TWI400238B - ２－酮基烷基－１－哌－２－酮衍生物、其製備及其治療用途 - Google Patents
２－酮基烷基－１－哌－２－酮衍生物、其製備及其治療用途 Download PDFInfo
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- TWI400238B TWI400238B TW098119565A TW98119565A TWI400238B TW I400238 B TWI400238 B TW I400238B TW 098119565 A TW098119565 A TW 098119565A TW 98119565 A TW98119565 A TW 98119565A TW I400238 B TWI400238 B TW I400238B
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Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR0803298A FR2932481B1 (fr) | 2008-06-13 | 2008-06-13 | Derives de 4-{2-°4-phenyl-3,6-dihydro-2h-pyridin-1-yl!-2- oxo-alkyl}-1-piperazin-2-one, leur preparation et leur application en therapeutique. |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| TW201002686A TW201002686A (en) | 2010-01-16 |
| TWI400238B true TWI400238B (zh) | 2013-07-01 |
Family
ID=40305319
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| TW098119565A TWI400238B (zh) | 2008-06-13 | 2009-06-11 | ２－酮基烷基－１－哌－２－酮衍生物、其製備及其治療用途 |
Country Status (31)
| Country | Link |
|---|---|
| US (2) | US8247404B2 (sr) |
| EP (1) | EP2310383B8 (sr) |
| JP (1) | JP5476372B2 (sr) |
| KR (1) | KR101601999B1 (sr) |
| CN (1) | CN102124001B (sr) |
| AR (1) | AR072102A1 (sr) |
| AT (1) | ATE535524T1 (sr) |
| AU (1) | AU2009259120B2 (sr) |
| BR (1) | BRPI0915482B8 (sr) |
| CA (1) | CA2726666C (sr) |
| CL (1) | CL2010001432A1 (sr) |
| CO (1) | CO6300943A2 (sr) |
| CY (1) | CY1112417T1 (sr) |
| DK (1) | DK2310383T3 (sr) |
| EA (1) | EA019924B1 (sr) |
| ES (1) | ES2378380T3 (sr) |
| FR (1) | FR2932481B1 (sr) |
| HR (1) | HRP20120187T1 (sr) |
| IL (1) | IL209903A (sr) |
| JO (1) | JO2773B1 (sr) |
| MX (1) | MX2010013694A (sr) |
| MY (1) | MY151228A (sr) |
| NZ (1) | NZ589842A (sr) |
| PL (1) | PL2310383T3 (sr) |
| PT (1) | PT2310383E (sr) |
| RS (1) | RS52252B (sr) |
| SI (1) | SI2310383T1 (sr) |
| TW (1) | TWI400238B (sr) |
| UY (1) | UY31894A (sr) |
| WO (1) | WO2009150387A1 (sr) |
| ZA (1) | ZA201008791B (sr) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2932481B1 (fr) | 2008-06-13 | 2010-10-08 | Sanofi Aventis | Derives de 4-{2-°4-phenyl-3,6-dihydro-2h-pyridin-1-yl!-2- oxo-alkyl}-1-piperazin-2-one, leur preparation et leur application en therapeutique. |
| FR2932482B1 (fr) * | 2008-06-13 | 2010-10-08 | Sanofi Aventis | Nouveaux derives de (phenyl-3,6-dihydro-2h-pyridinyl)- (piperazinyl ponte)-1-alcanone et leur utilisation comme inhibiteurs de p75 |
| FR2953836B1 (fr) | 2009-12-14 | 2012-03-16 | Sanofi Aventis | Nouveaux derives (heterocycle-tetrahydro-pyridine)-(piperazinyl)-1-alcanone et (heterocycle-dihydro-pyrrolidine)-(piperazinyl)-1-alcanone et leur utilisation comme inhibiteurs de p75 |
| FR2953839A1 (fr) | 2009-12-14 | 2011-06-17 | Sanofi Aventis | Nouveaux derives d'(heterocycle-piperidine condensee)-(piperazinyl)-1alcanone ou d'(heterocycle-pyrrolidine condensee)-(piperazinyl)-1alcanone et leur utilisation comme inhibiteurs de p75 |
| EP2606894A1 (en) | 2011-12-20 | 2013-06-26 | Sanofi | Novel therapeutic use of p75 receptor antagonists |
| EP2950095B1 (en) | 2014-05-28 | 2018-08-29 | Technische Universität Dresden | Cell-based assay and screening methods for modulators of p75NTR signaling |
Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4617309A (en) * | 1982-09-30 | 1986-10-14 | Merck Patent Gesellschaft Mit Beschrankter Haftung | Sulfur-containing indole derivatives |
| CN1212690A (zh) * | 1996-02-02 | 1999-03-31 | 皮埃尔法博赫药品公司 | 新的由1－(哌嗪－1－基)－芳基－(氧基/氨基)－羰基/－4－芳基－哌啶衍生的作为选择性5－HT1Dβ受体拮抗剂的哌啶类化合物 |
| WO2005054229A1 (fr) * | 2003-12-01 | 2005-06-16 | Sanofi-Aventis | Derives de 4-[(arylmethyl)aminomethyl]piperidine, leur preparation et leur application en therapeutique |
| WO2005054227A1 (fr) * | 2003-12-01 | 2005-06-16 | Sanofi-Aventis | Derives de (4-phenylpiperazin-1-yl)acylpiperidine, leur preparation et leur application en therapeutique |
