UA104880C2 - Заміщені тетрагідропіранспіропіролідинон і тетрагідропіранспіропіперидинон, спосіб їх одержання й застосування в лікувальних цілях - Google Patents
Заміщені тетрагідропіранспіропіролідинон і тетрагідропіранспіропіперидинон, спосіб їх одержання й застосування в лікувальних ціляхInfo
- Publication number
- UA104880C2 UA104880C2 UAA201108412A UAA201108412A UA104880C2 UA 104880 C2 UA104880 C2 UA 104880C2 UA A201108412 A UAA201108412 A UA A201108412A UA A201108412 A UAA201108412 A UA A201108412A UA 104880 C2 UA104880 C2 UA 104880C2
- Authority
- UA
- Ukraine
- Prior art keywords
- substituted
- preparation
- tetrahydropyranspiropyrrolidone
- tetrahydropyranspiropiperidinone
- medicinal use
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 2
- XTGBDFKDSPCHLQ-UHFFFAOYSA-N 1-oxa-8-azaspiro[5.5]undecan-7-one Chemical class N1C(C2(CCC1)OCCCC2)=O XTGBDFKDSPCHLQ-UHFFFAOYSA-N 0.000 title 1
- RYVLCQUGBMIDSI-UHFFFAOYSA-N 6-oxa-2-azaspiro[4.5]decan-1-one Chemical class O=C1NCCC11OCCCC1 RYVLCQUGBMIDSI-UHFFFAOYSA-N 0.000 title 1
- 102000004384 Histamine H3 receptors Human genes 0.000 abstract 2
- 108090000981 Histamine H3 receptors Proteins 0.000 abstract 2
- 201000010099 disease Diseases 0.000 abstract 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 2
- KFIOZBMCNUODPK-UHFFFAOYSA-N n-phenyl-1-pyrrolidin-1-ylpyrrolidine-2-carboxamide Chemical class C1CCN(N2CCCC2)C1C(=O)NC1=CC=CC=C1 KFIOZBMCNUODPK-UHFFFAOYSA-N 0.000 abstract 2
- 210000003169 central nervous system Anatomy 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 239000000543 intermediate Chemical class 0.000 abstract 1
- 239000008177 pharmaceutical agent Substances 0.000 abstract 1
- 230000002265 prevention Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/10—Spiro-condensed systems
- C07D491/107—Spiro-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/407—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with other heterocyclic ring systems, e.g. ketorolac, physostigmine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Biomedical Technology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Psychology (AREA)
- Epidemiology (AREA)
- Hospice & Palliative Care (AREA)
- Anesthesiology (AREA)
- Child & Adolescent Psychology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Hydrogenated Pyridines (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
Даний винахід розкриває й заявляє групу заміщених N-фенілбіпіролідинкарбоксамідів з формулою (І) EMBED ISISServer , (I) де R1, R2, m, n і р представлені відповідно до опису, наведеного в даному документі. Більш конкретно, сполуки даного винаходу є модуляторами рецепторів Н3 і, отже, придатні для використання як фармацевтичних засобів, особливо при лікуванні й (або) запобіганні різним захворюванням, модульованим рецепторами Н3, включаючи захворювання, пов'язані із центральною нервовою системою. Крім того, у даному винаході також розкриваються способи одержання заміщених N-фенілбіпіролідинкарбоксамідів і їх проміжних сполук.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US12008708P | 2008-12-05 | 2008-12-05 | |
| FR0955909 | 2009-08-28 | ||
| PCT/US2009/066666 WO2010065798A1 (en) | 2008-12-05 | 2009-12-04 | Substituted tetrahydropyran spiro pyrrolidinone and piperidinone, preparation and therapeutic use thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| UA104880C2 true UA104880C2 (uk) | 2014-03-25 |
Family
ID=41665099
