285 corn oil Substances 0.000 description 1
• 235000005687 corn oil Nutrition 0.000 description 1
• 230000008878 coupling Effects 0.000 description 1
• 238000010168 coupling process Methods 0.000 description 1
• 238000005859 coupling reaction Methods 0.000 description 1
• 239000006071 cream Substances 0.000 description 1
• 230000002354 daily effect Effects 0.000 description 1
• 230000006378 damage Effects 0.000 description 1
• 125000002704 decyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 description 1
• 238000013461 design Methods 0.000 description 1
• UREBDLICKHMUKA-CXSFZGCWSA-N dexamethasone Chemical compound C1CC2=CC(=O)C=C[C@]2(C)[C@]2(F)[C@@H]1[C@@H]1C[C@@H](C)[C@@](C(=O)CO)(O)[C@@]1(C)C[C@@H]2O UREBDLICKHMUKA-CXSFZGCWSA-N 0.000 description 1
• 239000008121 dextrose Substances 0.000 description 1
• 150000002009 diols Chemical class 0.000 description 1
• 239000002270 dispersing agent Substances 0.000 description 1
• 239000006185 dispersion Substances 0.000 description 1
• 238000009826 distribution Methods 0.000 description 1
• 230000002526 effect on cardiovascular system Effects 0.000 description 1
• 229940108623 eicosenoic acid Drugs 0.000 description 1
• 239000003974 emollient agent Substances 0.000 description 1
• 239000008393 encapsulating agent Substances 0.000 description 1
• 210000003038 endothelium Anatomy 0.000 description 1
• 239000003623 enhancer Substances 0.000 description 1
• 230000003203 everyday effect Effects 0.000 description 1
• 238000000605 extraction Methods 0.000 description 1
• 238000009313 farming Methods 0.000 description 1
• 229960005282 febantel Drugs 0.000 description 1
• 210000003608 fece Anatomy 0.000 description 1
• 229960005473 fenbendazole Drugs 0.000 description 1
• IRHZVMHXVHSMKB-UHFFFAOYSA-N fenbendazole Chemical compound [CH]1C2=NC(NC(=O)OC)=NC2=CC=C1SC1=CC=CC=C1 IRHZVMHXVHSMKB-UHFFFAOYSA-N 0.000 description 1
• 230000035558 fertility Effects 0.000 description 1
• 229930003935 flavonoid Natural products 0.000 description 1
• 235000017173 flavonoids Nutrition 0.000 description 1
• 150000002215 flavonoids Chemical class 0.000 description 1
• 229960004500 flubendazole Drugs 0.000 description 1
• CPEUVMUXAHMANV-UHFFFAOYSA-N flubendazole Chemical compound C1=C2NC(NC(=O)OC)=NC2=CC=C1C(=O)C1=CC=C(F)C=C1 CPEUVMUXAHMANV-UHFFFAOYSA-N 0.000 description 1
• GNBHRKFJIUUOQI-UHFFFAOYSA-N fluorescein Chemical compound O1C(=O)C2=CC=CC=C2C21C1=CC=C(O)C=C1OC1=CC(O)=CC=C21 GNBHRKFJIUUOQI-UHFFFAOYSA-N 0.000 description 1
• 235000013305 food Nutrition 0.000 description 1
• 230000008014 freezing Effects 0.000 description 1
• 238000007710 freezing Methods 0.000 description 1
• 230000002496 gastric effect Effects 0.000 description 1
• 210000001035 gastrointestinal tract Anatomy 0.000 description 1
• 238000007429 general method Methods 0.000 description 1
• 239000011521 glass Substances 0.000 description 1
• 229960003711 glyceryl trinitrate Drugs 0.000 description 1
• PCHJSUWPFVWCPO-UHFFFAOYSA-N gold Chemical compound [Au] PCHJSUWPFVWCPO-UHFFFAOYSA-N 0.000 description 1
• 239000010931 gold Substances 0.000 description 1
• 229910052737 gold Inorganic materials 0.000 description 1
• 239000003630 growth substance Substances 0.000 description 1
• 125000001475 halogen functional group Chemical group 0.000 description 1
• 230000036541 health Effects 0.000 description 1
• 238000004128 high performance liquid chromatography Methods 0.000 description 1
• 238000005984 hydrogenation reaction Methods 0.000 description 1
• 150000002440 hydroxy compounds Chemical class 0.000 description 1
• 238000002513 implantation Methods 0.000 description 1
