TW368397B - Oxaborole derivatives and their use as antimicrobial agent - Google Patents

Oxaborole derivatives and their use as antimicrobial agent

Info

Publication number: TW368397B
Authority: TW; Taiwan
Prior art keywords: oxaborole; group; phenyl; derivatives; antimicrobial agent
Prior art date: 1994-06-09

Application number

TW084105427A

Other languages

English (en)

Inventor

Peter William Austin

John Martin Clough

Patrick Jelf Crowley

Christopher Juan Kneale

Original Assignee

Zeneca Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1994-06-09

Filing date

1995-05-30

Publication date

1999-09-01

1995-05-30 Application filed by Zeneca Ltd filed Critical Zeneca Ltd

1999-09-01 Application granted granted Critical

1999-09-01 Publication of TW368397B publication Critical patent/TW368397B/zh

Links

OHENQANLQNOMAO-UHFFFAOYSA-N oxaborole Chemical class O1B=CC=C1 OHENQANLQNOMAO-UHFFFAOYSA-N 0.000 title abstract 4
239000004599 antimicrobial Substances 0.000 title abstract 2
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 3
125000004191 (C1-C6) alkoxy group Chemical group 0.000 abstract 2
150000002431 hydrogen Chemical class 0.000 abstract 2
229910052739 hydrogen Inorganic materials 0.000 abstract 2
239000001257 hydrogen Substances 0.000 abstract 2
125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 1
ZQXCQTAELHSNAT-UHFFFAOYSA-N 1-chloro-3-nitro-5-(trifluoromethyl)benzene Chemical group [O-][N+](=O)C1=CC(Cl)=CC(C(F)(F)F)=C1 ZQXCQTAELHSNAT-UHFFFAOYSA-N 0.000 abstract 1
CPHUUWJMAOTJLB-UHFFFAOYSA-N 2-methylidenepyrrolidine Chemical group C=C1CCCN1 CPHUUWJMAOTJLB-UHFFFAOYSA-N 0.000 abstract 1
YTPLMLYBLZKORZ-UHFFFAOYSA-N Thiophene Chemical group C=1C=CSC=1 YTPLMLYBLZKORZ-UHFFFAOYSA-N 0.000 abstract 1
125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 abstract 1
229910052736 halogen Inorganic materials 0.000 abstract 1
150000002367 halogens Chemical group 0.000 abstract 1
230000000813 microbial effect Effects 0.000 abstract 1
125000001624 naphthyl group Chemical group 0.000 abstract 1
125000005245 nitryl group Chemical group [N+](=O)([O-])* 0.000 abstract 1
-1 phenoxyl group Chemical group 0.000 abstract 1
125000002943 quinolinyl group Chemical group N1=C(C=CC2=CC=CC=C12)* 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
125000004001 thioalkyl group Chemical group 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N55/00—Biocides, pest repellants or attractants, or plant growth regulators, containing organic compounds containing elements other than carbon, hydrogen, halogen, oxygen, nitrogen and sulfur
- A01N55/08—Biocides, pest repellants or attractants, or plant growth regulators, containing organic compounds containing elements other than carbon, hydrogen, halogen, oxygen, nitrogen and sulfur containing boron
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N55/00—Biocides, pest repellants or attractants, or plant growth regulators, containing organic compounds containing elements other than carbon, hydrogen, halogen, oxygen, nitrogen and sulfur
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic Table
- C07F5/02—Boron compounds
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic Table
- C07F5/02—Boron compounds
- C07F5/025—Boronic and borinic acid compounds
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08K—Use of inorganic or non-macromolecular organic substances as compounding ingredients
- C08K5/00—Use of organic ingredients
- C08K5/0008—Organic ingredients according to more than one of the "one dot" groups of C08K5/01 - C08K5/59
- C08K5/0058—Biocides
- C—CHEMISTRY; METALLURGY
- C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
- C09D—COATING COMPOSITIONS, e.g. PAINTS, VARNISHES OR LACQUERS; FILLING PASTES; CHEMICAL PAINT OR INK REMOVERS; INKS; CORRECTING FLUIDS; WOODSTAINS; PASTES OR SOLIDS FOR COLOURING OR PRINTING; USE OF MATERIALS THEREFOR
- C09D5/00—Coating compositions, e.g. paints, varnishes or lacquers, characterised by their physical nature or the effects produced; Filling pastes
- C09D5/14—Paints containing biocides, e.g. fungicides, insecticides or pesticides