| TWI283671B (en) * | 2002-06-07 | 2007-07-11 | Sanofi Aventis | Piperazinylacylpiperidine derivatives, their preparation and therapeutic use thereof |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BR9810378A (pt) * | 1997-07-01 | 2000-08-29 | Novo Nordisk As | Composto,uso do mesmo, composição farmacêutica, e, processos de tratar a diabete do tipo i ou do tipo ii, de tratar a hiperglicemia, e de diminuir a glicose do sangue em um mamìfero |
| US6613942B1 (en) * | 1997-07-01 | 2003-09-02 | Novo Nordisk A/S | Glucagon antagonists/inverse agonists |
| WO2000059893A1 (en) | 1999-04-06 | 2000-10-12 | Krenitsky Pharmaceuticals Inc. | Neurotrophic thio substituted pyrimidines |
| FR2932481B1 (fr) | 2008-06-13 | 2010-10-08 | Sanofi Aventis | Derives de 4-{2-°4-phenyl-3,6-dihydro-2h-pyridin-1-yl!-2- oxo-alkyl}-1-piperazin-2-one, leur preparation et leur application en therapeutique. |
| FR2932482B1 (fr) * | 2008-06-13 | 2010-10-08 | Sanofi Aventis | Nouveaux derives de (phenyl-3,6-dihydro-2h-pyridinyl)- (piperazinyl ponte)-1-alcanone et leur utilisation comme inhibiteurs de p75 |
-
2008
- 2008-06-13 FR FR0803298A patent/FR2932481B1/fr not_active Expired - Fee Related
-
2009
- 2009-06-01 JO JO2009197A patent/JO2773B1/en active
- 2009-06-11 TW TW098119565A patent/TWI400238B/zh active
- 2009-06-11 AR ARP090102109A patent/AR072102A1/es active IP Right Grant
- 2009-06-12 BR BRPI0915482A patent/BRPI0915482B8/pt active IP Right Grant
- 2009-06-12 PL PL09761938T patent/PL2310383T3/pl unknown
- 2009-06-12 EP EP09761938A patent/EP2310383B8/fr active Active
- 2009-06-12 SI SI200930179T patent/SI2310383T1/sl unknown
- 2009-06-12 EA EA201170015A patent/EA019924B1/ru not_active IP Right Cessation
- 2009-06-12 CA CA2726666A patent/CA2726666C/fr active Active
- 2009-06-12 PT PT09761938T patent/PT2310383E/pt unknown
- 2009-06-12 CN CN200980131553.8A patent/CN102124001B/zh active Active
- 2009-06-12 UY UY0001031894A patent/UY31894A/es not_active Application Discontinuation
- 2009-06-12 NZ NZ589842A patent/NZ589842A/xx not_active IP Right Cessation
- 2009-06-12 AT AT09761938T patent/ATE535524T1/de active
- 2009-06-12 RS RS20120082A patent/RS52252B/sr unknown
- 2009-06-12 AU AU2009259120A patent/AU2009259120B2/en active Active
- 2009-06-12 WO PCT/FR2009/051117 patent/WO2009150387A1/fr not_active Ceased
- 2009-06-12 KR KR1020117000793A patent/KR101601999B1/ko active Active
- 2009-06-12 DK DK09761938.1T patent/DK2310383T3/da active
- 2009-06-12 ES ES09761938T patent/ES2378380T3/es active Active
- 2009-06-12 HR HR20120187T patent/HRP20120187T1/hr unknown
- 2009-06-12 MX MX2010013694A patent/MX2010013694A/es active IP Right Grant
- 2009-06-12 JP JP2011513037A patent/JP5476372B2/ja active Active
- 2009-06-12 MY MYPI20105853 patent/MY151228A/en unknown
-
2010
- 2010-12-07 ZA ZA2010/08791A patent/ZA201008791B/en unknown
- 2010-12-09 IL IL209903A patent/IL209903A/en active IP Right Grant
- 2010-12-13 CL CL2010001432A patent/CL2010001432A1/es unknown
- 2010-12-13 US US12/966,408 patent/US8247404B2/en active Active
- 2010-12-13 CO CO10156026A patent/CO6300943A2/es active IP Right Grant
-
2012
- 2012-02-29 CY CY20121100212T patent/CY1112417T1/el unknown
- 2012-07-24 US US13/556,328 patent/US20120289518A1/en not_active Abandoned
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4617309A (en) * | 1982-09-30 | 1986-10-14 | Merck Patent Gesellschaft Mit Beschrankter Haftung | Sulfur-containing indole derivatives |
| CN1212690A (zh) * | 1996-02-02 | 1999-03-31 | 皮埃尔法博赫药品公司 | 新的由1－(哌嗪－1－基)－芳基－(氧基/氨基)－羰基/－4－芳基－哌啶衍生的作为选择性5－HT1Dβ受体拮抗剂的哌啶类化合物 |
| TWI283671B (en) * | 2002-06-07 | 2007-07-11 | Sanofi Aventis | Piperazinylacylpiperidine derivatives, their preparation and therapeutic use thereof |
| WO2005054229A1 (fr) * | 2003-12-01 | 2005-06-16 | Sanofi-Aventis | Derives de 4-[(arylmethyl)aminomethyl]piperidine, leur preparation et leur application en therapeutique |
| WO2005054227A1 (fr) * | 2003-12-01 | 2005-06-16 | Sanofi-Aventis | Derives de (4-phenylpiperazin-1-yl)acylpiperidine, leur preparation et leur application en therapeutique |
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