UA100367C2 - Спосіб одержання мемантину і його гідрохлориду - Google Patents
Спосіб одержання мемантину і його гідрохлоридуInfo
- Publication number
- UA100367C2 UA100367C2 UAA200904316A UAA200904316A UA100367C2 UA 100367 C2 UA100367 C2 UA 100367C2 UA A200904316 A UAA200904316 A UA A200904316A UA A200904316 A UAA200904316 A UA A200904316A UA 100367 C2 UA100367 C2 UA 100367C2
- Authority
- UA
- Ukraine
- Prior art keywords
- memantine
- preparation
- hydrochloride
- dimethyladamantane
- synthesis
- Prior art date
Links
- BUGYDGFZZOZRHP-UHFFFAOYSA-N memantine Chemical compound C1C(C2)CC3(C)CC1(C)CC2(N)C3 BUGYDGFZZOZRHP-UHFFFAOYSA-N 0.000 title abstract 4
- 229960004640 memantine Drugs 0.000 title abstract 4
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 title abstract 3
- 238000000034 method Methods 0.000 title abstract 2
- 238000002360 preparation method Methods 0.000 title abstract 2
- 230000015572 biosynthetic process Effects 0.000 abstract 2
- 238000003786 synthesis reaction Methods 0.000 abstract 2
- BAMRISXQPCAUTQ-UHFFFAOYSA-N n-chloro-n-(3,5-dimethyl-1-adamantyl)acetamide Chemical compound C1C(C2)CC3(C)CC2(C)CC1(N(Cl)C(=O)C)C3 BAMRISXQPCAUTQ-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C233/00—Carboxylic acid amides
- C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C233/02—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having nitrogen atoms of carboxamide groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals
- C07C233/04—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having nitrogen atoms of carboxamide groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals with carbon atoms of carboxamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton
- C07C233/06—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having nitrogen atoms of carboxamide groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals with carbon atoms of carboxamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a ring other than a six-membered aromatic ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C209/00—Preparation of compounds containing amino groups bound to a carbon skeleton
- C07C209/62—Preparation of compounds containing amino groups bound to a carbon skeleton by cleaving carbon-to-nitrogen, sulfur-to-nitrogen, or phosphorus-to-nitrogen bonds, e.g. hydrolysis of amides, N-dealkylation of amines or quaternary ammonium compounds
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2603/00—Systems containing at least three condensed rings
- C07C2603/56—Ring systems containing bridged rings
- C07C2603/58—Ring systems containing bridged rings containing three rings
- C07C2603/70—Ring systems containing bridged rings containing three rings containing only six-membered rings
- C07C2603/74—Adamantanes
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Neurosurgery (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Psychiatry (AREA)
- Hospice & Palliative Care (AREA)
- Psychology (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP06020944A EP1908748A1 (en) | 2006-10-05 | 2006-10-05 | Process for the preparation of memantine and its hydrochloric acid salt form |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| UA100367C2 true UA100367C2 (uk) | 2012-12-25 |
Family
ID=37735099
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| UAA200904316A UA100367C2 (uk) | 2006-10-05 | 2007-05-10 | Спосіб одержання мемантину і його гідрохлориду |
Country Status (5)
| Country | Link |
|---|---|
| EP (2) | EP1908748A1 (ru) |
| EA (1) | EA019303B1 (ru) |
| SI (1) | SI2097372T1 (ru) |
| UA (1) | UA100367C2 (ru) |
