TWI528961B - 作為聚（ａｄｐ-核糖）聚合酶（ｐａｒｐ）抑制劑之經醯胺取代之吲唑 - Google Patents

作為聚（ａｄｐ-核糖）聚合酶（ｐａｒｐ）抑制劑之經醯胺取代之吲唑 Download PDF

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Publication number: TWI528961B
Authority: TW; Taiwan
Prior art keywords: compound; pharmaceutically acceptable; acceptable salt; tautomer; phenyl
Prior art date: 2007-01-10

Application number

TW097100730A

Other languages

English (en)

Chinese (zh)

Other versions

TW200836731A (en

Inventor

強森飛利浦

瑪利亞歐托利歐托利傑瑟斯

史卡沛利瑞塔

史奇特茲福得莫奇卡史單

Original Assignee

Ｍｓｄ義大利公司

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2007-01-10

Filing date

2008-01-08

Publication date

2016-04-11

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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=37809722&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=TWI528961(B) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

2008-01-08 Application filed by Ｍｓｄ義大利公司 filed Critical Ｍｓｄ義大利公司

2008-09-16 Publication of TW200836731A publication Critical patent/TW200836731A/zh

2016-04-11 Application granted granted Critical

2016-04-11 Publication of TWI528961B publication Critical patent/TWI528961B/zh

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Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing aromatic rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents

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Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Chemical Kinetics & Catalysis (AREA)
Animal Behavior & Ethology (AREA)
Medicinal Chemistry (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Pain & Pain Management (AREA)
Rheumatology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)

TW097100730A 2007-01-10 2008-01-08 作為聚（ａｄｐ-核糖）聚合酶（ｐａｒｐ）抑制劑之經醯胺取代之吲唑 TWI528961B (zh)

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GBGB0700432.8A GB0700432D0 (en)	2007-01-10	2007-01-10	Therapeutic compounds
US92131007P	2007-04-02	2007-04-02

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TWI528961B true TWI528961B (zh)	2016-04-11

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CN (1)	CN101578279B (fr)
AT (1)	ATE502933T1 (fr)
CR (1)	CR10910A (fr)
DE (1)	DE602008005711D1 (fr)
DK (2)	DK2109608T3 (fr)
ES (3)	ES2509115T3 (fr)
GB (1)	GB0700432D0 (fr)
HN (1)	HN2009001260A (fr)
HU (1)	HUE044513T2 (fr)
LT (1)	LT2805945T (fr)
LU (1)	LUC00072I2 (fr)
ME (1)	ME03481B (fr)
MY (1)	MY147789A (fr)
NI (1)	NI200900135A (fr)
NZ (1)	NZ578256A (fr)
PE (1)	PE20081558A1 (fr)
PT (3)	PT2109608E (fr)
SI (2)	SI2336120T1 (fr)
TW (1)	TWI528961B (fr)
UA (1)	UA97658C2 (fr)
ZA (1)	ZA200903898B (fr)

Families Citing this family (13)

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Publication number	Priority date	Publication date	Assignee	Title
CN106496187A (zh) *	2016-09-14	2017-03-15	陕西科技大学	一种制备PARP抑制剂Niraparib的合成方法
CN106432188A (zh) *	2016-09-17	2017-02-22	青岛辰达生物科技有限公司	一种抗癌药2‑[4‑((3s)‑3‑哌啶基)苯基]‑2h‑吲唑‑7‑甲酰胺的制备方法
CN106432187A (zh) *	2016-09-17	2017-02-22	青岛云天生物技术有限公司	2‑[4‑(‑3‑哌啶基)苯基]‑2h‑吲唑‑7‑甲酰胺的手性拆分方法
CN106632244A (zh) *	2016-09-30	2017-05-10	陕西科技大学	一种制备抗癌药物Niraparib的新型合成方法
CN106467513A (zh) *	2016-09-30	2017-03-01	陕西科技大学	一种制备Niraparib的合成方法
CN108201537A (zh) *	2016-12-16	2018-06-26	苏州苏融生物医药有限公司	一种尼拉帕尼缓控释药物组合物及其用途
EP3606523A1 (fr) *	2017-03-27	2020-02-12	Tesaro, Inc.	Formulations de niraparib
CN109081828B (zh) *	2017-06-14	2021-03-26	上海时莱生物技术有限公司	聚(adp-核糖)聚合酶抑制剂、制备方法及用途
CN111278433A (zh)	2017-09-26	2020-06-12	特沙诺有限公司	尼拉帕尼制剂
CN108084157A (zh) *	2018-02-12	2018-05-29	安庆奇创药业有限公司	一种尼拉帕尼的合成方法
CN108203404A (zh) *	2018-03-02	2018-06-26	上海博邦医药科技有限公司	(r)-3-苯基哌啶或/和(s)-3-苯基哌啶以及尼拉帕尼的手性中间体的合成方法
US20240016775A1 (en)	2020-02-24	2024-01-18	Fukang (Shanghai) Health Technology Co., Ltd	Anti-coronavirus application of poly adp ribose polymerase inhibitor
CN115611860B (zh) *	2021-07-13	2024-06-11	上海博璞诺科技发展有限公司	合成尼拉帕尼的方法

