TWI388550B - 反-４-（（１ｒ，３ｓ）-６-氯-３-苯基二氫茚-１-基）-１，２，２-三甲基哌之琥珀酸氫鹽和丙二酸氫鹽及其作為醫藥品之用途 - Google Patents

反-４-（（１ｒ，３ｓ）-６-氯-３-苯基二氫茚-１-基）-１，２，２-三甲基哌之琥珀酸氫鹽和丙二酸氫鹽及其作為醫藥品之用途 Download PDF

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TWI388550B
TWI388550B TW093124784A TW93124784A TWI388550B TW I388550 B TWI388550 B TW I388550B TW 093124784 A TW093124784 A TW 093124784A TW 93124784 A TW93124784 A TW 93124784A TW I388550 B TWI388550 B TW I388550B
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Taiwan
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compound
salt
formula
patent application
chloro
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TW093124784A
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Chinese (zh)
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TW200519098A (en
Inventor
Diego Heidi Lopez De
Ole Nielsen
Lone Munch Ringgard
Henrik Svane
Allan Dahl
Mark Howells
Benny Bang-Andersen
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Lundbeck & Co As H
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/06—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by halogen atoms or nitro radicals
    • C07D295/073—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by halogen atoms or nitro radicals with the ring nitrogen atoms and the substituents separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C17/00—Preparation of halogenated hydrocarbons
    • C07C17/093—Preparation of halogenated hydrocarbons by replacement by halogens
    • C07C17/16—Preparation of halogenated hydrocarbons by replacement by halogens of hydroxyl groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C25/00—Compounds containing at least one halogen atom bound to a six-membered aromatic ring
    • C07C25/18—Polycyclic aromatic halogenated hydrocarbons
    • C07C25/22—Polycyclic aromatic halogenated hydrocarbons with condensed rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C29/00—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring
    • C07C29/132—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring by reduction of an oxygen containing functional group
    • C07C29/136—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring by reduction of an oxygen containing functional group of >C=O containing groups, e.g. —COOH
    • C07C29/143—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring by reduction of an oxygen containing functional group of >C=O containing groups, e.g. —COOH of ketones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C35/00—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a ring other than a six-membered aromatic ring
    • C07C35/22—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a ring other than a six-membered aromatic ring polycyclic, at least one hydroxy group bound to a condensed ring system
    • C07C35/23—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a ring other than a six-membered aromatic ring polycyclic, at least one hydroxy group bound to a condensed ring system with hydroxy on a condensed ring system having two rings
    • C07C35/32—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a ring other than a six-membered aromatic ring polycyclic, at least one hydroxy group bound to a condensed ring system with hydroxy on a condensed ring system having two rings the condensed ring system being a (4.3.0) system, e.g. indenols
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
    • C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
    • C07D241/04—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P41/00—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture
    • C12P41/003—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture by ester formation, lactone formation or the inverse reactions
    • C12P41/004—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture by ester formation, lactone formation or the inverse reactions by esterification of alcohol- or thiol groups in the enantiomers or the inverse reaction
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/02—Preparation of oxygen-containing organic compounds containing a hydroxy group
    • C12P7/22—Preparation of oxygen-containing organic compounds containing a hydroxy group aromatic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/07—Optical isomers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Medicinal Chemistry (AREA)
  • Analytical Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
TW093124784A 2003-08-18 2004-08-18 反-４-（（１ｒ，３ｓ）-６-氯-３-苯基二氫茚-１-基）-１，２，２-三甲基哌之琥珀酸氫鹽和丙二酸氫鹽及其作為醫藥品之用途 TWI388550B (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DKPA200301180 2003-08-18
DKPA200301305 2003-09-11

Publications (2)

Publication Number Publication Date
TW200519098A TW200519098A (en) 2005-06-16
TWI388550B true TWI388550B (zh) 2013-03-11

Family

ID=58707237

Family Applications (2)

