TW438593B - A pharmaceutical composition used as an antiulcer agent and an adhesion inhibitor for helicobacter pylori - Google Patents

A pharmaceutical composition used as an antiulcer agent and an adhesion inhibitor for helicobacter pylori Download PDF

Info

Publication number: TW438593B
Authority: TW; Taiwan
Prior art keywords: fucoidan; pharmaceutical composition; application; item; helicobacter pylori
Prior art date: 1993-09-24

Application number

TW083108714A

Other languages

English (en)

Chinese (zh)

Inventor

Itsuko Kimura

Hideyuki Shibata

Masato Nagaoka

Shusuke Hashimoto

Haruji Sawada

Original Assignee

Yakult Honsha Kk

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1993-09-24

Filing date

1994-09-22

Publication date

2001-06-07

1994-09-22 Application filed by Yakult Honsha Kk filed Critical Yakult Honsha Kk

2001-06-07 Application granted granted Critical

2001-06-07 Publication of TW438593B publication Critical patent/TW438593B/zh

Links

229940037467 helicobacter pylori Drugs 0.000 title claims abstract description 17
241000590002 Helicobacter pylori Species 0.000 title claims abstract description 16
239000008194 pharmaceutical composition Substances 0.000 title claims abstract 7
239000003699 antiulcer agent Substances 0.000 title description 5
239000003112 inhibitor Substances 0.000 title description 4
229920000855 Fucoidan Polymers 0.000 claims abstract description 33
239000000284 extract Substances 0.000 claims abstract description 5
230000002401 inhibitory effect Effects 0.000 claims abstract description 5
241000206572 Rhodophyta Species 0.000 claims abstract description 4
208000007107 Stomach Ulcer Diseases 0.000 claims abstract description 4
239000004480 active ingredient Substances 0.000 claims abstract description 4
206010061968 Gastric neoplasm Diseases 0.000 claims abstract 2
235000000346 sugar Nutrition 0.000 claims description 17
150000004676 glycans Chemical class 0.000 claims description 10
239000011435 rock Substances 0.000 claims description 10
229920001282 polysaccharide Polymers 0.000 claims description 9
239000005017 polysaccharide Substances 0.000 claims description 8
238000011049 filling Methods 0.000 claims description 7
241000199919 Phaeophyceae Species 0.000 claims description 6
239000000203 mixture Substances 0.000 claims description 6
210000004877 mucosa Anatomy 0.000 claims description 6
241000736199 Paeonia Species 0.000 claims 2
235000006484 Paeonia officinalis Nutrition 0.000 claims 2
241000512259 Ascophyllum nodosum Species 0.000 claims 1
241000195495 Chordaria Species 0.000 claims 1
230000002265 prevention Effects 0.000 claims 1
210000001156 gastric mucosa Anatomy 0.000 abstract description 8
201000005917 gastric ulcer Diseases 0.000 abstract description 3
208000025865 Ulcer Diseases 0.000 description 21
231100000397 ulcer Toxicity 0.000 description 20
239000003814 drug Substances 0.000 description 16
QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 14
239000000243 solution Substances 0.000 description 13
229940079593 drug Drugs 0.000 description 11
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YBJHBAHKTGYVGT-ZKWXMUAHSA-N (+)-Biotin Chemical compound N1C(=O)N[C@@H]2[C@H](CCCCC(=O)O)SC[C@@H]21 YBJHBAHKTGYVGT-ZKWXMUAHSA-N 0.000 description 8
241000894006 Bacteria Species 0.000 description 8
SHZGCJCMOBCMKK-UHFFFAOYSA-N D-mannomethylose Natural products CC1OC(O)C(O)C(O)C1O SHZGCJCMOBCMKK-UHFFFAOYSA-N 0.000 description 8
PNNNRSAQSRJVSB-SLPGGIOYSA-N Fucose Natural products C[C@H](O)[C@@H](O)[C@H](O)[C@H](O)C=O PNNNRSAQSRJVSB-SLPGGIOYSA-N 0.000 description 8
SHZGCJCMOBCMKK-DHVFOXMCSA-N L-fucopyranose Chemical compound C[C@@H]1OC(O)[C@@H](O)[C@H](O)[C@@H]1O SHZGCJCMOBCMKK-DHVFOXMCSA-N 0.000 description 8
230000000694 effects Effects 0.000 description 8
230000000767 anti-ulcer Effects 0.000 description 6
238000000034 method Methods 0.000 description 6
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KHIWWQKSHDUIBK-UHFFFAOYSA-N periodic acid Chemical compound OI(=O)(=O)=O KHIWWQKSHDUIBK-UHFFFAOYSA-N 0.000 description 3
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HVCOBJNICQPDBP-UHFFFAOYSA-N 3-[3-[3,5-dihydroxy-6-methyl-4-(3,4,5-trihydroxy-6-methyloxan-2-yl)oxyoxan-2-yl]oxydecanoyloxy]decanoic acid;hydrate Chemical compound O.OC1C(OC(CC(=O)OC(CCCCCCC)CC(O)=O)CCCCCCC)OC(C)C(O)C1OC1C(O)C(O)C(O)C(C)O1 HVCOBJNICQPDBP-UHFFFAOYSA-N 0.000 description 2
QGZKDVFQNNGYKY-UHFFFAOYSA-N Ammonia Chemical compound N QGZKDVFQNNGYKY-UHFFFAOYSA-N 0.000 description 2
241000193830 Bacillus <bacterium> Species 0.000 description 2
108091003079 Bovine Serum Albumin Proteins 0.000 description 2
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241000209094 Oryza Species 0.000 description 2
