UA100865C2 - Твердый дисперсный продукт лекарственных средств на основе n-арилмочевины - Google Patents

Твердый дисперсный продукт лекарственных средств на основе n-арилмочевины

Info

Publication number
UA100865C2
UA100865C2 UAA201006029A UAA201006029A UA100865C2 UA 100865 C2 UA100865 C2 UA 100865C2 UA A201006029 A UAA201006029 A UA A201006029A UA A201006029 A UAA201006029 A UA A201006029A UA 100865 C2 UA100865 C2 UA 100865C2
Authority
UA
Ukraine
Prior art keywords
heading
solid dispersion
dispersion product
normal
aryl urea
Prior art date
Application number
UAA201006029A
Other languages
English (en)
Ukrainian (uk)
Inventor
Рудольф Шредер
Танья Хайтерманн
Original Assignee
Эбботт Гмбх Унд Ко. Кг
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Эбботт Гмбх Унд Ко. Кг filed Critical Эбботт Гмбх Унд Ко. Кг
Publication of UA100865C2 publication Critical patent/UA100865C2/ru

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1635—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/337—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having four-membered rings, e.g. taxol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1617—Organic compounds, e.g. phospholipids, fats
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Твердый дисперсный продукт, который включает, по меньшей мере, одно фармацевтически активное вещество на основе N-арилмочевины, получают путем а) получения жидкой смеси, содержащей, по меньшей мере, одно активное вещество по меньшей мере одно фармацевтически приемлемое вещество, которое образовывает матрицу, по меньшей мере одно фармацевтически приемлемое поверхностно-активное вещество и по меньшей мере один растворитель, и b) удаления растворителя (растворителей) из жидкой смеси с получением твердого дисперсного продукта.
UAA201006029A 2007-10-19 2008-10-17 Твердый дисперсный продукт лекарственных средств на основе n-арилмочевины UA100865C2 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US99961807P 2007-10-19 2007-10-19
PCT/EP2008/064076 WO2009050291A2 (en) 2007-10-19 2008-10-17 Solid dispersion product of n-aryl urea-based drugs

Publications (1)

Publication Number Publication Date
UA100865C2 true UA100865C2 (ru) 2013-02-11

Family

ID=40089463

Family Applications (1)

Application Number Title Priority Date Filing Date
UAA201006029A UA100865C2 (ru) 2007-10-19 2008-10-17 Твердый дисперсный продукт лекарственных средств на основе n-арилмочевины

Country Status (18)

Country Link
EP (1) EP2197425A2 (ru)
JP (1) JP2011500649A (ru)
KR (1) KR20100087170A (ru)
CN (1) CN101827584A (ru)
AU (1) AU2008313622A1 (ru)
BR (1) BRPI0818340A2 (ru)
CA (1) CA2699301A1 (ru)
CO (1) CO6270206A2 (ru)
CR (1) CR11442A (ru)
DO (1) DOP2010000117A (ru)
EC (1) ECSP10010183A (ru)
GT (1) GT201000102A (ru)
MX (1) MX2010004291A (ru)
PA (1) PA8800101A1 (ru)
RU (1) RU2010119929A (ru)
UA (1) UA100865C2 (ru)
WO (1) WO2009050291A2 (ru)
ZA (1) ZA201002095B (ru)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2009100176A2 (en) * 2008-02-07 2009-08-13 Abbott Laboratories Pharmaceutical dosage form for oral administration of tyrosine kinase inhibitor
JO3002B1 (ar) 2009-08-28 2016-09-05 Irm Llc مركبات و تركيبات كمثبطات كيناز بروتين
TW201202234A (en) * 2010-06-09 2012-01-16 Abbott Lab Solid dispersions containing kinase inhibitors
CN108542906A (zh) 2011-11-11 2018-09-18 诺华股份有限公司 治疗增生性疾病的方法
ES2695099T3 (es) * 2011-11-23 2019-01-02 Array Biopharma Inc Formulaciones farmacéuticas
WO2014003677A1 (en) * 2012-06-28 2014-01-03 Xspray Microparticles Ab Pharmaceutical compositions comprising solid dispersion particles containing tadalafil
WO2014003678A1 (en) * 2012-06-28 2014-01-03 Xspray Microparticles Ab Pharmaceutical compositions comprising ambrisentan and solid dispersion particles containing tadalafil
ES3063790T3 (en) 2015-06-09 2026-04-20 Lonza Sales Ag Formulations to achieve rapid dissolution of drug from spray-dried dispersions in capsules

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2007050574A1 (en) * 2005-10-25 2007-05-03 Abbott Laboratories Formulation comprising a drug of low water solubility and method of use thereof
WO2007066189A2 (en) * 2005-12-09 2007-06-14 Pfizer Products Inc. Salts, prodrugs and formulations of 1-[5-(4-amino-7-isopropyl-7h-pyrrolo[2,3-d]pyrimidine-5-carbonyl)-2-methoxy-phenyl]-3-(2,4-dichloro-phenyl)-urea
AU2007316558A1 (en) * 2006-11-09 2008-05-15 Abbott Gmbh & Co. Kg Pharmaceutical dosage form for oral administration of tyrosine kinase inhibitor

Also Published As

Publication number Publication date
CA2699301A1 (en) 2009-04-23
CR11442A (es) 2010-09-06
CO6270206A2 (es) 2011-04-20
DOP2010000117A (es) 2010-05-15
WO2009050291A3 (en) 2010-04-08
PA8800101A1 (es) 2009-05-15
KR20100087170A (ko) 2010-08-03
WO2009050291A2 (en) 2009-04-23
AU2008313622A1 (en) 2009-04-23
JP2011500649A (ja) 2011-01-06
BRPI0818340A2 (pt) 2015-04-22
RU2010119929A (ru) 2011-11-27
ZA201002095B (en) 2011-11-30
EP2197425A2 (en) 2010-06-23
GT201000102A (es) 2012-03-12
CN101827584A (zh) 2010-09-08
MX2010004291A (es) 2010-08-02
ECSP10010183A (es) 2010-06-29

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