UA103602C2 - АНТИТЕЛО, СПЕЦИФИЧНОЕ К β-АМИЛОИДНЫМ ПЕПТИДАМ, И ЕГО ПРИМЕНЕНИЕ В КАЧЕСТВЕ ДИАГНОСТИЧЕСКОГО ИЛИ ЛЕКАРСТВЕННОГО СРЕДСТВА - Google Patents

АНТИТЕЛО, СПЕЦИФИЧНОЕ К β-АМИЛОИДНЫМ ПЕПТИДАМ, И ЕГО ПРИМЕНЕНИЕ В КАЧЕСТВЕ ДИАГНОСТИЧЕСКОГО ИЛИ ЛЕКАРСТВЕННОГО СРЕДСТВА

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Publication number
UA103602C2
UA103602C2 UAA201006547A UAA201006547A UA103602C2 UA 103602 C2 UA103602 C2 UA 103602C2 UA A201006547 A UAA201006547 A UA A201006547A UA A201006547 A UAA201006547 A UA A201006547A UA 103602 C2 UA103602 C2 UA 103602C2
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UA
Ukraine
Prior art keywords
drug
antibody specific
diagnostic agent
amyloid peptides
peptide
Prior art date
Application number
UAA201006547A
Other languages
English (en)
Ukrainian (uk)
Inventor
Ежен Ванмешелен
П'єр Гроньє
Ніколя Сержан
Марі Гомпель
Андре Делакурт
Люк Бює
Лоран Прадьє
Веронік Бланшар-Брежон
Original Assignee
Енсерм (Енстітю Насьональ Де Ля Санте Е Де Ля Решер Медікалє)
Санофі-Авентіс
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=38925731&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=UA103602(C2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Енсерм (Енстітю Насьональ Де Ля Санте Е Де Ля Решер Медікалє), Санофі-Авентіс filed Critical Енсерм (Енстітю Насьональ Де Ля Санте Е Де Ля Решер Медікалє)
Publication of UA103602C2 publication Critical patent/UA103602C2/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4711—Alzheimer's disease; Amyloid plaque core protein
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Biomedical Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Neurology (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Toxicology (AREA)
  • Immunology (AREA)
  • Neurosurgery (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Hospice & Palliative Care (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Psychiatry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

Изобретение относится к моноклональному антителу TeiA 1.6, которое специфично связывается с N-концевой областью пептида A(8-x, где x составляет от 11 до 42, и не распознает ни A(1-40,ни A(1-42, и которое имеет высокую специфичность к пептиду A(8-x, которая определяется по образованию иммунологического комплекса между моноклональным антителом и пептидом A(8-x.
UAA201006547A 2007-10-29 2008-10-24 АНТИТЕЛО, СПЕЦИФИЧНОЕ К β-АМИЛОИДНЫМ ПЕПТИДАМ, И ЕГО ПРИМЕНЕНИЕ В КАЧЕСТВЕ ДИАГНОСТИЧЕСКОГО ИЛИ ЛЕКАРСТВЕННОГО СРЕДСТВА UA103602C2 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP07119537 2007-10-29
PCT/EP2008/064432 WO2009056490A1 (en) 2007-10-29 2008-10-24 NEW ANTIBODIES SPECIFIC OF THE β-AMYLOID PEPTIDES AND THEIR USES AS DIAGNOSTIC AGENTS OR DRUGS

Publications (1)

Publication Number Publication Date
UA103602C2 true UA103602C2 (ru) 2013-11-11

Family

ID=38925731

Family Applications (1)

Application Number Title Priority Date Filing Date
UAA201006547A UA103602C2 (ru) 2007-10-29 2008-10-24 АНТИТЕЛО, СПЕЦИФИЧНОЕ К β-АМИЛОИДНЫМ ПЕПТИДАМ, И ЕГО ПРИМЕНЕНИЕ В КАЧЕСТВЕ ДИАГНОСТИЧЕСКОГО ИЛИ ЛЕКАРСТВЕННОГО СРЕДСТВА

Country Status (27)

