TWI339663B - Spiro-piperidine derivatives - Google Patents

Spiro-piperidine derivatives

Info

Publication number: TWI339663B
Authority: TW; Taiwan
Prior art keywords: spiro; piperidine derivatives; piperidine; derivatives
Prior art date: 2006-12-22

Application number

TW096148784A

Other languages

English (en)

Other versions

TW200833696A (en

Inventor

Caterina Bissantz

Christophe Grundschober

Raffaello Masciadri

Hasane Ratni

Mark Rogers-Evans

Patrick Schnider

Original Assignee

Hoffmann La Roche

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2006-12-22

Filing date

2007-12-19

Publication date

2011-04-01

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=39301516&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=TWI339663(B) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

2007-12-19 Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche

2008-08-16 Publication of TW200833696A publication Critical patent/TW200833696A/zh

2011-04-01 Application granted granted Critical

2011-04-01 Publication of TWI339663B publication Critical patent/TWI339663B/zh

Links

JUXAVSAMVBLDKO-UHFFFAOYSA-N 1-(1-azabicyclo[2.2.2]octan-3-yl)-3-[3-(1h-indol-3-yl)-1-oxo-1-spiro[1,2-dihydroindene-3,4'-piperidine]-1'-ylpropan-2-yl]urea Chemical class C1N(CC2)CCC2C1NC(=O)NC(C(=O)N1CCC2(C3=CC=CC=C3CC2)CC1)CC1=CNC2=CC=CC=C12 JUXAVSAMVBLDKO-UHFFFAOYSA-N 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
- C07D211/10—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with radicals containing only carbon and hydrogen atoms attached to ring carbon atoms
- C07D211/16—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with radicals containing only carbon and hydrogen atoms attached to ring carbon atoms with acylated ring nitrogen atom
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/10—Antioedematous agents; Diuretics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/10—Spiro-condensed systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/10—Spiro-condensed systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Engineering & Computer Science (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Bioinformatics & Cheminformatics (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Heart & Thoracic Surgery (AREA)
Endocrinology (AREA)
Diabetes (AREA)
Cardiology (AREA)
Pain & Pain Management (AREA)
Hematology (AREA)
Psychiatry (AREA)
Urology & Nephrology (AREA)
Reproductive Health (AREA)
Gastroenterology & Hepatology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Other In-Based Heterocyclic Compounds (AREA)

TW096148784A 2006-12-22 2007-12-19 Spiro-piperidine derivatives TWI339663B (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
EP06127078		2006-12-22

Publications (2)

Publication Number	Publication Date
TW200833696A TW200833696A (en)	2008-08-16
TWI339663B true TWI339663B (en)	2011-04-01

Family

ID=39301516

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
TW096148784A TWI339663B (en)	2006-12-22	2007-12-19	Spiro-piperidine derivatives

Country Status (18)

Country	Link
US (3)	US7501432B2 (zh)
EP (1)	EP2125726B1 (zh)
JP (1)	JP2010513385A (zh)
KR (1)	KR101122969B1 (zh)
CN (1)	CN101563323B (zh)
AR (1)	AR064480A1 (zh)
AT (1)	ATE517866T1 (zh)
AU (1)	AU2007338116B2 (zh)
BR (1)	BRPI0720845A2 (zh)
CA (1)	CA2674518A1 (zh)
CL (1)	CL2007003719A1 (zh)
ES (1)	ES2370047T3 (zh)
MX (1)	MX2009006446A (zh)
NO (1)	NO20092264L (zh)
PE (1)	PE20081486A1 (zh)
RU (1)	RU2009123134A (zh)
TW (1)	TWI339663B (zh)
WO (1)	WO2008077811A1 (zh)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CN101563323B (zh) *	2006-12-22	2012-07-04	弗·哈夫曼-拉罗切有限公司	螺-哌啶衍生物
TWI466885B (zh)	2009-07-31	2015-01-01	Japan Tobacco Inc	含氮螺環化合物及其醫藥用途
BR112013019211A2 (pt) *	2011-02-02	2021-07-06	Vertex Pharma	amidas de piperidina espirocíclicas de pirrolopirazina como moduladores de canais de íon
SG11201604915PA (en) *	2013-12-19	2016-07-28	Hoffmann La Roche	Spiro-oxazolones
CN104557777B (zh) *	2015-01-09	2016-08-31	万华化学集团股份有限公司	一种n-甲基哌嗪的制备方法