• 238000010348 incorporation Methods 0.000 description 1
• 208000014674 injury Diseases 0.000 description 1
• 230000009027 insemination Effects 0.000 description 1
• 230000003993 interaction Effects 0.000 description 1
• 239000011229 interlayer Substances 0.000 description 1
• JEIPFZHSYJVQDO-UHFFFAOYSA-N iron(III) oxide Inorganic materials O=[Fe]O[Fe]=O JEIPFZHSYJVQDO-UHFFFAOYSA-N 0.000 description 1
• 230000001788 irregular Effects 0.000 description 1
• 230000002262 irrigation Effects 0.000 description 1
• 238000003973 irrigation Methods 0.000 description 1
• 230000000622 irritating effect Effects 0.000 description 1
• 125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 description 1
• 201000010982 kidney cancer Diseases 0.000 description 1
• 230000002147 killing effect Effects 0.000 description 1
• 239000008101 lactose Substances 0.000 description 1
• 229940039717 lanolin Drugs 0.000 description 1
• 235000019388 lanolin Nutrition 0.000 description 1
• 210000002414 leg Anatomy 0.000 description 1
• 201000010260 leiomyoma Diseases 0.000 description 1
• 235000020778 linoleic acid Nutrition 0.000 description 1
• OYHQOLUKZRVURQ-IXWMQOLASA-N linoleic acid Natural products CCCCC\C=C/C\C=C\CCCCCCCC(O)=O OYHQOLUKZRVURQ-IXWMQOLASA-N 0.000 description 1
• OYHQOLUKZRVURQ-HZJYTTRNSA-N linoleic acid group Chemical group C(CCCCCCC\C=C/C\C=C/CCCCC)(=O)O OYHQOLUKZRVURQ-HZJYTTRNSA-N 0.000 description 1
• 210000004185 liver Anatomy 0.000 description 1
• 230000007774 longterm Effects 0.000 description 1
• 239000007937 lozenge Substances 0.000 description 1
• 239000003120 macrolide antibiotic agent Substances 0.000 description 1
• 235000009973 maize Nutrition 0.000 description 1
• 235000013372 meat Nutrition 0.000 description 1
• FQQIIPAOSKSOJM-UHFFFAOYSA-N mebhydrolin Chemical compound C1N(C)CCC2=C1C1=CC=CC=C1N2CC1=CC=CC=C1 FQQIIPAOSKSOJM-UHFFFAOYSA-N 0.000 description 1
• 229960004934 mebhydrolin Drugs 0.000 description 1
• 230000007246 mechanism Effects 0.000 description 1
• 230000010534 mechanism of action Effects 0.000 description 1
• 229960003846 melengestrol acetate Drugs 0.000 description 1
• 230000009245 menopause Effects 0.000 description 1
• 230000003821 menstrual periods Effects 0.000 description 1
• 229940041616 menthol Drugs 0.000 description 1
• 239000002184 metal Substances 0.000 description 1
• 229910052751 metal Inorganic materials 0.000 description 1
• 230000001394 metastastic effect Effects 0.000 description 1
• 206010061289 metastatic neoplasm Diseases 0.000 description 1
• 229960001797 methadone Drugs 0.000 description 1
• 125000006216 methylsulfinyl group Chemical group [H]C([H])([H])S(*)=O 0.000 description 1
• IUBSYMUCCVWXPE-UHFFFAOYSA-N metoprolol Chemical compound COCCC1=CC=C(OCC(O)CNC(C)C)C=C1 IUBSYMUCCVWXPE-UHFFFAOYSA-N 0.000 description 1
• 229960002237 metoprolol Drugs 0.000 description 1
• 229960000282 metronidazole Drugs 0.000 description 1
• VAOCPAMSLUNLGC-UHFFFAOYSA-N metronidazole Chemical compound CC1=NC=C([N+]([O-])=O)N1CCO VAOCPAMSLUNLGC-UHFFFAOYSA-N 0.000 description 1
• 235000013336 milk Nutrition 0.000 description 1
• 239000008267 milk Substances 0.000 description 1
• 210000004080 milk Anatomy 0.000 description 1
• PYLWMHQQBFSUBP-UHFFFAOYSA-N monofluorobenzene Chemical compound FC1=CC=CC=C1 PYLWMHQQBFSUBP-UHFFFAOYSA-N 0.000 description 1
• 229960005121 morantel Drugs 0.000 description 1
• 201000003152 motion sickness Diseases 0.000 description 1
• 230000002232 neuromuscular Effects 0.000 description 1
• 239000010955 niobium Substances 0.000 description 1