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208000005718 Stomach Neoplasms Diseases 0.000 description 2
WNLRTRBMVRJNCN-UHFFFAOYSA-N adipic acid Chemical compound OC(=O)CCCCC(O)=O WNLRTRBMVRJNCN-UHFFFAOYSA-N 0.000 description 2
239000007864 aqueous solution Substances 0.000 description 2
SQVRNKJHWKZAKO-UHFFFAOYSA-N beta-N-Acetyl-D-neuraminic acid Natural products CC(=O)NC1C(O)CC(O)(C(O)=O)OC1C(O)C(O)CO SQVRNKJHWKZAKO-UHFFFAOYSA-N 0.000 description 2
230000033228 biological regulation Effects 0.000 description 2
229940098773 bovine serum albumin Drugs 0.000 description 2
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238000006731 degradation reaction Methods 0.000 description 2
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235000013305 food Nutrition 0.000 description 2
LNTHITQWFMADLM-UHFFFAOYSA-N gallic acid Chemical compound OC(=O)C1=CC(O)=C(O)C(O)=C1 LNTHITQWFMADLM-UHFFFAOYSA-N 0.000 description 2
206010017758 gastric cancer Diseases 0.000 description 2
230000002496 gastric effect Effects 0.000 description 2
210000004517 glycocalyx Anatomy 0.000 description 2
JVTAAEKCZFNVCJ-UHFFFAOYSA-N lactic acid Chemical compound CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 description 2
239000007788 liquid Substances 0.000 description 2
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210000001187 pylorus Anatomy 0.000 description 2
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235000009566 rice Nutrition 0.000 description 2
230000003248 secreting effect Effects 0.000 description 2
SQVRNKJHWKZAKO-OQPLDHBCSA-N sialic acid Chemical compound CC(=O)N[C@@H]1[C@@H](O)C[C@@](O)(C(O)=O)OC1[C@H](O)[C@H](O)CO SQVRNKJHWKZAKO-OQPLDHBCSA-N 0.000 description 2
230000003595 spectral effect Effects 0.000 description 2
201000011549 stomach cancer Diseases 0.000 description 2
239000000758 substrate Substances 0.000 description 2
150000008163 sugars Chemical class 0.000 description 2
230000001629 suppression Effects 0.000 description 2
238000001356 surgical procedure Methods 0.000 description 2
238000001644 13C nuclear magnetic resonance spectroscopy Methods 0.000 description 1
PUKLDDOGISCFCP-JSQCKWNTSA-N 21-Deoxycortisone Chemical compound C1CC2=CC(=O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@@](C(=O)C)(O)[C@@]1(C)CC2=O PUKLDDOGISCFCP-JSQCKWNTSA-N 0.000 description 1
206010002091 Anaesthesia Diseases 0.000 description 1
102100027205 B-cell antigen receptor complex-associated protein alpha chain Human genes 0.000 description 1
101710095183 B-cell antigen receptor complex-associated protein alpha chain Proteins 0.000 description 1
241000304886 Bacilli Species 0.000 description 1
241000186000 Bifidobacterium Species 0.000 description 1
241001260842 Bifurcaria Species 0.000 description 1
241000237519 Bivalvia Species 0.000 description 1
241000345998 Calamus manan Species 0.000 description 1
OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 description 1
UXVMQQNJUSDDNG-UHFFFAOYSA-L Calcium chloride Chemical compound [Cl-].[Cl-].[Ca+2] UXVMQQNJUSDDNG-UHFFFAOYSA-L 0.000 description 1
206010008635 Cholestasis Diseases 0.000 description 1
241000004452 Fucus evanescens Species 0.000 description 1
241000227647 Fucus vesiculosus Species 0.000 description 1
FCYKAQOGGFGCMD-UHFFFAOYSA-N Fulvic acid Natural products O1C2=CC(O)=C(O)C(C(O)=O)=C2C(=O)C2=C1CC(C)(O)OC2 FCYKAQOGGFGCMD-UHFFFAOYSA-N 0.000 description 1
VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 1
206010028116 Mucosal inflammation Diseases 0.000 description 1
239000004677 Nylon Substances 0.000 description 1
241001144972 Padina arborescens Species 0.000 description 1
102100021904 Potassium-transporting ATPase alpha chain 1 Human genes 0.000 description 1
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239000012506 Sephacryl® Substances 0.000 description 1
QAOWNCQODCNURD-UHFFFAOYSA-L Sulfate Chemical compound [O-]S([O-])(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 description 1
206010042674 Swelling Diseases 0.000 description 1
241001261506 Undaria pinnatifida Species 0.000 description 1
230000009858 acid secretion Effects 0.000 description 1
238000010306 acid treatment Methods 0.000 description 1
YBCVMFKXIKNREZ-UHFFFAOYSA-N acoh acetic acid Chemical compound CC(O)=O.CC(O)=O YBCVMFKXIKNREZ-UHFFFAOYSA-N 0.000 description 1
239000001361 adipic acid Substances 0.000 description 1
235000011037 adipic acid Nutrition 0.000 description 1
229910021529 ammonia Inorganic materials 0.000 description 1
230000037005 anaesthesia Effects 0.000 description 1
238000004458 analytical method Methods 0.000 description 1
230000002924 anti-infective effect Effects 0.000 description 1
229960005475 antiinfective agent Drugs 0.000 description 1