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP0450761A1 (en) *	1990-03-02	1991-10-09	Merck & Co. Inc.	Spirocyclic oxytocin antagonists
JPH08502474A (ja) *	1992-10-07	1996-03-19	メルクエンドカンパニーインコーポレーテッド	トコリティックオキシトシンレセプターアンタゴニスト
US5576321A (en)	1995-01-17	1996-11-19	Eli Lilly And Company	Compounds having effects on serotonin-related systems
US6166209A (en)	1997-12-11	2000-12-26	Hoffmann-La Roche Inc.	Piperidine derivatives
TWI279402B (en)	1999-08-20	2007-04-21	Banyu Pharma Co Ltd	Spiro compounds having NPY antagonistic activities and agents containing the same
EP1347982B1 (en) *	2000-12-12	2005-11-16	Neurogen Corporation	Spiro isobenzofuran-1,4'-piperidin]-3-ones and 3h-spiroisobenzofuran-1,4'-piperidines
US6596718B1 (en)	2001-11-27	2003-07-22	Hoffmann-La Roche Inc.	7-Morpholin-4yl-benzothiazole amide derivatives
BRPI0417267A (pt) *	2003-12-22	2007-04-17	Pfizer	derivados de triazol como antagonistas de vasopressina
CN101563323B (zh) *	2006-12-22	2012-07-04	弗·哈夫曼-拉罗切有限公司	螺-哌啶衍生物

2007
- 2007-12-13 CN CN2007800467055A patent/CN101563323B/zh not_active Expired - Fee Related
- 2007-12-13 ES ES07857529T patent/ES2370047T3/es active Active
- 2007-12-13 WO PCT/EP2007/063882 patent/WO2008077811A1/en not_active Ceased
- 2007-12-13 MX MX2009006446A patent/MX2009006446A/es active IP Right Grant
- 2007-12-13 AT AT07857529T patent/ATE517866T1/de active
- 2007-12-13 EP EP07857529A patent/EP2125726B1/en not_active Not-in-force
- 2007-12-13 JP JP2009542007A patent/JP2010513385A/ja active Pending
- 2007-12-13 AU AU2007338116A patent/AU2007338116B2/en not_active Expired - Fee Related
- 2007-12-13 US US11/955,440 patent/US7501432B2/en not_active Expired - Fee Related
- 2007-12-13 CA CA002674518A patent/CA2674518A1/en not_active Abandoned
- 2007-12-13 RU RU2009123134/04A patent/RU2009123134A/ru not_active Application Discontinuation
- 2007-12-13 BR BRPI0720845-6A patent/BRPI0720845A2/pt not_active IP Right Cessation
- 2007-12-13 US US11/955,425 patent/US7495008B2/en not_active Expired - Fee Related
- 2007-12-13 US US11/955,434 patent/US7678806B2/en not_active Expired - Fee Related
- 2007-12-13 KR KR1020097012843A patent/KR101122969B1/ko not_active Expired - Fee Related
- 2007-12-14 PE PE2007001812A patent/PE20081486A1/es not_active Application Discontinuation
- 2007-12-19 TW TW096148784A patent/TWI339663B/zh not_active IP Right Cessation
- 2007-12-20 AR ARP070105763A patent/AR064480A1/es not_active Application Discontinuation
- 2007-12-20 CL CL200703719A patent/CL2007003719A1/es unknown
2009
- 2009-06-12 NO NO20092264A patent/NO20092264L/no not_active Application Discontinuation

Also Published As

Publication number	Publication date
ES2370047T3 (es)	2011-12-12
KR101122969B1 (ko)	2012-03-22
US7501432B2 (en)	2009-03-10
AR064480A1 (es)	2009-04-01
BRPI0720845A2 (pt)	2014-03-04
TW200833696A (en)	2008-08-16
CN101563323B (zh)	2012-07-04
US7495008B2 (en)	2009-02-24
AU2007338116B2 (en)	2012-04-26
US7678806B2 (en)	2010-03-16
NO20092264L (no)	2009-06-24
WO2008077811A1 (en)	2008-07-03
CN101563323A (zh)	2009-10-21
CA2674518A1 (en)	2008-07-03
MX2009006446A (es)	2009-06-26
JP2010513385A (ja)	2010-04-30
EP2125726B1 (en)	2011-07-27
US20080161304A1 (en)	2008-07-03
ATE517866T1 (de)	2011-08-15
RU2009123134A (ru)	2011-01-27
PE20081486A1 (es)	2008-10-18
CL2007003719A1 (es)	2008-07-11
US20080280898A1 (en)	2008-11-13
KR20090082505A (ko)	2009-07-30
US20080167333A1 (en)	2008-07-10
AU2007338116A1 (en)	2008-07-03
EP2125726A1 (en)	2009-12-02

Legal Events

Date	Code	Title	Description
2013-01-01	MM4A	Annulment or lapse of patent due to non-payment of fees

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