• GUCVJGMIXFAOAE-UHFFFAOYSA-N niobium atom Chemical compound [Nb] GUCVJGMIXFAOAE-UHFFFAOYSA-N 0.000 description 1
• 231100000957 no side effect Toxicity 0.000 description 1
• 238000011580 nude mouse model Methods 0.000 description 1
• 230000035764 nutrition Effects 0.000 description 1
• 235000008935 nutritious Nutrition 0.000 description 1
• 229920001778 nylon Polymers 0.000 description 1
• 239000004006 olive oil Substances 0.000 description 1
• 235000008390 olive oil Nutrition 0.000 description 1
• 208000002042 onchocerciasis Diseases 0.000 description 1
• 230000003204 osmotic effect Effects 0.000 description 1
• 230000016087 ovulation Effects 0.000 description 1
• BEZZFPOZAYTVHN-UHFFFAOYSA-N oxfendazole Chemical compound C=1C=C2NC(NC(=O)OC)=NC2=CC=1S(=O)C1=CC=CC=C1 BEZZFPOZAYTVHN-UHFFFAOYSA-N 0.000 description 1
• 229960004454 oxfendazole Drugs 0.000 description 1
• 238000010422 painting Methods 0.000 description 1
• 244000045947 parasite Species 0.000 description 1
• 230000003071 parasitic effect Effects 0.000 description 1
• 235000020232 peanut Nutrition 0.000 description 1
• 239000010470 pecan oil Substances 0.000 description 1
• 230000037368 penetrate the skin Effects 0.000 description 1
• 230000008447 perception Effects 0.000 description 1
• 229940066842 petrolatum Drugs 0.000 description 1
• 239000000546 pharmaceutical excipient Substances 0.000 description 1
• ISWSIDIOOBJBQZ-UHFFFAOYSA-N phenol group Chemical group C1(=CC=CC=C1)O ISWSIDIOOBJBQZ-UHFFFAOYSA-N 0.000 description 1
• 239000000049 pigment Substances 0.000 description 1
• 239000006187 pill Substances 0.000 description 1
• 239000004014 plasticizer Substances 0.000 description 1
• 231100000614 poison Toxicity 0.000 description 1
• 230000007096 poisonous effect Effects 0.000 description 1
• 229920000728 polyester Polymers 0.000 description 1
• 229920001223 polyethylene glycol Polymers 0.000 description 1
• 235000013824 polyphenols Nutrition 0.000 description 1
• 229920001155 polypropylene Polymers 0.000 description 1
• 229920001451 polypropylene glycol Polymers 0.000 description 1
• 229920002635 polyurethane Polymers 0.000 description 1
• 239000004814 polyurethane Substances 0.000 description 1
• 239000011148 porous material Substances 0.000 description 1
• 235000021395 porridge Nutrition 0.000 description 1
• 230000003449 preventive effect Effects 0.000 description 1
• 238000007639 printing Methods 0.000 description 1
• RJKFOVLPORLFTN-UHFFFAOYSA-N progesterone acetate Natural products C1CC2=CC(=O)CCC2(C)C2C1C1CCC(C(=O)C)C1(C)CC2 RJKFOVLPORLFTN-UHFFFAOYSA-N 0.000 description 1
• 239000000583 progesterone congener Substances 0.000 description 1
• 229950000126 proligestone Drugs 0.000 description 1
• MQSDUYIXZDSLSZ-QSDCUGRSSA-N proligestone[ban:inn] Chemical compound C([C@@H]12)CC3=CC(=O)CC[C@]3(C)[C@H]2CC[C@]2(C)[C@@]3(C(C)=O)CC[C@]21OC(CC)O3 MQSDUYIXZDSLSZ-QSDCUGRSSA-N 0.000 description 1
• AQHHHDLHHXJYJD-UHFFFAOYSA-N propranolol Chemical compound C1=CC=C2C(OCC(O)CNC(C)C)=CC=CC2=C1 AQHHHDLHHXJYJD-UHFFFAOYSA-N 0.000 description 1
• 230000001681 protective effect Effects 0.000 description 1
• 230000002294 pubertal effect Effects 0.000 description 1
• YSAUAVHXTIETRK-AATRIKPKSA-N pyrantel Chemical compound CN1CCCN=C1\C=C\C1=CC=CS1 YSAUAVHXTIETRK-AATRIKPKSA-N 0.000 description 1
• 229960005134 pyrantel Drugs 0.000 description 1
• 230000000306 recurrent effect Effects 0.000 description 1
• 230000002829 reductive effect Effects 0.000 description 1
• 230000029058 respiratory gaseous exchange Effects 0.000 description 1
• 208000005687 scabies Diseases 0.000 description 1
