TWI325443B - - Google Patents

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Info

Publication number: TWI325443B
Authority: TW; Taiwan
Prior art keywords: biochip; fluorescent; light; spectrometer; signal
Prior art date: 2003-08-27

Application number

TW92123645A

Other languages

English (en)

Chinese (zh)

Other versions

TW200508396A (en

Inventor

Jiann Hua Wang

Tzu Chiang Wu

Chien Ho Chuang

Tsung Kai Chuang

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2003-08-27

Filing date

2003-08-27

Publication date

2010-06-01

2003-08-27 Application filed filed Critical

2003-08-27 Priority to TW092123645A priority Critical patent/TW200508396A/zh

2005-03-01 Publication of TW200508396A publication Critical patent/TW200508396A/zh

2010-06-01 Application granted granted Critical

2010-06-01 Publication of TWI325443B publication Critical patent/TWI325443B/zh

Links

238000000018 DNA microarray Methods 0.000 claims description 53
230000003287 optical effect Effects 0.000 claims description 16
238000004458 analytical method Methods 0.000 claims description 9
239000007850 fluorescent dye Substances 0.000 claims description 4
230000000694 effects Effects 0.000 claims description 3
238000001215 fluorescent labelling Methods 0.000 claims description 3
OAICVXFJPJFONN-UHFFFAOYSA-N Phosphorus Chemical compound [P] OAICVXFJPJFONN-UHFFFAOYSA-N 0.000 claims description 2
241000254158 Lampyridae Species 0.000 claims 1
238000006243 chemical reaction Methods 0.000 claims 1
239000000463 material Substances 0.000 claims 1
239000000523 sample Substances 0.000 description 18
235000012431 wafers Nutrition 0.000 description 15
108090000623 proteins and genes Proteins 0.000 description 10
238000001514 detection method Methods 0.000 description 6
230000005284 excitation Effects 0.000 description 5
239000003550 marker Substances 0.000 description 4
238000001228 spectrum Methods 0.000 description 4
239000000126 substance Substances 0.000 description 4
239000012634 fragment Substances 0.000 description 3
239000003298 DNA probe Substances 0.000 description 2
238000009825 accumulation Methods 0.000 description 2
238000010586 diagram Methods 0.000 description 2
238000005259 measurement Methods 0.000 description 2
102000004169 proteins and genes Human genes 0.000 description 2
ANRHNWWPFJCPAZ-UHFFFAOYSA-M thionine Chemical compound [Cl-].C1=CC(N)=CC2=[S+]C3=CC(N)=CC=C3N=C21 ANRHNWWPFJCPAZ-UHFFFAOYSA-M 0.000 description 2
OHOQEZWSNFNUSY-UHFFFAOYSA-N Cy3-bifunctional dye zwitterion Chemical compound O=C1CCC(=O)N1OC(=O)CCCCCN1C2=CC=C(S(O)(=O)=O)C=C2C(C)(C)C1=CC=CC(C(C1=CC(=CC=C11)S([O-])(=O)=O)(C)C)=[N+]1CCCCCC(=O)ON1C(=O)CCC1=O OHOQEZWSNFNUSY-UHFFFAOYSA-N 0.000 description 1
MGIODCZGPVDROX-UHFFFAOYSA-N Cy5-bifunctional dye Chemical compound O=C1CCC(=O)N1OC(=O)CCCCCN1C2=CC=C(S(O)(=O)=O)C=C2C(C)(C)C1=CC=CC=CC(C(C1=CC(=CC=C11)S([O-])(=O)=O)(C)C)=[N+]1CCCCCC(=O)ON1C(=O)CCC1=O MGIODCZGPVDROX-UHFFFAOYSA-N 0.000 description 1
108020003215 DNA Probes Proteins 0.000 description 1
XUIMIQQOPSSXEZ-UHFFFAOYSA-N Silicon Chemical compound [Si] XUIMIQQOPSSXEZ-UHFFFAOYSA-N 0.000 description 1
230000001186 cumulative effect Effects 0.000 description 1
238000007877 drug screening Methods 0.000 description 1
238000002189 fluorescence spectrum Methods 0.000 description 1
238000002032 lab-on-a-chip Methods 0.000 description 1
238000002372 labelling Methods 0.000 description 1
230000001795 light effect Effects 0.000 description 1
230000007246 mechanism Effects 0.000 description 1
230000002035 prolonged effect Effects 0.000 description 1
238000012216 screening Methods 0.000 description 1
230000035945 sensitivity Effects 0.000 description 1
229910052710 silicon Inorganic materials 0.000 description 1
239000010703 silicon Substances 0.000 description 1
239000007787 solid Substances 0.000 description 1
230000003595 spectral effect Effects 0.000 description 1
238000004611 spectroscopical analysis Methods 0.000 description 1
238000007619 statistical method Methods 0.000 description 1
210000002784 stomach Anatomy 0.000 description 1
238000005406 washing Methods 0.000 description 1

Landscapes

Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)

TW092123645A 2003-08-27 2003-08-27 Fluorescent marking molecular biochip array analyzer TW200508396A (en)

Priority Applications (1)

Application Number	Priority Date	Filing Date	Title
TW092123645A TW200508396A (en)	2003-08-27	2003-08-27	Fluorescent marking molecular biochip array analyzer

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
TW092123645A TW200508396A (en)	2003-08-27	2003-08-27	Fluorescent marking molecular biochip array analyzer

Publications (2)

Publication Number	Publication Date
TW200508396A TW200508396A (en)	2005-03-01
TWI325443B true TWI325443B (fr)	2010-06-01

Family

ID=45074254

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
TW092123645A TW200508396A (en)	2003-08-27	2003-08-27	Fluorescent marking molecular biochip array analyzer

Country Status (1)

Country	Link
TW (1)	TW200508396A (fr)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
TWI472217B (fr) *	2011-09-30	2015-02-01

2003
- 2003-08-27 TW TW092123645A patent/TW200508396A/zh not_active IP Right Cessation

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
TWI472217B (fr) *	2011-09-30	2015-02-01

Also Published As

Publication number	Publication date
TW200508396A (en)	2005-03-01

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Legal Events

Date	Code	Title	Description
2015-03-01	MM4A	Annulment or lapse of patent due to non-payment of fees