Landscapes

Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Organic Chemistry (AREA)
Engineering & Computer Science (AREA)
Wood Science & Technology (AREA)
Plant Pathology (AREA)
Health & Medical Sciences (AREA)
Environmental Sciences (AREA)
Dentistry (AREA)
General Health & Medical Sciences (AREA)
Pest Control & Pesticides (AREA)
Zoology (AREA)
Agronomy & Crop Science (AREA)
Polymers & Plastics (AREA)
Chemical Kinetics & Catalysis (AREA)
Medicinal Chemistry (AREA)
Biodiversity & Conservation Biology (AREA)
Materials Engineering (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Agricultural Chemicals And Associated Chemicals (AREA)
Catalysts (AREA)
Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)
Steroid Compounds (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

TW084105427A 1994-06-09 1995-05-30 Oxaborole derivatives and their use as antimicrobial agent TW368397B (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
GB9411587A GB9411587D0 (en)	1994-06-09	1994-06-09	Compound, composition and use

Publications (1)

Publication Number	Publication Date
TW368397B true TW368397B (en)	1999-09-01

Family

ID=10756481

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
TW084105427A TW368397B (en)	1994-06-09	1995-05-30	Oxaborole derivatives and their use as antimicrobial agent

Country Status (14)

Country	Link
US (1)	US5880188A (zh)
EP (1)	EP0765331B1 (zh)
JP (1)	JPH10500983A (zh)
KR (1)	KR970703349A (zh)
CN (1)	CN1068005C (zh)
AT (1)	ATE195316T1 (zh)
AU (1)	AU681291B2 (zh)
BR (1)	BR9507966A (zh)
CA (1)	CA2190155A1 (zh)
DE (1)	DE69518323T2 (zh)
GB (1)	GB9411587D0 (zh)
NO (1)	NO965235L (zh)
TW (1)	TW368397B (zh)
WO (1)	WO1995033754A1 (zh)