Application Number Title Priority Date Filing Date
TW099140932A TWI403505B (zh) 2003-08-18 2004-08-18 反－４－（（１ｒ，３ｓ）－６－氯－３－苯基二氫茚－１－基）－１，２，２－三甲基哌之琥珀酸鹽和丙二酸鹽及其作為藥物之用途
TW093124784A TWI388550B (zh) 2003-08-18 2004-08-18 反-４-（（１ｒ，３ｓ）-６-氯-３-苯基二氫茚-１-基）-１，２，２-三甲基哌之琥珀酸氫鹽和丙二酸氫鹽及其作為醫藥品之用途

Family Applications Before (1)

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TW099140932A TWI403505B (zh) 2003-08-18 2004-08-18 反－４－（（１ｒ，３ｓ）－６－氯－３－苯基二氫茚－１－基）－１，２，２－三甲基哌之琥珀酸鹽和丙二酸鹽及其作為藥物之用途

Country Status (15)

Country Link
KR (2) KR101227789B1 (is)
CN (1) CN101935305B (is)
AR (2) AR045279A1 (is)
AT (1) ATE552247T1 (is)
DK (1) DK1658277T3 (is)
EA (2) EA014641B1 (is)
ES (1) ES2383369T3 (is)
IS (1) IS8264A (is)
ME (1) MEP2408A (is)
MY (2) MY149089A (is)
PT (1) PT1658277E (is)
RS (3) RS20060121A (is)
SG (2) SG148183A1 (is)
SI (1) SI1658277T1 (is)
TW (2) TWI403505B (is)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI453198B (zh) * 2005-02-16 2014-09-21 Lundbeck & Co As H 製造反式-1-((1r,3s)-6-氯基-3-苯基茚滿-1-基) -3 , 3 -二甲基六氫吡與其鹽類之方法及製造4-((1r , 3s）-6 -氯基-3-苯基茚滿-1-基 )-1,2,2-三甲基六氫吡與其鹽類之方法
DK2720989T3 (en) 2011-06-20 2016-11-28 H Lundbeck As Deuterated 1-piperazino-3-phenyl-indanes used to treat schizophrenia
MX2021012248A (es) 2019-04-11 2022-03-11 Mei Pharma Inc Polimorfos de voruciclib y metodos de elaboracion y uso de los mismos.

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IE50867B1 (en) * 1980-02-29 1986-08-06 Kefalas As Indane derivatives
DK55192D0 (da) * 1992-04-28 1992-04-28 Lundbeck & Co As H 1-piperazino-1,2-dihydroindenderivater

Also Published As

Publication number Publication date
CN101935305A (zh) 2011-01-05
AR045278A1 (es) 2005-10-19
KR101227789B1 (ko) 2013-01-30
IS8264A (is) 2006-01-26
MEP2408A (xx) 2010-02-10
ATE552247T1 (de) 2012-04-15
SG148183A1 (en) 2008-12-31
RS20060121A (sr) 2008-09-29
RS20060083A (sr) 2008-08-07
HK1096089A1 (en) 2007-05-25
EA014641B1 (ru) 2010-12-30
DK1658277T3 (da) 2012-06-18
SI1658277T1 (sl) 2012-10-30
SG145723A1 (en) 2008-09-29
TWI403505B (zh) 2013-08-01
TW200519098A (en) 2005-06-16
EA200600441A1 (ru) 2006-08-25
AR045279A1 (es) 2005-10-19
RS53369B (sr) 2014-10-31
MY149089A (en) 2013-07-15
TW201111351A (en) 2011-04-01
HK1152699A1 (en) 2012-03-09
PT1658277E (pt) 2012-05-25
EA200600443A1 (ru) 2006-08-25
KR20060066094A (ko) 2006-06-15
CN101935305B (zh) 2013-04-10
ES2383369T3 (es) 2012-06-20
MY154535A (en) 2015-06-30
KR20060066104A (ko) 2006-06-15

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