UA103181C2 - Соединения, которые ингибируют дипептидилпептидазу-iv и фармацевтическая композиция, которая содержит их как активный агент - Google Patents

Соединения, которые ингибируют дипептидилпептидазу-iv и фармацевтическая композиция, которая содержит их как активный агент

Info

Publication number
UA103181C2
UA103181C2 UAA201007683A UAA201007683A UA103181C2 UA 103181 C2 UA103181 C2 UA 103181C2 UA A201007683 A UAA201007683 A UA A201007683A UA A201007683 A UAA201007683 A UA A201007683A UA 103181 C2 UA103181 C2 UA 103181C2
Authority
UA
Ukraine
Prior art keywords
active agent
dipeptidyl peptidase
pharmaceutical composition
compounds inhibiting
inhibiting dipeptidyl
Prior art date
Application number
UAA201007683A
Other languages
English (en)
Ukrainian (uk)
Inventor
Чанг-Сеок Лі
Хієон Дзоо Йім
Кіоунг-Хеє Кім
Чжеік Лі
Сунг-Хак Лі
Кіу Воонг Лі
Хеє Бонг Лі
Ван Су Парк
Чангхі Мінь
Original Assignee
Ел Джи Лайф Сайєнсіз, Лтд.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ел Джи Лайф Сайєнсіз, Лтд. filed Critical Ел Джи Лайф Сайєнсіз, Лтд.
Publication of UA103181C2 publication Critical patent/UA103181C2/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Diabetes (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Endocrinology (AREA)
  • Emergency Medicine (AREA)
  • Child & Adolescent Psychology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

В данном изобретении описываются соединения формулы (1), как указано в описании, которые имеют замечательную ингибиторную активность против дипептидилпептидазы-IV (DPP-IV), способа их получения и фармацевтические композиции, которые содержат их как активный агент. EMBED ISISServer (1)
UAA201007683A 2007-12-21 2008-12-19 Соединения, которые ингибируют дипептидилпептидазу-iv и фармацевтическая композиция, которая содержит их как активный агент UA103181C2 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
KR20070134887 2007-12-21
PCT/KR2008/007543 WO2009082134A2 (en) 2007-12-21 2008-12-19 Dipeptidyl peptidase-iv inhibiting compounds, methods of preparing the same, and pharmaceutical compositions containing the same as active agent

Publications (1)

Publication Number Publication Date
UA103181C2 true UA103181C2 (ru) 2013-09-25

Family

ID=40801676

Family Applications (1)

Application Number Title Priority Date Filing Date
UAA201007683A UA103181C2 (ru) 2007-12-21 2008-12-19 Соединения, которые ингибируют дипептидилпептидазу-iv и фармацевтическая композиция, которая содержит их как активный агент

Country Status (14)