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US6075014A (en) *	1997-06-13	2000-06-13	Northwestern University	Inhibitors of β-lactamases and uses therefor
US6184363B1 (en)	1997-06-13	2001-02-06	Northwestern University	Inhibitors of β-lactamases and uses therefor
BRPI0411582A (pt) *	2003-06-16	2006-08-08	Anacor Pharmaceuticals Inc	substáncias terapêuticas contendo boro hidroliticamente resistentes e método de uso
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US7767657B2 (en)	2005-02-16	2010-08-03	Anacor Pharmaceuticals, Inc.	Boron-containing small molecules
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JP5504454B2 (ja) *	2007-12-06	2014-05-28	国立大学法人京都大学	新規なホウ素化合物、それらの製造方法およびそれらを用いた機能性電子素子
JP5745279B2 (ja) *	2008-01-09	2015-07-08	アナコールファーマシューティカルズ，インコーポレイテッド	抗炎症剤としてのホウ素含有小分子
BRPI0908565A2 (pt) *	2008-03-06	2017-05-23	Anacor Pharmaceuticals Inc	composto, formulação farmacêutica, métodos para reduzir a liberação de uma citocina ou de uma quimiocina, para tratar uma condição em um animal e para inibir uma fosfodiesterase
US20100256092A1 (en) *	2008-05-12	2010-10-07	Anacor Pharmaceuticals, Inc.	Boron-containing small molecules
EP2348863A4 (en)	2008-09-04	2012-03-07	Anacor Pharmaceuticals Inc	BORN SMALL MOLECULES
US8461336B2 (en)	2008-09-04	2013-06-11	Anacor Pharmaceuticals, Inc.	Boron-containing small molecules
BRPI0919773A2 (pt)	2008-10-15	2015-12-08	Kissei Pharmaceutical	derivado de anel fundido e aplicação do mesmo na medicina
US9493489B2 (en) *	2008-10-15	2016-11-15	Anacor Pharmaceuticals, Inc.	Boron-containing small molecules as anti-protozoal agents
MX2011006334A (es) *	2008-12-17	2011-09-22	Anacor Pharmaceuticals Inc	Polimorfos de (s)-3-amino-metil-7-(3-hidroxi-propoxi)-3h-benzo-[c] [1,2]-oxaborol-1-ol.
KR20130031233A (ko)	2009-07-28	2013-03-28	아나코르 파마슈티칼스 인코포레이티드	삼치환된 붕소 함유 분자
AP4039A (en)	2009-08-14	2017-02-28	Daitao Chen	Boron-containing small molecules as antiprotozoal agents
MX2012002031A (es) *	2009-08-19	2012-07-04	Anacor Pharmaceuticals Inc	Moleculas pequeñas que contienen boro como agentes antiprotozoarios.
WO2011049971A1 (en)	2009-10-20	2011-04-28	Anacor Pharmaceuticals, Inc.	Boron-containing small molecules as antiprotozoal agents
US20110212918A1 (en) *	2009-11-11	2011-09-01	Anacor Pharmaceuticals, Inc.	Boron-containing small molecules
WO2011094450A1 (en)	2010-01-27	2011-08-04	Anacor Pharmaceuticals, Inc	Boron-containing small molecules
AP2012006482A0 (en)	2010-03-19	2012-10-31	Anacor Pharmacueticals Inc	Boron-containing small molecules as anti-protozoalagent
SG10201507032YA (en)	2010-09-07	2015-10-29	Anacor Pharmaceuticals Inc	Benzoxaborole derivatives for treating bacterial infections
CN103857289A (zh) *	2011-10-07	2014-06-11	先正达参股股份有限公司	用于保护有用植物或植物繁殖材料的方法
UY34367A (es) *	2011-10-07	2014-08-29	Syngenta Participations Ag	?método para proteger material de propagación vegetal o plantas útiles?.
US20220125049A1 (en) *	2013-01-30	2022-04-28	Agrofresh Inc.	Method and system for centralized management, monitoring, and controlled delivery of biological compounds to fruit storage rooms
US10070649B2 (en)	2013-01-30	2018-09-11	Agrofresh Inc.	Volatile applications against pathogens
US8669207B1 (en)	2013-01-30	2014-03-11	Dow Agrosciences, Llc.	Compounds and compositions
US9585396B2 (en)	2013-01-30	2017-03-07	Agrofresh Inc.	Volatile applications against pathogens
DK2950644T3 (en)	2013-01-30	2017-09-04	Agrofresh Inc	USE OF BENZOXABOROLS AS VOLATIVE ANTIMICROBIAL AGENTS IN MEAT, PLANTS OR PARTS
US11039617B2 (en)	2013-01-30	2021-06-22	Agrofresh Inc.	Large scale methods of uniformly coating packaging surfaces with a volatile antimicrobial to preserve food freshness
WO2014147009A1 (en) *	2013-03-18	2014-09-25	Syngenta Participations Ag	Novel microbiocides
WO2014173880A1 (en)	2013-04-22	2014-10-30	Syngenta Participations Ag	Novel microbiocides
