TWI754170B - Jak激酶抑制劑與egfr抑制劑聯合在製備治療腫瘤疾病的藥物中的用途 - Google Patents

Jak激酶抑制劑與egfr抑制劑聯合在製備治療腫瘤疾病的藥物中的用途 Download PDF

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TWI754170B
TWI754170B TW108132822A TW108132822A TWI754170B TW I754170 B TWI754170 B TW I754170B TW 108132822 A TW108132822 A TW 108132822A TW 108132822 A TW108132822 A TW 108132822A TW I754170 B TWI754170 B TW I754170B
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day
formula
egfr
pharmaceutically acceptable
inhibitor
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TW108132822A
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Chinese (zh)
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TW202024067A (zh
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唐蜜
鄧智臨
廖成
楊昌永
張連山
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大陸商江蘇恒瑞醫藥股份有限公司
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/66Phosphorus compounds
    • A61K31/675Phosphorus compounds having nitrogen as a ring hetero atom, e.g. pyridoxal phosphate
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents

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  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
TW108132822A 2018-09-12 2019-09-11 Jak激酶抑制劑與egfr抑制劑聯合在製備治療腫瘤疾病的藥物中的用途 TWI754170B (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CN201811060976 2018-09-12
CN201811060976.2 2018-09-12

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TW202024067A TW202024067A (zh) 2020-07-01
TWI754170B true TWI754170B (zh) 2022-02-01

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TW108132822A TWI754170B (zh) 2018-09-12 2019-09-11 Jak激酶抑制劑與egfr抑制劑聯合在製備治療腫瘤疾病的藥物中的用途

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CN (1) CN112533606B (fr)
TW (1) TWI754170B (fr)
WO (1) WO2020052575A1 (fr)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US12577278B2 (en) 2019-06-07 2026-03-17 Emory University KRAS G12V mutant binds to JAK1, inhibitors, pharmaceutical compositions, and methods related thereto
TW202211923A (zh) * 2020-07-27 2022-04-01 美商光譜製藥公司 波奇替尼(poziotinib)於非小細胞肺癌之治療
WO2022143629A1 (fr) * 2020-12-29 2022-07-07 上海岸阔医药科技有限公司 Réactif et procédé pour le traitement de maladies ou d'affections cutanées associées à un agent antitumoral
CN112933095A (zh) * 2020-12-29 2021-06-11 上海岸阔医药科技有限公司 预防或治疗egfr功能异常相关的副作用的方法
CN115137832B (zh) * 2022-07-07 2023-11-17 中国医学科学院皮肤病医院(中国医学科学院皮肤病研究所) 一种jak抑制剂的用途及其抗毛霉感染实验方法

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103415520A (zh) * 2011-12-21 2013-11-27 江苏恒瑞医药股份有限公司 吡咯并六元杂芳环类衍生物、其制备方法及其在医药上的应用
WO2016054987A1 (fr) * 2014-10-11 2016-04-14 上海翰森生物医药科技有限公司 Inhibiteur d'egfr, et préparation et application associées

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103415520A (zh) * 2011-12-21 2013-11-27 江苏恒瑞医药股份有限公司 吡咯并六元杂芳环类衍生物、其制备方法及其在医药上的应用
WO2016054987A1 (fr) * 2014-10-11 2016-04-14 上海翰森生物医药科技有限公司 Inhibiteur d'egfr, et préparation et application associées

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
Wei Wen ETAL:"Synergistic anti-tumor effect of combined inhibition of EGFR and JAK/STAT3 pathways in human ovarian cancer", Molecular Cancer, Vol 14(100),20150501, pages 1-11. *

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TW202024067A (zh) 2020-07-01
WO2020052575A1 (fr) 2020-03-19
CN112533606A (zh) 2021-03-19
CN112533606B (zh) 2023-04-04

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