OHDRQQURAXLVGJ-HLVWOLMTSA-N azane;(2e)-3-ethyl-2-[(e)-(3-ethyl-6-sulfo-1,3-benzothiazol-2-ylidene)hydrazinylidene]-1,3-benzothiazole-6-sulfonic acid Chemical compound [NH4+].[NH4+].S/1C2=CC(S([O-])(=O)=O)=CC=C2N(CC)C\1=N/N=C1/SC2=CC(S([O-])(=O)=O)=CC=C2N1CC OHDRQQURAXLVGJ-HLVWOLMTSA-N 0.000 description 1
230000001580 bacterial effect Effects 0.000 description 1
ITHZDDVSAWDQPZ-UHFFFAOYSA-L barium acetate Chemical compound [Ba+2].CC([O-])=O.CC([O-])=O ITHZDDVSAWDQPZ-UHFFFAOYSA-L 0.000 description 1
239000011230 binding agent Substances 0.000 description 1
229910052791 calcium Inorganic materials 0.000 description 1
239000011575 calcium Substances 0.000 description 1
239000001110 calcium chloride Substances 0.000 description 1
229910001628 calcium chloride Inorganic materials 0.000 description 1
239000002775 capsule Substances 0.000 description 1
210000004027 cell Anatomy 0.000 description 1
239000003795 chemical substances by application Substances 0.000 description 1
238000004587 chromatography analysis Methods 0.000 description 1
235000020639 clam Nutrition 0.000 description 1
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150000001875 compounds Chemical class 0.000 description 1
210000000877 corpus callosum Anatomy 0.000 description 1
238000003381 deacetylation reaction Methods 0.000 description 1
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239000002270 dispersing agent Substances 0.000 description 1
239000002552 dosage form Substances 0.000 description 1
239000003995 emulsifying agent Substances 0.000 description 1
239000004744 fabric Substances 0.000 description 1
239000000945 filler Substances 0.000 description 1
239000000706 filtrate Substances 0.000 description 1
125000002485 formyl group Chemical class [H]C(*)=O 0.000 description 1
239000002509 fulvic acid Substances 0.000 description 1
229940095100 fulvic acid Drugs 0.000 description 1
229940074391 gallic acid Drugs 0.000 description 1
235000004515 gallic acid Nutrition 0.000 description 1
238000002309 gasification Methods 0.000 description 1
210000001035 gastrointestinal tract Anatomy 0.000 description 1
239000012362 glacial acetic acid Substances 0.000 description 1
239000008187 granular material Substances 0.000 description 1
230000036571 hydration Effects 0.000 description 1
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OQUKIQWCVTZJAF-UHFFFAOYSA-N phenol;sulfuric acid Chemical compound OS(O)(=O)=O.OC1=CC=CC=C1 OQUKIQWCVTZJAF-UHFFFAOYSA-N 0.000 description 1
229920000642 polymer Polymers 0.000 description 1
238000002360 preparation method Methods 0.000 description 1
239000000612 proton pump inhibitor Substances 0.000 description 1
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235000012950 rattan cane Nutrition 0.000 description 1
230000002829 reductive effect Effects 0.000 description 1
238000013515 script Methods 0.000 description 1
235000011121 sodium hydroxide Nutrition 0.000 description 1
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JFALSRSLKYAFGM-UHFFFAOYSA-N uranium(0) Chemical compound [U] JFALSRSLKYAFGM-UHFFFAOYSA-N 0.000 description 1
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Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
- A61K31/737—Sulfated polysaccharides, e.g. chondroitin sulfate, dermatan sulfate
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/02—Algae
- A61K36/03—Phaeophycota or phaeophyta (brown algae), e.g. Fucus
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/02—Algae
- A61K36/04—Rhodophycota or rhodophyta (red algae), e.g. Porphyra
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/10—Preparation or pretreatment of starting material
- A61K2236/11—Preparation or pretreatment of starting material involving culturing conditions, e.g. cultivation in the dark or under defined water stress
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation or decoction
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Engineering & Computer Science (AREA)
Biotechnology (AREA)
Natural Medicines & Medicinal Plants (AREA)
Veterinary Medicine (AREA)
Chemical & Material Sciences (AREA)
Public Health (AREA)
Medicinal Chemistry (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
Epidemiology (AREA)
Botany (AREA)
Mycology (AREA)
Microbiology (AREA)
Medical Informatics (AREA)
Alternative & Traditional Medicine (AREA)
Molecular Biology (AREA)
Chemical Kinetics & Catalysis (AREA)
Bioinformatics & Cheminformatics (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Organic Chemistry (AREA)
Dermatology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicines Containing Plant Substances (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Polysaccharides And Polysaccharide Derivatives (AREA)