2007
- 2007-01-10 GB GBGB0700432.8A patent/GB0700432D0/en not_active Ceased
2008
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- 2008-01-08 ME MEP-2019-147A patent/ME03481B/fr unknown
- 2008-01-08 DK DK08702101.0T patent/DK2109608T3/da active
- 2008-01-08 CN CN2008800019265A patent/CN101578279B/zh active Active
- 2008-01-08 HU HUE14176452 patent/HUE044513T2/hu unknown
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- 2008-01-08 ES ES11157369.7T patent/ES2509115T3/es active Active
- 2008-01-08 ES ES14176452T patent/ES2728199T3/es active Active
- 2008-01-08 TW TW097100730A patent/TWI528961B/zh active
- 2008-01-08 AT AT08702101T patent/ATE502933T1/de active
- 2008-01-08 PT PT14176452T patent/PT2805945T/pt unknown
- 2008-01-08 ES ES08702101T patent/ES2362214T3/es active Active
- 2008-01-08 NZ NZ578256A patent/NZ578256A/en unknown
- 2008-01-08 DE DE602008005711T patent/DE602008005711D1/de active Active
- 2008-01-08 MY MYPI20092876A patent/MY147789A/en unknown
- 2008-01-08 DK DK11157369.7T patent/DK2336120T3/da active
- 2008-01-08 SI SI200830240T patent/SI2109608T1/sl unknown
- 2008-01-08 LT LTEP14176452.2T patent/LT2805945T/lt unknown
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- 2008-01-08 UA UAA200908335A patent/UA97658C2/ru unknown
- 2008-01-08 PE PE2008000097A patent/PE20081558A1/es active IP Right Grant
2009
- 2009-06-04 ZA ZA200903898A patent/ZA200903898B/xx unknown
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- 2009-07-02 NI NI200900135A patent/NI200900135A/es unknown
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PE20081558A1 (es)	2008-10-30
DE602008005711D1 (de)	2011-05-05
DK2336120T3 (da)	2014-10-06
HUE044513T2 (hu)	2019-10-28
CN101578279A (zh)	2009-11-11
HN2009001260A (es)	2012-03-26
PT2805945T (pt)	2019-06-06
SI2336120T1 (sl)	2014-10-30
MY147789A (en)	2013-01-31
ZA200903898B (en)	2010-04-28
PT2336120E (pt)	2014-10-01
LT2805945T (lt)	2019-06-25
ES2509115T3 (es)	2014-10-17
SI2109608T1 (sl)	2011-07-29
ATE502933T1 (de)	2011-04-15
PT2109608E (pt)	2011-05-30
ES2728199T3 (es)	2019-10-22
DK2109608T3 (da)	2011-07-11
ME03481B (fr)	2020-01-20
UA97658C2 (ru)	2012-03-12
NI200900135A (es)	2010-08-30
TW200836731A (en)	2008-09-16
LUC00072I2 (fr)	2018-07-04
ES2362214T3 (es)	2011-06-29
NZ578256A (en)	2011-12-22
GB0700432D0 (en)	2007-02-21
CR10910A (es)	2010-01-19
CN101578279B (zh)	2013-07-17

Publication	Publication Date	Title
US8071623B2 (en)	2011-12-06	Amide substituted indazoles as poly(ADP-ribose)polymerase(PARP) inhibitors
JP5989965B2 (ja)	2016-09-07	２−｛４−［（３ｓ）−ピペリジン−３−イル］フェニル｝−２ｈ−インダゾール−７−カルボキサミドの薬学的に許容される塩
ES2362214T3 (es)	2011-06-29	Indazoles sustituidos con amida como inhibidores de poli(adp-ribosa)polimerasa (parp).
HK40006670A (en)	2020-05-22	Amide substituted indazoles as poly(adp-ribose)polymerase (parp) inhibitors
HK1154386B (en)	2015-02-06	Combinations containing amide substituted indazoles as poly(adp-ribose)polymerase (parp) inhibitors
HK1131137B (en)	2011-12-09	Amide substituted indazoles as poly(adp-ribose)polymerase (parp) inhibitors