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| UAA201108412A UA104880C2 (uk) | 2008-12-05 | 2009-12-04 | Заміщені тетрагідропіранспіропіролідинон і тетрагідропіранспіропіперидинон, спосіб їх одержання й застосування в лікувальних цілях |
Country Status (27)
| Country | Link |
|---|---|
| US (2) | US8217052B2 (uk) |
| EP (1) | EP2373659B1 (uk) |
| JP (1) | JP5410544B2 (uk) |
| KR (1) | KR101682889B1 (uk) |
| CN (1) | CN102239170B (uk) |
| AR (1) | AR074467A1 (uk) |
| AU (1) | AU2009322243B2 (uk) |
| CA (1) | CA2745715C (uk) |
| CO (1) | CO6390059A2 (uk) |
| CR (1) | CR20110289A (uk) |
| DO (1) | DOP2011000166A (uk) |
| EC (1) | ECSP11011109A (uk) |
| ES (1) | ES2507574T3 (uk) |
| HN (1) | HN2011001487A (uk) |
| IL (1) | IL213292A (uk) |
| MA (1) | MA32945B1 (uk) |
| MX (1) | MX2011004791A (uk) |
| MY (1) | MY150789A (uk) |
| NZ (1) | NZ593150A (uk) |
| PA (1) | PA8852301A1 (uk) |
| PE (1) | PE20110773A1 (uk) |
| RU (1) | RU2519778C2 (uk) |
| TN (1) | TN2011000223A1 (uk) |
| TW (1) | TWI441826B (uk) |
| UA (1) | UA104880C2 (uk) |
| WO (1) | WO2010065798A1 (uk) |
| ZA (1) | ZA201103261B (uk) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AR074466A1 (es) | 2008-12-05 | 2011-01-19 | Sanofi Aventis | Piperidina espiro pirrolidinona y piperidinona sustituidas y su uso terapeutico en enfermedades mediadas por la modulacion de los receptores h3. |
| EP2569303A1 (en) | 2010-05-11 | 2013-03-20 | Sanofi | Substituted n-alkyl and n-acyl tetrahydro-isoquinoline derivatives, preparation and therapeutic use thereof |
| JP5784110B2 (ja) | 2010-05-11 | 2015-09-24 | サノフイ | 置換されたｎ−ヘテロアリールテトラヒドロ−イソキノリン誘導体、その製造及び治療上の使用 |
| EP2569296A1 (en) * | 2010-05-11 | 2013-03-20 | Sanofi | Substituted n-phenyl spirolactam bipyrrolidines, preparation and therapeutic use thereof |
| AR081383A1 (es) | 2010-05-11 | 2012-08-29 | Sanofi Aventis | N-heteroaril bipirrolidin carboxamidas sustituidas, composiciones farmaceuticas que las contienen y uso de las mismas para el tratamiento de enfermedades del sistema nervioso central. |
| TW201206939A (en) | 2010-05-11 | 2012-02-16 | Sanofi Aventis | Substituted phenyl cycloalkyl pyrrolidine (piperidine) spirolactams and amides, preparation and therapeutic use thereof |
| TW201202251A (en) * | 2010-05-11 | 2012-01-16 | Sanofi Aventis | Substituted N-heteroaryl spirolactam bipyrrolidines, preparation and therapeutic use thereof |
| JP2013529198A (ja) | 2010-05-11 | 2013-07-18 | サノフイ | 置換されたｎ−ヘテロシクロアルキルビピロリジニルフェニルアミド誘導体、その製造及び治療上の使用 |
Family Cites Families (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3256276A (en) * | 1961-02-17 | 1966-06-14 | Geschickter Fund Med Res | Substituted spiroimides |
| US3258276A (en) | 1964-04-06 | 1966-06-28 | Charles E Murcott | Utility chair |
| EP2243776A1 (en) * | 2001-10-12 | 2010-10-27 | High Point Pharmaceuticals, LLC | Substituted piperidines and their use for the treatment of diseases related to the histamine H3 receptor |
| US6889262B1 (en) | 2002-06-26 | 2005-05-03 | Advanced Micro Devices, Inc. | Direct transaction mode for peripheral devices |
| EP1556046A1 (en) * | 2002-10-23 | 2005-07-27 | Janssen Pharmaceutica N.V. | Phenylpiperidines and phenylpyrrolidines as histamine h3 receptor modulators |
| US7223788B2 (en) | 2003-02-14 | 2007-05-29 | Sanofi-Aventis Deutschland Gmbh | Substituted N-aryl heterocycles, process for their preparation and their use as medicaments |
| JP4765627B2 (ja) * | 2003-09-22 | 2011-09-07 | Ｍｓｄ株式会社 | 新規ピペリジン誘導体 |
| MX2007016216A (es) * | 2005-07-01 | 2008-03-11 | Lilly Co Eli | Agenes del receptor de histamina h3, preparacion y usos terapeuticos. |