TW083108714A 1993-09-24 1994-09-22 A pharmaceutical composition used as an antiulcer agent and an adhesion inhibitor for helicobacter pylori TW438593B (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
JP25888393		1993-09-24
JP11194694A JP3403496B2 (ja)	1993-09-24	1994-04-28	抗潰瘍剤およびヘリコバクター・ピロリの定着阻害剤

Publications (1)

Publication Number	Publication Date
TW438593B true TW438593B (en)	2001-06-07

Family

ID=26451212

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
TW083108714A TW438593B (en)	1993-09-24	1994-09-22	A pharmaceutical composition used as an antiulcer agent and an adhesion inhibitor for helicobacter pylori

Country Status (10)

Country	Link
EP (1)	EP0645143B1 (de)
JP (1)	JP3403496B2 (de)
KR (1)	KR100296089B1 (de)
CN (1)	CN1096867C (de)
AT (1)	ATE193449T1 (de)
AU (1)	AU7418794A (de)
CA (1)	CA2132150C (de)
DE (1)	DE69424731T2 (de)
NZ (1)	NZ264517A (de)
TW (1)	TW438593B (de)

Families Citing this family (31)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JP3916394B2 (ja) *	1996-01-26	2007-05-16	タカラバイオ株式会社	フコース硫酸含有多糖
AU720004B2 (en) *	1996-01-26	2000-05-18	Research Institute For Glycotechnology	Apoptosis inducers
CN1081903C (zh) *	1996-06-12	2002-04-03	宝酒造株式会社	食品或饮料
US6573250B2 (en)	1996-06-12	2003-06-03	Takara Shuzo Co., Ltd.	Food or beverage additive containing fucoidan and food and beverage containing fucoidan
KR20000022338A (ko) *	1996-07-01	2000-04-25	오쓰카 요시미쓰	네마시스티스 데시피엔스 열수 추출물 및 이의 용도
JPH1070970A (ja) *	1996-07-01	1998-03-17	Nisshinbo Ind Inc	モズク熱水抽出物及びその用途
JPH10191940A (ja) *	1997-01-16	1998-07-28	Yakult Honsha Co Ltd	モズク抽出物の品質改良法およびモズク抽出物
JPH1135591A (ja) *	1997-07-18	1999-02-09	Masakuni Tako	オキナワモズクから分離したフコイダンからのｌ−フコースの製造とそれの製造法
JPH1160590A (ja)	1997-08-22	1999-03-02	Yakult Honsha Co Ltd	オリゴフコース誘導体又はオリゴラムノース誘導体及びその製造法
JPH11228602A (ja) *	1998-02-09	1999-08-24	Yakult Honsha Co Ltd	免疫力強化剤及び免疫力強化食品
AU756864B2 (en) *	1998-02-17	2003-01-23	Takara Bio Inc.	Sulfated saccharides
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ATE193449T1 (de)	2000-06-15
EP0645143B1 (de)	2000-05-31
JPH07138166A (ja)	1995-05-30
DE69424731T2 (de)	2000-09-28
KR100296089B1 (ko)	2001-10-24
CA2132150A1 (en)	1995-03-25
KR950007868A (ko)	1995-04-15
CN1108572A (zh)	1995-09-20
AU7418794A (en)	1995-04-06
CN1096867C (zh)	2002-12-25
CA2132150C (en)	2004-05-04
EP0645143A1 (de)	1995-03-29
NZ264517A (en)	1995-12-21
JP3403496B2 (ja)	2003-05-06
DE69424731D1 (de)	2000-07-06

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