Country Link
US (1) US8343493B2 (ru)
EP (1) EP2205633A1 (ru)
JP (1) JP5421277B2 (ru)
KR (1) KR20100097651A (ru)
CN (1) CN101883792B (ru)
AP (1) AP2957A (ru)
AR (1) AR069085A1 (ru)
AU (1) AU2008317705B2 (ru)
CA (1) CA2703825A1 (ru)
CL (1) CL2008003197A1 (ru)
CO (1) CO6270369A2 (ru)
CR (1) CR11396A (ru)
EA (1) EA201070539A1 (ru)
EC (1) ECSP10010142A (ru)
HN (1) HN2010000880A (ru)
IL (1) IL205398A0 (ru)
MA (1) MA31793B1 (ru)
MX (1) MX2010004660A (ru)
MY (1) MY155144A (ru)
NI (1) NI201000075A (ru)
NZ (1) NZ585000A (ru)
TN (1) TN2010000197A1 (ru)
TW (1) TW200936605A (ru)
UA (1) UA103602C2 (ru)
UY (1) UY31433A1 (ru)
WO (1) WO2009056490A1 (ru)
ZA (1) ZA201002989B (ru)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PT2099826E (pt) * 2007-01-05 2014-01-09 Univ Zuerich Anticorpo anti-beta-amilóide e suas utilizações
HRP20140049T1 (hr) 2007-01-05 2014-02-28 University Of Zürich Anti beta-amiloid antitijela i njihova upotreba
WO2010069603A1 (en) 2008-12-19 2010-06-24 Neurimmune Therapeutics Ag Human anti-alpha-synuclein autoantibodies
MX2012002993A (es) 2009-09-11 2012-04-19 Probiodrug Ag Derivados heterociclicos como inhibidores de ciclasa glutaminilo.
US8337845B2 (en) 2010-03-03 2012-12-25 Boehringer Ingelheim International Gmbh A-beta binding polypeptides
EP2511296A1 (en) * 2011-04-12 2012-10-17 Araclón Biotech, S. L. Antibody, kit and method for determination of amyloid peptides
CN103796679B (zh) 2011-06-23 2016-10-19 比奥根国际神经科学公司 抗-α突触核蛋白结合分子
DK3269736T3 (da) 2012-05-10 2020-01-13 Georg August Univ Goettingen Stiftung Oeffentlichen Rechts Univsmedizin Konformationsspecifikke antistoffer mod oligomerer af amyloid beta
MA41115A (fr) 2014-12-02 2017-10-10 Biogen Int Neuroscience Gmbh Procédé de traitement de la maladie d'alzheimer
AU2016354688B2 (en) * 2015-11-09 2021-12-16 The University Of British Columbia Epitopes in Amyloid beta mid-region and conformationally-selective antibodies thereto
KR102550991B1 (ko) 2016-07-18 2023-07-04 더 유니버시티 오브 브리티쉬 콜롬비아 아밀로이드 베타에 대한 항체
EP4275747A3 (en) 2016-07-19 2024-01-24 Duke University Therapeutic applications of cpf1-based genome editing
US12286469B2 (en) 2017-07-18 2025-04-29 The University Of British Columbia Humanized antibodies binding to amyloid-beta (A-beta)
EP3658172A4 (en) 2017-07-25 2021-05-05 TrueBinding, Inc. TREATING CANCER BY BLOCKING THE INTERACTION OF TIM-3 AND HIS LIGAND
AU2018321335B2 (en) 2017-08-22 2025-08-14 Biogen Ma Inc. Pharmaceutical compositions containing anti-beta amyloid antibodies
PL3461819T3 (pl) 2017-09-29 2020-11-30 Probiodrug Ag Inhibitory cyklazy glutaminylowej
IL281979B2 (en) 2018-10-04 2025-09-01 Georg August Universit?T G?Ttingen Stiftung ?Ffentlichen Rechts Universit?Tsmedizin Human antibodies that bind amyloid peptides
CN113711036B (zh) 2019-01-30 2025-03-18 真和制药有限公司 抗gal3抗体及其用途
CN116157151A (zh) 2020-05-26 2023-05-23 真和制药有限公司 通过阻断半乳凝素-3治疗炎性疾病的方法
CN118382636A (zh) * 2021-12-17 2024-07-23 豪夫迈·罗氏有限公司 一种用于检测淀粉样蛋白β42(Aβ42)的新抗体

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1523499A2 (en) * 2002-07-24 2005-04-20 Innogenetics N.V. Fragments of beta-amyloid as targets for vaccination against alzheimer disease
DE10303974A1 (de) * 2003-01-31 2004-08-05 Abbott Gmbh & Co. Kg Amyloid-β(1-42)-Oligomere, Verfahren zu deren Herstellung und deren Verwendung

Also Published As

Publication number Publication date
HN2010000880A (es) 2014-03-10
AR069085A1 (es) 2009-12-30
JP2011502139A (ja) 2011-01-20
CN101883792B (zh) 2014-08-27
NZ585000A (en) 2012-08-31
MX2010004660A (es) 2010-07-30
EP2205633A1 (en) 2010-07-14
ECSP10010142A (es) 2010-07-30
AP2010005249A0 (en) 2010-06-30
JP5421277B2 (ja) 2014-02-19
CR11396A (es) 2012-10-18
TN2010000197A1 (en) 2011-11-11
UY31433A1 (es) 2009-05-29
EA201070539A1 (ru) 2010-10-29
AU2008317705B2 (en) 2014-06-05
KR20100097651A (ko) 2010-09-03
CN101883792A (zh) 2010-11-10
CA2703825A1 (en) 2009-05-07
WO2009056490A1 (en) 2009-05-07
MY155144A (en) 2015-09-15
US20110059092A1 (en) 2011-03-10
IL205398A0 (en) 2010-12-30
AP2957A (en) 2014-08-31
CO6270369A2 (es) 2011-04-20
TW200936605A (en) 2009-09-01
AU2008317705A1 (en) 2009-05-07
NI201000075A (es) 2010-09-23
US8343493B2 (en) 2013-01-01
ZA201002989B (en) 2011-07-27
CL2008003197A1 (es) 2010-01-15
MA31793B1 (fr) 2010-10-01

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