| WO (1) | WO2008040560A1 (ru) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MX2009006699A (es) * | 2006-12-21 | 2009-06-30 | Mallinckrodt Inc | Composicion y metodo para preparar tabletas oralmente disgregantes que contienen una alta dosis de ingredientes farmaceuticamente activos. |
| WO2008079342A2 (en) * | 2006-12-21 | 2008-07-03 | Mallinckrodt Inc. | Composition of and method for preparing orally disintegrating tablets |
| EP2583669A1 (en) * | 2007-10-10 | 2013-04-24 | Rubicon Research Private Limited | Taste-masked orally disintegrating tablets of memantine hydrochloride |
| US20110282100A1 (en) * | 2009-01-21 | 2011-11-17 | Merz Pharma Gmbh & Co. Kgaa | Process for preparing memantine |
| WO2011125062A1 (en) * | 2010-04-08 | 2011-10-13 | Hetero Research Foundation | Process for the preparation of memantine hydrochloride |
| WO2014024202A1 (en) * | 2012-08-07 | 2014-02-13 | Zcl Chemicals Limited | An improved process for the preparation of memantine hydrochloride |
| US9452971B2 (en) | 2013-01-23 | 2016-09-27 | Mitsubishi Gas Chemical Company, Inc. | Manufacturing process for memantine |
| CN104447352B (zh) * | 2013-09-20 | 2017-01-25 | 山东方明药业集团股份有限公司 | 一种盐酸美金刚的制备方法 |
| CN103483205B (zh) * | 2013-10-12 | 2015-02-04 | 合肥久诺医药科技有限公司 | 一种高纯度盐酸美金刚的制备方法 |
| CN103524353B (zh) * | 2013-10-12 | 2015-03-25 | 合肥久诺医药科技有限公司 | 一种高纯度盐酸美金刚的制备方法 |
| CN103539690B (zh) * | 2013-10-12 | 2015-12-09 | 合肥久诺医药科技有限公司 | 一种合成金刚烷胺类药物的中间体及其制备方法和应用 |
| JP2016169166A (ja) * | 2015-03-11 | 2016-09-23 | 株式会社トクヤマ | １‐アミノ‐３，５‐ジメチルアダマンタン塩酸塩の製造方法 |
| WO2017109547A1 (es) * | 2015-12-23 | 2017-06-29 | Laboratorios Bagó S.A. | Premezcla y composición farmacéutica para la administración oral de memantina como suspensión permanente o de preparación previa a la administración al paciente y optativamente por sonda de alimentación enteral y procedimientos correspondientes |
| CN106966909B (zh) * | 2016-09-06 | 2019-04-12 | 南京优科制药有限公司 | 一种盐酸美金刚的纯化方法 |
| JP7250305B2 (ja) * | 2018-10-02 | 2023-04-03 | 共和薬品工業株式会社 | メマンチン又はその薬物学的に許容される塩を含む医薬組成物及びその製造方法 |
| CN114681423B (zh) * | 2022-05-19 | 2024-02-27 | 海南林恒制药股份有限公司 | 一种盐酸美金刚片及其制备方法 |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3391342A (en) * | 1965-11-22 | 1968-07-02 | Janus Control Corp | Digital counter |
| US3391142A (en) * | 1966-02-09 | 1968-07-02 | Lilly Co Eli | Adamantyl secondary amines |
| NL7305644A (ru) * | 1972-04-20 | 1973-10-23 | ||
| US5599998A (en) * | 1994-10-24 | 1997-02-04 | Iowa State University Research Foundation, Inc. | Method for the synthesis of adamantane amines |
| CN1400205A (zh) * | 2002-08-30 | 2003-03-05 | 中国科学院广州化学研究所 | 美金刚胺盐酸盐的制备方法 |
| BRPI0411451A (pt) * | 2003-06-16 | 2006-07-18 | Allergan Inc | formas de dosagens orais de memantina |
| CN1240668C (zh) * | 2003-09-10 | 2006-02-08 | 上海医药工业研究院 | 一种新的盐酸美金刚制备方法 |
| CN1709229A (zh) * | 2005-06-10 | 2005-12-21 | 北京阜康仁生物制药科技有限公司 | 盐酸美金刚口腔崩解片及其制备方法 |
| EP1820792B1 (en) | 2006-02-21 | 2012-01-18 | Hexal AG | Process for the preparation of adamantanamines |
-
2006
- 2006-10-05 EP EP06020944A patent/EP1908748A1/en not_active Withdrawn
-
2007
- 2007-05-10 UA UAA200904316A patent/UA100367C2/ru unknown
- 2007-10-05 WO PCT/EP2007/008684 patent/WO2008040560A1/en not_active Ceased
- 2007-10-05 SI SI200731960T patent/SI2097372T1/sl unknown
- 2007-10-05 EA EA200900474A patent/EA019303B1/ru not_active IP Right Cessation
- 2007-10-05 EP EP07818760.6A patent/EP2097372B1/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| WO2008040560A1 (en) | 2008-04-10 |
| SI2097372T1 (sl) | 2017-10-30 |
| EP2097372B1 (en) | 2017-05-31 |
| EP1908748A1 (en) | 2008-04-09 |
| EA200900474A1 (ru) | 2009-08-28 |
| EA019303B1 (ru) | 2014-02-28 |
| EP2097372A1 (en) | 2009-09-09 |
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