| ES2381205T3 (es) * | 2005-11-10 | 2012-05-24 | Msd K.K. | Derivado espiro aza-sustituido |
| JP2009519293A (ja) | 2005-12-16 | 2009-05-14 | エフ．ホフマン−ラ ロシュ アーゲー | Ｈ３レセプター調節剤としてのピロロ［２，３−ｂ］ピリジン誘導体 |
| US20080247964A1 (en) * | 2006-05-08 | 2008-10-09 | Yuelian Xu | Substituted azaspiro derivatives |
| JP2009537596A (ja) * | 2006-05-23 | 2009-10-29 | ハイ ポイント ファーマシューティカルズ，リミティド ライアビリティ カンパニー | ６−（４−シクロプロピルピペリジン−１−イル）−２’−メチル−［３，４’］−ビピリジン及びその医薬としての使用 |
| JP2009544579A (ja) | 2006-06-29 | 2009-12-17 | ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ | 置換ベンジルアミン化合物 |
| WO2009039431A2 (en) | 2007-09-21 | 2009-03-26 | Neurogen Corporation | Substituted aryl-fused spirocyclic amines |
| CA2702834C (en) | 2007-10-17 | 2013-01-15 | Sanofi-Aventis | Substituted n-phenyl-pyrrolidinylmethylpyrrolidine amides and therapeutic use thereof |
| AU2008312638B2 (en) | 2007-10-17 | 2013-05-16 | Sanofi-Aventis | Substituted N-phenyl-bipyrrolidine carboxamides and therapeutic use thereof |
| MY151348A (en) * | 2007-10-17 | 2014-05-15 | Sanofi Aventis | Substituted n-phenyl-bipyrrolidine carboxamides and therapeutic use thereof |
| AR074466A1 (es) | 2008-12-05 | 2011-01-19 | Sanofi Aventis | Piperidina espiro pirrolidinona y piperidinona sustituidas y su uso terapeutico en enfermedades mediadas por la modulacion de los receptores h3. |
-
2009
- 2009-12-03 AR ARP090104667A patent/AR074467A1/es unknown
- 2009-12-04 CN CN200980148490.7A patent/CN102239170B/zh active Active
- 2009-12-04 MA MA33989A patent/MA32945B1/fr unknown
- 2009-12-04 RU RU2011127382/04A patent/RU2519778C2/ru not_active IP Right Cessation
- 2009-12-04 PE PE2011001127A patent/PE20110773A1/es not_active Application Discontinuation
- 2009-12-04 TW TW098141444A patent/TWI441826B/zh not_active IP Right Cessation
- 2009-12-04 WO PCT/US2009/066666 patent/WO2010065798A1/en not_active Ceased
- 2009-12-04 MY MYPI20112068 patent/MY150789A/en unknown
- 2009-12-04 EP EP09775421.2A patent/EP2373659B1/en active Active
- 2009-12-04 NZ NZ593150A patent/NZ593150A/xx not_active IP Right Cessation
- 2009-12-04 PA PA20098852301A patent/PA8852301A1/es unknown
- 2009-12-04 ES ES09775421.2T patent/ES2507574T3/es active Active
- 2009-12-04 UA UAA201108412A patent/UA104880C2/uk unknown
- 2009-12-04 CA CA2745715A patent/CA2745715C/en not_active Expired - Fee Related
- 2009-12-04 KR KR1020117014404A patent/KR101682889B1/ko not_active Expired - Fee Related
- 2009-12-04 MX MX2011004791A patent/MX2011004791A/es active IP Right Grant
- 2009-12-04 AU AU2009322243A patent/AU2009322243B2/en not_active Ceased
- 2009-12-04 JP JP2011539715A patent/JP5410544B2/ja active Active
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2011
- 2011-05-05 ZA ZA2011/03261A patent/ZA201103261B/en unknown
- 2011-05-06 TN TN2011000223A patent/TN2011000223A1/fr unknown
- 2011-05-27 CR CR20110289A patent/CR20110289A/es unknown
- 2011-05-31 IL IL213292A patent/IL213292A/en not_active IP Right Cessation
- 2011-06-01 DO DO2011000166A patent/DOP2011000166A/es unknown
- 2011-06-02 CO CO11068492A patent/CO6390059A2/es active IP Right Grant
- 2011-06-02 US US13/151,925 patent/US8217052B2/en active Active
- 2011-06-03 EC EC2011011109A patent/ECSP11011109A/es unknown
- 2011-06-03 HN HN2011001487A patent/HN2011001487A/es unknown
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2012
- 2012-05-30 US US13/483,503 patent/US8383814B2/en active Active
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