Country Link
US (1) US8470836B2 (ru)
EP (1) EP2220086A4 (ru)
JP (1) JP5358585B2 (ru)
KR (1) KR101105607B1 (ru)
CN (1) CN101903386B (ru)
AU (1) AU2008341352B2 (ru)
BR (1) BRPI0819719B8 (ru)
CA (1) CA2710109C (ru)
CO (1) CO6300861A2 (ru)
EA (1) EA201070635A1 (ru)
MA (1) MA31919B1 (ru)
UA (1) UA103181C2 (ru)
WO (1) WO2009082134A2 (ru)
ZA (1) ZA201004214B (ru)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2011107494A1 (de) 2010-03-03 2011-09-09 Sanofi Neue aromatische glykosidderivate, diese verbindungen enthaltende arzneimittel und deren verwendung
US8530413B2 (en) 2010-06-21 2013-09-10 Sanofi Heterocyclically substituted methoxyphenyl derivatives with an oxo group, processes for preparation thereof and use thereof as medicaments
TW201215388A (en) 2010-07-05 2012-04-16 Sanofi Sa (2-aryloxyacetylamino)phenylpropionic acid derivatives, processes for preparation thereof and use thereof as medicaments
TW201215387A (en) 2010-07-05 2012-04-16 Sanofi Aventis Spirocyclically substituted 1,3-propane dioxide derivatives, processes for preparation thereof and use thereof as a medicament
TW201221505A (en) 2010-07-05 2012-06-01 Sanofi Sa Aryloxyalkylene-substituted hydroxyphenylhexynoic acids, process for preparation thereof and use thereof as a medicament
MY157423A (en) * 2010-09-03 2016-06-15 Lg Life Sciences Ltd Production method of intermediate compound for synthesizing medicament
CN102617566B (zh) * 2011-01-30 2015-03-04 山东轩竹医药科技有限公司 吡啶并咪唑烷衍生物
CN102875567B (zh) * 2011-07-15 2015-03-11 天津药物研究院 一类含哌嗪化合物、制备及用途
WO2013037390A1 (en) 2011-09-12 2013-03-21 Sanofi 6-(4-hydroxy-phenyl)-3-styryl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors
EP2760862B1 (en) 2011-09-27 2015-10-21 Sanofi 6-(4-hydroxy-phenyl)-3-alkyl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors
KR101539761B1 (ko) * 2012-02-03 2015-07-28 주식회사 엘지생명과학 물 또는 다양한 산을 첨가제로 이용한 새로운 마이클-첨가 반응을 통하여 화합물을 제조하는 방법
CN105142621A (zh) 2012-10-24 2015-12-09 国家健康科学研究所 用于预防或治疗糖尿病和促进β-细胞存活的TPL2激酶抑制剂
CN105017244A (zh) * 2014-04-16 2015-11-04 上海药明康德新药开发有限公司 顺反叔丁基-4-氧六氢化-1H-吡咯[3,4-c]吡啶-2(3H)-羧酸叔丁酯的合成方法
CN104447511A (zh) * 2014-11-12 2015-03-25 江苏中邦制药有限公司 一种n-叔丁氧羰基-3-哌啶酮的合成方法
EP3273981B1 (en) 2015-03-24 2020-04-29 INSERM - Institut National de la Santé et de la Recherche Médicale Method and pharmaceutical composition for use in the treatment of diabetes
RU2741389C1 (ru) * 2017-11-16 2021-01-25 ЭлДжи КЕМ, ЛТД. Способ получения промежуточного соединения для синтеза лекарственного средства
WO2023150619A2 (en) * 2022-02-02 2023-08-10 The Katholieke Universiteit Leuven Tetrahydropyridopyrimidines and related analogs for inhibiting yap/taz-tead
CN118791425A (zh) * 2024-06-18 2024-10-18 浙江尚科生物医药有限公司 一种1-boc-3-哌啶酮及其类似环酮类化合物的合成方法
CN120004890B (zh) * 2025-02-17 2025-10-21 安徽峆一药业股份有限公司 一种吉格列汀盐酸盐微晶及其制备方法与应用

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CO5150173A1 (es) 1998-12-10 2002-04-29 Novartis Ag Compuestos n-(glicilo sustituido)-2-cianopirrolidinas inhibidores de peptidasa de dipeptidilo-iv (dpp-iv) los cuales son efectivos en el tratamiento de condiciones mediadas por la inhibicion de dpp-iv
UA74912C2 (en) 2001-07-06 2006-02-15 Merck & Co Inc Beta-aminotetrahydroimidazo-(1,2-a)-pyrazines and tetratriazolo-(4,3-a)-pyrazines as inhibitors of dipeptylpeptidase for the treatment or prevention of diabetes
US6861440B2 (en) 2001-10-26 2005-03-01 Hoffmann-La Roche Inc. DPP IV inhibitors
EP1490335B1 (en) * 2002-03-25 2007-09-19 Merck & Co., Inc. Beta-amino heterocyclic dipeptidyl peptidase inhibitors for the treatment or prevention of diabetes
CA2512546A1 (en) * 2003-01-17 2004-08-05 Merck & Co., Inc. 3-amino-4-phenylbutanoic acid derivatives as dipeptidyl peptidase inhibitors for the treatment or prevention of diabetes
WO2004089362A1 (en) * 2003-04-11 2004-10-21 Novo Nordisk A/S 2-cyanopyrroles and their analogues as ddp-iv inhibitors
TWI357902B (en) * 2005-04-01 2012-02-11 Lg Life Science Ltd Dipeptidyl peptidase-iv inhibiting compounds, meth