AU2014202928B1 (en) *	2013-06-05	2014-09-11	Agrofresh Inc.	Compounds and compositions
WO2015097237A1 (en) *	2013-12-23	2015-07-02	Syngenta Participations Ag	Benzoxaborole fungicides
EP3086645A1 (en) *	2013-12-23	2016-11-02	Syngenta Participations AG	Benzoxaborole fungicides
MA41495A (fr) *	2015-02-12	2017-12-19	Anacor Pharmaceuticals Inc	Composés benzoxaborole et leurs utilisations
CA2974396C (en) *	2015-02-12	2024-04-30	Agrofresh Inc.	Fungicidal compounds and compositions
BR112017021478B1 (pt)	2015-04-09	2022-04-19	The Penn State Research Foundation	Composição antifúngica sinérgica que contém benzoxaborol
CA3014757C (en) *	2015-08-06	2020-01-14	The Penn State Research Foundation	Benzoxaborole-containing coating resistant to cellulose-supportable fungus
US10633399B2 (en)	2015-08-17	2020-04-28	Channel Therapeutics, Inc.	Functionalized aminobenzoboroxoles
CN113321672A (zh) *	2016-03-02	2021-08-31	比尔及梅琳达盖茨基金会	含硼小分子
TW201733442A (zh)	2016-03-07	2017-10-01	農業保鮮股份有限公司	殺有害生物劑之汽化給予
NZ745681A (en)	2016-03-07	2022-05-27	Agrofresh Inc	Synergistic methods of using benzoxaborole compounds and preservative gases as an antimicrobial for crops
US11447506B2 (en)	2016-05-09	2022-09-20	Anacor Pharmaceuticals, Inc.	Crystal forms of crisaborole in free form and preparation method and use thereof
HK1258717A1 (zh)	2016-05-12	2019-11-15	安纳考尔医药公司	氧杂硼杂环戊烷酯类及其用途
EP4119566A1 (en)	2017-11-02	2023-01-18	Halcyon Labs Private Limited	Novel process for the preparation tavaborole and its intermediates
BR112020010927A2 (pt)	2017-11-30	2020-12-01	Boragen, Inc.	compostos de benzoxaborol e formulações dos mesmos
US11427603B2 (en)	2018-03-09	2022-08-30	University Of The Sciences	Protective groups and methods for protecting benzoxaboroles or oxaboroles
WO2020041200A1 (en)	2018-08-18	2020-02-27	Boragen Inc.	Solid forms of substituted benzoxaborole and compositions thereof
CU20210023A7 (es)	2018-10-05	2021-10-12	Pfizer	Inhibidores fenil sustituidos de la piridinil 1,2-oxaborolan-2-ol fosfodiesterasa 4
US12065456B2 (en)	2019-07-25	2024-08-20	National Institutes Of Health (Nih), U.S. Dept. Of Health And Human Services (Dhhs), U.S. Government	Boron-containing pharmacophore
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1994
- 1994-06-09 GB GB9411587A patent/GB9411587D0/en active Pending
1995
- 1995-05-26 US US08/750,081 patent/US5880188A/en not_active Expired - Fee Related
- 1995-05-26 BR BR9507966A patent/BR9507966A/pt not_active Application Discontinuation
- 1995-05-26 EP EP95919572A patent/EP0765331B1/en not_active Expired - Lifetime
- 1995-05-26 AU AU25348/95A patent/AU681291B2/en not_active Ceased
- 1995-05-26 DE DE69518323T patent/DE69518323T2/de not_active Expired - Fee Related
- 1995-05-26 AT AT95919572T patent/ATE195316T1/de not_active IP Right Cessation
- 1995-05-26 WO PCT/GB1995/001206 patent/WO1995033754A1/en not_active Ceased
- 1995-05-26 JP JP8500489A patent/JPH10500983A/ja not_active Withdrawn
- 1995-05-26 CN CN95194519A patent/CN1068005C/zh not_active Expired - Fee Related
- 1995-05-26 CA CA002190155A patent/CA2190155A1/en not_active Abandoned
- 1995-05-30 TW TW084105427A patent/TW368397B/zh active
1996
- 1996-12-06 NO NO965235A patent/NO965235L/no unknown
- 1996-12-07 KR KR1019960706993A patent/KR970703349A/ko not_active Withdrawn

Also Published As

Publication number	Publication date
KR970703349A (ko)	1997-07-03
DE69518323T2 (de)	2001-02-01
NO965235D0 (no)	1996-12-06
DE69518323D1 (de)	2000-09-14
BR9507966A (pt)	1997-09-02
US5880188A (en)	1999-03-09
JPH10500983A (ja)	1998-01-27
NO965235L (no)	1997-01-21
CA2190155A1 (en)	1995-12-14
GB9411587D0 (en)	1994-08-03
AU2534895A (en)	1996-01-04
ATE195316T1 (de)	2000-08-15
WO1995033754A1 (en)	1995-12-14
EP0765331B1 (en)	2000-08-09
CN1155286A (zh)	1997-07-23
AU681291B2 (en)	1997-08-21
EP0765331A1 (en)	1997-04-02
CN1068005C (zh)	2001-07-04

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