• 238000012216 screening Methods 0.000 description 1
• 239000008159 sesame oil Substances 0.000 description 1
• 235000011803 sesame oil Nutrition 0.000 description 1
• 239000002356 single layer Substances 0.000 description 1
• 229940125724 sleeping drug Drugs 0.000 description 1
• 159000000000 sodium salts Chemical class 0.000 description 1
• 241000894007 species Species 0.000 description 1
• 238000010186 staining Methods 0.000 description 1
• 230000001954 sterilising effect Effects 0.000 description 1
• 238000004659 sterilization and disinfection Methods 0.000 description 1
• 150000003431 steroids Chemical class 0.000 description 1
• 230000004936 stimulating effect Effects 0.000 description 1
• 238000003756 stirring Methods 0.000 description 1
• 210000002784 stomach Anatomy 0.000 description 1
• 239000004575 stone Substances 0.000 description 1
• 238000007920 subcutaneous administration Methods 0.000 description 1
• 235000020238 sunflower seed Nutrition 0.000 description 1
• 238000013268 sustained release Methods 0.000 description 1
• 239000012730 sustained-release form Substances 0.000 description 1
• 208000024891 symptom Diseases 0.000 description 1
• 229920001059 synthetic polymer Polymers 0.000 description 1
• 239000003826 tablet Substances 0.000 description 1
• 229940124597 therapeutic agent Drugs 0.000 description 1
• 230000001225 therapeutic effect Effects 0.000 description 1
• 239000012815 thermoplastic material Substances 0.000 description 1
• 239000004308 thiabendazole Substances 0.000 description 1
• 229960004546 thiabendazole Drugs 0.000 description 1
• WJCNZQLZVWNLKY-UHFFFAOYSA-N thiabendazole Chemical compound S1C=NC(C=2NC3=CC=CC=C3N=2)=C1 WJCNZQLZVWNLKY-UHFFFAOYSA-N 0.000 description 1
• 235000010296 thiabendazole Nutrition 0.000 description 1
• 210000001519 tissue Anatomy 0.000 description 1
• 238000003325 tomography Methods 0.000 description 1
• 231100000331 toxic Toxicity 0.000 description 1
• 230000002588 toxic effect Effects 0.000 description 1
• 239000011573 trace mineral Substances 0.000 description 1
• 235000013619 trace mineral Nutrition 0.000 description 1
• 238000002054 transplantation Methods 0.000 description 1
• 230000008736 traumatic injury Effects 0.000 description 1
• LADGBHLMCUINGV-UHFFFAOYSA-N tricaprin Chemical compound CCCCCCCCCC(=O)OCC(OC(=O)CCCCCCCCC)COC(=O)CCCCCCCCC LADGBHLMCUINGV-UHFFFAOYSA-N 0.000 description 1
• UFTFJSFQGQCHQW-UHFFFAOYSA-N triformin Chemical compound O=COCC(OC=O)COC=O UFTFJSFQGQCHQW-UHFFFAOYSA-N 0.000 description 1
• 230000036269 ulceration Effects 0.000 description 1
• 210000000689 upper leg Anatomy 0.000 description 1
• 206010046766 uterine cancer Diseases 0.000 description 1
• 238000009423 ventilation Methods 0.000 description 1
• 238000012795 verification Methods 0.000 description 1
• 230000035899 viability Effects 0.000 description 1
• 230000000007 visual effect Effects 0.000 description 1
• 239000011782 vitamin Substances 0.000 description 1
• 229930003231 vitamin Natural products 0.000 description 1
• 235000013343 vitamin Nutrition 0.000 description 1
• 229940088594 vitamin Drugs 0.000 description 1
• 235000019154 vitamin C Nutrition 0.000 description 1
• 239000011718 vitamin C Substances 0.000 description 1
• 235000020234 walnut Nutrition 0.000 description 1
• 239000008170 walnut oil Substances 0.000 description 1
• 239000001993 wax Substances 0.000 description 1
• 239000003871 white petrolatum Substances 0.000 description 1
• 238000004804 winding Methods 0.000 description 1
• 239000002759 woven fabric Substances 0.000 description 1
• 229960002300 zeranol Drugs 0.000 description 1