Also Published As

Publication number Publication date
BRPI0819719A8 (pt) 2015-09-22
JP5358585B2 (ja) 2013-12-04
US8470836B2 (en) 2013-06-25
JP2011507832A (ja) 2011-03-10
BRPI0819719B8 (pt) 2021-05-25
CA2710109A1 (en) 2009-07-02
WO2009082134A3 (en) 2009-09-24
WO2009082134A2 (en) 2009-07-02
BRPI0819719B1 (pt) 2020-09-24
EA201070635A1 (ru) 2010-12-30
CO6300861A2 (es) 2011-07-21
AU2008341352A1 (en) 2009-07-02
KR101105607B1 (ko) 2012-01-18
AU2008341352B2 (en) 2013-08-01
US20100274013A1 (en) 2010-10-28
KR20090068156A (ko) 2009-06-25
ZA201004214B (en) 2011-04-28
CN101903386B (zh) 2015-04-22
EP2220086A4 (en) 2010-12-22
EP2220086A2 (en) 2010-08-25
CA2710109C (en) 2016-07-19
MA31919B1 (fr) 2010-12-01
CN101903386A (zh) 2010-12-01
BRPI0819719A2 (pt) 2015-06-16

Similar Documents

Publication Publication Date Title
WO2009082134A3 (en) Dipeptidyl peptidase-iv inhibiting compounds, methods of preparing the same, and pharmaceutical compositions containing the same as active agent
TW200724542A (en) Dipeptidyl peptidase-IV inhibiting compounds, methods of preparing the same, and pharmaceutical compositions containing the same as an active agent
MX2008012490A (es) Aminotetrahidropiranos como inhibidores de dipeptidil peptidasa-iv para el tratamiento o prevencion de diabetes.
MY150787A (en) Aminotetrahydropyrans as dipeptidyl peptidase-iv inhibitors for the treatment or prevention of prevention of diabetes
WO2006106326A8 (en) Substituted heterocycles and their use as chk1, pdk1 and pak inhibitors
WO2007097931A3 (en) Aminotetrahydropyrans as dipeptidyl peptidase-iv inhibitors for the treatment or prevention of diabetes
WO2007136603A3 (en) Aminotetrahydropyrans as dipeptidyl peptidase-iv inhibitors for the treatment or prevention of diabetes
WO2007087231A3 (en) Aminocyclohexanes as dipeptidyl peptidase-iv inhibitors for the treatment or prevention of diabetes
MX2009009948A (es) Derivados de piridazinona utiles como inhibidores de glucano sintasa.
WO2005004818A3 (en) Heterocyclic compounds and their use as anticancer agents
WO2010003475A3 (de) Neue pyrrolidinderivate als metap-2 inhibitoren
MX2009000285A (es) Piperidinas sustituidas que incrementan la actividad de p53 y usos de las mismas.
WO2008148074A3 (en) Inhibitors of mtor and methods of treatment using same
WO2007011962A3 (en) Treatment of cancer
IN2012DN00721A (ru)
TNSN08370A1 (en) Tetrahydropyridothienopyrimidine compounds and methods of use thereof
WO2008014311A3 (en) Inhibitors of undecaprenyl pyrophosphate synthase
IL205696A0 (en) Heterocyclic derivatives, compositions comprising the same and uses thereof
WO2011047055A8 (en) Novel mek inhibitors, useful in the treatment of diseases
TW200738659A (en) Novel compounds
MY152040A (en) Triazolopyridazines as par1 inhibitors, production thereof, and use as medicaments
WO2009097973A3 (de) Imidazopyridazine als par1-inhibitoren, ihre herstellung und verwendung als arzneimittel
MX2009013667A (es) Inhibidores triciclicos de hidroxiesteroide deshidrogenasas.
NZ592567A (en) Pharmaceutical composition for prevention and treatment of diabetes or obesity comprising a compound that inhibits activity of dipeptidyl peptidase-iv, and other antidiabetic or antiobesity agents as active ingredients
TW200738611A (en) 9-Chloro-15-deoxyprostaglandin derivatives, process for their preparation and their use as medicaments