TWI754170B - Jak激酶抑制劑與egfr抑制劑聯合在製備治療腫瘤疾病的藥物中的用途 - Google Patents
Jak激酶抑制劑與egfr抑制劑聯合在製備治療腫瘤疾病的藥物中的用途 Download PDFInfo
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- TWI754170B TWI754170B TW108132822A TW108132822A TWI754170B TW I754170 B TWI754170 B TW I754170B TW 108132822 A TW108132822 A TW 108132822A TW 108132822 A TW108132822 A TW 108132822A TW I754170 B TWI754170 B TW I754170B
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/66—Phosphorus compounds
- A61K31/675—Phosphorus compounds having nitrogen as a ring hetero atom, e.g. pyridoxal phosphate
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| TW (1) | TWI754170B (fr) |
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| US12577278B2 (en) | 2019-06-07 | 2026-03-17 | Emory University | KRAS G12V mutant binds to JAK1, inhibitors, pharmaceutical compositions, and methods related thereto |
| TW202211923A (zh) * | 2020-07-27 | 2022-04-01 | 美商光譜製藥公司 | 波奇替尼(poziotinib)於非小細胞肺癌之治療 |
| WO2022143629A1 (fr) * | 2020-12-29 | 2022-07-07 | 上海岸阔医药科技有限公司 | Réactif et procédé pour le traitement de maladies ou d'affections cutanées associées à un agent antitumoral |
| CN112933095A (zh) * | 2020-12-29 | 2021-06-11 | 上海岸阔医药科技有限公司 | 预防或治疗egfr功能异常相关的副作用的方法 |
| CN115137832B (zh) * | 2022-07-07 | 2023-11-17 | 中国医学科学院皮肤病医院(中国医学科学院皮肤病研究所) | 一种jak抑制剂的用途及其抗毛霉感染实验方法 |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN103415520A (zh) * | 2011-12-21 | 2013-11-27 | 江苏恒瑞医药股份有限公司 | 吡咯并六元杂芳环类衍生物、其制备方法及其在医药上的应用 |
| WO2016054987A1 (fr) * | 2014-10-11 | 2016-04-14 | 上海翰森生物医药科技有限公司 | Inhibiteur d'egfr, et préparation et application associées |
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- 2019-09-11 TW TW108132822A patent/TWI754170B/zh not_active IP Right Cessation
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN103415520A (zh) * | 2011-12-21 | 2013-11-27 | 江苏恒瑞医药股份有限公司 | 吡咯并六元杂芳环类衍生物、其制备方法及其在医药上的应用 |
| WO2016054987A1 (fr) * | 2014-10-11 | 2016-04-14 | 上海翰森生物医药科技有限公司 | Inhibiteur d'egfr, et préparation et application associées |
Non-Patent Citations (1)
| Title |
|---|
| Wei Wen ETAL:"Synergistic anti-tumor effect of combined inhibition of EGFR and JAK/STAT3 pathways in human ovarian cancer", Molecular Cancer, Vol 14(100),20150501, pages 1-11. * |
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| TW202024067A (zh) | 2020-07-01 |
| WO2020052575A1 (fr) | 2020-03-19 |
| CN112533606A (zh) | 2021-03-19 |
| CN112533606B (zh) | 2023-04-04 |
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